AU2013390806B2 - Polymer chelator conjugates - Google Patents

Polymer chelator conjugates Download PDF

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Publication number
AU2013390806B2
AU2013390806B2 AU2013390806A AU2013390806A AU2013390806B2 AU 2013390806 B2 AU2013390806 B2 AU 2013390806B2 AU 2013390806 A AU2013390806 A AU 2013390806A AU 2013390806 A AU2013390806 A AU 2013390806A AU 2013390806 B2 AU2013390806 B2 AU 2013390806B2
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Australia
Prior art keywords
polymer
tissue
chelating
conjugate
collagen
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AU2013390806A1 (en
Inventor
Thomas J. Koob
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Mimedx Group Inc
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Mimedx Group Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6435—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a connective tissue peptide, e.g. collagen, fibronectin or gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2013390806A 2013-05-28 2013-10-30 Polymer chelator conjugates Active AU2013390806B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/903,878 2013-05-28
US13/903,878 US9446142B2 (en) 2013-05-28 2013-05-28 Polymer chelator conjugates
PCT/US2013/067620 WO2014193468A1 (en) 2013-05-28 2013-10-30 Polymer chelator conjugates

Publications (2)

Publication Number Publication Date
AU2013390806A1 AU2013390806A1 (en) 2015-12-24
AU2013390806B2 true AU2013390806B2 (en) 2019-02-28

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AU2013390806A Active AU2013390806B2 (en) 2013-05-28 2013-10-30 Polymer chelator conjugates

Country Status (5)

Country Link
US (1) US9446142B2 (https=)
EP (1) EP3003326A4 (https=)
JP (2) JP6496715B2 (https=)
AU (1) AU2013390806B2 (https=)
WO (1) WO2014193468A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9943551B2 (en) 2012-08-15 2018-04-17 Mimedx Group, Inc. Tissue grafts composed of micronized placental tissue and methods of making and using the same
US10857266B2 (en) 2012-08-15 2020-12-08 Mimedx Group, Inc. Reinforced placental tissue grafts and methods of making and using the same
US9180145B2 (en) 2012-10-12 2015-11-10 Mimedx Group, Inc. Compositions and methods for recruiting and localizing stem cells
US8946163B2 (en) 2012-11-19 2015-02-03 Mimedx Group, Inc. Cross-linked collagen comprising metallic anticancer agents
US9155799B2 (en) 2012-11-19 2015-10-13 Mimedx Group, Inc. Cross-linked collagen with at least one bound antimicrobial agent for in vivo release of the agent
US10206977B1 (en) 2013-01-18 2019-02-19 Mimedx Group, Inc. Isolated placental stem cell recruiting factors
US10111910B2 (en) 2013-01-18 2018-10-30 Mimedx Group, Inc. Methods for treating cardiac conditions
US10029030B2 (en) 2013-03-15 2018-07-24 Mimedx Group, Inc. Molded placental tissue compositions and methods of making and using the same
US10335433B2 (en) * 2013-04-10 2019-07-02 Mimedx Group, Inc. NDGA polymers and metal complexes thereof
US10449220B2 (en) 2013-08-30 2019-10-22 Mimedx Group, Inc. Micronized placental compositions comprising a chelator
EP3094336A4 (en) 2014-01-17 2018-02-14 MIMEDX Group Inc. Method for inducing angiogenesis
EP3185918B1 (en) 2014-08-28 2021-08-18 MiMedx Group, Inc. Collagen reinforced tissue grafts
US12551509B2 (en) 2015-11-18 2026-02-17 Lucina Patent Holdco, Llc Acellular regenerative products and methods of their manufacture

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD289135A5 (de) * 1989-11-16 1991-04-18 Adw Zi F. Molekularbiologie,De Verfahren zur bestimmung reduzierender oder oxidierender stoffe
US20120189571A1 (en) * 2009-02-04 2012-07-26 The Brigham And Women's Hospital., Inc. Nanoscale platinum compounds and methods of use thereof

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL74715A0 (en) 1984-03-27 1985-06-30 Univ New Jersey Med Biodegradable matrix and methods for producing same
USRE35748E (en) 1984-05-29 1998-03-17 Matrix Pharmaceutical, Inc. Treatments employing drug containing matrices for introduction into cellular lesion areas
US4619913A (en) 1984-05-29 1986-10-28 Matrix Pharmaceuticals, Inc. Treatments employing drug-containing matrices for introduction into cellular lesion areas
US4895727A (en) 1985-05-03 1990-01-23 Chemex Pharmaceuticals, Inc. Pharmaceutical vehicles for exhancing penetration and retention in the skin
AU6129486A (en) 1985-07-02 1987-01-30 Target Therapeutics, Inc. Vaso-occlusive collagen composition and method
US4847049A (en) 1985-12-18 1989-07-11 Vitaphore Corporation Method of forming chelated collagen having bactericidal properties
EP0290442A4 (en) 1986-11-19 1990-07-03 Chemex Pharmaceuticals Inc MEDICINAL PREPARATIONS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS.
EP0431164A4 (en) 1989-04-21 1992-06-03 Kishinevsky Selskokhozyaistvenny Institut Imeni M.V. Frunze Preparation with an anti-inflammatory, lactogenous and stimulating action, and method of obtaining it
US5290558A (en) 1989-09-21 1994-03-01 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
JPH03176064A (ja) 1989-12-05 1991-07-31 Hoechst Japan Ltd 創面被覆材
DE3942954A1 (de) 1989-12-23 1991-06-27 Hoechst Ag Verfahren zur herstellung von aldehyden
US5409690A (en) 1993-06-23 1995-04-25 Chemex Pharmaceuticals, Inc. Treatment of multidrug resistant diseases in cancer cell by potentiating with masoprocol
CA2140053C (en) 1994-02-09 2000-04-04 Joel S. Rosenblatt Collagen-based injectable drug delivery system and its use
US7101857B2 (en) 1996-11-05 2006-09-05 Gp Medical, Inc. Crosslinkable biological material and medical uses
US6013106A (en) 1997-01-22 2000-01-11 St. Jude Medical, Inc. Medical article with adhered antimicrobial metal ions and related methods
US6166184A (en) 1997-08-18 2000-12-26 Medtronic Inc. Process for making a bioprosthetic device
US6030635A (en) 1998-02-27 2000-02-29 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US6347241B2 (en) 1999-02-02 2002-02-12 Senorx, Inc. Ultrasonic and x-ray detectable biopsy site marker and apparatus for applying it
US6129757A (en) 1998-05-18 2000-10-10 Scimed Life Systems Implantable members for receiving therapeutically useful compositions
GB2345638A (en) 1998-09-11 2000-07-19 Tissue Science Lab Limited Injectable collagen compositions
ATE424181T1 (de) 1999-06-25 2009-03-15 Procter & Gamble Topische antimikrobielle zusammensetzungen
US6716895B1 (en) 1999-12-15 2004-04-06 C.R. Bard, Inc. Polymer compositions containing colloids of silver salts
US6682760B2 (en) 2000-04-18 2004-01-27 Colbar R&D Ltd. Cross-linked collagen matrices and methods for their preparation
KR100377921B1 (ko) 2000-05-04 2003-03-29 정원태 엑시머레이저 각막절제술에서의 안연고 제조방법
US6565960B2 (en) 2000-06-01 2003-05-20 Shriners Hospital Of Children Polymer composite compositions
ATE466069T1 (de) 2000-09-05 2010-05-15 Biosight Ltd Peptid-konjugierte antikrebs-prodrugs
EP2305795B1 (en) 2000-12-06 2019-07-03 Celularity, Inc. Method of collecting placental stem cells
US7311905B2 (en) 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
US20040028711A1 (en) 2001-02-01 2004-02-12 The Procter & Gamble Company Anhydrous cosmetic compositions
EP2316918B1 (en) 2001-02-14 2015-07-01 Anthrogenesis Corporation Post-partum mammalian placenta, its use and placental stem cells therefrom
ES2432493T3 (es) 2001-02-14 2013-12-03 Anthrogenesis Corporation Placenta de mamífero post-parto, su uso y células madre de la misma
US6503244B2 (en) 2001-03-07 2003-01-07 Micro Therapeutics, Inc. High pressure injection system
WO2002098937A1 (en) * 2001-06-01 2002-12-12 Shriners Hospital For Children Polymer composite compositions
EP1273308A1 (en) * 2001-07-03 2003-01-08 Fuji Photo Film B.V. Peptide-flavonoid conjugates, their preparation and use in uv protection
JP4451658B2 (ja) 2001-10-18 2010-04-14 ライフセル コーポレーション 組織および器官のリモデリング
US20030187515A1 (en) 2002-03-26 2003-10-02 Hariri Robert J. Collagen biofabric and methods of preparing and using the collagen biofabric
AU2003250666A1 (en) 2002-07-29 2004-02-16 Asahi Kasei Kabushiki Kaisha Stem cells for treating pancreatic damage
US20060252919A1 (en) 2002-12-17 2006-11-09 Technion Research & Development Foundation Ltd. Vegf variant that lacks vegfr-1 binding activity and its use in promotion of re-endothelization and prevention of in-stent restenosis
CA2540529C (en) 2003-10-03 2012-03-13 Vib Vzw Means and methods for the recruitment and identification of stem cells
US20050142161A1 (en) 2003-12-30 2005-06-30 Freeman Lynetta J. Collagen matrix for soft tissue augmentation
US8067044B2 (en) 2004-02-13 2011-11-29 Cognis France S.A.S. Cosmetic compositions containing an extract of leaves of the Castanea sativa plant and cosmetic treatments
CN1956733B (zh) * 2004-04-07 2012-10-10 白藜芦醇合伙人有限责任公司 营养补充剂及其加工方法
US7794490B2 (en) 2004-06-22 2010-09-14 Boston Scientific Scimed, Inc. Implantable medical devices with antimicrobial and biodegradable matrices
WO2006135843A2 (en) * 2005-06-10 2006-12-21 Celgene Corporation Human placental collagen compositions, processes for their preparation, methods of their use and kits comprising the compositions
US8568872B2 (en) * 2005-08-24 2013-10-29 Eth Zurich Catechol functionalized polymers and method for preparing them
US8182840B2 (en) 2005-09-27 2012-05-22 Tissue Tech, Inc. Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition
US20090311298A1 (en) 2005-10-18 2009-12-17 Oranogenesis, In.C Antimicrobial Collagenous Constructs
DK1948259T3 (en) 2005-10-26 2017-04-10 Genesis Tech Ltd ACELLULAR BIOabsorbable Tissue Regeneration Matrices Produced by Incubation of ACELLULAR BLOOD PRODUCTS
WO2007083984A1 (en) 2006-01-23 2007-07-26 Gwangju Institute Of Science And Technology Conjugate comprising pharmaceutical active compound covalently bound to mucoadhesive polymer and transmucosal delivery method of pharmaceutical active compound using the same
EP1998742A2 (en) 2006-03-08 2008-12-10 Nuviance, INC. Transdermal drug delivery compositions and topical compositions for application on the skin
US20070248575A1 (en) 2006-04-19 2007-10-25 Jerome Connor Bone graft composition
US8454934B2 (en) * 2006-05-25 2013-06-04 Canadian Blood Services High molecular weight chelation structure
KR20090031895A (ko) * 2006-06-09 2009-03-30 안트로제네시스 코포레이션 태반 니치 및 줄기 세포 배양을 위한 이의 용도
CN105327393A (zh) 2006-06-22 2016-02-17 南佛罗里达大学 胶原支架、具有其的医用植入物以及使用方法
TW200817019A (en) 2006-07-10 2008-04-16 Univ Columbia De novo formation and regeneration of vascularized tissue from tissue progenitor cells and vascular progenitor cells
US8372437B2 (en) 2006-08-17 2013-02-12 Mimedx Group, Inc. Placental tissue grafts
US20080050347A1 (en) 2006-08-23 2008-02-28 Ichim Thomas E Stem cell therapy for cardiac valvular dysfunction
CN101622007A (zh) * 2006-10-06 2010-01-06 人类起源公司 天然(端肽)胎盘胶原组合物
US20100028849A1 (en) 2006-10-18 2010-02-04 Nancy Jane Shelby Novel process for devitalized/acellular tissue for transplantation
WO2008085493A2 (en) 2006-12-27 2008-07-17 Shriners Hospitals For Children Tendon or ligament bioprostheses and methods of making same
CA2678821C (en) 2007-02-20 2015-12-01 Shriners Hospitals For Children In vivo hydraulic fixation including bio-rivets using biocompatible expandable fibers
US20080233552A1 (en) 2007-03-22 2008-09-25 David Hui-Kang Ma Method of cross-linking amnion to be an improved biomedical material
AU2008240191B2 (en) 2007-04-12 2013-09-19 Zimmer, Inc. Compositions and methods for tissue repair
US20090036996A1 (en) 2007-08-03 2009-02-05 Roeber Peter J Knit PTFE Articles and Mesh
EP4559488A3 (en) 2007-09-07 2025-08-13 MiMedx Group, Inc. Placental tissue grafts and improved methods of preparing and using the same
WO2009036000A2 (en) 2007-09-11 2009-03-19 University Of Maryland, Baltimore Methods of treating a microbial infection by modulating rnase-l expression and/or activity
US20090092664A1 (en) 2007-10-08 2009-04-09 University Of Kentucky Research Foundation Polymer-metal chelator conjugates and uses thereof
WO2009074807A2 (en) 2007-12-12 2009-06-18 Imperial Innovations Limited Methods
JP5492097B2 (ja) 2008-02-22 2014-05-14 マイメディクス，インコーポレイテッド 手首、手及びその他の靱帯置換術又は修復術のために適切なバイオステープル
US9694055B2 (en) 2008-05-09 2017-07-04 Wake Forest University Health Sciences Renal tissue regeneration
WO2009139871A2 (en) 2008-05-16 2009-11-19 Mimedx, Inc. Medical constructs of twisted lengths of collagen fibers and methods of making same
EP2349363B1 (en) 2008-10-09 2018-12-05 MiMedx Group, Inc. Methods of making biocomposite medical constructs and related constructs including artificial tissues, vessels and patches
DK2375907T3 (da) 2008-11-21 2019-06-11 Celularity Inc Behandling af sygdomme, lidelser eller tilstande i lungerne under anvendelse af placentaceller
CN101433556A (zh) 2008-12-05 2009-05-20 成都青山利康药业有限公司 含胎盘成分的保健品组合物及制备方法
US20100291182A1 (en) 2009-01-21 2010-11-18 Arsenal Medical, Inc. Drug-Loaded Fibers
KR101132625B1 (ko) 2010-02-03 2012-04-02 주식회사 바이오랜드 콘택트 렌즈 형태의 양막 드레싱의 제조 방법
EP3351625A1 (en) 2010-02-18 2018-07-25 Osiris Therapeutics, Inc. Methods of manufacture of immunocompatible amniotic membrane products
US9005285B2 (en) 2010-05-17 2015-04-14 Mimedx Group, Inc. Compressible tubes for placing implants and related medical kits and methods of using same
US8840665B2 (en) 2010-06-11 2014-09-23 Liventa Bioscience, Inc. Method of tendon repair with amnion and chorion constructs
US20120010708A1 (en) 2010-07-08 2012-01-12 AFcell Medical Amnion and chorion replacement cover and uses thereof in surgical repair of muscles
US20140093506A1 (en) 2010-11-15 2014-04-03 Marc Buehler Anti-fungal-agents
EP2458043A1 (en) 2010-11-24 2012-05-30 SpinPlant GmbH Product of crosslinked material and method for producing the same
US20120189586A1 (en) 2011-01-21 2012-07-26 Carl Randall Harrell Human Placental Derived Extracellular Matrix and Uses Therof
US20140205646A1 (en) 2011-02-14 2014-07-24 Mimedx Group, Inc. Tissue grafts modified with a cross-linking agent and method of making and using the same
EP2683864B1 (en) * 2011-03-08 2016-08-17 MiMedx Group, Inc. Collagen fiber ribbons with integrated fixation sutures and methods of making the same
US9327029B2 (en) 2011-05-05 2016-05-03 Celacare Technologies, Llc Antimicrobial silver hydrogel composition for the treatment of burns and wounds
WO2013082412A1 (en) 2011-12-02 2013-06-06 Mimedx Group, Inc. Placental tissue grafts produced by chemical dehydration/freeze-drying and methods for making and using same
EP2793745B1 (en) 2011-12-22 2019-07-31 MIMEDX Group Inc. Cross-linked dehydrated placental tissue grafts and methods for making and using the same
EP2897625B1 (en) * 2012-09-10 2019-10-23 Wake Forest University Health Sciences Amniotic membrane and its use in wound healing and tissue engineering constructs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD289135A5 (de) * 1989-11-16 1991-04-18 Adw Zi F. Molekularbiologie,De Verfahren zur bestimmung reduzierender oder oxidierender stoffe
US20120189571A1 (en) * 2009-02-04 2012-07-26 The Brigham And Women's Hospital., Inc. Nanoscale platinum compounds and methods of use thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Cai, W et al (2004) Journal of the American Chemical Society 126: 15030-15031 *
MA, HW et al (2006) Journal of Membrane Science 278: 373-380 *

Also Published As

Publication number Publication date
WO2014193468A1 (en) 2014-12-04
AU2013390806A1 (en) 2015-12-24
US9446142B2 (en) 2016-09-20
JP6496715B2 (ja) 2019-04-03
JP2019006802A (ja) 2019-01-17
EP3003326A4 (en) 2017-04-26
JP2016530217A (ja) 2016-09-29
US20140356451A1 (en) 2014-12-04
EP3003326A1 (en) 2016-04-13

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