JP6615207B2 - 複素環式化合物及びその使用 - Google Patents

複素環式化合物及びその使用 Download PDF

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JP6615207B2
JP6615207B2 JP2017535616A JP2017535616A JP6615207B2 JP 6615207 B2 JP6615207 B2 JP 6615207B2 JP 2017535616 A JP2017535616 A JP 2017535616A JP 2017535616 A JP2017535616 A JP 2017535616A JP 6615207 B2 JP6615207 B2 JP 6615207B2
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alkyl
preparation
heteroaryl
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JP2017530193A (ja
JP2017530193A5 (enExample
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ユ−シェン チャオ
カク−シャン シア
ジン−ジェ ジャン
ルン ケルビン ツォウ
チュン−トン チェン
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2017535616A 2014-09-22 2015-09-21 複素環式化合物及びその使用 Active JP6615207B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462053389P 2014-09-22 2014-09-22
US62/053,389 2014-09-22
PCT/US2015/051143 WO2016048861A2 (en) 2014-09-22 2015-09-21 Heterocyclic compounds and use thereof

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JP2017530193A JP2017530193A (ja) 2017-10-12
JP2017530193A5 JP2017530193A5 (enExample) 2018-11-01
JP6615207B2 true JP6615207B2 (ja) 2019-12-04

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EP (1) EP3197885B1 (enExample)
JP (1) JP6615207B2 (enExample)
KR (1) KR102509431B1 (enExample)
CN (1) CN107207465B (enExample)
AU (1) AU2015321654B2 (enExample)
BR (1) BR112017005713B1 (enExample)
CA (1) CA2962329C (enExample)
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EP3568137A4 (en) * 2017-01-10 2020-05-27 National Health Research Institutes HETEROCYCLIC COMPOUNDS AND USE THEREOF
HUE066413T2 (hu) * 2017-09-08 2024-08-28 Univ Leland Stanford Junior ENPP1 inhibitorok és alkalmazásuk rák kezelésére
WO2020060268A1 (ko) 2018-09-20 2020-03-26 한미약품 주식회사 상피세포 성장인자 수용체 돌연변이 저해 효과를 갖는 신규 융합 피리미딘 골격 설폰아마이드 유도체
CA3128044A1 (en) * 2019-02-01 2020-08-06 The Board Of Trustees Of The Leland Stanford Junior University Enpp1 inhibitors and methods of modulating immune response
CN111138417B (zh) * 2019-12-18 2021-03-23 浙江工业大学 一种三氮唑修饰的5-氟-2,4-嘧啶二胺类化合物及其应用
WO2023014611A1 (en) * 2021-08-02 2023-02-09 Yeh, Teng-Kuang Pyrimidine compounds and use thereof
JPWO2024101337A1 (enExample) * 2022-11-07 2024-05-16
TW202435887A (zh) 2023-03-01 2024-09-16 瑞士商諾華公司 用於治療疾病或障礙的氫喹唑啉衍生物

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CZ236494A3 (en) * 1992-04-03 1994-12-15 Upjohn Co Pharmaceutically active bicyclic-heterocyclic amines
US6156758A (en) * 1999-09-08 2000-12-05 Isis Pharmaceuticals, Inc. Antibacterial quinazoline compounds
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BRPI0909375A2 (pt) * 2008-03-28 2015-08-04 Altiris Therapeutics Moduladores de receptores de quimiocinas
WO2009123221A1 (ja) * 2008-03-31 2009-10-08 全薬工業株式会社 細胞保護作用を有するピリミジン誘導体およびその用途
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WO2016048861A2 (en) 2016-03-31
US20160083369A1 (en) 2016-03-24
AU2015321654B2 (en) 2019-10-31
JP2017530193A (ja) 2017-10-12
US20180009786A1 (en) 2018-01-11
CN107207465B (zh) 2021-09-10
TW201615637A (zh) 2016-05-01
US9862703B2 (en) 2018-01-09
RU2704008C2 (ru) 2019-10-23
EP3197885A4 (en) 2018-02-21
CN107207465A (zh) 2017-09-26
AU2015321654A1 (en) 2017-04-06
KR102509431B1 (ko) 2023-03-13
ES2849998T3 (es) 2021-08-24
BR112017005713A2 (pt) 2018-01-23
BR112017005713B1 (pt) 2023-09-26
EP3197885A2 (en) 2017-08-02
TWI598348B (zh) 2017-09-11
CA2962329C (en) 2023-12-19
RU2017109355A3 (enExample) 2019-04-04
RU2017109355A (ru) 2018-10-24
KR20170072894A (ko) 2017-06-27
EP3197885B1 (en) 2020-11-18
US9926298B2 (en) 2018-03-27
WO2016048861A3 (en) 2016-09-15
NZ730195A (en) 2023-12-22
CA2962329A1 (en) 2016-03-31

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