JP6614724B2 - シクロベンザプリン塩酸塩の共融製剤 - Google Patents

シクロベンザプリン塩酸塩の共融製剤 Download PDF

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Publication number
JP6614724B2
JP6614724B2 JP2017535609A JP2017535609A JP6614724B2 JP 6614724 B2 JP6614724 B2 JP 6614724B2 JP 2017535609 A JP2017535609 A JP 2017535609A JP 2017535609 A JP2017535609 A JP 2017535609A JP 6614724 B2 JP6614724 B2 JP 6614724B2
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mannitol
eutectic
cyclobenzaprine hcl
pharmaceutical composition
composition
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JP2017532374A5 (esLanguage
JP2017532374A (ja
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セス レーデルマン，
マリーノ ネブローニ，
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トニックス ファーマ ホールディングス リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2017535609A 2014-09-18 2015-09-18 シクロベンザプリン塩酸塩の共融製剤 Active JP6614724B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462052238P 2014-09-18 2014-09-18
US62/052,238 2014-09-18
PCT/US2015/051068 WO2016044796A1 (en) 2014-09-18 2015-09-18 Eutectic formulations of cyclobenzaprine hydrochloride

Related Child Applications (1)

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JP2018173466A Division JP6717902B6 (ja) 2014-09-18 2018-09-18 シクロベンザプリン塩酸塩の共融製剤

Publications (3)

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JP2017532374A JP2017532374A (ja) 2017-11-02
JP2017532374A5 JP2017532374A5 (esLanguage) 2018-11-01
JP6614724B2 true JP6614724B2 (ja) 2019-12-04

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JP2017535609A Active JP6614724B2 (ja) 2014-09-18 2015-09-18 シクロベンザプリン塩酸塩の共融製剤
JP2018173466A Active JP6717902B6 (ja) 2014-09-18 2018-09-18 シクロベンザプリン塩酸塩の共融製剤
JP2019236602A Withdrawn JP2020059757A (ja) 2014-09-18 2019-12-26 シクロベンザプリン塩酸塩の共融製剤
JP2021169539A Withdrawn JP2022001605A (ja) 2014-09-18 2021-10-15 シクロベンザプリン塩酸塩の共融製剤
JP2023116057A Withdrawn JP2023126486A (ja) 2014-09-18 2023-07-14 シクロベンザプリン塩酸塩の共融製剤
JP2025076812A Pending JP2025107355A (ja) 2014-09-18 2025-05-02 シクロベンザプリン塩酸塩の共融製剤

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JP2018173466A Active JP6717902B6 (ja) 2014-09-18 2018-09-18 シクロベンザプリン塩酸塩の共融製剤
JP2019236602A Withdrawn JP2020059757A (ja) 2014-09-18 2019-12-26 シクロベンザプリン塩酸塩の共融製剤
JP2021169539A Withdrawn JP2022001605A (ja) 2014-09-18 2021-10-15 シクロベンザプリン塩酸塩の共融製剤
JP2023116057A Withdrawn JP2023126486A (ja) 2014-09-18 2023-07-14 シクロベンザプリン塩酸塩の共融製剤
JP2025076812A Pending JP2025107355A (ja) 2014-09-18 2025-05-02 シクロベンザプリン塩酸塩の共融製剤

Country Status (12)

Country Link
US (2) US10357465B2 (esLanguage)
EP (1) EP3193854A4 (esLanguage)
JP (6) JP6614724B2 (esLanguage)
CN (2) CN107072968B (esLanguage)
AU (2) AU2015317336B2 (esLanguage)
BR (1) BR112017005231A2 (esLanguage)
IL (2) IL251218B (esLanguage)
MX (1) MX387402B (esLanguage)
MY (1) MY186047A (esLanguage)
SG (2) SG10201902203VA (esLanguage)
WO (1) WO2016044796A1 (esLanguage)
ZA (1) ZA201701637B (esLanguage)

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MX2017003644A (es) 2017-10-31
MY186047A (en) 2021-06-17
EP3193854A1 (en) 2017-07-26
EP3193854A4 (en) 2018-05-02
AU2015317336A1 (en) 2017-04-13
JP2022001605A (ja) 2022-01-06
US11026898B2 (en) 2021-06-08
US20170281568A1 (en) 2017-10-05
AU2020289838B2 (en) 2022-11-24
CA2961822A1 (en) 2016-03-24
BR112017005231A2 (pt) 2018-03-13
AU2020289838A1 (en) 2021-01-28
IL251218A0 (en) 2017-05-29
US20190336458A1 (en) 2019-11-07
CN107072968B (zh) 2021-01-12
SG10201902203VA (en) 2019-04-29
JP2025107355A (ja) 2025-07-17
IL277814B (en) 2021-12-01
IL251218B (en) 2020-10-29
SG11201701995PA (en) 2017-04-27
NZ730379A (en) 2023-10-27
JP2018193409A (ja) 2018-12-06
JP2023126486A (ja) 2023-09-07
JP2017532374A (ja) 2017-11-02
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