JP6640126B2 - セレブロン及び他のｅ３ユビキチンリガーゼの立体構造の変化を誘導するための組成物及び方法 - Google Patents

セレブロン及び他のｅ３ユビキチンリガーゼの立体構造の変化を誘導するための組成物及び方法 Download PDF

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JP6640126B2
JP6640126B2 JP2016575370A JP2016575370A JP6640126B2 JP 6640126 B2 JP6640126 B2 JP 6640126B2 JP 2016575370 A JP2016575370 A JP 2016575370A JP 2016575370 A JP2016575370 A JP 2016575370A JP 6640126 B2 JP6640126 B2 JP 6640126B2
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crbn
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dimensional structure
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チャンバーライン フィリップ
チャンバーライン フィリップ
イー．キャザース ブライアン
イー．キャザース ブライアン
ロペズ‐ジラオナ アントニア
ロペズ‐ジラオナ アントニア
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
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    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment

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JP2016575370A 2014-06-27 2015-06-26 セレブロン及び他のｅ３ユビキチンリガーゼの立体構造の変化を誘導するための組成物及び方法 Active JP6640126B2 (ja)

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Application Number Priority Date Filing Date Title
US201462018445P 2014-06-27 2014-06-27
US62/018,445 2014-06-27
PCT/US2015/037980 WO2015200795A1 (en) 2014-06-27 2015-06-26 Compositions and methods for inducing conformational changes in cereblon other e3 ubiquitin ligases

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JP2017528690A JP2017528690A (ja) 2017-09-28
JP2017528690A5 JP2017528690A5 (enExample) 2018-08-02
JP6640126B2 true JP6640126B2 (ja) 2020-02-05

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US (3) US10092555B2 (enExample)
EP (2) EP3827836A1 (enExample)
JP (1) JP6640126B2 (enExample)
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WO (1) WO2015200795A1 (enExample)

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