JP6518690B2 - （５，６−ジヒドロ）ピリミド［４，５−ｅ］インドリジン - Google Patents

（５，６−ジヒドロ）ピリミド［４，５−ｅ］インドリジン Download PDF

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JP6518690B2
JP6518690B2 JP2016560952A JP2016560952A JP6518690B2 JP 6518690 B2 JP6518690 B2 JP 6518690B2 JP 2016560952 A JP2016560952 A JP 2016560952A JP 2016560952 A JP2016560952 A JP 2016560952A JP 6518690 B2 JP6518690 B2 JP 6518690B2
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carboxamide
anilino
dihydropyrimido
indolizine
methoxy
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JP2017510595A (ja
JP2017510595A5 (OSRAM
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マン，アドリアヌス ペトルス アントニウス デ
マン，アドリアヌス ペトルス アントニウス デ
クリスティアン ブイスマン，ロジエ
クリスティアン ブイスマン，ロジエ
ゲラルド ステーレンバーグ，ヤン
ゲラルド ステーレンバーグ，ヤン
コルネリス マリヌス ウイッデハーグ，ヨースト
コルネリス マリヌス ウイッデハーグ，ヨースト
ヴィット，ヨエリ ヨハネス ペトルス デ
ヴィット，ヨエリ ヨハネス ペトルス デ
ジェニー ルドルフ ザマン，グイド
ジェニー ルドルフ ザマン，グイド
Original Assignee
ネザーランズ トランスレーショナル リサーチ センター ビー．ブイ．
ネザーランズ トランスレーショナル リサーチ センター ビー．ブイ．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016560952A 2014-04-07 2015-03-30 （５，６−ジヒドロ）ピリミド［４，５−ｅ］インドリジン Active JP6518690B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP14163734.8 2014-04-07
EP14163734 2014-04-07
EP15153207.4 2015-01-30
EP15153207 2015-01-30
PCT/EP2015/056839 WO2015155042A1 (en) 2014-04-07 2015-03-30 (5,6-dihydro)pyrimido[4,5-e]indolizines

Publications (3)

Publication Number Publication Date
JP2017510595A JP2017510595A (ja) 2017-04-13
JP2017510595A5 JP2017510595A5 (OSRAM) 2018-05-17
JP6518690B2 true JP6518690B2 (ja) 2019-05-22

Family

ID=52774240

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JP2016560952A Active JP6518690B2 (ja) 2014-04-07 2015-03-30 （５，６−ジヒドロ）ピリミド［４，５−ｅ］インドリジン

Country Status (16)

Country Link
US (3) USRE50082E1 (OSRAM)
EP (1) EP3129374B1 (OSRAM)
JP (1) JP6518690B2 (OSRAM)
KR (1) KR102432420B1 (OSRAM)
CN (1) CN106132963B (OSRAM)
AU (1) AU2015243694B2 (OSRAM)
BR (1) BR112016022342B1 (OSRAM)
CA (1) CA2944610C (OSRAM)
DK (1) DK3129374T3 (OSRAM)
ES (1) ES2716165T3 (OSRAM)
HU (1) HUE043108T2 (OSRAM)
MX (1) MX368767B (OSRAM)
PL (1) PL3129374T3 (OSRAM)
PT (1) PT3129374T (OSRAM)
RU (1) RU2692479C2 (OSRAM)
WO (1) WO2015155042A1 (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2944610C (en) * 2014-04-07 2024-01-09 Netherlands Translational Research Center B.V. (5,6-dihydro)pyrimido[4,5-e]indolizines
CA2981844A1 (en) 2015-04-17 2016-10-20 Netherlands Translational Research Center B.V. Prognostic biomarkers for ttk inhibitor chemotherapy
US9771366B2 (en) * 2016-02-19 2017-09-26 Phoenix Molecular Design Substituted tetrahydropyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazine-2-carboxamides as RSK inhibitors
EA202092442A3 (ru) 2016-06-07 2021-08-31 Джакобио Фармасьютикалс Ко., Лтд. Новые гетероциклические производные, применимые в качестве ингибиторов shp2
CN106551938B (zh) * 2016-11-26 2017-11-24 广东安诺药业股份有限公司 一种治疗非酒精性脂肪肝的药物及其应用
KR102317480B1 (ko) 2017-03-23 2021-10-25 자코바이오 파마슈티칼스 컴퍼니 리미티드 Shp2 억제제로서 유용한 신규한 헤테로환형 유도체
WO2020063760A1 (en) 2018-09-26 2020-04-02 Jacobio Pharmaceuticals Co., Ltd. Novel heterocyclic derivatives useful as shp2 inhibitors
EP3924352A4 (en) 2019-02-11 2022-11-16 Phoenix Molecular Designs CRYSTALLINE FORMS OF AN RSK INHIBITOR
CA3241213A1 (en) * 2021-12-15 2023-06-22 Heidi Lane Pharmaceutical combinations for use in the treatment of neoplastic diseases
JP2024544083A (ja) * 2021-12-15 2024-11-27 シルラジェン，インコーポレイテッド 修飾ベータ－シクロデキストリンを含む医薬組成物
KR20240107329A (ko) * 2021-12-15 2024-07-09 신라젠(주) 신생물성 질환을 치료하는 방법
AU2023228543A1 (en) * 2022-03-04 2024-08-22 Sillajen, Inc. Pharmaceutical combinations for use in the treatment of neoplastic diseases.

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003024967A2 (en) * 2001-09-19 2003-03-27 Aventis Pharma S.A. Indolizines as kinase protein inhibitors
RS20050944A (sr) 2003-05-22 2008-06-05 Nerviano Medical Sciences S.R.L., Derivati pirazolo- hinazolina,postupci za njihovo dobijanje i njihova upotreba kao inhibitora kinaze
WO2008065054A1 (en) 2006-11-28 2008-06-05 Nerviano Medical Sciences S.R.L. Tricyclic indoles and (4,5-dihydro) indoles
WO2009156315A1 (en) 2008-06-26 2009-12-30 Nerviano Medical Sciences S.R.L. Pyrazolo-quinazolines
WO2010111406A2 (en) 2009-03-24 2010-09-30 Myriad Pharmaceuticals, Inc. Compounds and therapeutic uses thereof
ES2660146T3 (es) 2009-04-29 2018-03-21 Nerviano Medical Sciences S.R.L. Sales del inhibidor de cdk
CN103626777B (zh) 2009-07-29 2015-10-21 内尔维阿诺医学科学有限公司 Plk抑制剂的盐类
TW201107329A (en) 2009-07-30 2011-03-01 Oncotherapy Science Inc Fused imidazole derivative having ttk inhibitory action
EP2343297A1 (en) 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridines
CA2821829A1 (en) 2010-12-17 2012-06-21 Bayer Intellectual Property Gmbh Imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
EP2668190B1 (en) 2011-01-26 2016-08-17 Nerviano Medical Sciences S.r.l. Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors
CN105658650B (zh) 2013-06-24 2019-01-08 默克专利有限公司 用作卵泡刺激素受体调节剂的咪唑化合物及其用途
CA2944610C (en) * 2014-04-07 2024-01-09 Netherlands Translational Research Center B.V. (5,6-dihydro)pyrimido[4,5-e]indolizines

Also Published As

Publication number Publication date
CA2944610A1 (en) 2015-10-15
EP3129374A1 (en) 2017-02-15
CA2944610C (en) 2024-01-09
BR112016022342A8 (pt) 2021-07-20
RU2016141405A3 (OSRAM) 2018-10-02
DK3129374T3 (en) 2019-04-08
AU2015243694A1 (en) 2016-11-03
PT3129374T (pt) 2019-03-25
BR112016022342A2 (pt) 2017-08-15
EP3129374B1 (en) 2018-12-19
USRE48974E1 (en) 2022-03-15
KR20170013866A (ko) 2017-02-07
USRE50082E1 (en) 2024-08-20
CN106132963A (zh) 2016-11-16
PL3129374T3 (pl) 2019-07-31
MX368767B (es) 2019-10-15
MX2016012997A (es) 2016-12-07
KR102432420B1 (ko) 2022-08-17
AU2015243694B2 (en) 2019-01-17
HUE043108T2 (hu) 2019-07-29
US9856258B2 (en) 2018-01-02
BR112016022342B1 (pt) 2022-10-04
ES2716165T3 (es) 2019-06-10
US20170096432A1 (en) 2017-04-06
WO2015155042A1 (en) 2015-10-15
JP2017510595A (ja) 2017-04-13
RU2016141405A (ru) 2018-05-07
RU2692479C2 (ru) 2019-06-25
CN106132963B (zh) 2019-08-06

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