JP6637885B2 - マイクロバイオームの特性解明、モニタリング、および処置のための方法およびシステム - Google Patents
マイクロバイオームの特性解明、モニタリング、および処置のための方法およびシステム Download PDFInfo
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Families Citing this family (169)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12279989B2 (en) | 2011-02-04 | 2025-04-22 | Seed Health, Inc. | Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity |
| US11998479B2 (en) | 2011-02-04 | 2024-06-04 | Seed Health, Inc. | Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure |
| US11844720B2 (en) | 2011-02-04 | 2023-12-19 | Seed Health, Inc. | Method and system to reduce the likelihood of dental caries and halitosis |
| US11951140B2 (en) | 2011-02-04 | 2024-04-09 | Seed Health, Inc. | Modulation of an individual's gut microbiome to address osteoporosis and bone disease |
| US11951139B2 (en) | 2015-11-30 | 2024-04-09 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
| US12257272B2 (en) | 2015-12-24 | 2025-03-25 | Seed Health, Inc. | Method and system for reducing the likelihood of developing depression in an individual |
| US10940169B2 (en) | 2015-11-30 | 2021-03-09 | Joseph E. Kovarik | Method for reducing the likelihood of developing cancer in an individual human being |
| GB201112091D0 (en) | 2011-07-14 | 2011-08-31 | Gt Biolog Ltd | Bacterial strains isolated from pigs |
| GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
| US10039777B2 (en) | 2012-03-20 | 2018-08-07 | Neuro-Lm Sas | Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders |
| GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
| CN105593372A (zh) | 2013-06-18 | 2016-05-18 | 普罗皮肤检测股份有限公司 | 基于皮肤菌群的分析的定制皮肤护理品和个人护理品 |
| GB2535034A (en) | 2013-07-21 | 2016-08-10 | Whole Biome Inc | Methods and systems for microbiome characterization, monitoring and treatment |
| US11213552B2 (en) | 2015-11-30 | 2022-01-04 | Joseph E. Kovarik | Method for treating an individual suffering from a chronic infectious disease and cancer |
| US11026982B2 (en) | 2015-11-30 | 2021-06-08 | Joseph E. Kovarik | Method for reducing the likelihood of developing bladder or colorectal cancer in an individual human being |
| US11969445B2 (en) | 2013-12-20 | 2024-04-30 | Seed Health, Inc. | Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH |
| US11998574B2 (en) | 2013-12-20 | 2024-06-04 | Seed Health, Inc. | Method and system for modulating an individual's skin microbiome |
| US12005085B2 (en) | 2013-12-20 | 2024-06-11 | Seed Health, Inc. | Probiotic method and composition for maintaining a healthy vaginal microbiome |
| US12246043B2 (en) | 2013-12-20 | 2025-03-11 | Seed Health, Inc. | Topical application to treat acne vulgaris |
| US12329783B2 (en) | 2013-12-20 | 2025-06-17 | Seed Health, Inc. | Method and system to improve the health of a person's skin microbiome |
| US11839632B2 (en) | 2013-12-20 | 2023-12-12 | Seed Health, Inc. | Topical application of CRISPR-modified bacteria to treat acne vulgaris |
| US11833177B2 (en) | 2013-12-20 | 2023-12-05 | Seed Health, Inc. | Probiotic to enhance an individual's skin microbiome |
| US11642382B2 (en) | 2013-12-20 | 2023-05-09 | Seed Health, Inc. | Method for treating an individual suffering from bladder cancer |
| US11529379B2 (en) | 2013-12-20 | 2022-12-20 | Seed Health, Inc. | Method and system for reducing the likelihood of developing colorectal cancer in an individual human being |
| US11672835B2 (en) | 2013-12-20 | 2023-06-13 | Seed Health, Inc. | Method for treating individuals having cancer and who are receiving cancer immunotherapy |
| US11980643B2 (en) | 2013-12-20 | 2024-05-14 | Seed Health, Inc. | Method and system to modify an individual's gut-brain axis to provide neurocognitive protection |
| US11826388B2 (en) | 2013-12-20 | 2023-11-28 | Seed Health, Inc. | Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation |
| US10361003B2 (en) | 2014-04-28 | 2019-07-23 | Yeda Research And Development Co. Ltd. | Method and apparatus for predicting response to food |
| EP3209803A4 (en) | 2014-10-21 | 2018-06-13 | Ubiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics |
| US10789334B2 (en) | 2014-10-21 | 2020-09-29 | Psomagen, Inc. | Method and system for microbial pharmacogenomics |
| US10325685B2 (en) | 2014-10-21 | 2019-06-18 | uBiome, Inc. | Method and system for characterizing diet-related conditions |
| US10311973B2 (en) | 2014-10-21 | 2019-06-04 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for autoimmune system conditions |
| US10346592B2 (en) | 2014-10-21 | 2019-07-09 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for neurological health issues |
| US10410749B2 (en) | 2014-10-21 | 2019-09-10 | uBiome, Inc. | Method and system for microbiome-derived characterization, diagnostics and therapeutics for cutaneous conditions |
| US9710606B2 (en) | 2014-10-21 | 2017-07-18 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for neurological health issues |
| US10265009B2 (en) | 2014-10-21 | 2019-04-23 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with microbiome taxonomic features |
| US10793907B2 (en) | 2014-10-21 | 2020-10-06 | Psomagen, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for endocrine system conditions |
| US10395777B2 (en) | 2014-10-21 | 2019-08-27 | uBiome, Inc. | Method and system for characterizing microorganism-associated sleep-related conditions |
| US10073952B2 (en) | 2014-10-21 | 2018-09-11 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for autoimmune system conditions |
| US9760676B2 (en) | 2014-10-21 | 2017-09-12 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for endocrine system conditions |
| US10388407B2 (en) | 2014-10-21 | 2019-08-20 | uBiome, Inc. | Method and system for characterizing a headache-related condition |
| US9758839B2 (en) | 2014-10-21 | 2017-09-12 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with microbiome functional features |
| US10357157B2 (en) | 2014-10-21 | 2019-07-23 | uBiome, Inc. | Method and system for microbiome-derived characterization, diagnostics and therapeutics for conditions associated with functional features |
| US11783914B2 (en) | 2014-10-21 | 2023-10-10 | Psomagen, Inc. | Method and system for panel characterizations |
| US9754080B2 (en) | 2014-10-21 | 2017-09-05 | uBiome, Inc. | Method and system for microbiome-derived characterization, diagnostics and therapeutics for cardiovascular disease conditions |
| US10381112B2 (en) | 2014-10-21 | 2019-08-13 | uBiome, Inc. | Method and system for characterizing allergy-related conditions associated with microorganisms |
| US10169541B2 (en) | 2014-10-21 | 2019-01-01 | uBiome, Inc. | Method and systems for characterizing skin related conditions |
| US10409955B2 (en) | 2014-10-21 | 2019-09-10 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for locomotor system conditions |
| US10777320B2 (en) | 2014-10-21 | 2020-09-15 | Psomagen, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for mental health associated conditions |
| US10366793B2 (en) | 2014-10-21 | 2019-07-30 | uBiome, Inc. | Method and system for characterizing microorganism-related conditions |
| SG10201903823QA (en) | 2014-10-31 | 2019-05-30 | Whole Biome Inc | Methods and compositions relating to microbial treatment and diagnosis of disorders |
| US10369174B2 (en) * | 2014-12-08 | 2019-08-06 | Gi Biome | Pharmaceutical composition for preventing or treating metabolic diseases, comprising bacteroides acidifaciens as active ingredient |
| EP3193901B1 (en) | 2014-12-23 | 2018-04-04 | 4D Pharma Research Limited | Pirin polypeptide and immune modulation |
| ES2658310T3 (es) | 2014-12-23 | 2018-03-09 | 4D Pharma Research Limited | Una cepa de bacteroides thetaiotaomicron y su uso en la reducción de la inflamación |
| AU2016248050A1 (en) * | 2015-04-13 | 2017-11-09 | Psomagen, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for neurological health issues |
| WO2016168359A1 (en) * | 2015-04-13 | 2016-10-20 | uBiome, Inc. | Method and system for microbiome-derived diaganostics and therapeutics for mental health associated conditions |
| EP3283086A4 (en) * | 2015-04-13 | 2019-04-24 | Ubiome Inc. | METHOD AND SYSTEM FOR MICROBIOMY-DERIVED DIAGNOSTICS AND THERAPEUTIC FOR DISEASES RELATED TO MICROBIOMIC FUNCTIONAL PROPERTIES |
| WO2016168350A1 (en) * | 2015-04-13 | 2016-10-20 | uBiome, Inc. | Method and system for microbiome-derived characterization, diagnostics and therapeutics for cutaneous conditions |
| CN107849616B (zh) * | 2015-04-13 | 2022-03-29 | 普梭梅根公司 | 用于功能特征相关的状况的微生物组来源的表征、诊断和治疗的方法及系统 |
| AU2016248063A1 (en) * | 2015-04-13 | 2017-11-09 | Psomagen, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for autoimmune system conditions |
| US10246753B2 (en) | 2015-04-13 | 2019-04-02 | uBiome, Inc. | Method and system for characterizing mouth-associated conditions |
| AU2016250102A1 (en) * | 2015-04-13 | 2017-11-09 | Psomagen, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with microbiome taxonomic features |
| WO2016168336A1 (en) * | 2015-04-14 | 2016-10-20 | uBiome, Inc. | Method and system for microbiome-derived characterization, diagnostics, and therapeutics for cardiovascular disease conditions |
| EP3283651A4 (en) | 2015-04-14 | 2018-12-05 | Ubiome Inc. | Method and system for microbiome-derived diagnostics and therapeutics for locomotor system conditions |
| EP3283087A4 (en) * | 2015-04-14 | 2019-03-13 | Ubiome Inc. | METHOD AND SYSTEM FOR MICROBIOMEDIVED DIAGNOSTICS AND THERAPEUTICS FOR DISEASES OF THE ENDOCRINE SYSTEM |
| US10788452B2 (en) | 2015-04-21 | 2020-09-29 | General Automation Lab Technologies Inc. | High resolution systems, kits, apparatus, and methods for bacterial community relationship determination and other high throughput microbiology applications |
| MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| MA55434B1 (fr) | 2015-06-15 | 2022-02-28 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| TWI759266B (zh) | 2015-06-15 | 2022-04-01 | 英商4D製藥研究有限公司 | 包含細菌菌株之組合物之用途 |
| MA41060B1 (fr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| PT3307288T (pt) | 2015-06-15 | 2019-10-17 | 4D Pharma Res Ltd | Composições compreendendo estirpes bacterianas |
| US11001900B2 (en) | 2015-06-30 | 2021-05-11 | Psomagen, Inc. | Method and system for characterization for female reproductive system-related conditions associated with microorganisms |
| JP6046849B1 (ja) * | 2015-07-21 | 2016-12-21 | ＴＡＫ−Ｃｉｒｃｕｌａｔｏｒ株式会社 | 身体状態の評価方法、情報の提示方法、および身体状態を改善又は予防する物質のスクリーニング方法 |
| CN108350502B (zh) * | 2015-09-09 | 2022-07-22 | 普梭梅根公司 | 用于口腔健康的源自微生物群系的诊断及治疗方法和系统 |
| US20190085396A1 (en) * | 2015-09-09 | 2019-03-21 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with gastrointestinal health |
| US20190087536A1 (en) * | 2015-09-09 | 2019-03-21 | uBiome. Inc | Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with thyroid health issues |
| EP3256609B1 (en) | 2015-09-15 | 2021-12-22 | Neogen Corporation | Methods of detecting listeria from an environmental sample |
| US10679725B2 (en) | 2015-09-17 | 2020-06-09 | Prodermiq, Inc. | Predicting skin age based on the analysis of skin flora and lifestyle data |
| MA45287A (fr) | 2015-11-20 | 2018-08-22 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| GB201520497D0 (en) | 2015-11-20 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201520631D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201520638D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| CN108472506B (zh) * | 2015-12-09 | 2022-03-29 | 普梭梅根公司 | 用于表征艰难梭菌相关病症的方法和系统 |
| EP3394289B1 (en) * | 2015-12-22 | 2025-03-26 | Vib Vzw | Microbial marker in spondyloarthritis diseases |
| EP3416653B1 (en) * | 2016-02-16 | 2022-05-25 | Tata Consultancy Services Limited | Method and system for early risk assessment of preterm delivery outcome |
| PT3313423T (pt) | 2016-03-04 | 2019-07-10 | 4D Pharma Plc | Composições que compreendem a estirpe blautia bacteriana para tratar a hipersensibilidade visceral |
| GB201612191D0 (en) | 2016-07-13 | 2016-08-24 | 4D Pharma Plc | Compositions comprising bacterial strains |
| WO2017156031A1 (en) * | 2016-03-07 | 2017-09-14 | uBiome, Inc. | Method and system for characterizing mouth-associated conditions |
| US10894990B2 (en) * | 2016-05-17 | 2021-01-19 | Shoreline Biome, Llc | High throughput method for identification and sequencing of unknown microbial and eukaryotic genomes from complex mixtures |
| WO2017205302A1 (en) | 2016-05-23 | 2017-11-30 | California Institute Of Technology | Regulate gut microbiota to treat neurodegenerative disorders |
| CN107541544A (zh) * | 2016-06-27 | 2018-01-05 | 卡尤迪生物科技（北京）有限公司 | 用于确定微生物分布谱的方法、系统、试剂盒、用途和组合物 |
| TWI802545B (zh) | 2016-07-13 | 2023-05-21 | 英商４Ｄ製藥有限公司 | 包含細菌菌株之組合物 |
| CN109475305B (zh) * | 2016-07-13 | 2022-01-25 | 普梭梅根公司 | 用于微生物药物基因组学的方法和系统 |
| CN109219656B (zh) * | 2016-09-06 | 2025-12-09 | 深圳华大生命科学研究院 | 长栖粪杆菌（Faecalibacterium longum）及其应用 |
| US11959125B2 (en) | 2016-09-15 | 2024-04-16 | Sun Genomics, Inc. | Universal method for extracting nucleic acid molecules from a diverse population of one or more types of microbes in a sample |
| CN109715059A (zh) * | 2016-09-16 | 2019-05-03 | 优比欧迈公司 | 用于组表征的方法和系统 |
| SG11201901730QA (en) | 2016-09-27 | 2019-03-28 | Ubiome Inc | Method and system for crispr-based library preparation and sequencing |
| CN109843435A (zh) * | 2016-09-28 | 2019-06-04 | 通用自动化实验技术公司 | 用于细菌群落关系确定和其他高通量微生物学应用的高分辨率系统、试剂盒、设备和方法 |
| US11015154B2 (en) | 2016-11-09 | 2021-05-25 | The Regents Of The University Of California | Methods for identifying interactions amongst microorganisms |
| JP6955860B2 (ja) * | 2016-11-30 | 2021-10-27 | 花王株式会社 | デリケートエリアのかぶれ判定方法 |
| GB201621123D0 (en) | 2016-12-12 | 2017-01-25 | 4D Pharma Plc | Compositions comprising bacterial strains |
| EP3775257A4 (en) * | 2016-12-15 | 2022-03-09 | Psomagen, Inc. | METHOD AND SYSTEM FOR CHARACTERIZING ALLERGY RELATED CONDITIONS ASSOCIATED WITH MICROORGANISMS |
| EP3776285A4 (en) * | 2016-12-16 | 2022-03-09 | Psomagen, Inc. | METHOD AND SYSTEM FOR CHARACTERIZING MICRO-ORGANISM-RELATED CONDITIONS |
| EP3587596B1 (en) * | 2017-02-24 | 2023-09-27 | MD Healthcare Inc. | Method for diagnosing chronic obstructive airway disease through bacterial metagenome analysis |
| KR20200019116A (ko) * | 2017-03-10 | 2020-02-21 | 프로더믹, 인코포레이티드 | 피부 균총의 분석에 기반한 맞춤형 피부 케어 제품 및 개인 케어 제품 |
| CN107034279A (zh) * | 2017-05-05 | 2017-08-11 | 中山大学 | 结核病微生物标志物在制备诊断结核病的试剂中的应用 |
| WO2018213204A1 (en) | 2017-05-15 | 2018-11-22 | Axial Biotherapeutics, Inc. | Inhibitors of microbially induced amyloid |
| RS61872B1 (sr) | 2017-05-22 | 2021-06-30 | 4D Pharma Res Ltd | Kompozicije koje sadrže bakterijske sojeve |
| WO2018215782A1 (en) | 2017-05-24 | 2018-11-29 | 4D Pharma Research Limited | Compositions comprising bacterial strain |
| EP3638271B1 (en) | 2017-06-14 | 2020-10-14 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
| RS63393B1 (sr) | 2017-06-14 | 2022-08-31 | 4D Pharma Res Ltd | Kompozicije koje sadrže bakterijske sojeve |
| CN109082479B (zh) * | 2017-06-14 | 2022-04-19 | 深圳华大生命科学研究院 | 从样本中鉴定微生物物种的方法和装置 |
| JP6840272B2 (ja) | 2017-06-14 | 2021-03-10 | フォーディー ファーマ リサーチ リミテッド４Ｄ Ｐｈａｒｍａ Ｒｅｓｅａｒｃｈ Ｌｉｍｉｔｅｄ | 細菌株を含む組成物 |
| AU2018323509A1 (en) * | 2017-08-28 | 2020-04-09 | Psomagen, Inc. | Method and system for characterization for female reproductive system-related conditions associated with microorganisms |
| WO2019041140A1 (zh) * | 2017-08-29 | 2019-03-07 | 深圳华大基因研究院 | 沙氏别样杆菌在制备预防和/或治疗脂质代谢性相关疾病组合物中的应用 |
| WO2019046646A1 (en) | 2017-08-30 | 2019-03-07 | Whole Biome Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT OF MICROBIOMA ASSOCIATED DISORDERS |
| KR101831416B1 (ko) * | 2017-09-04 | 2018-02-22 | 이화여자대학교 산학협력단 | 시료 내 미생물 군집의 변화를 이용한 조산 위험성 예측 |
| EP3707280A1 (en) * | 2017-11-06 | 2020-09-16 | Psomagen, Inc. | Control processes for microorganism-related characterization processes |
| WO2019094702A1 (en) | 2017-11-10 | 2019-05-16 | Cocoon Biotech Inc. | Ocular applications of silk-based products |
| WO2019118984A2 (en) | 2017-12-15 | 2019-06-20 | Solarea Bio, Inc. | Microbial compositions and methods for treating type 2 diabetes, obesity, and metabolic syndrome |
| WO2019125299A1 (en) * | 2017-12-22 | 2019-06-27 | Gutfeeling Labs Ab | Method for analysis of health status |
| PE20210322A1 (es) * | 2018-01-05 | 2021-02-18 | Nubiyota Llc | Composiciones que comprenden microbiota coseleccionada y metodos para su uso |
| WO2019151825A1 (ko) * | 2018-02-02 | 2019-08-08 | 주식회사 엠디헬스케어 | 비피도박테리움 속 세균 유래 나노소포 및 이의 용도 |
| WO2019156449A1 (ko) * | 2018-02-08 | 2019-08-15 | 주식회사 엠디헬스케어 | 락토코커스 속 세균 유래 나노소포 및 이의 용도 |
| KR102194286B1 (ko) | 2018-02-08 | 2020-12-22 | 주식회사 엠디헬스케어 | 락토코커스 속 세균 유래 나노소포 및 이의 용도 |
| KR102118989B1 (ko) * | 2018-03-05 | 2020-06-05 | 주식회사 엠디헬스케어 | 엔히드로박터 세균 유래 나노소포 및 이의 용도 |
| US11525164B2 (en) | 2018-03-27 | 2022-12-13 | The Trustees Of Columbia University In The City Of New York | Spatial metagenomic characterization of microbial biogeography |
| KR101872457B1 (ko) * | 2018-04-20 | 2018-06-28 | 이화여자대학교 산학협력단 | 혈액 내 미생물 군집의 변화를 이용한 조산 위험성의 예측 |
| EP4512910A3 (en) | 2018-06-29 | 2025-06-11 | Osaka University | Method of detecting conjunctival disease using ocular surface tissue, and aging biomarker |
| CN113164526A (zh) | 2018-07-19 | 2021-07-23 | 潘德勒姆治疗公司 | 用于微生物植入的方法和组合物 |
| CA3111795A1 (en) | 2018-09-05 | 2020-03-12 | Solarea Bio, Inc. | Methods and compositions for treating musculoskeletal diseases |
| US11980647B2 (en) | 2018-09-05 | 2024-05-14 | Solarea Bio, Inc. | Methods and compositions for treating musculoskeletal diseases, treating inflammation, and managing symptoms of menopause |
| EP3852738A4 (en) * | 2018-09-19 | 2022-06-22 | Baylor College of Medicine | ACCURATE DIAGNOSIS OF DIFFICULT CLOSTRIDIOIDES INFECTION USING SYSTEMS-BASED BIOMARKERS |
| CN109273046B (zh) * | 2018-10-19 | 2022-04-22 | 江苏东南证据科学研究院有限公司 | 一种基于概率统计模型的生物学全同胞鉴定方法 |
| CA3116010A1 (en) * | 2018-10-26 | 2020-04-30 | Sun Genomics Inc. | Universal method for extracting nucleic acid molecules from a diverse population of microbes |
| CN113348367A (zh) * | 2018-10-31 | 2021-09-03 | 卡尤迪医学检验实验室（北京）有限公司 | 用于预测早产状况的方法、系统和试剂盒 |
| EP3874068A4 (en) * | 2018-11-02 | 2022-08-17 | The Regents of the University of California | METHODS OF DIAGNOSIS AND TREATMENT OF CANCER USING NON-HUMAN NUCLEIC ACIDS |
| JPWO2020213732A1 (ja) * | 2019-04-18 | 2021-04-30 | 株式会社サイキンソー | 過敏性腸症候群の検査方法 |
| US11884958B2 (en) | 2019-04-30 | 2024-01-30 | Mayo Foundation For Medical Education And Research | Assessing and treating functional gastrointestinal disorders |
| CN110541026A (zh) * | 2019-08-17 | 2019-12-06 | 昆明医科大学第一附属医院 | 一种检测溃疡性结肠炎的生物标志物及应用 |
| WO2021044415A1 (en) * | 2019-09-02 | 2021-03-11 | My-Or Diagnostics Ltd. | Skin microbiome monitoring for improving systemic health |
| WO2021067941A2 (en) * | 2019-10-04 | 2021-04-08 | Vytelle, Llc | Compositions, methods, and kits for selection of donors and recipients for in vitro fertilization |
| CN110903999B (zh) * | 2019-10-23 | 2021-11-23 | 上海市第十人民医院 | 一株人类肠道分离的具核梭杆菌动物亚种菌株及其应用 |
| EP3839072A1 (en) * | 2019-12-17 | 2021-06-23 | Luxia Scientific | Bacterial combinations predictive of the activity of multiple sclerosis |
| WO2021156718A2 (en) * | 2020-01-29 | 2021-08-12 | Tata Consultancy Services Limited | Method and composition for microbiome based amelioration of skin associated autoimmune inflammatory diseases |
| US20210265029A1 (en) * | 2020-02-21 | 2021-08-26 | Zoe Global Limited | Generating microbiome fingerprints, dietary fingerprints, and microbiome ancestry |
| US20230178173A1 (en) * | 2020-03-30 | 2023-06-08 | The Regents Of The University Of California | Systems and methods for gut microbiome precision medicine |
| US20210319848A1 (en) * | 2020-04-08 | 2021-10-14 | Fred Hutchinson Cancer Research Center | Systems and methods for identifying associations between microbial strains and phenotypic features |
| CN114078568B (zh) * | 2020-09-14 | 2022-07-05 | 青岛欧易生物科技有限公司 | 基于iib型限制性内切酶特征的宏基因组测序数据处理系统及处理方法 |
| US12322493B2 (en) * | 2020-12-29 | 2025-06-03 | Kpn Innovations, Llc. | Systems and methods for generating a lifestyle-based disease prevention plan |
| US11139063B1 (en) | 2020-12-29 | 2021-10-05 | Kpn Innovations, Llc. | Systems and methods for generating a microbiome balance plan for prevention of bacterial infection |
| US12322491B2 (en) | 2021-03-01 | 2025-06-03 | Kpn Innovations, Llc. | System and method for generating a geographically linked nourishment program |
| KR102304402B1 (ko) * | 2021-03-26 | 2021-09-24 | 주식회사 에이치이엠파마 | 머신러닝 모델을 이용하여 비만 여부를 판별하는 방법 및 진단 장치 |
| JP7643909B2 (ja) * | 2021-03-30 | 2025-03-11 | 株式会社日立ハイテク | 分析装置、分析システム、分析方法、およびプログラム |
| CN112961807B (zh) * | 2021-03-30 | 2023-01-20 | 中国科学院成都生物研究所 | 一种微生物组合物及在促进青稞种子发芽和生长上的应用 |
| WO2022211796A1 (en) * | 2021-03-31 | 2022-10-06 | Neogen Corporation | Detecting salmonella from an environmental sample |
| CA3238788A1 (en) | 2021-11-22 | 2023-05-25 | Eric Michael Schott | Methods and compositions for treating musculoskeletal diseases, treating inflammation, and managing symptoms of menopause |
| CN114807392B (zh) * | 2021-12-08 | 2025-02-25 | 杭州拓宏生物科技有限公司 | 精神分裂症标志微生物及其应用 |
| US20230190834A1 (en) | 2021-12-21 | 2023-06-22 | Solarea Bio, Inc. | Immunomodulatory compositions comprising microbial entities |
| CN114373505B (zh) * | 2021-12-29 | 2022-11-01 | 浙江大学 | 一种基于肠道微生物早期预测奶牛产后亚临床酮病的系统 |
| KR102760485B1 (ko) * | 2022-01-03 | 2025-02-03 | 연세대학교 산학협력단 | 자궁내막증 진단을 위한 정보 제공 방법 |
| WO2023164493A1 (en) * | 2022-02-23 | 2023-08-31 | Jona, Inc. | System and method for using the microbiome to improve healthcare |
| US20250349433A1 (en) * | 2022-05-11 | 2025-11-13 | J. Craig Venter Institute, Inc. | Methods and systems for determining dental caries |
| JP7748113B2 (ja) * | 2022-12-14 | 2025-10-02 | イムノバイオーム インコーポレイテッド | マシンラーニングモデルを使用して特定の疾病に関連する微生物群集データを導出する方法 |
| CN115980346B (zh) * | 2022-12-26 | 2025-07-15 | 云南大学 | 一种基于金属有机框架材料构建比色免疫传感器检测新型冠状病毒的方法 |
| WO2024200517A1 (en) * | 2023-03-28 | 2024-10-03 | Zoe Limited | Microbiome and dietary fingerprints, and methods including directional alteration of microbiome composition |
| CN117965384B (zh) * | 2024-02-08 | 2025-11-21 | 北京林业大学 | 一种用于液化降解餐厨垃圾的降解菌及包含其的菌剂和应用 |
| CN118813503B (zh) * | 2024-09-19 | 2025-05-27 | 中国海洋大学 | 一种索氏鲸杆菌、索氏鲸杆菌后生元及其制备方法和应用 |
| CN119614730B (zh) * | 2025-02-17 | 2025-05-13 | 美益添生物医药(武汉)有限公司 | 一种与帕金森综合征相关的肠道菌群标志物及其应用 |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3625214A (en) | 1970-05-18 | 1971-12-07 | Alza Corp | Drug-delivery device |
| US4906474A (en) | 1983-03-22 | 1990-03-06 | Massachusetts Institute Of Technology | Bioerodible polyanhydrides for controlled drug delivery |
| US4789734A (en) | 1985-08-06 | 1988-12-06 | La Jolla Cancer Research Foundation | Vitronectin specific cell receptor derived from mammalian mesenchymal tissue |
| US4925673A (en) | 1986-08-18 | 1990-05-15 | Clinical Technologies Associates, Inc. | Delivery systems for pharmacological agents encapsulated with proteinoids |
| US6024983A (en) | 1986-10-24 | 2000-02-15 | Southern Research Institute | Composition for delivering bioactive agents for immune response and its preparation |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| US4897268A (en) | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| WO1994015635A1 (en) | 1993-01-11 | 1994-07-21 | Dana-Farber Cancer Institute | Inducing cytotoxic t lymphocyte responses |
| US6241983B1 (en) | 1994-10-28 | 2001-06-05 | Metagenics, Inc. | Bacteria-and fiber-containing composition for human gastrointestinal health |
| US5531989A (en) | 1994-10-28 | 1996-07-02 | Metagenics, Inc. | Immunoglobulin and fiber-containing composition for human gastrointestinal health |
| ID29150A (id) | 1999-01-15 | 2001-08-02 | Entpr Ireland Cs | Penggunaan lactobacillus salivarius |
| US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
| JP4580542B2 (ja) | 2000-05-17 | 2010-11-17 | 株式會社バイオニア | 肥満又は糖尿病治療用微生物及びその微生物を含む医薬組成物 |
| AUPQ899700A0 (en) | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
| WO2002085415A1 (en) | 2001-04-17 | 2002-10-31 | Biomatrix, Inc | Non-digestible sugar-coated products and process |
| US7101565B2 (en) | 2002-02-05 | 2006-09-05 | Corpak Medsystems, Inc. | Probiotic/prebiotic composition and delivery method |
| ITBO20020564A1 (it) | 2002-09-06 | 2004-03-07 | Alfa Wassermann Spa | Bifidobatteri e preparazioni che li contengono. |
| EP1600060A1 (en) | 2004-05-25 | 2005-11-30 | Cognis IP Management GmbH | Oral and/or topical compositions comprising prebiotics and fatty acid |
| US20060115465A1 (en) | 2004-10-29 | 2006-06-01 | Macfarlane George | Treatment of gastrointestinal disorders |
| JP5565991B2 (ja) | 2004-12-15 | 2014-08-06 | 株式会社島津製作所 | 微生物菌種推定システム及び方法 |
| CN101095698B (zh) | 2006-06-26 | 2010-12-01 | 青岛东海药业有限公司 | 酪酸梭菌防治便臭毒素引起的相关症状和疾病的用途 |
| WO2008076696A2 (en) | 2006-12-18 | 2008-06-26 | Washington University In St. Louis | The gut microbiome as a biomarker and therapeutic target for treating obesity or an obesity related disorder |
| BRPI0810087A2 (pt) | 2007-03-28 | 2014-10-21 | Alimentary Health Ltd | Cepas de bifidobacterium probióticas |
| KR20090127180A (ko) | 2007-03-28 | 2009-12-09 | 앨러멘터리 헬스 리미티드 | 프로바이오틱 비피도박테리움 스트레인 |
| EP1985712A1 (en) * | 2007-04-17 | 2008-10-29 | Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patiëntenzorg | Microbial population analysis |
| US8478544B2 (en) * | 2007-11-21 | 2013-07-02 | Cosmosid Inc. | Direct identification and measurement of relative populations of microorganisms with direct DNA sequencing and probabilistic methods |
| EP2110028A1 (en) | 2008-04-15 | 2009-10-21 | Nestec S.A. | Bifidobacterium longum and hippocampal BDNF expression |
| WO2010146568A2 (en) | 2009-06-19 | 2010-12-23 | Danisco A/S | Bifidobacteria for treating diabetes and related conditions |
| US9848760B2 (en) * | 2009-06-29 | 2017-12-26 | Gearbox, Llc | Devices for continual monitoring and introduction of gastrointestinal microbes |
| ES2708450T3 (es) | 2009-07-30 | 2019-04-09 | Dupont Nutrition Biosci Aps | Bacterias ácido lácticas y bifidobacterias para tratar endotoxemia |
| EP2289527B1 (en) | 2009-08-25 | 2018-02-21 | Nestec S.A. | Bifidobacterium longum and functional GI disorders |
| CN101792807B (zh) * | 2010-03-25 | 2012-12-05 | 复旦大学 | 一种微生物群落结构的分析方法 |
| FI20105478A0 (fi) | 2010-04-30 | 2010-04-30 | Valtion Teknillinen | Menetelmä tyypin 1 diabeteksen diagnosoimiseksi ja menetelmiä ja koostumuksia tyypin 1 diabeteksen puhkeamisen estämiseksi |
| US8951512B2 (en) | 2010-05-04 | 2015-02-10 | New York University | Methods for treating bone disorders by characterizing and restoring mammalian bacterial microbiota |
| WO2011151941A1 (ja) | 2010-06-04 | 2011-12-08 | 国立大学法人東京大学 | 制御性ｔ細胞の増殖または集積を誘導する作用を有する組成物 |
| ITMI20110793A1 (it) | 2011-05-09 | 2012-11-10 | Probiotical Spa | Ceppi di batteri probiotici e composizione sinbiotica contenente gli stessi destinata alla alimentazione dei neonati. |
| JP6116568B2 (ja) | 2011-08-30 | 2017-04-19 | アカデミッシュ メディッシュ セントラム | インスリン抵抗性を予防および／または処置する方法 |
| US20130121968A1 (en) * | 2011-10-03 | 2013-05-16 | Atossa Genetics, Inc. | Methods of combining metagenome and the metatranscriptome in multiplex profiles |
| FI20116008A0 (fi) | 2011-10-12 | 2011-10-12 | Maeyrae Maekinen Annika | Viskeraalisen rasvan estäminen ja diagnostisointi |
| IN2014DN07752A (enExample) | 2012-02-29 | 2015-05-15 | Ethicon Endo Surgery Inc | |
| EP3692999A1 (en) | 2012-03-17 | 2020-08-12 | The Regents of the University of California | Fast diagnosis and personalized treatments for acne |
| KR20150118084A (ko) | 2012-09-20 | 2015-10-21 | 프로테라 인코포레이티드 | 비만 및 비만 관련 질환을 치료하기 위한 프로바이오틱 조성물 및 방법 |
| WO2014075745A1 (en) | 2012-11-19 | 2014-05-22 | Université Catholique de Louvain | Use of akkermansia for treating metabolic disorders |
| US8906668B2 (en) | 2012-11-23 | 2014-12-09 | Seres Health, Inc. | Synergistic bacterial compositions and methods of production and use thereof |
| CN104955466A (zh) | 2012-11-23 | 2015-09-30 | 赛里斯治疗公司 | 协同细菌组合物和其制造方法和用途 |
| WO2014121304A1 (en) | 2013-02-04 | 2014-08-07 | Seres Health, Inc. | Compositions and methods |
| KR102222273B1 (ko) | 2013-02-04 | 2021-03-08 | 세레스 테라퓨틱스, 인코포레이티드 | 조성물 및 방법 |
| KR20150134356A (ko) | 2013-03-05 | 2015-12-01 | 리엑스유니버시테이트 그로닝겐 | 염증을 억제하기 위한 페칼리 박테리움 프라우스니치이 htf-f (dsm 26943)의 용도 |
| HK1220495A1 (zh) | 2013-03-14 | 2017-05-05 | Seres Therapeutics, Inc. | 从材料和组合物中检测和富集病原体的方法 |
| WO2014145958A2 (en) | 2013-03-15 | 2014-09-18 | Seres Health, Inc. | Network-based microbial compositions and methods |
| GB2535034A (en) | 2013-07-21 | 2016-08-10 | Whole Biome Inc | Methods and systems for microbiome characterization, monitoring and treatment |
| WO2015051323A1 (en) | 2013-10-03 | 2015-04-09 | Trustees Of The University Of Pennsylvania | Compositions comprising a defined microbiome and methods of use thereof |
| GB201319540D0 (en) | 2013-11-05 | 2013-12-18 | Optibiotix Health Ltd | Composition |
| GB201319525D0 (en) | 2013-11-05 | 2013-12-18 | Optibiotix Health Ltd | Composition |
| GB201319531D0 (en) | 2013-11-05 | 2013-12-18 | Optibiotix Health Ltd | Composition & methods of screening |
| GB201319538D0 (en) | 2013-11-05 | 2013-12-18 | Optibiotix Health Ltd | Composition |
| GB201319539D0 (en) | 2013-11-05 | 2013-12-18 | Optibiotix Health Ltd | Composition & methods of screening |
| EP3074027B1 (en) | 2013-11-25 | 2024-12-18 | Seres Therapeutics, Inc. | Synergistic bacterial compositions and methods of production and use thereof |
| EP3082431A4 (en) | 2013-12-16 | 2017-11-15 | Seres Therapeutics, Inc. | Bacterial compositions and methods of use thereof for treatment of immune system disorders |
| US20150246081A1 (en) | 2014-03-03 | 2015-09-03 | Shayne Kenneth Morris | Probiotics with methods for growth and use separately and in combination |
| FI127483B (en) | 2014-06-11 | 2018-07-13 | Gut Guide Oy | Microbial marker for celiac disease and related product |
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Free format text: JAPANESE INTERMEDIATE CODE: R250 |
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| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
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| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |