CA2902903A1 - Nanofluidic devices with integrated components for the controlled capture, trapping, and transport of macromolecules and related methods of analysis - Google Patents
Nanofluidic devices with integrated components for the controlled capture, trapping, and transport of macromolecules and related methods of analysis Download PDFInfo
- Publication number
- CA2902903A1 CA2902903A1 CA2902903A CA2902903A CA2902903A1 CA 2902903 A1 CA2902903 A1 CA 2902903A1 CA 2902903 A CA2902903 A CA 2902903A CA 2902903 A CA2902903 A CA 2902903A CA 2902903 A1 CA2902903 A1 CA 2902903A1
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- Canada
- Prior art keywords
- nanochannel
- transport
- segments
- fluid transport
- fluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0663—Stretching or orienting elongated molecules or particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0896—Nanoscaled
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Nanotechnology (AREA)
- Clinical Laboratory Science (AREA)
- Fluid Mechanics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Electrochemistry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361770586P | 2013-02-28 | 2013-02-28 | |
| US61/770,586 | 2013-02-28 | ||
| PCT/US2014/018488 WO2014134095A1 (en) | 2013-02-28 | 2014-02-26 | Nanofluidic devices with integrated components for the controlled capture, trapping, and transport of macromolecules and related methods of analysis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2902903A1 true CA2902903A1 (en) | 2014-09-04 |
Family
ID=51387047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2902903A Abandoned CA2902903A1 (en) | 2013-02-28 | 2014-02-26 | Nanofluidic devices with integrated components for the controlled capture, trapping, and transport of macromolecules and related methods of analysis |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10261065B2 (enExample) |
| EP (2) | EP2962117B1 (enExample) |
| JP (1) | JP6510984B2 (enExample) |
| KR (1) | KR20150132125A (enExample) |
| CN (1) | CN105122070B (enExample) |
| AU (1) | AU2014223620B2 (enExample) |
| CA (1) | CA2902903A1 (enExample) |
| WO (1) | WO2014134095A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013039778A2 (en) | 2011-09-12 | 2013-03-21 | The University Of North Carolina At Chapel Hill | Devices with a fluid transport nanochannel intersected by a fluid sensing nanochannel and related methods |
| EP3591408A1 (en) | 2012-02-10 | 2020-01-08 | The University of North Carolina at Chapel Hill | Devices with fluidic nanofunnels, associated methods, fabrication and analysis systems |
| EP2864764B1 (en) * | 2012-06-20 | 2018-03-07 | The University of North Carolina At Chapel Hill | Integrated sample processing for electrospray ionization devices |
| CA2903481A1 (en) | 2013-03-13 | 2014-10-09 | The University Of North Carolina At Chapel Hill | Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis |
| EP3957983B1 (en) * | 2013-06-03 | 2023-12-13 | LUMICKS DSM Holding B.V. | Method and system for imaging a molecular strand |
| US9255905B1 (en) | 2015-05-11 | 2016-02-09 | The University Of North Carolina At Chapel Hill | Pressure driven microfluidic injection for chemical separations |
| WO2016182811A1 (en) * | 2015-05-11 | 2016-11-17 | The University Of North Carolina At Chapel Hill | Fluidic devices with nanoscale manifolds for molecular transport, related systems and methods of analysis |
| US10734216B2 (en) | 2015-05-11 | 2020-08-04 | The University Of North Carolina At Chapel Hill | Pressure driven fluidic injection for chemical separations by electrophoresis |
| US9606082B2 (en) | 2015-05-11 | 2017-03-28 | The University Of North Carolina At Chapel Hill | Pressure driven microfluidic injection for chemical separations |
| CN107614675B (zh) * | 2015-07-16 | 2021-08-17 | 香港科技大学 | 用于单分子dna分析的纳米通道的动态形成 |
| US9728387B2 (en) | 2015-10-20 | 2017-08-08 | The University Of North Carolina At Chapel Hill | Solid phase extraction with capillary electrophoresis |
| GB201704769D0 (en) | 2017-01-03 | 2017-05-10 | Illumina Inc | Flowcell cartridge with floating seal bracket |
| EP3396355A1 (en) * | 2017-04-27 | 2018-10-31 | Pharmafluidics NV | Lateral detection of fluid properties |
| US10539528B2 (en) | 2017-12-19 | 2020-01-21 | International Business Machines Corporation | Stacked nanofluidics structure |
| CN110354925B (zh) * | 2019-08-21 | 2023-09-19 | 苏州大学 | 一种包含可形变液态金属电极的微流控芯片及其制备方法 |
| CN113546696B (zh) * | 2020-04-23 | 2022-08-09 | 京东方科技集团股份有限公司 | 纳流体富集器件、其制作方法、富集方法及检测装置 |
| KR102716109B1 (ko) * | 2023-12-06 | 2024-10-11 | 주식회사 에모닉 | 눈물 삼투압 센서 및 이의 제조 방법 |
Family Cites Families (101)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5296116A (en) * | 1992-06-17 | 1994-03-22 | Beckman Instruments, Inc. | Capillary electrophoresis using time-varying field strength |
| US6001229A (en) | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
| US7775368B2 (en) | 1995-04-03 | 2010-08-17 | Wisconsin Alumni Research Foundation | Micro-channel long molecule manipulation system |
| US5872010A (en) | 1995-07-21 | 1999-02-16 | Northeastern University | Microscale fluid handling system |
| CN1329729C (zh) * | 1996-06-28 | 2007-08-01 | 卡钳生命科学股份有限公司 | 微流体系统 |
| US6074827A (en) | 1996-07-30 | 2000-06-13 | Aclara Biosciences, Inc. | Microfluidic method for nucleic acid purification and processing |
| US5858187A (en) * | 1996-09-26 | 1999-01-12 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing electrodynamic focusing on a microchip |
| US6316213B1 (en) | 1997-03-19 | 2001-11-13 | The Board Of Trustees Of The University Of Arkansas | Methods for the early diagnosis of ovarian, breast and lung cancer |
| US7033474B1 (en) * | 1997-04-25 | 2006-04-25 | Caliper Life Sciences, Inc. | Microfluidic devices incorporating improved channel geometries |
| US6969488B2 (en) | 1998-05-22 | 2005-11-29 | Solexa, Inc. | System and apparatus for sequential processing of analytes |
| US5900130A (en) * | 1997-06-18 | 1999-05-04 | Alcara Biosciences, Inc. | Method for sample injection in microchannel device |
| US5965410A (en) * | 1997-09-02 | 1999-10-12 | Caliper Technologies Corp. | Electrical current for controlling fluid parameters in microchannels |
| DE19826020C2 (de) * | 1998-06-10 | 2000-11-02 | Max Planck Gesellschaft | Vorrichtung und Verfahren zur miniaturisierten, hochparallelen elektrophoretischen Trennung |
| US6627446B1 (en) | 1998-07-02 | 2003-09-30 | Amersham Biosciences (Sv) Corp | Robotic microchannel bioanalytical instrument |
| US6790671B1 (en) | 1998-08-13 | 2004-09-14 | Princeton University | Optically characterizing polymers |
| WO2000042233A1 (en) | 1999-01-13 | 2000-07-20 | Cornell Research Foundation, Inc. | Monolithic fabrication of fluidic structures |
| US6500323B1 (en) | 1999-03-26 | 2002-12-31 | Caliper Technologies Corp. | Methods and software for designing microfluidic devices |
| US6690004B2 (en) | 1999-07-21 | 2004-02-10 | The Charles Stark Draper Laboratory, Inc. | Method and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry |
| US6524456B1 (en) | 1999-08-12 | 2003-02-25 | Ut-Battelle, Llc | Microfluidic devices for the controlled manipulation of small volumes |
| US6762059B2 (en) | 1999-08-13 | 2004-07-13 | U.S. Genomics, Inc. | Methods and apparatuses for characterization of single polymers |
| IL148088A0 (en) | 1999-08-13 | 2002-09-12 | Us Genomics Inc | Methods and apparatuses for stretching polymers |
| US6592733B1 (en) * | 1999-11-12 | 2003-07-15 | Motorola, Inc. | Capillary electrophoresis devices incorporating optical waveguides |
| ATE538490T1 (de) | 1999-12-30 | 2012-01-15 | Advion Biosystems Inc | Mehrfach-elektrospray-einrichtung, systeme und verfahren |
| US6537433B1 (en) * | 2000-03-10 | 2003-03-25 | Applera Corporation | Methods and apparatus for the location and concentration of polar analytes using an alternating electric field |
| US6994826B1 (en) * | 2000-09-26 | 2006-02-07 | Sandia National Laboratories | Method and apparatus for controlling cross contamination of microfluid channels |
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- 2014-02-26 KR KR1020157023761A patent/KR20150132125A/ko not_active Abandoned
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| KR20150132125A (ko) | 2015-11-25 |
| AU2014223620B2 (en) | 2017-09-14 |
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| AU2014223620A1 (en) | 2015-08-27 |
| EP2962117A1 (en) | 2016-01-06 |
| JP6510984B2 (ja) | 2019-05-08 |
| US20190187123A1 (en) | 2019-06-20 |
| CN105122070A (zh) | 2015-12-02 |
| US10261065B2 (en) | 2019-04-16 |
| EP2962117B1 (en) | 2019-10-09 |
| EP2962117A4 (en) | 2016-10-12 |
| US11073507B2 (en) | 2021-07-27 |
| JP2016508616A (ja) | 2016-03-22 |
| US20140238856A1 (en) | 2014-08-28 |
| CN105122070B (zh) | 2018-06-26 |
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