JP6653807B1 - プラズマローゲンを含有する組成物を製造する方法 - Google Patents
プラズマローゲンを含有する組成物を製造する方法 Download PDFInfo
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- JP6653807B1 JP6653807B1 JP2019541215A JP2019541215A JP6653807B1 JP 6653807 B1 JP6653807 B1 JP 6653807B1 JP 2019541215 A JP2019541215 A JP 2019541215A JP 2019541215 A JP2019541215 A JP 2019541215A JP 6653807 B1 JP6653807 B1 JP 6653807B1
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- plasmalogen
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Classifications
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- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
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- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
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- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/36—Freezing; Subsequent thawing; Cooling
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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Abstract
Description
〔1〕 (A)プラズマローゲン含有動物組織のアルコール抽出液を濃縮すること、及び
(B)前記(A)で得られた濃縮物を希釈した後、冷蔵静置すること
を含む、該動物組織由来のプラズマローゲンを含有する組成物を製造する方法。
〔2〕 前記(B)における冷蔵静置が、2〜15℃で行われる、〔1〕に記載の方法。
〔3〕 前記(B)における冷蔵静置が、1〜7日間行われる、〔1〕又は〔2〕に記載の方法。
〔4〕 プラズマローゲン含有動物組織が乾燥されたものである、〔1〕〜〔3〕のいずれかに記載の方法。
〔5〕 前記乾燥が、25〜59℃の風を前記動物組織に当てることによって行われる、〔4〕に記載の方法。
〔6〕 動物組織が、水産無脊椎動物由来である、〔1〕〜〔5〕のいずれかに記載の方法。
〔7〕 水産無脊椎動物が、脊索動物門尾索動物亜門ホヤ綱の水産無脊椎動物である、〔6〕に記載の方法。
〔8〕 脊索動物門尾索動物亜門ホヤ綱の水産無脊椎動物が、Halocynthia属の水産無脊椎動物である、〔7〕に記載の方法。
〔9〕 Halocynthia属の水産無脊椎動物が、マボヤ又はアカボヤである、〔8〕に記載の方法。
〔10〕 動物組織由来のプラズマローゲンが、ドコサヘキサエン酸又はエイコサペンタエン酸の脂肪族炭化水素部分に相当する基を含む、〔1〕〜〔9〕のいずれかに記載の方法。
〔11〕 組成物が食品組成物又は医薬組成物である、〔1〕〜〔10〕のいずれかに記載の方法。
〔12〕 組成物が食品組成物である、〔11〕に記載の方法。
〔13〕 食品組成物が、機能性表示食品若しくは特定保健用食品、又はこれら以外の健康食品である、〔12〕に記載の方法。
(A)プラズマローゲン含有動物組織のアルコール抽出液を濃縮すること、及び
(B)前記(A)で得られた濃縮物を希釈した後、冷蔵静置すること
を含む、該動物組織由来のプラズマローゲンを含有する組成物を製造する方法
を提供する。
R2は、脂肪族炭化水素基であって、通常脂肪酸の脂肪族炭化水素部分に相当する基である。R2としては、これらに限定されるものではないが、例えば、オクタデカジエン酸、オクタデカトリエン酸、エイコサテトラエン酸、エイコサペンタエン酸、ドコサテトラエン酸、ドコサペンタエン酸、ドコサヘキサエン酸などの脂肪酸の脂肪族炭化水素部分に相当する基が挙げられる。
Xは、極性基を示し、これらに限定されるものではないが、例えば、−CH2CH2N+H3、−CH2CH2N+(CH3)3、−CH2CH(NH2)COOHなどが挙げられる。
「アルコールを含有する溶媒」としては、アルコールのみからなる溶媒であってもよいし、アルコールとその他の溶媒との混合溶媒であってもよい。
抽出に用いられる「アルコール」としては、これらに限定されるものではないが、例えば、メタノール、エタノール、プロパノール、1−ブタノールなどの第一級アルコール;イソプロパノール、2−ブタノールなどの第二級アルコール;tert−ブタノールなどの第三級アルコールなどが挙げられ、これらは、単独で用いても、2種以上を組み合わせて用いてもよい。なかでも、食品組成物又は医薬組成物に適していることから、アルコールとしては、エタノールが好ましい。
アルコールと組み合わせて用いられる「その他の溶媒」としては、これらに限定されるものではないが、例えば、水(例えば、常水、天然水、水道水、硬水、軟水、イオン交換水、精製水、滅菌水などが挙げられ、これらは、単独で用いても、2種以上を組み合わせて用いてもよい);酢酸、プロパン酸、ブタン酸、ペンタン酸、ヘキサン酸、ヘプタン酸、オクタン酸、ノナン酸、オレイン酸などの脂肪酸又はそのエステル;これら以外のアセトンなどの親水性有機溶媒;クロロホルム、ヘキサン、ヘプタン、シクロヘキサン、石油エーテルなどの疎水性有機溶媒;などが挙げられ、これらは単独で用いても、2種以上を組み合わせて用いてもよい。なかでも、食品組成物又は医薬組成物に適していることから、アルコールと組み合わせて用いるその他の溶媒としては、水が好ましい。
プラズマローゲン含有動物組織を、アルコールを含有する溶媒中、約1〜50℃、好ましくは約20〜50℃、より好ましくは約40〜50℃で、約0.5〜24時間、好ましくは約1〜10時間、より好ましくは約2〜6時間、静置、混和又は撹拌などをすることより抽出処理をする。固液を、ストレーナーなどを用いて、固相1と液相1とに分離する。液相1を吸引濾過などの方法により濾過することで、固形物を取り除いて、液相2を得、これをアルコール抽出液として用いることができる。
或いは、抽出効率を高めるために、上記で分離した固相1に、アルコールを含有する溶媒を更に加え、約1〜50℃、好ましくは約20〜50℃、より好ましくは約40〜50℃で、約0.5〜24時間、好ましくは約1〜10時間、より好ましくは約2〜6時間、浸漬した後に、固液を、ストレーナーなどを用いて、固相2と液相3とに分離する。液相3を吸引濾過などの方法により濾過することで、固形物を取り除いて、液相4を得る。液相2と液相4を合わせたものをアルコール抽出液として用いることができる。
或いは、固相からのアルコールを含有する溶媒を用いた再抽出を更に繰り返すことで得られる1つ以上の液相と、上記の液相2及び4とを合わせたものを、アルコール抽出液として用いることができる。
水のpHの調整に使用するpH調整剤としては、これらに限定されるものではないが、例えば、酢酸、乳酸、酒石酸、シュウ酸、グリコール酸、リンゴ酸、クエン酸、コハク酸、フマル酸、リン酸、塩酸、シュウ酸、硫酸、硝酸、及びこれらの塩、水酸化ナトリウム、水酸化カリウム、炭酸水素ナトリウム、炭酸カリウムなどが挙げられ、これらは、単独で用いても、2種以上を組み合わせて用いてもよい。
脊索動物門尾索動物亜門の水産無脊椎動物としては、例えば、脊索動物門尾索動物亜門ホヤ綱、脊索動物門尾索動物亜門タリア綱、脊索動物門尾索動物亜門オタマボヤ綱などの水産無脊椎動物が挙げられる。
殻つきのマボヤを2等分し、冷風乾燥機内で、約45℃の風を約24時間当てて乾燥させた(冷風乾燥機内の温度(周囲温度)は、約45℃になる)。乾燥させたものにエタノールと水の混液(95容量%:5容量%)を加え、約40℃で約2時間、撹拌抽出した。固液をステンレスストレーナー(200メッシュ)により、固相1と液相1とに分離した。液相1を吸引濾過して、固形物を取り除いて、液相2を得た。固相1にはエタノールと水との混液(95容量%:5容量%)を加え、室温で約10時間、浸漬した後に、固液をステンレスストレーナー(200メッシュ)により、固相2と液相3とに分離した。液相3を吸引濾過して、固形物を取り除いて、液相4を得た。液相2と液相4を合わせ、約45℃で約24時間、減圧濃縮した。濃縮したものを、約5℃で約8日間、窒素バブリング下で、密閉状態にて保管した。その後、水を加えて希釈し、以下に示す温度で、約3日間、静置した。その後、約4℃でデカント処理をすることで上清を除去して液相5を回収し、液相5中のプラズマローゲン含量を、高速液体クロマトグラフィーにて測定した。
したがって、実施例1の製造方法は、プラズマローゲン含有動物組織由来のプラズマローゲン量が著しく低下することなく、該動物組織由来のプラズマローゲンを含有する組成物を製造することができるものである。
殻つきのマボヤを2等分し、冷風乾燥機内で、以下の表に示す温度の風を約24時間当てて乾燥させた(冷風乾燥機内の温度(周囲温度)は、各実施例又は比較例における風の温度とほぼ同じになる)。乾燥させたものにエタノールと水の混液(95容量%:5容量%)を加え、約40℃で約2時間、撹拌抽出した。固液をステンレスストレーナー(200メッシュ)により、固相1と液相1とに分離した。液相1を吸引濾過して、固形物を取り除いて、液相2を得た。固相1にはエタノールと水の混液(95容量%:5容量%)を加え、室温で約10時間、浸漬した後に、固液をステンレスストレーナー(200メッシュ)により、固相2と液相3とに分離した。液相3を吸引濾過して、固形物を取り除いて、液相4を得た。液相2と液相4を合わせた後、合わせた液相中のプラズマローゲン含量を、高速液体クロマトグラフィーにて測定した。
したがって、実施例2の製造方法は、該動物組織由来のプラズマローゲンをより高濃度に含有する組成物を製造することができるものである。
Claims (12)
- (A)プラズマローゲン含有動物組織のアルコール抽出液を濃縮すること、及び
(B)前記(A)で得られた濃縮物を、水又は水を含む溶媒で希釈した後、1〜7日間冷蔵静置すること
を含む、該動物組織由来のプラズマローゲンを含有する組成物を製造する方法。 - 前記(B)における冷蔵静置が、2〜15℃で行われる、請求項1に記載の方法。
- プラズマローゲン含有動物組織が乾燥されたものである、請求項1又は2に記載の方法。
- 前記乾燥が、25〜59℃の風を前記動物組織に当てることによって行われる、請求項3に記載の方法。
- 動物組織が、水産無脊椎動物由来である、請求項1〜4のいずれか一項に記載の方法。
- 水産無脊椎動物が、脊索動物門尾索動物亜門ホヤ綱の水産無脊椎動物である、請求項5に記載の方法。
- 脊索動物門尾索動物亜門ホヤ綱の水産無脊椎動物が、Halocynthia属の水産無脊椎動物である、請求項6に記載の方法。
- Halocynthia属の水産無脊椎動物が、マボヤ又はアカボヤである、請求項7に記載の方法。
- 動物組織由来のプラズマローゲンが、ドコサヘキサエン酸又はエイコサペンタエン酸の脂肪族炭化水素部分に相当する基を含む、請求項1〜8のいずれか一項に記載の方法。
- 組成物が食品組成物又は医薬組成物である、請求項1〜9のいずれか一項に記載の方法。
- 組成物が食品組成物である、請求項10に記載の方法。
- 食品組成物が、機能性表示食品若しくは特定保健用食品、又はこれら以外の健康食品である、請求項11に記載の方法。
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