JP6689854B2 - Ｅ−セレクチンおよびｃｘｃｒ４ケモカイン受容体のヘテロ二官能性阻害剤 - Google Patents
Ｅ−セレクチンおよびｃｘｃｒ４ケモカイン受容体のヘテロ二官能性阻害剤 Download PDFInfo
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Classifications
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- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
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- C—CHEMISTRY; METALLURGY
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
Landscapes
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- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| JP7272956B2 (ja) | 2017-03-15 | 2023-05-12 | グリコミメティクス， インコーポレイテッド | Ｅ－セレクチンアンタゴニストとしてのガラクトピラノシル－シクロヘキシル誘導体 |
| EP3717013A1 (en) | 2017-11-30 | 2020-10-07 | GlycoMimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
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| EP3893936A2 (en) | 2018-12-10 | 2021-10-20 | GlycoMimetics, Inc. | Methods of treating hiv and aids and the elimination of latent reservoirs of hiv infection using selectin, galectin, and siglec antagonists |
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| EP3911307A1 (en) | 2019-01-14 | 2021-11-24 | GlycoMimetics, Inc. | Selectin or galectin antagonists for treating cytokine release syndrome and crs-induced neurotoxicity |
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| WO2021195465A1 (en) | 2020-03-27 | 2021-09-30 | Magnani John L | Treatment of acute respiratory distress syndrome and related conditions with antagonists of e-selectin |
| JP2023527411A (ja) | 2020-05-31 | 2023-06-28 | グリコミメティクス， インコーポレイテッド | がん細胞の負荷を減少させ、正常な造血を保護するための化合物および方法 |
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| WO2012151576A1 (en) | 2011-05-05 | 2012-11-08 | Robert Sackstein | Methods of treating complications and disorders associated with g-csf administration |
| WO2013096926A1 (en) * | 2011-12-22 | 2013-06-27 | Glycomimetics, Inc. | E-selectin antagonist compounds, compositions, and methods of use |
| CA2888527A1 (en) | 2012-10-31 | 2014-05-08 | Glycomimetics, Inc. | E-selectin antagonists compounds and methods of use |
| ES2668045T3 (es) | 2012-12-07 | 2018-05-16 | Glycomimetics, Inc. | Compuestos, composiciones y métodos que usan antagonistas de la E-selectina para la movilización de las células hematopoyéticas |
| WO2014149837A1 (en) | 2013-03-15 | 2014-09-25 | Glycomimetics, Inc. | Compounds and methods to enhance the oral availability of glycomimetics |
| CA2925119A1 (en) | 2013-09-30 | 2015-04-02 | Glycomimetics, Inc. | Methods and compositions for treating and/or preventing mucositis |
| US20160333043A1 (en) | 2014-01-17 | 2016-11-17 | Glycomimetics, Inc. | E-Selectin Antagonists Modified By Macrocycle Formation to the Galactose |
| US10519181B2 (en) | 2014-12-03 | 2019-12-31 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors |
| WO2016164394A1 (en) | 2015-04-08 | 2016-10-13 | Glycomimetics, Inc. | 2-halo-galactose-containing selectin antagonists |
| WO2017095904A1 (en) | 2015-12-02 | 2017-06-08 | Glycomimetics, Inc. | Heterobifunctional pan-selectin antagonists having a triazole linker |
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| SI3227310T1 (sl) | 2019-11-29 |
| CN107108679A (zh) | 2017-08-29 |
| CA2968391A1 (en) | 2016-06-09 |
| CN107108679B (zh) | 2020-10-23 |
| EP3227310B1 (en) | 2019-07-31 |
| US20170305951A1 (en) | 2017-10-26 |
| PL3227310T3 (pl) | 2020-02-28 |
| EP3227310A1 (en) | 2017-10-11 |
| CA2968391C (en) | 2022-04-26 |
| EP3227310A4 (en) | 2018-07-25 |
| BR112017011446A2 (pt) | 2018-02-27 |
| HUE045542T2 (hu) | 2019-12-30 |
| JP2017536395A (ja) | 2017-12-07 |
| KR20170085594A (ko) | 2017-07-24 |
| AU2015355136B2 (en) | 2020-06-25 |
| US10519181B2 (en) | 2019-12-31 |
| WO2016089872A1 (en) | 2016-06-09 |
| EP3569609A1 (en) | 2019-11-20 |
| KR102542750B1 (ko) | 2023-06-12 |
| CY1122038T1 (el) | 2020-10-14 |
| JP2020090553A (ja) | 2020-06-11 |
| LT3227310T (lt) | 2019-09-10 |
| AU2015355136A1 (en) | 2017-06-08 |
| DK3227310T3 (da) | 2019-09-30 |
| ES2754549T3 (es) | 2020-04-20 |
| PT3227310T (pt) | 2019-11-06 |
| NZ732034A (en) | 2022-03-25 |
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