JP6510984B2 - 巨大分子の制御される捕捉、捕獲、及び輸送の為の統合された構成要素を有するナノ流体の装置、及び関連する分析方法 - Google Patents

巨大分子の制御される捕捉、捕獲、及び輸送の為の統合された構成要素を有するナノ流体の装置、及び関連する分析方法 Download PDF

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JP6510984B2
JP6510984B2 JP2015560260A JP2015560260A JP6510984B2 JP 6510984 B2 JP6510984 B2 JP 6510984B2 JP 2015560260 A JP2015560260 A JP 2015560260A JP 2015560260 A JP2015560260 A JP 2015560260A JP 6510984 B2 JP6510984 B2 JP 6510984B2
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fluid transport
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マイケル ラムジー，ジョン
マイケル ラムジー，ジョン
メナード，ローレント
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University of North Carolina at Chapel Hill
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
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    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
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    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0663—Stretching or orienting elongated molecules or particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/0896—Nanoscaled
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
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  • Clinical Laboratory Science (AREA)
  • Fluid Mechanics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
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JP2015560260A 2013-02-28 2014-02-26 巨大分子の制御される捕捉、捕獲、及び輸送の為の統合された構成要素を有するナノ流体の装置、及び関連する分析方法 Expired - Fee Related JP6510984B2 (ja)

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US201361770586P 2013-02-28 2013-02-28
US61/770,586 2013-02-28
PCT/US2014/018488 WO2014134095A1 (en) 2013-02-28 2014-02-26 Nanofluidic devices with integrated components for the controlled capture, trapping, and transport of macromolecules and related methods of analysis

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JP2016508616A JP2016508616A (ja) 2016-03-22
JP2016508616A5 JP2016508616A5 (enExample) 2017-03-02
JP6510984B2 true JP6510984B2 (ja) 2019-05-08

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US (2) US10261065B2 (enExample)
EP (2) EP2962117B1 (enExample)
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KR (1) KR20150132125A (enExample)
CN (1) CN105122070B (enExample)
AU (1) AU2014223620B2 (enExample)
CA (1) CA2902903A1 (enExample)
WO (1) WO2014134095A1 (enExample)

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AU2014223620A1 (en) 2015-08-27
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US20190187123A1 (en) 2019-06-20
CN105122070A (zh) 2015-12-02
US10261065B2 (en) 2019-04-16
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EP2962117A4 (en) 2016-10-12
US11073507B2 (en) 2021-07-27
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