JP6581655B2 - 多能性幹細胞由来ケラチノサイトの生成およびケラチノサイト培養の維持 - Google Patents
多能性幹細胞由来ケラチノサイトの生成およびケラチノサイト培養の維持 Download PDFInfo
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- JP6581655B2 JP6581655B2 JP2017519905A JP2017519905A JP6581655B2 JP 6581655 B2 JP6581655 B2 JP 6581655B2 JP 2017519905 A JP2017519905 A JP 2017519905A JP 2017519905 A JP2017519905 A JP 2017519905A JP 6581655 B2 JP6581655 B2 JP 6581655B2
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- C—CHEMISTRY; METALLURGY
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0629—Keratinocytes; Whole skin
- C12N5/063—Kereatinocyte stem cells; Keratinocyte progenitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5073—Stem cells
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin
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- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Genetics & Genomics (AREA)
- Dermatology (AREA)
- Wood Science & Technology (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
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- General Chemical & Material Sciences (AREA)
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- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
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- Food Science & Technology (AREA)
- Epidemiology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462063720P | 2014-10-14 | 2014-10-14 | |
| US62/063,720 | 2014-10-14 | ||
| PCT/US2015/055284 WO2016061071A1 (en) | 2014-10-14 | 2015-10-13 | Generation of keratinocytes from pluripotent stem cells and mantenance of keratinocyte cultures |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017532047A JP2017532047A (ja) | 2017-11-02 |
| JP2017532047A5 JP2017532047A5 (enExample) | 2018-11-22 |
| JP6581655B2 true JP6581655B2 (ja) | 2019-09-25 |
Family
ID=54352509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017519905A Active JP6581655B2 (ja) | 2014-10-14 | 2015-10-13 | 多能性幹細胞由来ケラチノサイトの生成およびケラチノサイト培養の維持 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10047341B2 (enExample) |
| EP (1) | EP3207122B1 (enExample) |
| JP (1) | JP6581655B2 (enExample) |
| WO (1) | WO2016061071A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| EP3149156B1 (en) | 2014-05-28 | 2021-02-17 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| JP6804438B2 (ja) | 2014-10-17 | 2020-12-23 | チルドレンズ ホスピタル メディカル センター | 多能性幹細胞を使用するヒト小腸のin vivoモデル、並びにそれを作製、及び使用する方法 |
| US10273549B2 (en) * | 2016-04-21 | 2019-04-30 | Vitrolabs Inc. | Engineered skin equivalent, method of manufacture thereof and products derived therefrom |
| EP4177335A1 (en) | 2016-05-05 | 2023-05-10 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
| EP3534976A4 (en) | 2016-11-04 | 2020-09-16 | Children's Hospital Medical Center | PATHOLOGICAL MODELS OF HEPATIC ORGANOIDS AND ASSOCIATED METHODS OF MANUFACTURE AND USE |
| EP3548507A4 (en) | 2016-12-05 | 2020-07-15 | Children's Hospital Medical Center | COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF |
| EP3609997A4 (en) | 2017-04-14 | 2021-03-03 | Children's Hospital Medical Center | COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES |
| CN110914407A (zh) * | 2017-05-05 | 2020-03-24 | 新加坡国立大学 | 人角质形成细胞的培养方法 |
| KR102100608B1 (ko) * | 2017-06-30 | 2020-04-14 | 주식회사 차바이오텍 | 줄기세포 유래 피부전구세포 배양액 및 이의 제조 방법 |
| EP3694603A4 (en) | 2017-10-10 | 2021-07-14 | Children's Hospital Medical Center | ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF |
| US12379372B2 (en) | 2017-12-21 | 2025-08-05 | Children's Hospital Medical Center | Digitalized human organoids and methods of using same |
| EP3513780A1 (en) * | 2018-01-23 | 2019-07-24 | DSM IP Assets B.V. | Method for supporting epidermal stem cell self-renewal |
| KR102887406B1 (ko) | 2018-07-26 | 2025-11-19 | 칠드런즈 호스피탈 메디칼 센터 | 간-담도-췌장 조직 및 이를 제조하는 방법 |
| WO2020056158A1 (en) | 2018-09-12 | 2020-03-19 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| CN111088213B (zh) * | 2018-10-24 | 2022-04-08 | 澳门大学 | 一种诱导干细胞逐步分化形成角质细胞的方法以及角质细胞 |
| WO2021133724A1 (en) * | 2019-12-23 | 2021-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | Genetically corrected cells for therapeutic use |
| EP3875580A1 (en) | 2020-03-02 | 2021-09-08 | Centre d'Etude des Cellules Souches (CECS) | Methods for preparing keratinocytes |
| EP3875581A1 (en) | 2020-03-02 | 2021-09-08 | Centre d'Etude des Cellules Souches (CECS) | Automated method for preparing keratinocytes |
| JP7315184B2 (ja) * | 2022-02-16 | 2023-07-26 | 株式会社コーセー | 多能性幹細胞から表皮角化細胞への分化誘導方法 |
| JPWO2024024561A1 (enExample) * | 2022-07-29 | 2024-02-01 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2197915B (en) | 1986-11-19 | 1990-11-14 | Rolls Royce Plc | Improvements in or relating to fluid bearings |
| IT1207525B (it) | 1987-06-23 | 1989-05-25 | Ist Naz Ric Sul Cancro | Metodo per la preservazione difogli trapiantabili di epitelio coltivato in vitro vitale. |
| US5145770A (en) | 1990-06-04 | 1992-09-08 | Biosurface Technology, Inc. | Cryopreservation of cultured epithelial sheets |
| EP0790767B1 (en) | 1994-11-09 | 2001-10-10 | Celadon Science, LLC | Wound repair dressings and methods for their preservation |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5905042A (en) | 1996-04-01 | 1999-05-18 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Cultured inner cell mass cell lines derived from bovine or porcine embryos |
| EP0986635A4 (en) | 1997-01-10 | 2001-11-07 | Life Technologies Inc | SERUM SUBSTITUTE FOR EMBRYONIC STEM CELLS |
| CA2409703A1 (en) | 2000-05-16 | 2001-11-22 | Shin-Ichi Nishikawa | Novel differentiation inducing process of embryonic stem cell to ectodermal cell and its use |
| AU2001263199B2 (en) | 2000-05-17 | 2004-09-16 | Asterias Biotherapeutics, Inc. | Neural progenitor cell populations |
| US20030211603A1 (en) | 2001-08-14 | 2003-11-13 | Earp David J. | Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells |
| WO2005080554A1 (ja) | 2004-02-23 | 2005-09-01 | Kyoto University | 胚性幹細胞の分化調節方法 |
| EP1783205B1 (en) | 2004-06-18 | 2024-02-21 | Riken | Method of inducing the differentiation of embryonic stem cells into nerve by serum-free suspension culture |
| US7442548B2 (en) | 2004-09-08 | 2008-10-28 | Wisconsin Alumni Research Foundation | Culturing human embryonic stem cells in medium containing pipecholic acid and gamma amino butyric acid |
| US20070116680A1 (en) | 2005-11-18 | 2007-05-24 | Rensselaer Polytechnic Institute | Stem cells within gel microenvironments |
| JP5419279B2 (ja) | 2007-01-17 | 2014-02-19 | ウィスコンシン アラムニ リサーチ ファンデーション | 改良された幹細胞の培養 |
| EP3447128A1 (en) | 2008-06-04 | 2019-02-27 | FUJIFILM Cellular Dynamics, Inc. | Methods for the production of ips cells using non-viral approach |
| WO2010134619A1 (ja) * | 2009-05-18 | 2010-11-25 | 国立大学法人東北大学 | 人工多能性幹細胞からの上皮系前駆細胞・幹細胞群及び角膜上皮細胞群の分化誘導方法 |
| CN103087991B (zh) | 2009-06-05 | 2018-06-12 | 富士胶片细胞动力公司 | 重编程t细胞和造血细胞的方法 |
| KR101785347B1 (ko) | 2010-11-19 | 2017-10-17 | (주)아모레퍼시픽 | 피부 세포 분화 촉진 물질의 스크리닝 방법 |
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2015
- 2015-10-13 EP EP15785007.4A patent/EP3207122B1/en active Active
- 2015-10-13 JP JP2017519905A patent/JP6581655B2/ja active Active
- 2015-10-13 WO PCT/US2015/055284 patent/WO2016061071A1/en not_active Ceased
- 2015-10-13 US US14/881,747 patent/US10047341B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017532047A (ja) | 2017-11-02 |
| WO2016061071A8 (en) | 2016-05-26 |
| WO2016061071A1 (en) | 2016-04-21 |
| US20160102289A1 (en) | 2016-04-14 |
| US10047341B2 (en) | 2018-08-14 |
| EP3207122A1 (en) | 2017-08-23 |
| EP3207122B1 (en) | 2019-05-08 |
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