JP6577491B2 - ベルビンの酸化的脱芳香族化 - Google Patents

ベルビンの酸化的脱芳香族化 Download PDF

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Publication number
JP6577491B2
JP6577491B2 JP2016569059A JP2016569059A JP6577491B2 JP 6577491 B2 JP6577491 B2 JP 6577491B2 JP 2016569059 A JP2016569059 A JP 2016569059A JP 2016569059 A JP2016569059 A JP 2016569059A JP 6577491 B2 JP6577491 B2 JP 6577491B2
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formula
compound
hydrogen
halogen
substituted
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Japanese (ja)
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JP2017518987A (ja
JP2017518987A5 (enExample
Inventor
クリストファー ダブリュー． グローテ，
クリストファー ダブリュー． グローテ，
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スペックジーエックス エルエルシー
スペックジーエックス エルエルシー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2016569059A 2014-06-11 2015-06-11 ベルビンの酸化的脱芳香族化 Active JP6577491B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462010648P 2014-06-11 2014-06-11
US62/010,648 2014-06-11
PCT/US2015/035300 WO2015191837A1 (en) 2014-06-11 2015-06-11 Oxidative dearomatization of berbines

Publications (3)

Publication Number Publication Date
JP2017518987A JP2017518987A (ja) 2017-07-13
JP2017518987A5 JP2017518987A5 (enExample) 2018-05-17
JP6577491B2 true JP6577491B2 (ja) 2019-09-18

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ID=54834304

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016569059A Active JP6577491B2 (ja) 2014-06-11 2015-06-11 ベルビンの酸化的脱芳香族化

Country Status (9)

Country Link
US (1) US9593111B2 (enExample)
EP (1) EP3154968B1 (enExample)
JP (1) JP6577491B2 (enExample)
AU (1) AU2015274545B2 (enExample)
BR (1) BR112016027834B1 (enExample)
CA (1) CA2950768C (enExample)
ES (1) ES2813678T3 (enExample)
MX (1) MX376440B (enExample)
WO (1) WO2015191837A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015051106A1 (en) * 2013-10-04 2015-04-09 Mallinckrodt Llc Substituted berbines and their synthesis
CA2950768C (en) 2014-06-11 2023-03-28 Mallinckrodt Llc Oxidative dearomatization of berbines

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5019781A (enExample) * 1973-06-25 1975-03-01
JPS5116698A (en) * 1974-07-27 1976-02-10 Kanebo Ltd Jibenzo * a*g * kinorijiniumujudotaino shinkigoseiho
US4033966A (en) 1975-06-24 1977-07-05 Kanebo, Ltd. Novel berbine derivatives
KR100706309B1 (ko) * 2006-02-14 2007-04-12 한국생명공학연구원 항진균 활성이 우수한 베르베루빈 유도체
US9458109B2 (en) * 2008-09-03 2016-10-04 Mallinckrodt Llc Substituted berbines and processes for their synthesis
CN101665491B (zh) * 2009-09-17 2011-09-28 长春工业大学 小檗碱13位衍生物和小檗红碱13位衍生物的合成方法
CN101798285B (zh) * 2010-02-10 2012-05-23 中国科学院上海有机化学研究所 一种青藤碱衍生物、合成方法及其用途
JOP20200043A1 (ar) * 2011-05-10 2017-06-16 Amgen Inc طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول
CN102850346A (zh) * 2012-09-27 2013-01-02 四川大学 小檗红碱12-位衍生物及其制备方法和用途
CA2950768C (en) 2014-06-11 2023-03-28 Mallinckrodt Llc Oxidative dearomatization of berbines

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Publication number Publication date
JP2017518987A (ja) 2017-07-13
ES2813678T3 (es) 2021-03-24
MX2016015507A (es) 2017-04-25
BR112016027834A2 (enExample) 2017-08-22
US9593111B2 (en) 2017-03-14
CA2950768A1 (en) 2015-12-17
AU2015274545B2 (en) 2019-02-28
US20150361076A1 (en) 2015-12-17
BR112016027834B1 (pt) 2023-12-26
EP3154968A4 (en) 2018-02-07
MX376440B (es) 2025-03-07
EP3154968A1 (en) 2017-04-19
EP3154968B1 (en) 2020-08-05
WO2015191837A1 (en) 2015-12-17
CA2950768C (en) 2023-03-28
AU2015274545A1 (en) 2016-12-15

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