JP6570124B2 - 口腔ケア組成物 - Google Patents
口腔ケア組成物 Download PDFInfo
- Publication number
- JP6570124B2 JP6570124B2 JP2016089763A JP2016089763A JP6570124B2 JP 6570124 B2 JP6570124 B2 JP 6570124B2 JP 2016089763 A JP2016089763 A JP 2016089763A JP 2016089763 A JP2016089763 A JP 2016089763A JP 6570124 B2 JP6570124 B2 JP 6570124B2
- Authority
- JP
- Japan
- Prior art keywords
- saliva
- calcium
- oral cavity
- care composition
- phosphorylated oligosaccharide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title claims description 40
- 210000000214 mouth Anatomy 0.000 claims description 62
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 52
- 239000011575 calcium Substances 0.000 claims description 52
- 229910052791 calcium Inorganic materials 0.000 claims description 52
- 229920001542 oligosaccharide Polymers 0.000 claims description 48
- 150000002482 oligosaccharides Chemical class 0.000 claims description 47
- 102000010445 Lactoferrin Human genes 0.000 claims description 32
- 108010063045 Lactoferrin Proteins 0.000 claims description 32
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims description 32
- 235000021242 lactoferrin Nutrition 0.000 claims description 32
- 229940078795 lactoferrin Drugs 0.000 claims description 32
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 claims description 25
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 claims description 25
- 235000012538 ammonium bicarbonate Nutrition 0.000 claims description 25
- 239000001099 ammonium carbonate Substances 0.000 claims description 25
- 230000036541 health Effects 0.000 claims description 11
- 210000003296 saliva Anatomy 0.000 description 80
- 235000001465 calcium Nutrition 0.000 description 51
- 230000028327 secretion Effects 0.000 description 30
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 24
- 108010023244 Lactoperoxidase Proteins 0.000 description 22
- 102000045576 Lactoperoxidases Human genes 0.000 description 22
- 229940057428 lactoperoxidase Drugs 0.000 description 22
- 230000000052 comparative effect Effects 0.000 description 21
- 230000009471 action Effects 0.000 description 20
- 230000001965 increasing effect Effects 0.000 description 19
- 230000000694 effects Effects 0.000 description 18
- 102000016611 Proteoglycans Human genes 0.000 description 16
- 108010067787 Proteoglycans Proteins 0.000 description 16
- 208000002925 dental caries Diseases 0.000 description 16
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 12
- 235000017557 sodium bicarbonate Nutrition 0.000 description 12
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 11
- 230000001680 brushing effect Effects 0.000 description 11
- 235000018102 proteins Nutrition 0.000 description 11
- 102000004169 proteins and genes Human genes 0.000 description 11
- 108090000623 proteins and genes Proteins 0.000 description 11
- 230000000844 anti-bacterial effect Effects 0.000 description 9
- 235000013305 food Nutrition 0.000 description 9
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 8
- 229910001424 calcium ion Inorganic materials 0.000 description 8
- 239000001506 calcium phosphate Substances 0.000 description 7
- 229910000389 calcium phosphate Inorganic materials 0.000 description 7
- 235000011010 calcium phosphates Nutrition 0.000 description 7
- 239000003205 fragrance Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 238000005115 demineralization Methods 0.000 description 6
- 230000002328 demineralizing effect Effects 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 6
- 239000002994 raw material Substances 0.000 description 6
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 229920001353 Dextrin Polymers 0.000 description 5
- 239000004375 Dextrin Substances 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 5
- 239000000551 dentifrice Substances 0.000 description 5
- 235000019425 dextrin Nutrition 0.000 description 5
- 229910052500 inorganic mineral Inorganic materials 0.000 description 5
- 235000013336 milk Nutrition 0.000 description 5
- 210000004080 milk Anatomy 0.000 description 5
- 239000008267 milk Substances 0.000 description 5
- 235000010755 mineral Nutrition 0.000 description 5
- 239000011707 mineral Substances 0.000 description 5
- 230000003248 secreting effect Effects 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 206010039424 Salivary hypersecretion Diseases 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 230000003139 buffering effect Effects 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 4
- 230000007935 neutral effect Effects 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 208000026451 salivation Diseases 0.000 description 4
- 229920006395 saturated elastomer Polymers 0.000 description 4
- 230000002195 synergetic effect Effects 0.000 description 4
- 229940034610 toothpaste Drugs 0.000 description 4
- 239000000606 toothpaste Substances 0.000 description 4
- 239000000811 xylitol Substances 0.000 description 4
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 4
- 229960002675 xylitol Drugs 0.000 description 4
- 235000010447 xylitol Nutrition 0.000 description 4
- 102000013142 Amylases Human genes 0.000 description 3
- 108010065511 Amylases Proteins 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 3
- 235000013539 calcium stearate Nutrition 0.000 description 3
- 239000008116 calcium stearate Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000029087 digestion Effects 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 3
- 210000003681 parotid gland Anatomy 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000004382 Amylase Substances 0.000 description 2
- 206010006326 Breath odour Diseases 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 244000061456 Solanum tuberosum Species 0.000 description 2
- 235000002595 Solanum tuberosum Nutrition 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 235000019418 amylase Nutrition 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229960005069 calcium Drugs 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 239000010794 food waste Substances 0.000 description 2
- 239000004083 gastrointestinal agent Substances 0.000 description 2
- 229940127227 gastrointestinal drug Drugs 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 230000006058 immune tolerance Effects 0.000 description 2
- -1 pentose sugar alcohol Chemical class 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 235000012015 potatoes Nutrition 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- 210000001913 submandibular gland Anatomy 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241000972773 Aulopiformes Species 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 description 1
- 102100022624 Glucoamylase Human genes 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000008133 Iron-Binding Proteins Human genes 0.000 description 1
- 108010035210 Iron-Binding Proteins Proteins 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 240000003183 Manihot esculenta Species 0.000 description 1
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 208000001388 Opportunistic Infections Diseases 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 239000004115 Sodium Silicate Substances 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 206010062129 Tongue neoplasm Diseases 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 230000002491 angiogenic effect Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 239000004067 bulking agent Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 230000001013 cariogenic effect Effects 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 210000003022 colostrum Anatomy 0.000 description 1
- 235000021277 colostrum Nutrition 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 239000004081 narcotic agent Substances 0.000 description 1
- 210000002184 nasal cartilage Anatomy 0.000 description 1
- 230000014399 negative regulation of angiogenesis Effects 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 235000019645 odor Nutrition 0.000 description 1
- 229940005483 opioid analgesics Drugs 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
- 229910052911 sodium silicate Inorganic materials 0.000 description 1
- 235000014214 soft drink Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 201000006134 tongue cancer Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Seasonings (AREA)
- Non-Alcoholic Beverages (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
リン酸化オリゴ糖カルシウムは、北海道産のジャガイモを原料とした澱粉由来の成分である。ジャガイモの澱粉にはリン酸基が結合している部位があり、その澱粉に酵素を作用させて抽出及び精製し、カルシウム塩として調製したものが、リン酸化オリゴ糖カルシウムである。このリン酸化オリゴ糖カルシウムは、口腔内に含ませることにより、唾液を大量に分泌させる作用を引き起こさせる。また、このリン酸化オリゴ糖カルシウムは、カルシウム源としての機能を発揮することに加え、う蝕原性細菌であるミュータンスレンサ球菌の栄養源にならず、更に口腔内のpH低下を緩衝作用によって抑制する機能も発揮しえる。リン酸化オリゴ糖カルシウムは、溶解したカルシウムイオンが唾液中において増強されることにより、歯の再石灰化も促進させることが可能となる。
タンパク質は、カルシウムイオンが結合され、高分子量(分子量約8万以上)のタンパク質である。このタンパク質は、口腔内でカルシウムイオンが結合されることで、タンパク質分解酵素に破壊されにくくなり、構造的に安定化する。また、タンパク質は、口腔内を刺激して耳下腺からの唾液を分泌させる作用を引き起こさせる。
重炭酸塩は、例えば、重炭酸ナトリウム(炭酸水素ナトリウム)、重炭酸アンモニウム等である。重炭酸ナトリウムは、一般に重曹と称されるもので、ふくらし粉、清涼飲料などの添加剤として各種の食品分野や、人工透析剤、胃腸薬などの医薬品分野において、さらに消火剤、浴用剤、洗浄剤などとして広く使用されている。このような重炭酸ナトリウムを、口腔内に含ませることにより、唾液を大量に分泌させる作用を引き起こさせる。
ラクトパーオキシターゼは、ラクトフェリンと同様に、唾液や乳に含まれる生体防御成分であり、歯周病菌等の各種細菌に対して抗菌作用を示す酵素である。このようなラクトパーオキシターゼを含有することにより、唾液の分泌を促す。このラクトパーオキシターゼが全質量に対する質量%で1%未満である場合には、抗菌作用をより効果的に発現させることができない。一方、このラクトパーオキシターゼが全質量に対する質量%で20%超である場合には、効果が飽和してしまう。このため、このラクトパーオキシターゼによる唾液分泌作用と抗菌作用を好適に発現させるためには、ラクトパーオキシターゼの含有量は1〜20%とする。
難消化性デキストリンは、とうもろこし、小麦、米、豆類、イモ類、タピオカなどの植物由来の澱粉を加酸および/または加熱して得た焙焼デキストリンを、必要に応じてαアミラーゼ及び/又はグルコアミラーゼで処理した後、必要に応じて脱塩、脱色した水溶性食物繊維であり、難消化性の特徴を持つものをいう。本発明を適用した口腔ケア組成物では、錠剤として構成する場合における増量剤として使用され、その含有量は特に限定されるものではなく適量添加される。
Claims (1)
- 口腔内に含ませることにより口腔内の健康を増進する口腔ケア組成物において、
組成物全質量に対する質量%で、
リン酸化オリゴ糖カルシウム:1〜30%、
ラクトフェリン:0.01〜10% 、
重炭酸アンモニウム:1〜20%を含有すること
を特徴とする口腔ケア組成物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2015095075 | 2015-05-07 | ||
JP2015095075 | 2015-05-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2016210768A JP2016210768A (ja) | 2016-12-15 |
JP6570124B2 true JP6570124B2 (ja) | 2019-09-04 |
Family
ID=57550478
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015227257A Active JP6256770B2 (ja) | 2015-04-27 | 2015-11-20 | 口腔ケア組成物、錠剤、顆粒状薬剤 |
JP2016070214A Pending JP2016210762A (ja) | 2015-04-27 | 2016-03-31 | 低体温改善剤 |
JP2016089763A Expired - Fee Related JP6570124B2 (ja) | 2015-05-07 | 2016-04-27 | 口腔ケア組成物 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015227257A Active JP6256770B2 (ja) | 2015-04-27 | 2015-11-20 | 口腔ケア組成物、錠剤、顆粒状薬剤 |
JP2016070214A Pending JP2016210762A (ja) | 2015-04-27 | 2016-03-31 | 低体温改善剤 |
Country Status (1)
Country | Link |
---|---|
JP (3) | JP6256770B2 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6256770B2 (ja) * | 2015-05-07 | 2018-01-10 | ジャパンモード株式会社 | 口腔ケア組成物、錠剤、顆粒状薬剤 |
JP7272214B2 (ja) * | 2019-09-24 | 2023-05-12 | 日油株式会社 | デンタルプラーク・ステイン付着防止剤および口腔用組成物 |
WO2023112209A1 (ja) * | 2021-12-15 | 2023-06-22 | 株式会社げいほく薬局 | 水溶性組成物及びその製造方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1736388B (zh) * | 2001-02-28 | 2010-04-14 | 江崎格力高株式会社 | 具有抗龋齿功能的组合物 |
JP2002322088A (ja) * | 2001-04-24 | 2002-11-08 | Kakunai Juyotai Kenkyusho:Kk | 口腔貼付用製剤 |
WO2005084703A1 (ja) * | 2004-03-09 | 2005-09-15 | Nrl Pharma, Inc. | 徐放性の口腔用組成物 |
JP2007332072A (ja) * | 2006-06-15 | 2007-12-27 | Snow Brand Milk Prod Co Ltd | 歯質硬度維持剤 |
WO2010061932A1 (ja) * | 2008-11-28 | 2010-06-03 | 江崎グリコ株式会社 | リン酸化糖、ポリフェノールおよびフッ素を含む、食品および組成物 |
JP5747274B1 (ja) * | 2015-01-26 | 2015-07-08 | ジャパンモード株式会社 | 口腔ケア組成物 |
JP5924604B1 (ja) * | 2015-04-27 | 2016-05-25 | ジャパンモード株式会社 | 口腔ケア組成物 |
JP6256770B2 (ja) * | 2015-05-07 | 2018-01-10 | ジャパンモード株式会社 | 口腔ケア組成物、錠剤、顆粒状薬剤 |
JP6570112B2 (ja) * | 2015-06-18 | 2019-09-04 | ジャパンモード株式会社 | 医薬品の製造方法 |
-
2015
- 2015-11-20 JP JP2015227257A patent/JP6256770B2/ja active Active
-
2016
- 2016-03-31 JP JP2016070214A patent/JP2016210762A/ja active Pending
- 2016-04-27 JP JP2016089763A patent/JP6570124B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2016210758A (ja) | 2016-12-15 |
JP2016210762A (ja) | 2016-12-15 |
JP2016210768A (ja) | 2016-12-15 |
JP6256770B2 (ja) | 2018-01-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR101992927B1 (ko) | 잇몸질환 예방 및 개선용 치약 조성물 | |
KR20120086685A (ko) | 치마제 조성물 | |
JP6570124B2 (ja) | 口腔ケア組成物 | |
JP5747274B1 (ja) | 口腔ケア組成物 | |
KR20120117387A (ko) | 잇몸질환예방 및 완화를 위한 구강 조성물 | |
AU2016255815B2 (en) | Oral care composition | |
JP5924604B1 (ja) | 口腔ケア組成物 | |
CN102342363A (zh) | 竹盐健康爽口怡 | |
KR20110128516A (ko) | 천연생약성분과 죽염, 자일리톨, 천연계면활성제(소듐코코일애플아미노산)를 주성분으로 하는 천연 한방치약조성물 | |
KR20180064161A (ko) | D-테트라히드로팔마틴을 포함하는 구강질환 예방 또는 치료용 조성물 | |
JP6570112B2 (ja) | 医薬品の製造方法 | |
WO2016174861A1 (ja) | 口腔ケア組成物 | |
US10894004B2 (en) | Composition | |
US20250161171A1 (en) | Toothpaste tablet having xylitol and nano-hydroxyapatite and associated method of making | |
AU2011383389A1 (en) | Improvements in oral health, products and methods therefor | |
CN101524109B (zh) | 奶精营养口香糖 | |
JP6479547B2 (ja) | 動物用デンタルケア用組成物 | |
KR20180055520A (ko) | 네페린을 포함하는 구강질환 예방 또는 치료용 조성물 | |
JP2023079784A (ja) | 口腔用組成物 | |
KR20180046244A (ko) | 코디세핀을 포함하는 구강질환 예방 또는 치료용 조성물 | |
JP6075345B2 (ja) | コンドロイチン製剤 | |
WO2025111132A2 (en) | Toothpaste tablet having xylitol and nano-hydroxyapatite and associated method of making | |
KR20220157691A (ko) | 레몬즙에 크림제형을 혼합한 동물 링웜 혼합크림 및 제조방법 | |
CN102511627A (zh) | 健口消疾口香糖及泡泡糖 | |
TW201836583A (zh) | 潔牙劑組成物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20180320 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20190507 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190619 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20190723 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20190802 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6570124 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
LAPS | Cancellation because of no payment of annual fees |