JP6539585B2 - 抗ｃｄ８３抗体及びその使用 - Google Patents

抗ｃｄ８３抗体及びその使用 Download PDF

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Publication number
JP6539585B2
JP6539585B2 JP2015555498A JP2015555498A JP6539585B2 JP 6539585 B2 JP6539585 B2 JP 6539585B2 JP 2015555498 A JP2015555498 A JP 2015555498A JP 2015555498 A JP2015555498 A JP 2015555498A JP 6539585 B2 JP6539585 B2 JP 6539585B2
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Japan
Prior art keywords
binding protein
cells
binding
antibody
protein
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Expired - Fee Related
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JP2015555498A
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Japanese (ja)
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JP2016507521A (ja
JP2016507521A5 (enExample
Inventor
アン セルダン、テレーズ
アン セルダン、テレーズ
ジョン マンスター、デイヴィッド
ジョン マンスター、デイヴィッド
ナイジェル ジョン ハート、デレク
ナイジェル ジョン ハート、デレク
ルイーズ ジョーンズ、マーティナ
ルイーズ ジョーンズ、マーティナ
フィリップ マンロー、トレント
フィリップ マンロー、トレント
マイケル マーラー、スティーヴン
マイケル マーラー、スティーヴン
ユー チョウ、ユーニス
ユー チョウ、ユーニス
ディー マークス、ジェイムズ
ディー マークス、ジェイムズ
Original Assignee
デンドロサイト バイオテック ピーティーワイ リミテッド
デンドロサイト バイオテック ピーティーワイ リミテッド
ザ ユニヴァーシティ オヴ クイーンズランド
ザ ユニヴァーシティ オヴ クイーンズランド
ザ リージェンツ オヴ ザ ユニヴァーシティ オヴ カリフォルニア
ザ リージェンツ オヴ ザ ユニヴァーシティ オヴ カリフォルニア
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Publication of JP2016507521A publication Critical patent/JP2016507521A/ja
Publication of JP2016507521A5 publication Critical patent/JP2016507521A5/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2015555498A 2013-02-01 2014-01-31 抗ｃｄ８３抗体及びその使用 Expired - Fee Related JP6539585B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361759780P 2013-02-01 2013-02-01
US61/759,780 2013-02-01
PCT/AU2014/000066 WO2014117220A1 (en) 2013-02-01 2014-01-31 Anti-cd83 antibodies and use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019000340A Division JP2019076102A (ja) 2013-02-01 2019-01-04 抗ｃｄ８３抗体及びその使用

Publications (3)

Publication Number Publication Date
JP2016507521A JP2016507521A (ja) 2016-03-10
JP2016507521A5 JP2016507521A5 (enExample) 2017-02-23
JP6539585B2 true JP6539585B2 (ja) 2019-07-03

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015555498A Expired - Fee Related JP6539585B2 (ja) 2013-02-01 2014-01-31 抗ｃｄ８３抗体及びその使用
JP2019000340A Pending JP2019076102A (ja) 2013-02-01 2019-01-04 抗ｃｄ８３抗体及びその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019000340A Pending JP2019076102A (ja) 2013-02-01 2019-01-04 抗ｃｄ８３抗体及びその使用

Country Status (13)

Country Link
US (3) US9840559B2 (enExample)
EP (2) EP2951208B1 (enExample)
JP (2) JP6539585B2 (enExample)
KR (2) KR102204127B1 (enExample)
CN (1) CN105531289B (enExample)
AU (1) AU2014213009B2 (enExample)
CA (1) CA2899960C (enExample)
DK (1) DK2951208T3 (enExample)
ES (1) ES2762622T3 (enExample)
MX (1) MX2015010023A (enExample)
NZ (1) NZ711543A (enExample)
PT (1) PT2951208T (enExample)
WO (1) WO2014117220A1 (enExample)

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AU2014213009B2 (en) * 2013-02-01 2019-01-03 Kira Biotech Pty Limited Anti-CD83 antibodies and use thereof
AU2015336931B2 (en) * 2014-10-23 2021-04-29 Kira Biotech Pty Limited CD83 binding proteins and uses thereof
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US12492254B2 (en) * 2018-02-23 2025-12-09 H. Lee Moffitt Cancer Center and Research Intitute. Inc. CD83-binding chimeric antigen receptors
US11634501B2 (en) 2019-07-19 2023-04-25 Oncoresponse, Inc. Immunomodulatory antibodies and methods of use thereof
EP4013447A4 (en) * 2019-08-16 2024-05-29 H. Lee Moffitt Cancer Center & Research Institute, Inc. T CELLS EXPRESSING A CHIMERIC ANTI-CD83 ANTIGEN RECEPTOR
EP4674865A3 (en) * 2021-03-09 2026-03-25 GI Innovation, Inc. Formulation of fusion protein including extracellular domain of alpha subunit of ige fc receptor
WO2022260909A1 (en) * 2021-06-09 2022-12-15 H. Lee Moffitt Cancer Center And Research Institute Inc. Methods of using anti-cd83 chimeric antigen receptor expressing t cells
CN117547553A (zh) * 2023-11-21 2024-02-13 中国人民解放军陆军特色医学中心 Cd83+、cd83+pd-l1+间充质干细胞及其制备方法和应用
CN121975013A (zh) * 2026-04-09 2026-05-05 天津旷博同生生物技术有限公司 一种抗人cd83抗体及应用

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AU2015336931B2 (en) 2014-10-23 2021-04-29 Kira Biotech Pty Limited CD83 binding proteins and uses thereof
KR20200066613A (ko) 2017-09-13 2020-06-10 키라 바이오테크 피티와이 리미티드 치료 방법

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Publication number Publication date
CA2899960A1 (en) 2014-08-07
JP2016507521A (ja) 2016-03-10
US20180201681A1 (en) 2018-07-19
AU2014213009B2 (en) 2019-01-03
CN105531289B (zh) 2019-02-22
KR102449868B1 (ko) 2022-10-04
NZ711543A (en) 2020-08-28
DK2951208T3 (da) 2020-01-13
EP3626743A1 (en) 2020-03-25
US20200339684A1 (en) 2020-10-29
EP2951208B1 (en) 2019-11-13
US9840559B2 (en) 2017-12-12
KR20200120967A (ko) 2020-10-22
KR102204127B1 (ko) 2021-01-20
EP2951208A1 (en) 2015-12-09
CN105531289A (zh) 2016-04-27
WO2014117220A1 (en) 2014-08-07
AU2014213009A1 (en) 2015-09-17
PT2951208T (pt) 2019-12-30
EP2951208A4 (en) 2016-10-19
JP2019076102A (ja) 2019-05-23
KR20150135250A (ko) 2015-12-02
ES2762622T3 (es) 2020-05-25
MX2015010023A (es) 2017-11-17
US10781255B2 (en) 2020-09-22
CA2899960C (en) 2022-05-03
US20150376277A1 (en) 2015-12-31
US11725054B2 (en) 2023-08-15

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