IL245467B - A modified t cell receptor, or antigen-binding fragment thereof, a therapeutic agent comprising the same and uses thereof - Google Patents

A modified t cell receptor, or antigen-binding fragment thereof, a therapeutic agent comprising the same and uses thereof

Info

Publication number
IL245467B
IL245467B IL245467A IL24546716A IL245467B IL 245467 B IL245467 B IL 245467B IL 245467 A IL245467 A IL 245467A IL 24546716 A IL24546716 A IL 24546716A IL 245467 B IL245467 B IL 245467B
Authority
IL
Israel
Prior art keywords
antigen
binds
receptor
cells
modified
Prior art date
Application number
IL245467A
Other languages
English (en)
Hebrew (he)
Other versions
IL245467A0 (en
Original Assignee
Hutchinson Fred Cancer Res
Univ Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hutchinson Fred Cancer Res, Univ Illinois filed Critical Hutchinson Fred Cancer Res
Publication of IL245467A0 publication Critical patent/IL245467A0/en
Publication of IL245467B publication Critical patent/IL245467B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL245467A 2013-11-22 2016-05-04 A modified t cell receptor, or antigen-binding fragment thereof, a therapeutic agent comprising the same and uses thereof IL245467B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361907887P 2013-11-22 2013-11-22
PCT/US2014/066903 WO2015077615A1 (en) 2013-11-22 2014-11-21 Engineered high-affinity human t cell receptors

Publications (2)

Publication Number Publication Date
IL245467A0 IL245467A0 (en) 2016-06-30
IL245467B true IL245467B (en) 2020-04-30

Family

ID=53180203

Family Applications (2)

Application Number Title Priority Date Filing Date
IL245467A IL245467B (en) 2013-11-22 2016-05-04 A modified t cell receptor, or antigen-binding fragment thereof, a therapeutic agent comprising the same and uses thereof
IL245468A IL245468B (en) 2013-11-22 2016-05-04 A modified t cell receptor, or antigen-binding fragment thereof, a therapeutic agent comprises the same and uses thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL245468A IL245468B (en) 2013-11-22 2016-05-04 A modified t cell receptor, or antigen-binding fragment thereof, a therapeutic agent comprises the same and uses thereof

Country Status (20)

Country Link
US (4) US10023625B2 (enExample)
EP (2) EP3071593B1 (enExample)
JP (4) JP6697386B2 (enExample)
KR (2) KR20160085345A (enExample)
CN (2) CN105873945B (enExample)
AU (4) AU2014352826B2 (enExample)
BR (1) BR112016011567A2 (enExample)
CA (2) CA2930852C (enExample)
DK (1) DK3071593T3 (enExample)
ES (1) ES2729406T3 (enExample)
IL (2) IL245467B (enExample)
MX (3) MX371202B (enExample)
PL (1) PL3071593T3 (enExample)
PT (1) PT3071593T (enExample)
RU (2) RU2729383C2 (enExample)
SA (1) SA516371174B1 (enExample)
SG (2) SG10201804335QA (enExample)
TR (1) TR201908404T4 (enExample)
WO (2) WO2015077607A1 (enExample)
ZA (2) ZA201603116B (enExample)

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RU2019116312A (ru) * 2016-11-14 2020-12-14 Фред Хатчинсон Кэнсер Рисерч Сентер Высокоаффинные tcr, специфичные к t-антигену полиомавируса клеток меркеля, и их применения
CA3055983A1 (en) * 2017-03-15 2018-09-20 Fred Hutchinson Cancer Research Center High affinity mage-a1-specific tcrs and uses thereof
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JP7181517B2 (ja) * 2018-01-23 2022-12-01 国立大学法人三重大学 Ｔ細胞レセプター
CN112739339B (zh) * 2018-07-23 2024-12-27 海德堡医药研究有限责任公司 抗cd137抗体药物缀合物(adc)在同种异体细胞疗法中的用途
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Also Published As

Publication number Publication date
SG10201804335QA (en) 2018-06-28
CN105873945A (zh) 2016-08-17
CA2930852C (en) 2024-01-23
JP2022023196A (ja) 2022-02-07
JP6697386B2 (ja) 2020-05-20
EP3071593A4 (en) 2017-05-03
RU2729383C2 (ru) 2020-08-06
SA516371174B1 (ar) 2019-04-14
US10344075B2 (en) 2019-07-09
CN105873945B (zh) 2020-07-17
IL245467A0 (en) 2016-06-30
MX2021006932A (es) 2021-07-07
EP3071594A1 (en) 2016-09-28
SG10201804330YA (en) 2018-07-30
KR20160085345A (ko) 2016-07-15
CA2930852A1 (en) 2015-05-28
WO2015077615A1 (en) 2015-05-28
MX371202B (es) 2020-01-22
US10023625B2 (en) 2018-07-17
AU2021202274A1 (en) 2021-05-06
US20160280755A1 (en) 2016-09-29
IL245468A0 (en) 2016-06-30
EP3071593A1 (en) 2016-09-28
CN105899530A (zh) 2016-08-24
WO2015077607A1 (en) 2015-05-28
CA2930847A1 (en) 2015-05-28
US20190055298A1 (en) 2019-02-21
AU2014352834B2 (en) 2019-08-29
KR20160087866A (ko) 2016-07-22
US20220396606A1 (en) 2022-12-15
IL245468B (en) 2020-10-29
AU2019272003A1 (en) 2019-12-19
TR201908404T4 (tr) 2019-07-22
NZ719720A (en) 2020-09-25
RU2016124179A (ru) 2017-12-27
US20160280756A1 (en) 2016-09-29
EP3071594A4 (en) 2017-05-03
PL3071593T3 (pl) 2019-11-29
DK3071593T3 (da) 2019-06-11
AU2014352826A1 (en) 2016-05-26
KR102415259B1 (ko) 2022-06-30
MX2016006620A (es) 2017-05-11
JP6476182B2 (ja) 2019-02-27
JP6970724B2 (ja) 2021-11-24
ZA201603116B (en) 2018-12-19
AU2019272003B2 (en) 2021-05-06
EP3071593B1 (en) 2019-03-13
ES2729406T3 (es) 2019-11-04
CN105899530B (zh) 2020-05-08
NZ719707A (en) 2020-09-25
MX383471B (es) 2025-03-14
BR112016011567A2 (pt) 2017-10-24
AU2014352826B2 (en) 2019-08-01
AU2014352834A1 (en) 2016-05-26
JP2017501129A (ja) 2017-01-12
RU2016124163A (ru) 2017-12-27
ZA201603169B (en) 2020-05-27
RU2740648C2 (ru) 2021-01-19
JP2017501130A (ja) 2017-01-12
PT3071593T (pt) 2019-06-27
MX2016006625A (es) 2016-12-02
BR112016011583A2 (pt) 2017-09-26
JP2020007374A (ja) 2020-01-16

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