JP6495904B2 - 薬物送達装置 - Google Patents
薬物送達装置 Download PDFInfo
- Publication number
- JP6495904B2 JP6495904B2 JP2016530597A JP2016530597A JP6495904B2 JP 6495904 B2 JP6495904 B2 JP 6495904B2 JP 2016530597 A JP2016530597 A JP 2016530597A JP 2016530597 A JP2016530597 A JP 2016530597A JP 6495904 B2 JP6495904 B2 JP 6495904B2
- Authority
- JP
- Japan
- Prior art keywords
- drive element
- drive
- delivery device
- housing
- drug delivery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/3157—Means providing feedback signals when administration is completed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
- A61M5/3204—Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/36—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
- A61M2005/3107—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle for needles
- A61M2005/3109—Caps sealing the needle bore by use of, e.g. air-hardening adhesive, elastomer or epoxy resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
- A61M2005/3121—Means preventing contamination of the medicament compartment of a syringe via the proximal end of a syringe, i.e. syringe end opposite to needle cannula mounting end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M2005/31521—Pistons with a forward extending skirt at their front end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/1782—Devices aiding filling of syringes in situ
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
- A61M5/2459—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1313782.3A GB201313782D0 (en) | 2013-08-01 | 2013-08-01 | Drug delivery device |
| GB1313782.3 | 2013-08-01 | ||
| PCT/GB2014/052282 WO2015015170A1 (en) | 2013-08-01 | 2014-07-25 | Drug delivery device |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019041249A Division JP6843909B2 (ja) | 2013-08-01 | 2019-03-07 | 薬物送達装置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016525424A JP2016525424A (ja) | 2016-08-25 |
| JP2016525424A5 JP2016525424A5 (enExample) | 2017-09-07 |
| JP6495904B2 true JP6495904B2 (ja) | 2019-04-03 |
Family
ID=49223997
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016530597A Active JP6495904B2 (ja) | 2013-08-01 | 2014-07-25 | 薬物送達装置 |
| JP2019041249A Expired - Fee Related JP6843909B2 (ja) | 2013-08-01 | 2019-03-07 | 薬物送達装置 |
| JP2021027858A Pending JP2021090826A (ja) | 2013-08-01 | 2021-02-24 | 薬物送達装置 |
| JP2023143296A Pending JP2023164935A (ja) | 2013-08-01 | 2023-09-04 | 薬物送達装置 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019041249A Expired - Fee Related JP6843909B2 (ja) | 2013-08-01 | 2019-03-07 | 薬物送達装置 |
| JP2021027858A Pending JP2021090826A (ja) | 2013-08-01 | 2021-02-24 | 薬物送達装置 |
| JP2023143296A Pending JP2023164935A (ja) | 2013-08-01 | 2023-09-04 | 薬物送達装置 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US10207051B2 (enExample) |
| EP (3) | EP3027247B1 (enExample) |
| JP (4) | JP6495904B2 (enExample) |
| CN (3) | CN105636623B (enExample) |
| GB (1) | GB201313782D0 (enExample) |
| WO (1) | WO2015015170A1 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090093793A1 (en) | 2007-10-02 | 2009-04-09 | Yossi Gross | External drug pump |
| EP2399635A1 (en) | 2010-06-28 | 2011-12-28 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
| EP2823841A1 (en) | 2013-07-09 | 2015-01-14 | Sanofi-Aventis Deutschland GmbH | Autoinjector |
| GB201313782D0 (en) * | 2013-08-01 | 2013-09-18 | Oval Medical Technologies Ltd | Drug delivery device |
| EP2923714A1 (en) * | 2014-03-28 | 2015-09-30 | Sanofi-Aventis Deutschland GmbH | Autoinjector triggered by skin contact |
| TWI689326B (zh) * | 2014-08-06 | 2020-04-01 | 加拿大商複製細胞生命科學公司 | 注射裝置 |
| CA2980004C (en) | 2015-03-24 | 2023-10-10 | Kaleo, Inc. | Devices and methods for delivering a lyophilized medicament |
| TW201707744A (zh) | 2015-06-03 | 2017-03-01 | 賽諾菲阿凡提斯德意志有限公司 | 藥物輸送裝置(二) |
| EP4166170A1 (en) | 2015-06-30 | 2023-04-19 | Kaleo, Inc. | Auto-injectors for administration of a medicament within a prefilled syringe |
| US10576207B2 (en) | 2015-10-09 | 2020-03-03 | West Pharma. Services IL, Ltd. | Angled syringe patch injector |
| CN113648488B (zh) | 2015-10-09 | 2024-03-29 | 西医药服务以色列分公司 | 至预填充的流体储存器的弯曲流体路径附加装置 |
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| JP6898932B2 (ja) * | 2015-12-30 | 2021-07-07 | ノボ・ノルデイスク・エー/エス | 薬剤汚染のリスクを低減させるための機構 |
| JP6885960B2 (ja) | 2016-01-21 | 2021-06-16 | ウェスト ファーマ サービシーズ イスラエル リミテッド | 視覚的インジケータを有する薬剤デリバリデバイス |
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| EP3405227B1 (en) | 2016-01-21 | 2020-06-17 | West Pharma. Services Il, Ltd. | Force containment in an automatic injector |
| US11389597B2 (en) | 2016-03-16 | 2022-07-19 | West Pharma. Services IL, Ltd. | Staged telescopic screw assembly having different visual indicators |
| USD830538S1 (en) * | 2016-05-04 | 2018-10-09 | Nuance Designs Of Ct, Llc | Autoinjector |
| USD831822S1 (en) * | 2016-05-17 | 2018-10-23 | Nuance Designs Of Ct, Llc | Autoinjector |
| DK3622986T3 (da) | 2016-06-03 | 2021-05-25 | Shl Medical Ag | Medikamenttilførselsanordning |
| US10773024B2 (en) | 2016-06-09 | 2020-09-15 | Becton, Dickinson And Company | Drive assembly for drug delivery system |
| CN109562229B (zh) | 2016-08-01 | 2021-07-13 | 西医药服务以色列有限公司 | 抗旋转药筒销 |
| JP7059251B2 (ja) | 2016-08-01 | 2022-04-25 | ウェスト ファーマ サービシーズ イスラエル リミテッド | ドアの半閉じを防止するスプリング |
| KR20190088073A (ko) | 2016-12-16 | 2019-07-25 | 소렌토 쎄라퓨틱스, 인코포레이티드 | 유체 전달 장치용 부착 밴드 및 그 이용 방법 |
| CA3047282A1 (en) | 2016-12-16 | 2018-06-21 | Sorrento Therapeutics, Inc. | Method for administering a medicament suitable for treating a migraine or cluster headache |
| CA3046799A1 (en) | 2016-12-16 | 2018-06-21 | Sorrento Therapeutics, Inc. | Fluid delivery apparatus and method of assembly |
| CN110300612B (zh) | 2016-12-16 | 2022-04-22 | 索伦托治疗有限公司 | 具有控制器组件的流体递送装置及其使用方法 |
| USD836774S1 (en) | 2016-12-16 | 2018-12-25 | Sorrento Therapeutics, Inc. | Cartridge for a fluid delivery apparatus |
| CN113730789A (zh) | 2016-12-16 | 2021-12-03 | 索伦托治疗有限公司 | 具有抽气机构的流体递送装置及其使用方法 |
| KR102590629B1 (ko) * | 2016-12-16 | 2023-10-19 | 소렌토 쎄라퓨틱스, 인코포레이티드 | 유체 전달 장치용 어플리케이션 디바이스 및 그 이용 방법 |
| USD819197S1 (en) | 2016-12-16 | 2018-05-29 | Kimberly-Clark Worldwide, Inc. | Fluid delivery apparatus |
| CA3046228A1 (en) | 2016-12-23 | 2018-06-28 | Kaleo, Inc. | Medicament delivery device and methods for delivering drugs to infants and children |
| KR101811846B1 (ko) * | 2017-03-15 | 2017-12-22 | 김휘화 | 안전성을 향상시킨 반자동 주사기 |
| CN110869072B (zh) | 2017-05-30 | 2021-12-10 | 西部制药服务有限公司(以色列) | 用于穿戴式注射器的模块化驱动机构 |
| DK3727524T3 (da) * | 2017-12-18 | 2025-06-30 | Patients Pending Ltd | Hætteenhed til væskelevering, systemer og fremgangsmåder |
| USD890332S1 (en) | 2018-02-08 | 2020-07-14 | Nuance Designs Of Ct, Llc | Autoinjector |
| EP3860692B1 (en) * | 2018-10-05 | 2024-06-19 | Phillips-Medisize A/S | Auto injector with effective insertion system |
| EP3870258A4 (en) * | 2018-10-23 | 2022-08-10 | AktiVax, Inc. | INTRANASAL DRUG DELIVERY DEVICE BY PRESSURE |
| WO2020140040A1 (en) | 2018-12-29 | 2020-07-02 | Kaleo, Inc. | Devices and methods for delivery of substances within a prefilled syringe |
| AU2020331302B2 (en) | 2019-08-09 | 2025-09-25 | Kaleo, Inc. | Devices and methods for delivery of substances within a prefilled syringe |
| FI4037735T3 (fi) | 2019-09-30 | 2025-11-25 | Amgen Inc | Lääkeaineen annostelulaite |
| CN114901330A (zh) | 2020-01-13 | 2022-08-12 | 美国安进公司 | 针头护罩移除器、药物递送装置、以及相关方法 |
| US11850402B2 (en) * | 2020-07-09 | 2023-12-26 | Eli Lilly And Company | Automatic injection device with reusable portion |
| US12268847B1 (en) | 2021-02-10 | 2025-04-08 | Kaleo, Inc. | Devices and methods for delivery of substances within a medicament container |
| WO2023222391A1 (en) * | 2022-05-18 | 2023-11-23 | Shl Medical Ag | A rotator for a medicament delivery device |
| EP4306151A1 (en) * | 2022-07-12 | 2024-01-17 | ALK-Abelló A/S | Autoinjector |
| TWI876810B (zh) * | 2022-10-14 | 2025-03-11 | 群康生技股份有限公司 | 藥物注射系統的安全控制機構 |
| WO2025153305A1 (en) * | 2024-01-19 | 2025-07-24 | Shl Medical Ag | Medicament delivery assembly with end of delivery signaling |
| WO2025227129A2 (en) | 2024-04-25 | 2025-10-30 | Starrock Pharma Llc | Delivery vehicles comprising proglucagon derived polypeptides and anabolic polypeptides and uses thereof |
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| SE9803662D0 (sv) * | 1998-10-26 | 1998-10-26 | Pharmacia & Upjohn Ab | Autoinjector |
| DE19955652A1 (de) * | 1999-11-19 | 2001-06-13 | Schott Glas | Verschluß für eine vorfüllbare Einmalspritze |
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| AU2010303987B2 (en) * | 2009-10-08 | 2012-10-18 | Shl Medical Ag | Medicament delivery device |
| DK2548597T3 (en) * | 2010-03-18 | 2016-11-07 | Daikyo Seiko Ltd | Syringe needle cover |
| AU2011290668B2 (en) | 2010-08-19 | 2014-08-14 | Novo Nordisk A/S | Medical auto-injection device for manual needle insertion having needle shield, damping mechanism and audible and tactile feedback |
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| GB201020475D0 (en) * | 2010-12-02 | 2011-01-19 | Oval Medical Technologies Ltd | Delivery mechanism for an autoinjector |
| GB201021764D0 (en) * | 2010-12-22 | 2011-02-02 | Owen Mumford Ltd | Autoinjectors |
| EP2489381A1 (en) * | 2011-02-18 | 2012-08-22 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
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| GB201313782D0 (en) * | 2013-08-01 | 2013-09-18 | Oval Medical Technologies Ltd | Drug delivery device |
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2013
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2014
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- 2014-07-25 CN CN201910301065.2A patent/CN109966594B/zh not_active Expired - Fee Related
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| US20190117893A1 (en) | 2019-04-25 |
| CN109966594A (zh) | 2019-07-05 |
| EP4566643A3 (en) | 2025-08-13 |
| JP2019103857A (ja) | 2019-06-27 |
| JP2016525424A (ja) | 2016-08-25 |
| EP3027247B1 (en) | 2022-05-11 |
| JP2023164935A (ja) | 2023-11-14 |
| WO2015015170A1 (en) | 2015-02-05 |
| JP2021090826A (ja) | 2021-06-17 |
| JP6843909B2 (ja) | 2021-03-17 |
| GB201313782D0 (en) | 2013-09-18 |
| EP4088763A1 (en) | 2022-11-16 |
| CN105636623A (zh) | 2016-06-01 |
| US10207051B2 (en) | 2019-02-19 |
| CN105636623B (zh) | 2019-06-11 |
| EP3027247A1 (en) | 2016-06-08 |
| US20250360270A1 (en) | 2025-11-27 |
| EP4566643A2 (en) | 2025-06-11 |
| US20160193412A1 (en) | 2016-07-07 |
| US11058820B2 (en) | 2021-07-13 |
| CN113577459A (zh) | 2021-11-02 |
| US20210299356A1 (en) | 2021-09-30 |
| CN109966594B (zh) | 2021-09-14 |
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