KR20160085345A - 조작된 고-친화도의 인간 t 세포 수용체 - Google Patents

조작된 고-친화도의 인간 t 세포 수용체 Download PDF

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KR20160085345A
KR20160085345A KR1020167016132A KR20167016132A KR20160085345A KR 20160085345 A KR20160085345 A KR 20160085345A KR 1020167016132 A KR1020167016132 A KR 1020167016132A KR 20167016132 A KR20167016132 A KR 20167016132A KR 20160085345 A KR20160085345 A KR 20160085345A
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tcr
cell
cell receptor
modified
antigen
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Korean (ko)
Inventor
시나 엔. 스미스
다니엘 티. 해리스
데이비드 엠. 크란츠
토마스 엠. 슈미트
필립 디. 그린버그
Original Assignee
더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈
프레드 헛친슨 켄서 리서치 센터
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Publication of KR20160085345A publication Critical patent/KR20160085345A/ko
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747Apoptosis related proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020167016132A 2013-11-22 2014-11-21 조작된 고-친화도의 인간 t 세포 수용체 Ceased KR20160085345A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361907887P 2013-11-22 2013-11-22
US61/907,887 2013-11-22
PCT/US2014/066903 WO2015077615A1 (en) 2013-11-22 2014-11-21 Engineered high-affinity human t cell receptors

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KR20160085345A true KR20160085345A (ko) 2016-07-15

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KR1020167016131A Active KR102415259B1 (ko) 2013-11-22 2014-11-21 조작된 고-친화도의 인간 t 세포 수용체

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US (4) US10023625B2 (enExample)
EP (2) EP3071594A4 (enExample)
JP (4) JP6476182B2 (enExample)
KR (2) KR20160085345A (enExample)
CN (2) CN105873945B (enExample)
AU (4) AU2014352834B2 (enExample)
BR (1) BR112016011567A2 (enExample)
CA (2) CA2930847A1 (enExample)
DK (1) DK3071593T3 (enExample)
ES (1) ES2729406T3 (enExample)
IL (2) IL245467B (enExample)
MX (3) MX371202B (enExample)
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PT (1) PT3071593T (enExample)
RU (2) RU2729383C2 (enExample)
SA (1) SA516371174B1 (enExample)
SG (2) SG10201804335QA (enExample)
TR (1) TR201908404T4 (enExample)
WO (2) WO2015077607A1 (enExample)
ZA (2) ZA201603116B (enExample)

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US20160280755A1 (en) 2016-09-29
ZA201603116B (en) 2018-12-19
SG10201804335QA (en) 2018-06-28
US10023625B2 (en) 2018-07-17
US20190055298A1 (en) 2019-02-21
PT3071593T (pt) 2019-06-27
JP2017501130A (ja) 2017-01-12
JP6697386B2 (ja) 2020-05-20
IL245467B (en) 2020-04-30
MX2016006625A (es) 2016-12-02
JP2022023196A (ja) 2022-02-07
MX371202B (es) 2020-01-22
KR20160087866A (ko) 2016-07-22
RU2016124179A (ru) 2017-12-27
CA2930847A1 (en) 2015-05-28
EP3071593B1 (en) 2019-03-13
ZA201603169B (en) 2020-05-27
SG10201804330YA (en) 2018-07-30
US20220396606A1 (en) 2022-12-15
EP3071594A4 (en) 2017-05-03
DK3071593T3 (da) 2019-06-11
KR102415259B1 (ko) 2022-06-30
IL245467A0 (en) 2016-06-30
NZ719720A (en) 2020-09-25
CN105899530B (zh) 2020-05-08
TR201908404T4 (tr) 2019-07-22
EP3071593A1 (en) 2016-09-28
CA2930852A1 (en) 2015-05-28
JP2020007374A (ja) 2020-01-16
US20160280756A1 (en) 2016-09-29
WO2015077607A1 (en) 2015-05-28
IL245468B (en) 2020-10-29
PL3071593T3 (pl) 2019-11-29
CN105873945A (zh) 2016-08-17
JP6970724B2 (ja) 2021-11-24
AU2019272003A1 (en) 2019-12-19
RU2729383C2 (ru) 2020-08-06
BR112016011583A2 (pt) 2017-09-26
BR112016011567A2 (pt) 2017-10-24
RU2016124163A (ru) 2017-12-27
AU2014352834A1 (en) 2016-05-26
SA516371174B1 (ar) 2019-04-14
MX2021006932A (es) 2021-07-07
ES2729406T3 (es) 2019-11-04
AU2014352826B2 (en) 2019-08-01
US10344075B2 (en) 2019-07-09
IL245468A0 (en) 2016-06-30
EP3071593A4 (en) 2017-05-03
CN105899530A (zh) 2016-08-24
WO2015077615A1 (en) 2015-05-28
MX2016006620A (es) 2017-05-11
RU2740648C2 (ru) 2021-01-19
EP3071594A1 (en) 2016-09-28
AU2021202274A1 (en) 2021-05-06
AU2019272003B2 (en) 2021-05-06
CA2930852C (en) 2024-01-23
AU2014352826A1 (en) 2016-05-26
MX383471B (es) 2025-03-14
JP6476182B2 (ja) 2019-02-27
JP2017501129A (ja) 2017-01-12
CN105873945B (zh) 2020-07-17
NZ719707A (en) 2020-09-25
AU2014352834B2 (en) 2019-08-29

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