JP6496715B2 - ポリマー−キレーター複合体 - Google Patents

ポリマー−キレーター複合体 Download PDF

Info

Publication number
JP6496715B2
JP6496715B2 JP2016516633A JP2016516633A JP6496715B2 JP 6496715 B2 JP6496715 B2 JP 6496715B2 JP 2016516633 A JP2016516633 A JP 2016516633A JP 2016516633 A JP2016516633 A JP 2016516633A JP 6496715 B2 JP6496715 B2 JP 6496715B2
Authority
JP
Japan
Prior art keywords
biomaterial
tissue
complex
polymer
chelating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016516633A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016530217A5 (https=
JP2016530217A (ja
Inventor
ジェイ． コオブ，トーマス
ジェイ． コオブ，トーマス
Original Assignee
ミメディクス グループ インコーポレイテッド
ミメディクス グループ インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ミメディクス グループ インコーポレイテッド, ミメディクス グループ インコーポレイテッド filed Critical ミメディクス グループ インコーポレイテッド
Publication of JP2016530217A publication Critical patent/JP2016530217A/ja
Publication of JP2016530217A5 publication Critical patent/JP2016530217A5/ja
Application granted granted Critical
Publication of JP6496715B2 publication Critical patent/JP6496715B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6435—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a connective tissue peptide, e.g. collagen, fibronectin or gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2016516633A 2013-05-28 2013-10-30 ポリマー−キレーター複合体 Active JP6496715B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/903,878 2013-05-28
US13/903,878 US9446142B2 (en) 2013-05-28 2013-05-28 Polymer chelator conjugates
PCT/US2013/067620 WO2014193468A1 (en) 2013-05-28 2013-10-30 Polymer chelator conjugates

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018163086A Division JP2019006802A (ja) 2013-05-28 2018-08-31 ポリマー−キレーター複合体

Publications (3)

Publication Number Publication Date
JP2016530217A JP2016530217A (ja) 2016-09-29
JP2016530217A5 JP2016530217A5 (https=) 2016-12-08
JP6496715B2 true JP6496715B2 (ja) 2019-04-03

Family

ID=51985370

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016516633A Active JP6496715B2 (ja) 2013-05-28 2013-10-30 ポリマー−キレーター複合体
JP2018163086A Pending JP2019006802A (ja) 2013-05-28 2018-08-31 ポリマー−キレーター複合体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018163086A Pending JP2019006802A (ja) 2013-05-28 2018-08-31 ポリマー−キレーター複合体

Country Status (5)

Country Link
US (1) US9446142B2 (https=)
EP (1) EP3003326A4 (https=)
JP (2) JP6496715B2 (https=)
AU (1) AU2013390806B2 (https=)
WO (1) WO2014193468A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9943551B2 (en) 2012-08-15 2018-04-17 Mimedx Group, Inc. Tissue grafts composed of micronized placental tissue and methods of making and using the same
US10857266B2 (en) 2012-08-15 2020-12-08 Mimedx Group, Inc. Reinforced placental tissue grafts and methods of making and using the same
US9180145B2 (en) 2012-10-12 2015-11-10 Mimedx Group, Inc. Compositions and methods for recruiting and localizing stem cells
US8946163B2 (en) 2012-11-19 2015-02-03 Mimedx Group, Inc. Cross-linked collagen comprising metallic anticancer agents
US9155799B2 (en) 2012-11-19 2015-10-13 Mimedx Group, Inc. Cross-linked collagen with at least one bound antimicrobial agent for in vivo release of the agent
US10206977B1 (en) 2013-01-18 2019-02-19 Mimedx Group, Inc. Isolated placental stem cell recruiting factors
US10111910B2 (en) 2013-01-18 2018-10-30 Mimedx Group, Inc. Methods for treating cardiac conditions
US10029030B2 (en) 2013-03-15 2018-07-24 Mimedx Group, Inc. Molded placental tissue compositions and methods of making and using the same
US10335433B2 (en) * 2013-04-10 2019-07-02 Mimedx Group, Inc. NDGA polymers and metal complexes thereof
US10449220B2 (en) 2013-08-30 2019-10-22 Mimedx Group, Inc. Micronized placental compositions comprising a chelator
EP3094336A4 (en) 2014-01-17 2018-02-14 MIMEDX Group Inc. Method for inducing angiogenesis
EP3185918B1 (en) 2014-08-28 2021-08-18 MiMedx Group, Inc. Collagen reinforced tissue grafts
US12551509B2 (en) 2015-11-18 2026-02-17 Lucina Patent Holdco, Llc Acellular regenerative products and methods of their manufacture

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL74715A0 (en) 1984-03-27 1985-06-30 Univ New Jersey Med Biodegradable matrix and methods for producing same
USRE35748E (en) 1984-05-29 1998-03-17 Matrix Pharmaceutical, Inc. Treatments employing drug containing matrices for introduction into cellular lesion areas
US4619913A (en) 1984-05-29 1986-10-28 Matrix Pharmaceuticals, Inc. Treatments employing drug-containing matrices for introduction into cellular lesion areas
US4895727A (en) 1985-05-03 1990-01-23 Chemex Pharmaceuticals, Inc. Pharmaceutical vehicles for exhancing penetration and retention in the skin
AU6129486A (en) 1985-07-02 1987-01-30 Target Therapeutics, Inc. Vaso-occlusive collagen composition and method
US4847049A (en) 1985-12-18 1989-07-11 Vitaphore Corporation Method of forming chelated collagen having bactericidal properties
EP0290442A4 (en) 1986-11-19 1990-07-03 Chemex Pharmaceuticals Inc MEDICINAL PREPARATIONS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS.
EP0431164A4 (en) 1989-04-21 1992-06-03 Kishinevsky Selskokhozyaistvenny Institut Imeni M.V. Frunze Preparation with an anti-inflammatory, lactogenous and stimulating action, and method of obtaining it
US5290558A (en) 1989-09-21 1994-03-01 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
DD289135A5 (de) * 1989-11-16 1991-04-18 Adw Zi F. Molekularbiologie,De Verfahren zur bestimmung reduzierender oder oxidierender stoffe
JPH03176064A (ja) 1989-12-05 1991-07-31 Hoechst Japan Ltd 創面被覆材
DE3942954A1 (de) 1989-12-23 1991-06-27 Hoechst Ag Verfahren zur herstellung von aldehyden
US5409690A (en) 1993-06-23 1995-04-25 Chemex Pharmaceuticals, Inc. Treatment of multidrug resistant diseases in cancer cell by potentiating with masoprocol
CA2140053C (en) 1994-02-09 2000-04-04 Joel S. Rosenblatt Collagen-based injectable drug delivery system and its use
US7101857B2 (en) 1996-11-05 2006-09-05 Gp Medical, Inc. Crosslinkable biological material and medical uses
US6013106A (en) 1997-01-22 2000-01-11 St. Jude Medical, Inc. Medical article with adhered antimicrobial metal ions and related methods
US6166184A (en) 1997-08-18 2000-12-26 Medtronic Inc. Process for making a bioprosthetic device
US6030635A (en) 1998-02-27 2000-02-29 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US6347241B2 (en) 1999-02-02 2002-02-12 Senorx, Inc. Ultrasonic and x-ray detectable biopsy site marker and apparatus for applying it
US6129757A (en) 1998-05-18 2000-10-10 Scimed Life Systems Implantable members for receiving therapeutically useful compositions
GB2345638A (en) 1998-09-11 2000-07-19 Tissue Science Lab Limited Injectable collagen compositions
ATE424181T1 (de) 1999-06-25 2009-03-15 Procter & Gamble Topische antimikrobielle zusammensetzungen
US6716895B1 (en) 1999-12-15 2004-04-06 C.R. Bard, Inc. Polymer compositions containing colloids of silver salts
US6682760B2 (en) 2000-04-18 2004-01-27 Colbar R&D Ltd. Cross-linked collagen matrices and methods for their preparation
KR100377921B1 (ko) 2000-05-04 2003-03-29 정원태 엑시머레이저 각막절제술에서의 안연고 제조방법
US6565960B2 (en) 2000-06-01 2003-05-20 Shriners Hospital Of Children Polymer composite compositions
ATE466069T1 (de) 2000-09-05 2010-05-15 Biosight Ltd Peptid-konjugierte antikrebs-prodrugs
EP2305795B1 (en) 2000-12-06 2019-07-03 Celularity, Inc. Method of collecting placental stem cells
US7311905B2 (en) 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
US20040028711A1 (en) 2001-02-01 2004-02-12 The Procter & Gamble Company Anhydrous cosmetic compositions
EP2316918B1 (en) 2001-02-14 2015-07-01 Anthrogenesis Corporation Post-partum mammalian placenta, its use and placental stem cells therefrom
ES2432493T3 (es) 2001-02-14 2013-12-03 Anthrogenesis Corporation Placenta de mamífero post-parto, su uso y células madre de la misma
US6503244B2 (en) 2001-03-07 2003-01-07 Micro Therapeutics, Inc. High pressure injection system
WO2002098937A1 (en) * 2001-06-01 2002-12-12 Shriners Hospital For Children Polymer composite compositions
EP1273308A1 (en) * 2001-07-03 2003-01-08 Fuji Photo Film B.V. Peptide-flavonoid conjugates, their preparation and use in uv protection
JP4451658B2 (ja) 2001-10-18 2010-04-14 ライフセル コーポレーション 組織および器官のリモデリング
US20030187515A1 (en) 2002-03-26 2003-10-02 Hariri Robert J. Collagen biofabric and methods of preparing and using the collagen biofabric
AU2003250666A1 (en) 2002-07-29 2004-02-16 Asahi Kasei Kabushiki Kaisha Stem cells for treating pancreatic damage
US20060252919A1 (en) 2002-12-17 2006-11-09 Technion Research & Development Foundation Ltd. Vegf variant that lacks vegfr-1 binding activity and its use in promotion of re-endothelization and prevention of in-stent restenosis
CA2540529C (en) 2003-10-03 2012-03-13 Vib Vzw Means and methods for the recruitment and identification of stem cells
US20050142161A1 (en) 2003-12-30 2005-06-30 Freeman Lynetta J. Collagen matrix for soft tissue augmentation
US8067044B2 (en) 2004-02-13 2011-11-29 Cognis France S.A.S. Cosmetic compositions containing an extract of leaves of the Castanea sativa plant and cosmetic treatments
CN1956733B (zh) * 2004-04-07 2012-10-10 白藜芦醇合伙人有限责任公司 营养补充剂及其加工方法
US7794490B2 (en) 2004-06-22 2010-09-14 Boston Scientific Scimed, Inc. Implantable medical devices with antimicrobial and biodegradable matrices
WO2006135843A2 (en) * 2005-06-10 2006-12-21 Celgene Corporation Human placental collagen compositions, processes for their preparation, methods of their use and kits comprising the compositions
US8568872B2 (en) * 2005-08-24 2013-10-29 Eth Zurich Catechol functionalized polymers and method for preparing them
US8182840B2 (en) 2005-09-27 2012-05-22 Tissue Tech, Inc. Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition
US20090311298A1 (en) 2005-10-18 2009-12-17 Oranogenesis, In.C Antimicrobial Collagenous Constructs
DK1948259T3 (en) 2005-10-26 2017-04-10 Genesis Tech Ltd ACELLULAR BIOabsorbable Tissue Regeneration Matrices Produced by Incubation of ACELLULAR BLOOD PRODUCTS
WO2007083984A1 (en) 2006-01-23 2007-07-26 Gwangju Institute Of Science And Technology Conjugate comprising pharmaceutical active compound covalently bound to mucoadhesive polymer and transmucosal delivery method of pharmaceutical active compound using the same
EP1998742A2 (en) 2006-03-08 2008-12-10 Nuviance, INC. Transdermal drug delivery compositions and topical compositions for application on the skin
US20070248575A1 (en) 2006-04-19 2007-10-25 Jerome Connor Bone graft composition
US8454934B2 (en) * 2006-05-25 2013-06-04 Canadian Blood Services High molecular weight chelation structure
KR20090031895A (ko) * 2006-06-09 2009-03-30 안트로제네시스 코포레이션 태반 니치 및 줄기 세포 배양을 위한 이의 용도
CN105327393A (zh) 2006-06-22 2016-02-17 南佛罗里达大学 胶原支架、具有其的医用植入物以及使用方法
TW200817019A (en) 2006-07-10 2008-04-16 Univ Columbia De novo formation and regeneration of vascularized tissue from tissue progenitor cells and vascular progenitor cells
US8372437B2 (en) 2006-08-17 2013-02-12 Mimedx Group, Inc. Placental tissue grafts
US20080050347A1 (en) 2006-08-23 2008-02-28 Ichim Thomas E Stem cell therapy for cardiac valvular dysfunction
CN101622007A (zh) * 2006-10-06 2010-01-06 人类起源公司 天然(端肽)胎盘胶原组合物
US20100028849A1 (en) 2006-10-18 2010-02-04 Nancy Jane Shelby Novel process for devitalized/acellular tissue for transplantation
WO2008085493A2 (en) 2006-12-27 2008-07-17 Shriners Hospitals For Children Tendon or ligament bioprostheses and methods of making same
CA2678821C (en) 2007-02-20 2015-12-01 Shriners Hospitals For Children In vivo hydraulic fixation including bio-rivets using biocompatible expandable fibers
US20080233552A1 (en) 2007-03-22 2008-09-25 David Hui-Kang Ma Method of cross-linking amnion to be an improved biomedical material
AU2008240191B2 (en) 2007-04-12 2013-09-19 Zimmer, Inc. Compositions and methods for tissue repair
US20090036996A1 (en) 2007-08-03 2009-02-05 Roeber Peter J Knit PTFE Articles and Mesh
EP4559488A3 (en) 2007-09-07 2025-08-13 MiMedx Group, Inc. Placental tissue grafts and improved methods of preparing and using the same
WO2009036000A2 (en) 2007-09-11 2009-03-19 University Of Maryland, Baltimore Methods of treating a microbial infection by modulating rnase-l expression and/or activity
US20090092664A1 (en) 2007-10-08 2009-04-09 University Of Kentucky Research Foundation Polymer-metal chelator conjugates and uses thereof
WO2009074807A2 (en) 2007-12-12 2009-06-18 Imperial Innovations Limited Methods
JP5492097B2 (ja) 2008-02-22 2014-05-14 マイメディクス，インコーポレイテッド 手首、手及びその他の靱帯置換術又は修復術のために適切なバイオステープル
US9694055B2 (en) 2008-05-09 2017-07-04 Wake Forest University Health Sciences Renal tissue regeneration
WO2009139871A2 (en) 2008-05-16 2009-11-19 Mimedx, Inc. Medical constructs of twisted lengths of collagen fibers and methods of making same
EP2349363B1 (en) 2008-10-09 2018-12-05 MiMedx Group, Inc. Methods of making biocomposite medical constructs and related constructs including artificial tissues, vessels and patches
DK2375907T3 (da) 2008-11-21 2019-06-11 Celularity Inc Behandling af sygdomme, lidelser eller tilstande i lungerne under anvendelse af placentaceller
CN101433556A (zh) 2008-12-05 2009-05-20 成都青山利康药业有限公司 含胎盘成分的保健品组合物及制备方法
US20100291182A1 (en) 2009-01-21 2010-11-18 Arsenal Medical, Inc. Drug-Loaded Fibers
JP5844642B2 (ja) * 2009-02-04 2016-01-20 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． ナノスケール白金化合物およびその使用方法
KR101132625B1 (ko) 2010-02-03 2012-04-02 주식회사 바이오랜드 콘택트 렌즈 형태의 양막 드레싱의 제조 방법
EP3351625A1 (en) 2010-02-18 2018-07-25 Osiris Therapeutics, Inc. Methods of manufacture of immunocompatible amniotic membrane products
US9005285B2 (en) 2010-05-17 2015-04-14 Mimedx Group, Inc. Compressible tubes for placing implants and related medical kits and methods of using same
US8840665B2 (en) 2010-06-11 2014-09-23 Liventa Bioscience, Inc. Method of tendon repair with amnion and chorion constructs
US20120010708A1 (en) 2010-07-08 2012-01-12 AFcell Medical Amnion and chorion replacement cover and uses thereof in surgical repair of muscles
US20140093506A1 (en) 2010-11-15 2014-04-03 Marc Buehler Anti-fungal-agents
EP2458043A1 (en) 2010-11-24 2012-05-30 SpinPlant GmbH Product of crosslinked material and method for producing the same
US20120189586A1 (en) 2011-01-21 2012-07-26 Carl Randall Harrell Human Placental Derived Extracellular Matrix and Uses Therof
US20140205646A1 (en) 2011-02-14 2014-07-24 Mimedx Group, Inc. Tissue grafts modified with a cross-linking agent and method of making and using the same
EP2683864B1 (en) * 2011-03-08 2016-08-17 MiMedx Group, Inc. Collagen fiber ribbons with integrated fixation sutures and methods of making the same
US9327029B2 (en) 2011-05-05 2016-05-03 Celacare Technologies, Llc Antimicrobial silver hydrogel composition for the treatment of burns and wounds
WO2013082412A1 (en) 2011-12-02 2013-06-06 Mimedx Group, Inc. Placental tissue grafts produced by chemical dehydration/freeze-drying and methods for making and using same
EP2793745B1 (en) 2011-12-22 2019-07-31 MIMEDX Group Inc. Cross-linked dehydrated placental tissue grafts and methods for making and using the same
EP2897625B1 (en) * 2012-09-10 2019-10-23 Wake Forest University Health Sciences Amniotic membrane and its use in wound healing and tissue engineering constructs

Also Published As

Publication number Publication date
WO2014193468A1 (en) 2014-12-04
AU2013390806A1 (en) 2015-12-24
AU2013390806B2 (en) 2019-02-28
US9446142B2 (en) 2016-09-20
JP2019006802A (ja) 2019-01-17
EP3003326A4 (en) 2017-04-26
JP2016530217A (ja) 2016-09-29
US20140356451A1 (en) 2014-12-04
EP3003326A1 (en) 2016-04-13

Similar Documents

Publication Publication Date Title
JP6496715B2 (ja) ポリマー−キレーター複合体
Zhang et al. Magnetic nanocomposite hydrogel for potential cartilage tissue engineering: synthesis, characterization, and cytocompatibility with bone marrow derived mesenchymal stem cells
CA2737542C (en) Bionanocomposite for tissue regeneration and soft tissue repair
Kang et al. Magnetic manipulation of reversible nanocaging controls in vivo adhesion and polarization of macrophages
CN102256609B (zh) 衍生自前胃胞外基质的组织支架
US12076348B2 (en) Micronized placental compositions comprising a chelator
Datta et al. Oleoyl-chitosan-based nanofiber mats impregnated with amniotic membrane derived stem cells for accelerated full-thickness excisional wound healing
CN105228665A (zh) 抗血栓形成移植物
Bankoti et al. Dual functionalized injectable hybrid extracellular matrix hydrogel for burn wounds
Li et al. Facile engineering of interactive double network hydrogels for heart valve regeneration
Zhao et al. A sustained H2S-releasing nanocellulose-based hydrogel with anti-inflammatory and antibacterial properties for promoting infected wound healing
Chan et al. Amine functionalization of cholecyst-derived extracellular matrix with generation 1 PAMAM dendrimer
Taskin et al. Inducing immunomodulatory effects on human macrophages by multifunctional NCO-sP (EO-stat-PO)/gelatin hydrogel nanofibers
Moody et al. Enhanced Cell Proliferation, Migration, and Fibroblast Differentiation with Electrospun PCL–Zinc Scaffolds Coated with Fibroblast-Derived ECM
KR100970193B1 (ko) 각막 제조용 투명 콜라겐 기질의 제조방법
CN119587751A (zh) 不对称粘附性生物补片及其制备方法和用途
CN111246895B (zh) 一种用于医用植入物表面改性的组合物以及由此表面改性的医用植入物
Liu et al. Polyamino acid antibacterial hydrogel with photothermal effect for wound healing
Ma et al. Chitosan and ibuprofen grafted electrospun polylactic acid/gelatin membrane mitigates inflammatory response
KR102671293B1 (ko) 생착 향상을 위한 접착성 이식재
Zhu et al. Bioprosthetic heart valves with zwitterionic copolymer grafting to improve the properties of endothelialization and anti-calcification
Marín Silk bionanocomposites: design, characterization and potential applications
Tao Development and study of biological coating materials for enhancement of host-graft interfacing affinity and biocompatibility

Legal Events

Date Code Title Description
A529 Written submission of copy of amendment under article 34 pct

Free format text: JAPANESE INTERMEDIATE CODE: A529

Effective date: 20160113

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161021

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20161021

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170725

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20171024

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20171222

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180124

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20180501

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180831

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20181101

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20181218

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190129

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20190212

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20190311

R150 Certificate of patent or registration of utility model

Ref document number: 6496715

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250