JP6666858B2 - 滞留構造体および関連方法 - Google Patents

滞留構造体および関連方法 Download PDF

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Publication number
JP6666858B2
JP6666858B2 JP2016572445A JP2016572445A JP6666858B2 JP 6666858 B2 JP6666858 B2 JP 6666858B2 JP 2016572445 A JP2016572445 A JP 2016572445A JP 2016572445 A JP2016572445 A JP 2016572445A JP 6666858 B2 JP6666858 B2 JP 6666858B2
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Japan
Prior art keywords
retention structure
gastric retention
polymer
configuration
polymer element
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Japanese (ja)
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JP2017524662A5 (enExample
JP2017524662A (ja
Inventor
アンドリュー ベリンガー，
アンドリュー ベリンガー，
シーイー ザン，
シーイー ザン，
カルロ ジョバンニ トラバーソ，
カルロ ジョバンニ トラバーソ，
ランガー，　ロバート　エス．
ロバート エス． ランガー，
ステイシー モ，
ステイシー モ，
タイラー グラント，
タイラー グラント，
ムーサ ジャファリ，
ムーサ ジャファリ，
ディーン リャン グレッティグ，
ディーン リャン グレッティグ，
アンジェラ ディシッチオ，
アンジェラ ディシッチオ，
ローウェル エル． ジュニア ウッド，
ローウェル エル． ジュニア ウッド，
フィリップ エー． エックホフ，
フィリップ エー． エックホフ，
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Brigham and Womens Hospital Inc
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Brigham and Womens Hospital Inc
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Application filed by Brigham and Womens Hospital Inc filed Critical Brigham and Womens Hospital Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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    • A61K31/65—Tetracyclines
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
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    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4266—Polycondensates having carboxylic or carbonic ester groups in the main chain prepared from hydroxycarboxylic acids and/or lactones
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    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
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    • C08L33/02—Homopolymers or copolymers of acids; Metal or ammonium salts thereof
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    • C08L2203/00—Applications
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Prostheses (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2016572445A 2014-06-11 2015-06-11 滞留構造体および関連方法 Active JP6666858B2 (ja)

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Application Number Priority Date Filing Date Title
US201462010992P 2014-06-11 2014-06-11
US62/010,992 2014-06-11
PCT/US2015/035423 WO2015191920A1 (en) 2014-06-11 2015-06-11 Residence structures and related methods

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JP2020028439A Division JP2020097623A (ja) 2014-06-11 2020-02-21 滞留構造体および関連方法

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JP2017524662A JP2017524662A (ja) 2017-08-31
JP2017524662A5 JP2017524662A5 (enExample) 2019-02-07
JP6666858B2 true JP6666858B2 (ja) 2020-03-18

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JP2016572439A Pending JP2017519003A (ja) 2014-06-11 2015-06-11 自己集合滞留デバイスおよび関連方法
JP2017517216A Active JP6681390B2 (ja) 2014-06-11 2015-06-11 腸溶性エラストマー
JP2020000278A Pending JP2020056042A (ja) 2014-06-11 2020-01-06 腸溶性エラストマー
JP2020028439A Withdrawn JP2020097623A (ja) 2014-06-11 2020-02-21 滞留構造体および関連方法
JP2020074561A Active JP7337746B2 (ja) 2014-06-11 2020-04-20 自己集合滞留デバイスおよび関連方法
JP2021202475A Active JP7405820B2 (ja) 2014-06-11 2021-12-14 自己集合滞留デバイスおよび関連方法
JP2022197093A Active JP7629898B2 (ja) 2014-06-11 2022-12-09 滞留構造体および関連方法
JP2024227227A Pending JP2025041821A (ja) 2014-06-11 2024-12-24 滞留構造体および関連方法

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JP2017517216A Active JP6681390B2 (ja) 2014-06-11 2015-06-11 腸溶性エラストマー
JP2020000278A Pending JP2020056042A (ja) 2014-06-11 2020-01-06 腸溶性エラストマー
JP2020028439A Withdrawn JP2020097623A (ja) 2014-06-11 2020-02-21 滞留構造体および関連方法
JP2020074561A Active JP7337746B2 (ja) 2014-06-11 2020-04-20 自己集合滞留デバイスおよび関連方法
JP2021202475A Active JP7405820B2 (ja) 2014-06-11 2021-12-14 自己集合滞留デバイスおよび関連方法
JP2022197093A Active JP7629898B2 (ja) 2014-06-11 2022-12-09 滞留構造体および関連方法
JP2024227227A Pending JP2025041821A (ja) 2014-06-11 2024-12-24 滞留構造体および関連方法

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US (16) US10849853B2 (enExample)
EP (5) EP3154553B1 (enExample)
JP (9) JP6666858B2 (enExample)
KR (2) KR102471095B1 (enExample)
CN (4) CN106714893B (enExample)
AU (6) AU2015274456B2 (enExample)
BR (2) BR122021018078B1 (enExample)
CA (3) CA2951884A1 (enExample)
DK (2) DK3155024T4 (enExample)
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FI (2) FI3725357T3 (enExample)
IL (1) IL249435B (enExample)
MX (2) MX2016016406A (enExample)
NZ (1) NZ727659A (enExample)
PL (1) PL3725357T3 (enExample)
RU (1) RU2766335C2 (enExample)
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