JP6546161B2 - B型肝炎ウイルスを治療するための有機化合物 - Google Patents
B型肝炎ウイルスを治療するための有機化合物 Download PDFInfo
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- JP6546161B2 JP6546161B2 JP2016519839A JP2016519839A JP6546161B2 JP 6546161 B2 JP6546161 B2 JP 6546161B2 JP 2016519839 A JP2016519839 A JP 2016519839A JP 2016519839 A JP2016519839 A JP 2016519839A JP 6546161 B2 JP6546161 B2 JP 6546161B2
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- 239000012312 sodium hydride Substances 0.000 description 1
- RSIJVJUOQBWMIM-UHFFFAOYSA-L sodium sulfate decahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[O-]S([O-])(=O)=O RSIJVJUOQBWMIM-UHFFFAOYSA-L 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 description 1
- FAQYAMRNWDIXMY-UHFFFAOYSA-N trichloroborane Chemical compound ClB(Cl)Cl FAQYAMRNWDIXMY-UHFFFAOYSA-N 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
- 238000005866 tritylation reaction Methods 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 230000009265 virologic response Effects 0.000 description 1
- 238000013389 whole blood assay Methods 0.000 description 1
- WCNMEQDMUYVWMJ-JPZHCBQBSA-N wybutoxosine Chemical compound C1=NC=2C(=O)N3C(CC([C@H](NC(=O)OC)C(=O)OC)OO)=C(C)N=C3N(C)C=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O WCNMEQDMUYVWMJ-JPZHCBQBSA-N 0.000 description 1
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
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US201361886760P | 2013-10-04 | 2013-10-04 | |
US61/886,760 | 2013-10-04 | ||
PCT/US2014/058314 WO2015050871A2 (en) | 2013-10-04 | 2014-09-30 | Organic compounds to treat hepatitis b virus |
Publications (3)
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JP2016534031A JP2016534031A (ja) | 2016-11-04 |
JP2016534031A5 JP2016534031A5 (da) | 2017-11-09 |
JP6546161B2 true JP6546161B2 (ja) | 2019-07-17 |
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JP2016519839A Active JP6546161B2 (ja) | 2013-10-04 | 2014-09-30 | B型肝炎ウイルスを治療するための有機化合物 |
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US (1) | US10519446B2 (da) |
EP (1) | EP3052107B1 (da) |
JP (1) | JP6546161B2 (da) |
CN (1) | CN105792832B (da) |
HK (1) | HK1221912A1 (da) |
WO (1) | WO2015050871A2 (da) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US11008570B2 (en) | 2013-10-04 | 2021-05-18 | Novartis Ag | 3′ end caps for RNAi agents for use in RNA interference |
Families Citing this family (9)
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MX342731B (es) | 2011-06-30 | 2016-10-11 | Arrowhead Res Corp | Composiciones y metodos para inhibir la expresion genica del virus de hepatitis b. |
JP6546161B2 (ja) | 2013-10-04 | 2019-07-17 | ノバルティス アーゲー | B型肝炎ウイルスを治療するための有機化合物 |
US9988627B2 (en) | 2013-10-04 | 2018-06-05 | Novartis Ag | Formats for organic compounds for use in RNA interference |
US20170137821A1 (en) | 2015-07-17 | 2017-05-18 | Arcturus Therapeutics, Inc. | Molecules and agents for treating hepatitis b virus |
AU2016296592B2 (en) * | 2015-07-17 | 2021-08-19 | Arcturus Therapeutics, Inc. | Compositions and agents against Hepatitis B virus and uses thereof |
KR20180038465A (ko) | 2015-08-07 | 2018-04-16 | 애로우헤드 파마슈티컬스 인코포레이티드 | B형 간염 바이러스 감염에 대한 rnai 치료법 |
JOP20170161A1 (ar) | 2016-08-04 | 2019-01-30 | Arrowhead Pharmaceuticals Inc | عوامل RNAi للعدوى بفيروس التهاب الكبد ب |
CN110446259B (zh) * | 2018-05-04 | 2022-04-15 | 大唐移动通信设备有限公司 | 一种寻呼机会的位置确定方法及通信设备 |
WO2022038211A2 (en) * | 2020-08-21 | 2022-02-24 | F. Hoffmann-La Roche Ag | Use of a1cf inhibitors for treating hepatitis b virus infection |
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- 2014-09-30 WO PCT/US2014/058314 patent/WO2015050871A2/en active Application Filing
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EP3052107A2 (en) | 2016-08-10 |
EP3052107B1 (en) | 2018-05-02 |
CN105792832B (zh) | 2021-03-23 |
JP2016534031A (ja) | 2016-11-04 |
US20160215288A1 (en) | 2016-07-28 |
US10519446B2 (en) | 2019-12-31 |
HK1221912A1 (zh) | 2017-06-16 |
WO2015050871A2 (en) | 2015-04-09 |
WO2015050871A3 (en) | 2015-07-02 |
CN105792832A (zh) | 2016-07-20 |
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