CN107849616B - 用于功能特征相关的状况的微生物组来源的表征、诊断和治疗的方法及系统 - Google Patents
用于功能特征相关的状况的微生物组来源的表征、诊断和治疗的方法及系统 Download PDFInfo
- Publication number
- CN107849616B CN107849616B CN201680034379.5A CN201680034379A CN107849616B CN 107849616 B CN107849616 B CN 107849616B CN 201680034379 A CN201680034379 A CN 201680034379A CN 107849616 B CN107849616 B CN 107849616B
- Authority
- CN
- China
- Prior art keywords
- kegg
- derived feature
- genus
- family
- feature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 244000005700 microbiome Species 0.000 title claims abstract description 170
- 238000000034 method Methods 0.000 title claims abstract description 161
- 238000012512 characterization method Methods 0.000 title claims abstract description 85
- 238000003745 diagnosis Methods 0.000 title description 27
- 238000011282 treatment Methods 0.000 title description 16
- 239000000203 mixture Substances 0.000 claims abstract description 67
- 108090000623 proteins and genes Proteins 0.000 claims description 58
- 230000004060 metabolic process Effects 0.000 claims description 54
- 238000009826 distribution Methods 0.000 claims description 45
- 230000006870 function Effects 0.000 claims description 40
- 230000015572 biosynthetic process Effects 0.000 claims description 38
- 238000012545 processing Methods 0.000 claims description 37
- 230000015556 catabolic process Effects 0.000 claims description 29
- 230000003321 amplification Effects 0.000 claims description 26
- 238000006731 degradation reaction Methods 0.000 claims description 26
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 26
- 238000012163 sequencing technique Methods 0.000 claims description 24
- 150000007523 nucleic acids Chemical class 0.000 claims description 23
- 238000004458 analytical method Methods 0.000 claims description 22
- 230000001580 bacterial effect Effects 0.000 claims description 22
- 241000606125 Bacteroides Species 0.000 claims description 21
- 208000015943 Coeliac disease Diseases 0.000 claims description 21
- 108020004707 nucleic acids Proteins 0.000 claims description 21
- 102000039446 nucleic acids Human genes 0.000 claims description 21
- 235000018102 proteins Nutrition 0.000 claims description 21
- 102000004169 proteins and genes Human genes 0.000 claims description 21
- 241000588921 Enterobacteriaceae Species 0.000 claims description 18
- 241000194017 Streptococcus Species 0.000 claims description 18
- 230000000153 supplemental effect Effects 0.000 claims description 18
- 230000037361 pathway Effects 0.000 claims description 16
- 241000894007 species Species 0.000 claims description 16
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 claims description 16
- 208000030507 AIDS Diseases 0.000 claims description 14
- 241000186660 Lactobacillus Species 0.000 claims description 14
- 229940039696 lactobacillus Drugs 0.000 claims description 13
- 230000002068 genetic effect Effects 0.000 claims description 12
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 10
- 241001261005 Verrucomicrobia Species 0.000 claims description 10
- 206010017758 gastric cancer Diseases 0.000 claims description 10
- 201000011549 stomach cancer Diseases 0.000 claims description 10
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 claims description 9
- 230000001747 exhibiting effect Effects 0.000 claims description 9
- 210000004027 cell Anatomy 0.000 claims description 8
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims description 8
- 238000007619 statistical method Methods 0.000 claims description 8
- 229960005322 streptomycin Drugs 0.000 claims description 8
- 238000013519 translation Methods 0.000 claims description 8
- 241000186361 Actinobacteria <class> Species 0.000 claims description 7
- 102000004190 Enzymes Human genes 0.000 claims description 7
- 108090000790 Enzymes Proteins 0.000 claims description 7
- 230000002776 aggregation Effects 0.000 claims description 7
- 238000004220 aggregation Methods 0.000 claims description 7
- 238000013518 transcription Methods 0.000 claims description 7
- 230000035897 transcription Effects 0.000 claims description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- 241000605861 Prevotella Species 0.000 claims description 6
- 229960004050 aminobenzoic acid Drugs 0.000 claims description 6
- 238000006065 biodegradation reaction Methods 0.000 claims description 6
- 210000000750 endocrine system Anatomy 0.000 claims description 6
- 230000010076 replication Effects 0.000 claims description 6
- 230000019491 signal transduction Effects 0.000 claims description 6
- 230000032258 transport Effects 0.000 claims description 6
- 229940088594 vitamin Drugs 0.000 claims description 6
- 239000011782 vitamin Substances 0.000 claims description 6
- 235000013343 vitamin Nutrition 0.000 claims description 6
- 229930003231 vitamin Natural products 0.000 claims description 6
- 206010028980 Neoplasm Diseases 0.000 claims description 5
- 241000194020 Streptococcus thermophilus Species 0.000 claims description 5
- 230000037354 amino acid metabolism Effects 0.000 claims description 5
- 201000011510 cancer Diseases 0.000 claims description 5
- 230000023852 carbohydrate metabolic process Effects 0.000 claims description 5
- 235000021256 carbohydrate metabolism Nutrition 0.000 claims description 5
- 230000002596 correlated effect Effects 0.000 claims description 5
- 230000007613 environmental effect Effects 0.000 claims description 5
- 230000037356 lipid metabolism Effects 0.000 claims description 5
- 230000004770 neurodegeneration Effects 0.000 claims description 5
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 5
- 230000028706 ribosome biogenesis Effects 0.000 claims description 5
- 229930000044 secondary metabolite Natural products 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 5
- 241000186000 Bifidobacterium Species 0.000 claims description 4
- 241000606161 Chlamydia Species 0.000 claims description 4
- YNQLUTRBYVCPMQ-UHFFFAOYSA-N Ethylbenzene Chemical compound CCC1=CC=CC=C1 YNQLUTRBYVCPMQ-UHFFFAOYSA-N 0.000 claims description 4
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 4
- 241000192041 Micrococcus Species 0.000 claims description 4
- 241000919947 Microspongium Species 0.000 claims description 4
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 4
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 4
- 241001430183 Veillonellaceae Species 0.000 claims description 4
- 238000004891 communication Methods 0.000 claims description 4
- 230000037149 energy metabolism Effects 0.000 claims description 4
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 4
- 230000006801 homologous recombination Effects 0.000 claims description 4
- 238000002744 homologous recombination Methods 0.000 claims description 4
- 208000026278 immune system disease Diseases 0.000 claims description 4
- 230000010365 information processing Effects 0.000 claims description 4
- 230000003993 interaction Effects 0.000 claims description 4
- 229940087305 limonene Drugs 0.000 claims description 4
- 235000001510 limonene Nutrition 0.000 claims description 4
- 230000033607 mismatch repair Effects 0.000 claims description 4
- 229960003966 nicotinamide Drugs 0.000 claims description 4
- 235000005152 nicotinamide Nutrition 0.000 claims description 4
- 239000011570 nicotinamide Substances 0.000 claims description 4
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 4
- 230000008439 repair process Effects 0.000 claims description 4
- UZKQTCBAMSWPJD-UQCOIBPSSA-N trans-Zeatin Natural products OCC(/C)=C\CNC1=NC=NC2=C1N=CN2 UZKQTCBAMSWPJD-UQCOIBPSSA-N 0.000 claims description 4
- UZKQTCBAMSWPJD-FARCUNLSSA-N trans-zeatin Chemical compound OCC(/C)=C/CNC1=NC=NC2=C1N=CN2 UZKQTCBAMSWPJD-FARCUNLSSA-N 0.000 claims description 4
- 229940023877 zeatin Drugs 0.000 claims description 4
- 241001112695 Clostridiales Species 0.000 claims description 3
- 108010006519 Molecular Chaperones Proteins 0.000 claims description 3
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 claims description 3
- 102000035195 Peptidases Human genes 0.000 claims description 3
- 108091005804 Peptidases Proteins 0.000 claims description 3
- 108010013639 Peptidoglycan Proteins 0.000 claims description 3
- 241000909295 Selenomonadales Species 0.000 claims description 3
- 229940024606 amino acid Drugs 0.000 claims description 3
- 235000001014 amino acid Nutrition 0.000 claims description 3
- 150000001413 amino acids Chemical class 0.000 claims description 3
- 229940064734 aminobenzoate Drugs 0.000 claims description 3
- 230000030833 cell death Effects 0.000 claims description 3
- 230000010261 cell growth Effects 0.000 claims description 3
- 230000033077 cellular process Effects 0.000 claims description 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 3
- 229930195729 fatty acid Natural products 0.000 claims description 3
- 239000000194 fatty acid Substances 0.000 claims description 3
- 150000004665 fatty acids Chemical class 0.000 claims description 3
- 230000004110 gluconeogenesis Effects 0.000 claims description 3
- 150000004676 glycans Chemical class 0.000 claims description 3
- 230000034659 glycolysis Effects 0.000 claims description 3
- 229910001410 inorganic ion Inorganic materials 0.000 claims description 3
- 230000037427 ion transport Effects 0.000 claims description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- 230000037360 nucleotide metabolism Effects 0.000 claims description 3
- 108091008146 restriction endonucleases Proteins 0.000 claims description 3
- 230000001131 transforming effect Effects 0.000 claims description 3
- 239000002676 xenobiotic agent Substances 0.000 claims description 3
- 230000002034 xenobiotic effect Effects 0.000 claims description 3
- INAPMGSXUVUWAF-UHFFFAOYSA-L (2,3,4,5,6-pentahydroxycyclohexyl) phosphate Chemical compound OC1C(O)C(O)C(OP([O-])([O-])=O)C(O)C1O INAPMGSXUVUWAF-UHFFFAOYSA-L 0.000 claims description 2
- XEQLFNPSYWZPOW-NUOYRARPSA-N (2r)-4-amino-n-[(1r,2s,3r,4r,5s)-5-amino-4-[(2r,3r,4r,5s,6r)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-2-hydroxycyclohexyl]-2-hydroxybutanamide Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O[C@@H]1[C@@H]([C@H](O)[C@@H](CO)O1)O)O)NC(=O)[C@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1N XEQLFNPSYWZPOW-NUOYRARPSA-N 0.000 claims description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 2
- XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical compound OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 claims description 2
- 241000186046 Actinomyces Species 0.000 claims description 2
- 241000222382 Agaricomycotina Species 0.000 claims description 2
- 239000004475 Arginine Substances 0.000 claims description 2
- 241000927512 Barnesiella Species 0.000 claims description 2
- 229930183180 Butirosin Natural products 0.000 claims description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 claims description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
- 241000863012 Caulobacter Species 0.000 claims description 2
- 241000193403 Clostridium Species 0.000 claims description 2
- 241000222356 Coriolus Species 0.000 claims description 2
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 2
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims description 2
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 claims description 2
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 claims description 2
- WHUUTDBJXJRKMK-GSVOUGTGSA-N D-glutamic acid Chemical compound OC(=O)[C@H](N)CCC(O)=O WHUUTDBJXJRKMK-GSVOUGTGSA-N 0.000 claims description 2
- 229930182847 D-glutamic acid Natural products 0.000 claims description 2
- ZDXPYRJPNDTMRX-GSVOUGTGSA-N D-glutamine Chemical compound OC(=O)[C@H](N)CCC(N)=O ZDXPYRJPNDTMRX-GSVOUGTGSA-N 0.000 claims description 2
- 229930195715 D-glutamine Natural products 0.000 claims description 2
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims description 2
- 230000033616 DNA repair Effects 0.000 claims description 2
- 230000004543 DNA replication Effects 0.000 claims description 2
- 101710160937 DNA replication protein Proteins 0.000 claims description 2
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 claims description 2
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 claims description 2
- 241001135761 Deltaproteobacteria Species 0.000 claims description 2
- 241001143779 Dorea Species 0.000 claims description 2
- 241000305071 Enterobacterales Species 0.000 claims description 2
- 241000186394 Eubacterium Species 0.000 claims description 2
- 241000206602 Eukaryota Species 0.000 claims description 2
- 241001608234 Faecalibacterium Species 0.000 claims description 2
- 241000589565 Flavobacterium Species 0.000 claims description 2
- 229930091371 Fructose Natural products 0.000 claims description 2
- 239000005715 Fructose Substances 0.000 claims description 2
- 102000004310 Ion Channels Human genes 0.000 claims description 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 2
- 241001134638 Lachnospira Species 0.000 claims description 2
- 241001112693 Lachnospiraceae Species 0.000 claims description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims description 2
- 241000604449 Megasphaera Species 0.000 claims description 2
- 241001467578 Microbacterium Species 0.000 claims description 2
- 241000098695 Moryella Species 0.000 claims description 2
- 241000186360 Mycobacteriaceae Species 0.000 claims description 2
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 2
- 229930193140 Neomycin Natural products 0.000 claims description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 2
- 241000192497 Oscillatoria Species 0.000 claims description 2
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 claims description 2
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 claims description 2
- 108091000080 Phosphotransferase Proteins 0.000 claims description 2
- 208000031951 Primary immunodeficiency Diseases 0.000 claims description 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims description 2
- 241001655512 Pseudobacteroides Species 0.000 claims description 2
- 241000589516 Pseudomonas Species 0.000 claims description 2
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims description 2
- 101710198868 Recombination and repair protein Proteins 0.000 claims description 2
- 241000192031 Ruminococcus Species 0.000 claims description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims description 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 2
- 230000006978 adaptation Effects 0.000 claims description 2
- 150000001348 alkyl chlorides Chemical class 0.000 claims description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 2
- 230000033590 base-excision repair Effects 0.000 claims description 2
- 229950004527 butirosin Drugs 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 239000003054 catalyst Substances 0.000 claims description 2
- 230000005754 cellular signaling Effects 0.000 claims description 2
- 230000035605 chemotaxis Effects 0.000 claims description 2
- 210000000349 chromosome Anatomy 0.000 claims description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 2
- 235000018417 cysteine Nutrition 0.000 claims description 2
- 239000002158 endotoxin Substances 0.000 claims description 2
- 229960000304 folic acid Drugs 0.000 claims description 2
- 235000019152 folic acid Nutrition 0.000 claims description 2
- 239000011724 folic acid Substances 0.000 claims description 2
- 229930182830 galactose Natural products 0.000 claims description 2
- 229940097042 glucuronate Drugs 0.000 claims description 2
- 150000002327 glycerophospholipids Chemical class 0.000 claims description 2
- 150000002337 glycosamines Chemical class 0.000 claims description 2
- HHLFWLYXYJOTON-UHFFFAOYSA-N glyoxylic acid Chemical compound OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 claims description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 2
- 229960000310 isoleucine Drugs 0.000 claims description 2
- 229920006008 lipopolysaccharide Polymers 0.000 claims description 2
- 229930182817 methionine Natural products 0.000 claims description 2
- 229960004927 neomycin Drugs 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 230000020520 nucleotide-excision repair Effects 0.000 claims description 2
- 230000010627 oxidative phosphorylation Effects 0.000 claims description 2
- 229940014662 pantothenate Drugs 0.000 claims description 2
- 235000019161 pantothenic acid Nutrition 0.000 claims description 2
- 239000011713 pantothenic acid Substances 0.000 claims description 2
- 230000004108 pentose phosphate pathway Effects 0.000 claims description 2
- 150000002972 pentoses Chemical class 0.000 claims description 2
- 230000000858 peroxisomal effect Effects 0.000 claims description 2
- 102000020233 phosphotransferase Human genes 0.000 claims description 2
- 244000000003 plant pathogen Species 0.000 claims description 2
- 125000005575 polycyclic aromatic hydrocarbon group Chemical group 0.000 claims description 2
- 239000011148 porous material Substances 0.000 claims description 2
- 235000019833 protease Nutrition 0.000 claims description 2
- 230000004144 purine metabolism Effects 0.000 claims description 2
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 2
- 230000004147 pyrimidine metabolism Effects 0.000 claims description 2
- 230000006798 recombination Effects 0.000 claims description 2
- 238000005215 recombination Methods 0.000 claims description 2
- 229960002477 riboflavin Drugs 0.000 claims description 2
- 235000019192 riboflavin Nutrition 0.000 claims description 2
- 239000002151 riboflavin Substances 0.000 claims description 2
- 230000004137 sphingolipid metabolism Effects 0.000 claims description 2
- 229910052717 sulfur Inorganic materials 0.000 claims description 2
- 239000011593 sulfur Substances 0.000 claims description 2
- 150000003505 terpenes Chemical group 0.000 claims description 2
- 235000019157 thiamine Nutrition 0.000 claims description 2
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 claims description 2
- 229960003495 thiamine Drugs 0.000 claims description 2
- 239000011721 thiamine Substances 0.000 claims description 2
- 201000008827 tuberculosis Diseases 0.000 claims description 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 2
- 239000004474 valine Substances 0.000 claims description 2
- 239000011726 vitamin B6 Substances 0.000 claims description 2
- 235000019158 vitamin B6 Nutrition 0.000 claims description 2
- 229940011671 vitamin b6 Drugs 0.000 claims description 2
- 241001662464 Coriobacteriales Species 0.000 claims 1
- 241000566961 Thelephora Species 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 abstract description 105
- 239000012472 biological sample Substances 0.000 abstract description 57
- 239000000523 sample Substances 0.000 description 60
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 59
- 201000010099 disease Diseases 0.000 description 57
- 239000013598 vector Substances 0.000 description 29
- 230000001225 therapeutic effect Effects 0.000 description 27
- 125000000524 functional group Chemical group 0.000 description 26
- 238000004422 calculation algorithm Methods 0.000 description 25
- 230000036541 health Effects 0.000 description 25
- 230000008569 process Effects 0.000 description 23
- 238000012360 testing method Methods 0.000 description 22
- 239000006041 probiotic Substances 0.000 description 21
- 235000018291 probiotics Nutrition 0.000 description 21
- 230000000529 probiotic effect Effects 0.000 description 19
- 241000894006 Bacteria Species 0.000 description 17
- 238000013507 mapping Methods 0.000 description 15
- 239000000047 product Substances 0.000 description 15
- 239000003550 marker Substances 0.000 description 13
- 230000002441 reversible effect Effects 0.000 description 13
- 229940079593 drug Drugs 0.000 description 12
- 239000003814 drug Substances 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- 230000003542 behavioural effect Effects 0.000 description 10
- 230000000875 corresponding effect Effects 0.000 description 10
- 230000000813 microbial effect Effects 0.000 description 9
- 238000003752 polymerase chain reaction Methods 0.000 description 9
- 238000000746 purification Methods 0.000 description 9
- 238000010801 machine learning Methods 0.000 description 8
- 238000003066 decision tree Methods 0.000 description 7
- 238000000605 extraction Methods 0.000 description 7
- 235000013406 prebiotics Nutrition 0.000 description 7
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 6
- 238000013459 approach Methods 0.000 description 6
- 239000011324 bead Substances 0.000 description 6
- 230000000295 complement effect Effects 0.000 description 6
- 235000005911 diet Nutrition 0.000 description 6
- 108020004465 16S ribosomal RNA Proteins 0.000 description 5
- 238000012350 deep sequencing Methods 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 229920001542 oligosaccharide Polymers 0.000 description 5
- 238000000926 separation method Methods 0.000 description 5
- 230000001568 sexual effect Effects 0.000 description 5
- 230000014616 translation Effects 0.000 description 5
- 108020004414 DNA Proteins 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 241000736262 Microbiota Species 0.000 description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 description 4
- 102000002278 Ribosomal Proteins Human genes 0.000 description 4
- 108010000605 Ribosomal Proteins Proteins 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 230000006399 behavior Effects 0.000 description 4
- 238000001574 biopsy Methods 0.000 description 4
- 235000015872 dietary supplement Nutrition 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 239000012634 fragment Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000007637 random forest analysis Methods 0.000 description 4
- 108091093088 Amplicon Proteins 0.000 description 3
- 241000193749 Bacillus coagulans Species 0.000 description 3
- 244000063299 Bacillus subtilis Species 0.000 description 3
- 235000014469 Bacillus subtilis Nutrition 0.000 description 3
- 108091026890 Coding region Proteins 0.000 description 3
- 241000186869 Lactobacillus salivarius Species 0.000 description 3
- 238000001790 Welch's t-test Methods 0.000 description 3
- 238000013528 artificial neural network Methods 0.000 description 3
- 229940054340 bacillus coagulans Drugs 0.000 description 3
- 238000013398 bayesian method Methods 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000002405 diagnostic procedure Methods 0.000 description 3
- 230000037213 diet Effects 0.000 description 3
- 230000000378 dietary effect Effects 0.000 description 3
- 235000006694 eating habits Nutrition 0.000 description 3
- -1 etc.) Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000013467 fragmentation Methods 0.000 description 3
- 238000006062 fragmentation reaction Methods 0.000 description 3
- 230000003862 health status Effects 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 230000037081 physical activity Effects 0.000 description 3
- 230000008092 positive effect Effects 0.000 description 3
- 238000000513 principal component analysis Methods 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 150000003384 small molecules Chemical class 0.000 description 3
- 230000004936 stimulating effect Effects 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 238000012706 support-vector machine Methods 0.000 description 3
- 238000012549 training Methods 0.000 description 3
- 238000010200 validation analysis Methods 0.000 description 3
- FVVCFHXLWDDRHG-UPLOTWCNSA-N (2s,3r,4s,5r,6r)-2-[(2r,3s,4r,5r,6r)-6-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)O1 FVVCFHXLWDDRHG-UPLOTWCNSA-N 0.000 description 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 2
- VOJUXHHACRXLTD-UHFFFAOYSA-N 1,4-dihydroxy-2-naphthoic acid Chemical compound C1=CC=CC2=C(O)C(C(=O)O)=CC(O)=C21 VOJUXHHACRXLTD-UHFFFAOYSA-N 0.000 description 2
- 102100021546 60S ribosomal protein L10 Human genes 0.000 description 2
- 229920000856 Amylose Polymers 0.000 description 2
- 241000193755 Bacillus cereus Species 0.000 description 2
- 241001328122 Bacillus clausii Species 0.000 description 2
- 241000194108 Bacillus licheniformis Species 0.000 description 2
- 241000194103 Bacillus pumilus Species 0.000 description 2
- 241000186016 Bifidobacterium bifidum Species 0.000 description 2
- 241000186012 Bifidobacterium breve Species 0.000 description 2
- 241001608472 Bifidobacterium longum Species 0.000 description 2
- 241000186148 Bifidobacterium pseudolongum Species 0.000 description 2
- 241000193764 Brevibacillus brevis Species 0.000 description 2
- 108010078791 Carrier Proteins Proteins 0.000 description 2
- 241000193171 Clostridium butyricum Species 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 241000520130 Enterococcus durans Species 0.000 description 2
- 241000194032 Enterococcus faecalis Species 0.000 description 2
- 241000194031 Enterococcus faecium Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 238000001276 Kolmogorov–Smirnov test Methods 0.000 description 2
- 238000007397 LAMP assay Methods 0.000 description 2
- 240000001046 Lactobacillus acidophilus Species 0.000 description 2
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 2
- 240000001929 Lactobacillus brevis Species 0.000 description 2
- 235000013957 Lactobacillus brevis Nutrition 0.000 description 2
- 241000186606 Lactobacillus gasseri Species 0.000 description 2
- 240000006024 Lactobacillus plantarum Species 0.000 description 2
- 235000013965 Lactobacillus plantarum Nutrition 0.000 description 2
- 241000186604 Lactobacillus reuteri Species 0.000 description 2
- 241000218588 Lactobacillus rhamnosus Species 0.000 description 2
- 241000192130 Leuconostoc mesenteroides Species 0.000 description 2
- 102000003843 Metalloendopeptidases Human genes 0.000 description 2
- 108090000131 Metalloendopeptidases Proteins 0.000 description 2
- 241000191998 Pediococcus acidilactici Species 0.000 description 2
- 241000191996 Pediococcus pentosaceus Species 0.000 description 2
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 2
- 229920000294 Resistant starch Polymers 0.000 description 2
- 244000057717 Streptococcus lactis Species 0.000 description 2
- 235000014897 Streptococcus lactis Nutrition 0.000 description 2
- 238000000692 Student's t-test Methods 0.000 description 2
- 102000008579 Transposases Human genes 0.000 description 2
- 108010020764 Transposases Proteins 0.000 description 2
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 2
- UGXQOOQUZRUVSS-ZZXKWVIFSA-N [5-[3,5-dihydroxy-2-(1,3,4-trihydroxy-5-oxopentan-2-yl)oxyoxan-4-yl]oxy-3,4-dihydroxyoxolan-2-yl]methyl (e)-3-(4-hydroxyphenyl)prop-2-enoate Chemical compound OC1C(OC(CO)C(O)C(O)C=O)OCC(O)C1OC1C(O)C(O)C(COC(=O)\C=C\C=2C=CC(O)=CC=2)O1 UGXQOOQUZRUVSS-ZZXKWVIFSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000003044 adaptive effect Effects 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 229920000617 arabinoxylan Polymers 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 229940002008 bifidobacterium bifidum Drugs 0.000 description 2
- 229940009291 bifidobacterium longum Drugs 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000009534 blood test Methods 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000009089 cytolysis Effects 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 238000001839 endoscopy Methods 0.000 description 2
- 229940032049 enterococcus faecalis Drugs 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 210000002175 goblet cell Anatomy 0.000 description 2
- 244000005702 human microbiome Species 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000003064 k means clustering Methods 0.000 description 2
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 2
- 229940072205 lactobacillus plantarum Drugs 0.000 description 2
- 229940001882 lactobacillus reuteri Drugs 0.000 description 2
- 238000007834 ligase chain reaction Methods 0.000 description 2
- 238000007477 logistic regression Methods 0.000 description 2
- 230000002934 lysing effect Effects 0.000 description 2
- 150000003272 mannan oligosaccharides Chemical class 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 230000037353 metabolic pathway Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 210000000653 nervous system Anatomy 0.000 description 2
- 231100001160 nonlethal Toxicity 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000001766 physiological effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000004800 psychological effect Effects 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 238000013139 quantization Methods 0.000 description 2
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 2
- 235000021254 resistant starch Nutrition 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 238000000528 statistical test Methods 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 238000012353 t test Methods 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 238000007862 touchdown PCR Methods 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 102100039882 40S ribosomal protein S17 Human genes 0.000 description 1
- 102100033051 40S ribosomal protein S19 Human genes 0.000 description 1
- 102100033409 40S ribosomal protein S3 Human genes 0.000 description 1
- 102100024088 40S ribosomal protein S7 Human genes 0.000 description 1
- 102100037663 40S ribosomal protein S8 Human genes 0.000 description 1
- PVXPPJIGRGXGCY-TZLCEDOOSA-N 6-O-alpha-D-glucopyranosyl-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)C(O)(CO)O1 PVXPPJIGRGXGCY-TZLCEDOOSA-N 0.000 description 1
- PVXPPJIGRGXGCY-DJHAAKORSA-N 6-O-alpha-D-glucopyranosyl-alpha-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@](O)(CO)O1 PVXPPJIGRGXGCY-DJHAAKORSA-N 0.000 description 1
- 102100035916 60S ribosomal protein L11 Human genes 0.000 description 1
- 102100033094 ATP-binding cassette sub-family G member 4 Human genes 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 241000702462 Akkermansia muciniphila Species 0.000 description 1
- 241000203069 Archaea Species 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 241001226430 Bacillus polyfermenticus Species 0.000 description 1
- 108020000946 Bacterial DNA Proteins 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 241001134770 Bifidobacterium animalis Species 0.000 description 1
- 206010068051 Chimerism Diseases 0.000 description 1
- 108010077544 Chromatin Proteins 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 241001112696 Clostridia Species 0.000 description 1
- 108091035707 Consensus sequence Proteins 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 206010017943 Gastrointestinal conditions Diseases 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000800393 Homo sapiens ATP-binding cassette sub-family G member 4 Proteins 0.000 description 1
- 108010056651 Hydroxymethylbilane synthase Proteins 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 208000029462 Immunodeficiency disease Diseases 0.000 description 1
- 229920001202 Inulin Polymers 0.000 description 1
- AYRXSINWFIIFAE-SCLMCMATSA-N Isomaltose Natural products OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@@H](O)[C@@H](O)[C@@H]1O AYRXSINWFIIFAE-SCLMCMATSA-N 0.000 description 1
- 244000199866 Lactobacillus casei Species 0.000 description 1
- 235000013958 Lactobacillus casei Nutrition 0.000 description 1
- 108090000364 Ligases Proteins 0.000 description 1
- 102000003960 Ligases Human genes 0.000 description 1
- 238000007476 Maximum Likelihood Methods 0.000 description 1
- 102000003939 Membrane transport proteins Human genes 0.000 description 1
- 108090000301 Membrane transport proteins Proteins 0.000 description 1
- 108060004795 Methyltransferase Proteins 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 108010077519 Peptide Elongation Factor 2 Proteins 0.000 description 1
- 102100035215 Phenylalanine-tRNA ligase alpha subunit Human genes 0.000 description 1
- 101710147128 Phenylalanine-tRNA ligase alpha subunit Proteins 0.000 description 1
- 102100035312 Phenylalanine-tRNA ligase beta subunit Human genes 0.000 description 1
- 101710182373 Phenylalanine-tRNA ligase beta subunit Proteins 0.000 description 1
- 101710110580 Phenylalanine-tRNA ligase beta subunit, chloroplastic Proteins 0.000 description 1
- 241000425347 Phyla <beetle> Species 0.000 description 1
- 102100034391 Porphobilinogen deaminase Human genes 0.000 description 1
- 241001299661 Prevotella bryantii Species 0.000 description 1
- 101710202161 Probable phenylalanine-tRNA ligase alpha subunit Proteins 0.000 description 1
- 101710119935 Probable phenylalanine-tRNA ligase beta subunit Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 238000011529 RT qPCR Methods 0.000 description 1
- 102000004285 Ribosomal Protein L3 Human genes 0.000 description 1
- 108090000894 Ribosomal Protein L3 Proteins 0.000 description 1
- 102000004191 Ribosomal protein L1 Human genes 0.000 description 1
- 108090000792 Ribosomal protein L1 Proteins 0.000 description 1
- 108090000986 Ribosomal protein L10 Proteins 0.000 description 1
- 102000013817 Ribosomal protein L13 Human genes 0.000 description 1
- 108050003655 Ribosomal protein L13 Proteins 0.000 description 1
- 102000003926 Ribosomal protein L18 Human genes 0.000 description 1
- 108090000343 Ribosomal protein L18 Proteins 0.000 description 1
- 102000004208 Ribosomal protein L2 Human genes 0.000 description 1
- 108090000775 Ribosomal protein L2 Proteins 0.000 description 1
- 102000017358 Ribosomal protein L4/L1e Human genes 0.000 description 1
- 108050005388 Ribosomal protein L4/L1e Proteins 0.000 description 1
- 102000004209 Ribosomal protein L5 Human genes 0.000 description 1
- 108090000776 Ribosomal protein L5 Proteins 0.000 description 1
- 102000004394 Ribosomal protein S10 Human genes 0.000 description 1
- 108090000928 Ribosomal protein S10 Proteins 0.000 description 1
- 102000018489 Ribosomal protein S12/S23 Human genes 0.000 description 1
- 108050007707 Ribosomal protein S12/S23 Proteins 0.000 description 1
- 102000010983 Ribosomal protein S13 Human genes 0.000 description 1
- 108050001197 Ribosomal protein S13 Proteins 0.000 description 1
- 102000009463 Ribosomal protein S15P Human genes 0.000 description 1
- 108050000360 Ribosomal protein S15P Proteins 0.000 description 1
- 102000004339 Ribosomal protein S2 Human genes 0.000 description 1
- 108090000904 Ribosomal protein S2 Proteins 0.000 description 1
- 102000004282 Ribosomal protein S9 Human genes 0.000 description 1
- 108090000878 Ribosomal protein S9 Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 238000012300 Sequence Analysis Methods 0.000 description 1
- 241000566950 Thelephoraceae Species 0.000 description 1
- 102000000591 Tight Junction Proteins Human genes 0.000 description 1
- 108010002321 Tight Junction Proteins Proteins 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 229910000754 Wrought iron Inorganic materials 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002467 anti-pepsin effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 238000013473 artificial intelligence Methods 0.000 description 1
- 229940104704 bacillus polyfermenticus Drugs 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 238000002869 basic local alignment search tool Methods 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- 238000013542 behavioral therapy Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 229940118852 bifidobacterium animalis Drugs 0.000 description 1
- 230000008436 biogenesis Effects 0.000 description 1
- 238000003766 bioinformatics method Methods 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 238000010170 biological method Methods 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 208000027503 bloody stool Diseases 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000003196 chaotropic effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000007705 chemical test Methods 0.000 description 1
- 238000000546 chi-square test Methods 0.000 description 1
- 230000035606 childbirth Effects 0.000 description 1
- 210000003483 chromatin Anatomy 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000011281 clinical therapy Methods 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 238000009225 cognitive behavioral therapy Methods 0.000 description 1
- 230000001149 cognitive effect Effects 0.000 description 1
- 238000009226 cognitive therapy Methods 0.000 description 1
- 238000002052 colonoscopy Methods 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000000205 computational method Methods 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000003436 cytoskeletal effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000013135 deep learning Methods 0.000 description 1
- 210000004443 dendritic cell Anatomy 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 208000030172 endocrine system disease Diseases 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000009207 exercise therapy Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 230000007849 functional defect Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000005095 gastrointestinal system Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000002575 gastroscopy Methods 0.000 description 1
- 230000008571 general function Effects 0.000 description 1
- 238000012252 genetic analysis Methods 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 208000035474 group of disease Diseases 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 208000024798 heartburn Diseases 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 238000012165 high-throughput sequencing Methods 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000007849 hot-start PCR Methods 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000007813 immunodeficiency Effects 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 201000009863 inflammatory diarrhea Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000010189 intracellular transport Effects 0.000 description 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 238000011005 laboratory method Methods 0.000 description 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
- 229960003451 lactitol Drugs 0.000 description 1
- 239000000832 lactitol Substances 0.000 description 1
- 235000010448 lactitol Nutrition 0.000 description 1
- 229940017800 lactobacillus casei Drugs 0.000 description 1
- JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 description 1
- 229960000511 lactulose Drugs 0.000 description 1
- PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000007403 mPCR Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000009061 membrane transport Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000000394 mitotic effect Effects 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 230000007659 motor function Effects 0.000 description 1
- 208000005264 motor neuron disease Diseases 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 230000004682 mucosal barrier function Effects 0.000 description 1
- 210000002346 musculoskeletal system Anatomy 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 238000007857 nested PCR Methods 0.000 description 1
- 238000007481 next generation sequencing Methods 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000013488 ordinary least square regression Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 238000010238 partial least squares regression Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000001558 permutation test Methods 0.000 description 1
- 238000011338 personalized therapy Methods 0.000 description 1
- 239000007793 ph indicator Substances 0.000 description 1
- 238000002205 phenol-chloroform extraction Methods 0.000 description 1
- 238000011202 physical detection method Methods 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 230000004481 post-translational protein modification Effects 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000004844 protein turnover Effects 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 238000002601 radiography Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000022983 regulation of cell cycle Effects 0.000 description 1
- 210000003289 regulatory T cell Anatomy 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 108090000731 ribonuclease HII Proteins 0.000 description 1
- 108010025552 ribosomal protein L11 Proteins 0.000 description 1
- 102000004291 ribosomal protein L6 Human genes 0.000 description 1
- 108090000892 ribosomal protein L6 Proteins 0.000 description 1
- 102000004413 ribosomal protein S11 Human genes 0.000 description 1
- 108090000930 ribosomal protein S11 Proteins 0.000 description 1
- 108010093121 ribosomal protein S17 Proteins 0.000 description 1
- 108010093046 ribosomal protein S19 Proteins 0.000 description 1
- 108010033804 ribosomal protein S3 Proteins 0.000 description 1
- 102000004337 ribosomal protein S5 Human genes 0.000 description 1
- 108090000902 ribosomal protein S5 Proteins 0.000 description 1
- 108010033405 ribosomal protein S7 Proteins 0.000 description 1
- 108010033800 ribosomal protein S8 Proteins 0.000 description 1
- 229960002181 saccharomyces boulardii Drugs 0.000 description 1
- 235000015598 salt intake Nutrition 0.000 description 1
- 230000019702 secondary metabolite biosynthetic process Effects 0.000 description 1
- 230000009049 secondary transport Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 230000003997 social interaction Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000000551 statistical hypothesis test Methods 0.000 description 1
- 238000002901 structure similarity search Methods 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 101710194142 tRNA pseudouridine synthase B Proteins 0.000 description 1
- 238000002626 targeted therapy Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 210000001578 tight junction Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 208000014001 urinary system disease Diseases 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/20—Supervised data analysis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Data Mining & Analysis (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biophysics (AREA)
- Theoretical Computer Science (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Databases & Information Systems (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Epidemiology (AREA)
- Artificial Intelligence (AREA)
- Biomedical Technology (AREA)
- Software Systems (AREA)
- Bioethics (AREA)
- Genetics & Genomics (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Evolutionary Computation (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Hematology (AREA)
- Primary Health Care (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Description
Claims (12)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562146818P | 2015-04-13 | 2015-04-13 | |
US62/146,818 | 2015-04-13 | ||
US201562147096P | 2015-04-14 | 2015-04-14 | |
US201562147334P | 2015-04-14 | 2015-04-14 | |
US62/147,334 | 2015-04-14 | ||
US62/147,096 | 2015-04-14 | ||
PCT/US2016/027349 WO2016168344A1 (en) | 2015-04-13 | 2016-04-13 | Method and system for microbiome-derived characterization, diaganostics and therapeutics for conditions associated with functional features |
Publications (2)
Publication Number | Publication Date |
---|---|
CN107849616A CN107849616A (zh) | 2018-03-27 |
CN107849616B true CN107849616B (zh) | 2022-03-29 |
Family
ID=57126060
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201680034379.5A Active CN107849616B (zh) | 2015-04-13 | 2016-04-13 | 用于功能特征相关的状况的微生物组来源的表征、诊断和治疗的方法及系统 |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP3283650A4 (zh) |
CN (1) | CN107849616B (zh) |
AU (2) | AU2016250096A1 (zh) |
WO (1) | WO2016168344A1 (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3687375A4 (en) * | 2016-11-21 | 2022-01-19 | Psomagen, Inc. | METHOD AND SYSTEM FOR CHARACTERIZING A HEADACHE RELATED CONDITION |
EP3768851A4 (en) * | 2016-12-15 | 2022-03-09 | Psomagen, Inc. | METHOD AND SYSTEM FOR CHARACTERIZING DIET-RELATED CONDITIONS |
WO2018112437A1 (en) * | 2016-12-15 | 2018-06-21 | uBiome, Inc. | Method and system for characterizing allergy-related conditions associated with microorganisms |
EP3776285A4 (en) * | 2016-12-16 | 2022-03-09 | Psomagen, Inc. | METHOD AND SYSTEM FOR CHARACTERIZING MICRO-ORGANISM-RELATED CONDITIONS |
WO2019234246A1 (en) * | 2018-06-07 | 2019-12-12 | 4D Pharma Plc | Method for stratifying ibs patients |
WO2020205542A1 (en) * | 2019-03-29 | 2020-10-08 | Psomagen, Inc. | Microbiome byproducts and uses thereof |
CN115691813A (zh) * | 2022-12-30 | 2023-02-03 | 神州医疗科技股份有限公司 | 基于基因组学和微生物组学的遗传性胃癌评估方法及系统 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130121968A1 (en) * | 2011-10-03 | 2013-05-16 | Atossa Genetics, Inc. | Methods of combining metagenome and the metatranscriptome in multiplex profiles |
WO2015013214A3 (en) * | 2013-07-21 | 2015-03-26 | Whole Biome, Inc. | Methods and systems for microbiome characterization, monitoring and treatment |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006097949A1 (en) * | 2005-03-16 | 2006-09-21 | Actial Farmacêutica, Lda. | Mixture of at least 6 species of lactic acid bacteria and/or bifidobacteria in the manufacture of sourdough |
WO2007056463A2 (en) * | 2005-11-09 | 2007-05-18 | Primera Biosystems, Inc. | Multiplexed quantitative detection of pathogens |
WO2012050513A1 (en) * | 2010-10-11 | 2012-04-19 | Baeckhed Fredrik | Method for identifying a risk of cardiovascular disease by analysing oral microbiota |
JP6363502B2 (ja) * | 2011-04-28 | 2018-07-25 | スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ | Hsp90併用療法 |
US20140341853A1 (en) * | 2013-05-14 | 2014-11-20 | Vanna Hovanky | Bacteria-Mediated Therapy for Cancer |
-
2016
- 2016-04-13 CN CN201680034379.5A patent/CN107849616B/zh active Active
- 2016-04-13 AU AU2016250096A patent/AU2016250096A1/en not_active Abandoned
- 2016-04-13 EP EP16780662.9A patent/EP3283650A4/en active Pending
- 2016-04-13 WO PCT/US2016/027349 patent/WO2016168344A1/en active Application Filing
-
2022
- 2022-05-18 AU AU2022203347A patent/AU2022203347A1/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130121968A1 (en) * | 2011-10-03 | 2013-05-16 | Atossa Genetics, Inc. | Methods of combining metagenome and the metatranscriptome in multiplex profiles |
WO2015013214A3 (en) * | 2013-07-21 | 2015-03-26 | Whole Biome, Inc. | Methods and systems for microbiome characterization, monitoring and treatment |
Also Published As
Publication number | Publication date |
---|---|
EP3283650A1 (en) | 2018-02-21 |
WO2016168344A1 (en) | 2016-10-20 |
AU2016250096A1 (en) | 2017-11-09 |
EP3283650A4 (en) | 2019-04-10 |
WO2016168344A8 (en) | 2018-07-26 |
AU2022203347A1 (en) | 2022-06-09 |
AU2016250096A8 (en) | 2018-12-06 |
CN107849616A (zh) | 2018-03-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10383519B2 (en) | Method and system for microbiome-derived characterization, diagnostics and therapeutics for conditions associated with functional features | |
US10790060B2 (en) | Method and system for microbiome-derived diagnostics and therapeutics for mental health associated conditions | |
US10290376B2 (en) | Method and system for microbiome-derived diagnostics and therapeutics for autoimmune system conditions | |
CN107708715B (zh) | 用于微生物组功能特征相关的状况的微生物组来源的诊断和治疗的方法及系统 | |
CN107708716B (zh) | 用于微生物组分类学特征相关的状况的微生物组来源的诊断和治疗的方法及系统 | |
CN107709576B (zh) | 用于神经系统健康问题的微生物组来源的诊断和治疗的方法及系统 | |
CN107849616B (zh) | 用于功能特征相关的状况的微生物组来源的表征、诊断和治疗的方法及系统 | |
CN107835692B (zh) | 用于皮肤系统状况的微生物组来源的表征、诊断和治疗的方法及系统 | |
CN107849609B (zh) | 用于心理健康相关状况的微生物组来源的诊断和治疗的方法及系统 | |
CN108283012B (zh) | 用于自身免疫系统状况的微生物组来源的诊断和治疗的方法及系统 | |
US10311973B2 (en) | Method and system for microbiome-derived diagnostics and therapeutics for autoimmune system conditions | |
CN107708714B (zh) | 用于内分泌系统状况的微生物组来源的诊断和治疗的方法及系统 | |
CN107835859B (zh) | 用于运动系统状况的微生物组来源的诊断和治疗的方法及系统 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20200507 Address after: American Maryland Applicant after: Prosomegen Address before: California, USA Applicant before: UBIOME Inc. |
|
TA01 | Transfer of patent application right | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20240822 Address after: Seoul, South Kerean Patentee after: MacroGenics, Inc. Country or region after: Republic of Korea Address before: American Maryland Patentee before: Prosomegen Country or region before: U.S.A. |
|
TR01 | Transfer of patent right |