JP6563482B2 - 修飾ヌクレオチドリンカー - Google Patents
修飾ヌクレオチドリンカー Download PDFInfo
- Publication number
- JP6563482B2 JP6563482B2 JP2017506886A JP2017506886A JP6563482B2 JP 6563482 B2 JP6563482 B2 JP 6563482B2 JP 2017506886 A JP2017506886 A JP 2017506886A JP 2017506886 A JP2017506886 A JP 2017506886A JP 6563482 B2 JP6563482 B2 JP 6563482B2
- Authority
- JP
- Japan
- Prior art keywords
- nucleotide
- nucleoside
- formula
- linker
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1414098.2A GB201414098D0 (en) | 2014-08-08 | 2014-08-08 | Modified nucleotide linkers |
| GB1414098.2 | 2014-08-08 | ||
| PCT/GB2015/052282 WO2016020691A1 (en) | 2014-08-08 | 2015-08-06 | Modified nucleotide linkers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019136261A Division JP2020015722A (ja) | 2014-08-08 | 2019-07-24 | 修飾ヌクレオチドリンカー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017525695A JP2017525695A (ja) | 2017-09-07 |
| JP2017525695A5 JP2017525695A5 (enExample) | 2018-06-28 |
| JP6563482B2 true JP6563482B2 (ja) | 2019-08-21 |
Family
ID=51629525
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017506886A Active JP6563482B2 (ja) | 2014-08-08 | 2015-08-06 | 修飾ヌクレオチドリンカー |
| JP2019136261A Pending JP2020015722A (ja) | 2014-08-08 | 2019-07-24 | 修飾ヌクレオチドリンカー |
| JP2021148730A Active JP7726707B2 (ja) | 2014-08-08 | 2021-09-13 | 修飾ヌクレオチドリンカー |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019136261A Pending JP2020015722A (ja) | 2014-08-08 | 2019-07-24 | 修飾ヌクレオチドリンカー |
| JP2021148730A Active JP7726707B2 (ja) | 2014-08-08 | 2021-09-13 | 修飾ヌクレオチドリンカー |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US10190157B2 (enExample) |
| EP (2) | EP3564252B1 (enExample) |
| JP (3) | JP6563482B2 (enExample) |
| KR (2) | KR102287718B1 (enExample) |
| CN (2) | CN106604926B (enExample) |
| AU (2) | AU2015298469B2 (enExample) |
| BR (2) | BR122020018717B1 (enExample) |
| CA (1) | CA2957382C (enExample) |
| DK (2) | DK3564252T3 (enExample) |
| ES (2) | ES2773438T3 (enExample) |
| GB (1) | GB201414098D0 (enExample) |
| IL (1) | IL250498B (enExample) |
| MX (2) | MX385213B (enExample) |
| MY (1) | MY195167A (enExample) |
| NZ (1) | NZ728810A (enExample) |
| RU (1) | RU2699993C2 (enExample) |
| SG (3) | SG10202000850XA (enExample) |
| WO (1) | WO2016020691A1 (enExample) |
| ZA (1) | ZA201700838B (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201414098D0 (en) | 2014-08-08 | 2014-09-24 | Illumina Cambridge Ltd | Modified nucleotide linkers |
| EP3091026B1 (en) * | 2015-05-08 | 2019-02-20 | Centrillion Technology Holdings Corporation | Disulfide-linked reversible terminators |
| WO2017058953A1 (en) | 2015-09-28 | 2017-04-06 | The Trustees Of Columbia University In The City Of New York | Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis |
| CN116656795A (zh) | 2016-05-23 | 2023-08-29 | 纽约哥伦比亚大学董事会 | 核苷酸衍生物及其使用方法 |
| MY203439A (en) * | 2016-12-22 | 2024-06-28 | Illumina Inc | Array including sequencing primer and non-sequencing entity |
| EP3596099B1 (en) | 2017-03-06 | 2024-07-24 | Singular Genomics Systems, Inc. | Nucleic acid sequencing-by-synthesis (sbs) methods that combine sbs cycle steps |
| CN119639879A (zh) | 2017-03-28 | 2025-03-18 | 哥伦比亚大学董事会 | 用于连接荧光标记与用于dna合成测序的碱基的具有不同可裂解连接子的3'-o-改性的核苷酸类似物 |
| CN110650968B (zh) * | 2017-10-11 | 2022-07-05 | 深圳华大智造科技股份有限公司 | 修饰的核苷或核苷酸 |
| US12215124B2 (en) | 2018-02-21 | 2025-02-04 | Singular Genomics Systems, Inc. | Fluorinated nucleotides and uses thereof |
| US12188086B2 (en) | 2018-03-15 | 2025-01-07 | The Trustees Of Columbia University In The City Of New York | Nucleotide analogues and use thereof for nucleic acid sequencing and analysis preliminary class |
| EP3870593A4 (en) | 2018-10-25 | 2022-11-16 | Singular Genomics Systems, Inc. | NUCLEOTIDE ANALOGUES |
| CN112639126A (zh) | 2018-12-14 | 2021-04-09 | 伊卢米纳剑桥有限公司 | 降低测序期间用未标记的核苷酸的定相 |
| US11293061B2 (en) | 2018-12-26 | 2022-04-05 | Illumina Cambridge Limited | Sequencing methods using nucleotides with 3′ AOM blocking group |
| EP3908286A4 (en) | 2019-01-08 | 2022-10-12 | Singular Genomics Systems, Inc. | NUCLEOTIDE CLEAVABLE LINKERS AND USES THEREOF |
| NL2023327B1 (en) | 2019-03-01 | 2020-09-17 | Illumina Inc | Multiplexed fluorescent detection of analytes |
| MX2020013384A (es) | 2019-03-01 | 2021-04-28 | Illumina Cambridge Ltd | Compuestos de comarina sustituidos con amina exocíclica y sus usos como etiquetas fluorescentes. |
| JP2022521866A (ja) | 2019-03-01 | 2022-04-13 | イルミナ ケンブリッジ リミテッド | 第三級アミン置換クマリン化合物およびそれらの蛍光標識としての使用 |
| WO2020178231A1 (en) | 2019-03-01 | 2020-09-10 | Illumina, Inc. | Multiplexed fluorescent detection of analytes |
| US11421271B2 (en) | 2019-03-28 | 2022-08-23 | Illumina Cambridge Limited | Methods and compositions for nucleic acid sequencing using photoswitchable labels |
| JP2023510454A (ja) | 2019-11-27 | 2023-03-14 | イルミナ ケンブリッジ リミテッド | シクロオクタテトラエンを含有する色素及び組成物 |
| JP7287299B2 (ja) | 2020-01-31 | 2023-06-06 | トヨタ自動車株式会社 | 車両および車両制御インターフェース |
| EP4168421A1 (en) | 2020-06-22 | 2023-04-26 | Illumina Cambridge Limited | Nucleosides and nucleotides with 3' acetal blocking group |
| US11981964B2 (en) | 2020-07-28 | 2024-05-14 | Illumina Cambridge Limited | Substituted coumarin dyes and uses as fluorescent labels |
| US20220195196A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Alkylpyridinium coumarin dyes and uses in sequencing applications |
| US20220195517A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Long stokes shift chromenoquinoline dyes and uses in sequencing applications |
| US20220195516A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Methods, systems and compositions for nucleic acid sequencing |
| US20220195518A1 (en) | 2020-12-22 | 2022-06-23 | Illumina Cambridge Limited | Methods and compositions for nucleic acid sequencing |
| AU2022269804A1 (en) | 2021-05-05 | 2023-11-02 | Illumina Cambridge Limited | Fluorescent dyes containing bis-boron fused heterocycles and uses in sequencing |
| WO2022243480A1 (en) | 2021-05-20 | 2022-11-24 | Illumina, Inc. | Compositions and methods for sequencing by synthesis |
| KR20240026950A (ko) | 2021-05-26 | 2024-02-29 | 일루미나, 인코포레이티드 | 3'-차단된 뉴클레오티드의 정제 및 중합 |
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| US20230332197A1 (en) | 2022-03-31 | 2023-10-19 | Illumina Singapore Pte. Ltd. | Nucleosides and nucleotides with 3' vinyl blocking group |
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| CN119604513A (zh) | 2022-06-28 | 2025-03-11 | 因美纳公司 | 含有稠合四环双硼杂环的荧光染料及其在测序中的用途 |
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