JP6660369B2 - 神経障害を治療する方法 - Google Patents

神経障害を治療する方法 Download PDF

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JP6660369B2
JP6660369B2 JP2017501186A JP2017501186A JP6660369B2 JP 6660369 B2 JP6660369 B2 JP 6660369B2 JP 2017501186 A JP2017501186 A JP 2017501186A JP 2017501186 A JP2017501186 A JP 2017501186A JP 6660369 B2 JP6660369 B2 JP 6660369B2
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JP2017519807A5 (show.php
JP2017519807A (ja
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ジョン ジャハンガー アラム，
ジョン ジャハンガー アラム，
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イーアイピー ファーマ， エルエルシー
イーアイピー ファーマ， エルエルシー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017501186A 2014-07-09 2015-07-08 神経障害を治療する方法 Active JP6660369B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462022586P 2014-07-09 2014-07-09
US62/022,586 2014-07-09
PCT/US2015/039539 WO2016007616A1 (en) 2014-07-09 2015-07-08 Methods for treating neurologic disorders

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JP2017519807A JP2017519807A (ja) 2017-07-20
JP2017519807A5 JP2017519807A5 (show.php) 2018-08-16
JP6660369B2 true JP6660369B2 (ja) 2020-03-11

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JP2017501186A Active JP6660369B2 (ja) 2014-07-09 2015-07-08 神経障害を治療する方法

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US (1) US9579322B2 (show.php)
EP (1) EP3166610B1 (show.php)
JP (1) JP6660369B2 (show.php)
CN (3) CN113018300B (show.php)
WO (1) WO2016007616A1 (show.php)

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Publication number Priority date Publication date Assignee Title
WO2016007616A1 (en) 2014-07-09 2016-01-14 Eip Pharma, Llc Methods for treating neurologic disorders
EP3368040B1 (en) * 2015-10-26 2022-08-17 Eip Pharma, LLC Methods and compositions for recovery from stroke
EP3445369A4 (en) 2016-04-21 2020-03-04 Eip Pharma, LLC COMPOSITIONS AND METHODS FOR TREATING DEMENTIA
US11466008B2 (en) 2017-09-18 2022-10-11 Eip Pharma, Llc Co-crystals of neflamapimod (VX-745)
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
JP7012152B2 (ja) 2017-10-05 2022-02-10 フルクラム セラピューティクス，インコーポレイテッド Ｆｓｈｄの治療のためにｄｕｘ４および下流遺伝子発現を低減するｐ３８キナーゼ阻害剤
WO2019178153A1 (en) * 2018-03-12 2019-09-19 Eip Pharma, Llc Pharmaceutical formulations of neflamapimod
BR112021009653A2 (pt) * 2018-11-20 2021-08-17 Sparrow Pharmaceuticals, Inc. método para administrar um corticosteroide a um paciente em necessidade do mesmo, método para reduzir ou prevenir os efeitos colaterais associados à administração de corticosteroides a um paciente em necessidade do mesmo, e produto farmacêutico
US11471437B2 (en) 2019-06-18 2022-10-18 Opiant Pharmaceuticals, Inc. Compositions and methods for treating cannabinoid hyperemesis syndrome with a cannabinoid receptor antagonist
AU2020295410A1 (en) * 2019-06-18 2022-01-20 Indivior Uk Limited Compositions and methods for treating acute cannabinoid overdose with a cannabinoid receptor antagonist
CN115066245A (zh) * 2019-07-12 2022-09-16 Eip制药公司 用于治疗路易体痴呆的组合物和方法
WO2022099095A1 (en) * 2020-11-06 2022-05-12 Eip Pharma, Inc. Treatment of gait dysfunction in neurodegenerative disease
CN113616795B (zh) * 2021-08-31 2023-06-20 上海交通大学医学院附属瑞金医院 Pp2a激动剂防治由正常衰老或pp2a活性或表达降低所导致的精神障碍
KR20240104105A (ko) * 2021-11-05 2024-07-04 이아이피 파마 엘엘씨 루이소체 치매를 갖는 선택적 환자 집단의 치료
AU2024263955A1 (en) * 2023-04-27 2025-11-20 Remepy Health Ltd Digital therapeutics

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US6147080A (en) 1996-12-18 2000-11-14 Vertex Pharmaceuticals Incorporated Inhibitors of p38
CN100571701C (zh) * 2002-12-24 2009-12-23 贝卢斯健康(国际）有限公司 治疗β淀粉样蛋白相关疾病的治疗性制品
AU2005227192A1 (en) 2004-03-11 2005-10-06 Kythera Biopharmaceuticals, Inc. Compositions and methods for preventing and treating skin and hair conditions
US20050203111A1 (en) 2004-03-12 2005-09-15 Vvii Newco 2003, Inc. Compositions and methods for preventing and treating skin and hair conditions
WO2007054896A1 (en) 2005-11-08 2007-05-18 Ranbaxy Laboratories Limited Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
WO2008002465A2 (en) 2006-06-23 2008-01-03 The Feinstein Institute For Medical Research INHIBITORS OF Aβ AND SYNUCLEIN AGGREGATION
MX2010012848A (es) * 2008-06-03 2011-03-01 Intermune Inc Compuestos y metodos para tratar trastornos inflamatorios y fibroticos.
TW201300385A (zh) * 2011-04-08 2013-01-01 Afraxis Inc 用於治療ｃｎｓ病症和癌症的８－乙基－６－（芳基）吡啶并［２，３－ｄ］嘧啶－７（８ｈ）－酮
CN103842362B (zh) 2011-05-09 2017-05-24 爱普制药有限责任公司 用于治疗阿尔茨海默氏病的组合物和方法
WO2016007616A1 (en) 2014-07-09 2016-01-14 Eip Pharma, Llc Methods for treating neurologic disorders

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Publication number Publication date
EP3166610A1 (en) 2017-05-17
WO2016007616A1 (en) 2016-01-14
EP3166610B1 (en) 2022-11-02
CN113018300A (zh) 2021-06-25
US9579322B2 (en) 2017-02-28
CN113018300B (zh) 2025-11-25
CN106659723A (zh) 2017-05-10
EP3166610A4 (en) 2017-11-29
JP2017519807A (ja) 2017-07-20
US20160008364A1 (en) 2016-01-14
CN114010641A (zh) 2022-02-08

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