JP6486002B2 - Cxcr2モジュレーターとしてのアミノピリジンカルボキサミドおよびアミノピリミジンカルボキサミド - Google Patents
Cxcr2モジュレーターとしてのアミノピリジンカルボキサミドおよびアミノピリミジンカルボキサミド Download PDFInfo
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- JP6486002B2 JP6486002B2 JP2013526073A JP2013526073A JP6486002B2 JP 6486002 B2 JP6486002 B2 JP 6486002B2 JP 2013526073 A JP2013526073 A JP 2013526073A JP 2013526073 A JP2013526073 A JP 2013526073A JP 6486002 B2 JP6486002 B2 JP 6486002B2
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- C07—ORGANIC CHEMISTRY
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- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Biomedical Technology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37622410P | 2010-08-23 | 2010-08-23 | |
| US61/376,224 | 2010-08-23 | ||
| PCT/US2011/048668 WO2012027289A1 (en) | 2010-08-23 | 2011-08-22 | Aminopyridine- and aminopyrimidinecarboxamides as cxcr2 modulators |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016077977A Division JP2016164177A (ja) | 2010-08-23 | 2016-04-08 | Cxcr2モジュレーターとしてのアミノピリジンカルボキサミドおよびアミノピリミジンカルボキサミド |
| JP2018222400A Division JP2019069946A (ja) | 2010-08-23 | 2018-11-28 | Cxcr2モジュレーターとしてのアミノピリジンカルボキサミドおよびアミノピリミジンカルボキサミド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013536234A JP2013536234A (ja) | 2013-09-19 |
| JP2013536234A5 JP2013536234A5 (enExample) | 2019-01-24 |
| JP6486002B2 true JP6486002B2 (ja) | 2019-03-20 |
Family
ID=45594546
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013526073A Active JP6486002B2 (ja) | 2010-08-23 | 2011-08-22 | Cxcr2モジュレーターとしてのアミノピリジンカルボキサミドおよびアミノピリミジンカルボキサミド |
| JP2016077977A Withdrawn JP2016164177A (ja) | 2010-08-23 | 2016-04-08 | Cxcr2モジュレーターとしてのアミノピリジンカルボキサミドおよびアミノピリミジンカルボキサミド |
| JP2018222400A Withdrawn JP2019069946A (ja) | 2010-08-23 | 2018-11-28 | Cxcr2モジュレーターとしてのアミノピリジンカルボキサミドおよびアミノピリミジンカルボキサミド |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016077977A Withdrawn JP2016164177A (ja) | 2010-08-23 | 2016-04-08 | Cxcr2モジュレーターとしてのアミノピリジンカルボキサミドおよびアミノピリミジンカルボキサミド |
| JP2018222400A Withdrawn JP2019069946A (ja) | 2010-08-23 | 2018-11-28 | Cxcr2モジュレーターとしてのアミノピリジンカルボキサミドおよびアミノピリミジンカルボキサミド |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US8779149B2 (enExample) |
| EP (1) | EP2608672B1 (enExample) |
| JP (3) | JP6486002B2 (enExample) |
| AU (1) | AU2011293612B2 (enExample) |
| CA (1) | CA2811990C (enExample) |
| WO (1) | WO2012027289A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019069946A (ja) * | 2010-08-23 | 2019-05-09 | シントリックス・バイオシステムズ・インコーポレイテッドSyntrix Biosystems, Inc. | Cxcr2モジュレーターとしてのアミノピリジンカルボキサミドおよびアミノピリミジンカルボキサミド |
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| US8969365B2 (en) | 2013-08-02 | 2015-03-03 | Syntrix Biosystems, Inc. | Thiopyrimidinecarboxamides as CXCR1/2 modulators |
| CN105683202B (zh) * | 2013-08-02 | 2019-05-10 | Syntrix生物系统公司 | 一种硼酸化合物 |
| US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
| WO2017070589A1 (en) * | 2015-10-22 | 2017-04-27 | Duke University | Methods and compositions for the diagnosis and treatment of central nervous system autoimmune diseases |
| CN109152780B (zh) * | 2016-03-11 | 2021-10-01 | 阿迪亚生命科学公司 | 用于治疗结晶性关节病症的cxcr-2抑制剂 |
| WO2018071687A1 (en) * | 2016-10-13 | 2018-04-19 | The Regents Of The University Of California | Methods of treating pruritis |
| US10660909B2 (en) | 2016-11-17 | 2020-05-26 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019069946A (ja) * | 2010-08-23 | 2019-05-09 | シントリックス・バイオシステムズ・インコーポレイテッドSyntrix Biosystems, Inc. | Cxcr2モジュレーターとしてのアミノピリジンカルボキサミドおよびアミノピリミジンカルボキサミド |
Also Published As
| Publication number | Publication date |
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| JP2019069946A (ja) | 2019-05-09 |
| USRE47740E1 (en) | 2019-11-26 |
| JP2013536234A (ja) | 2013-09-19 |
| US8779149B2 (en) | 2014-07-15 |
| AU2011293612A1 (en) | 2013-04-11 |
| EP2608672A1 (en) | 2013-07-03 |
| US8993541B2 (en) | 2015-03-31 |
| US20140256678A1 (en) | 2014-09-11 |
| US20120046243A1 (en) | 2012-02-23 |
| CA2811990A1 (en) | 2012-03-01 |
| AU2011293612B2 (en) | 2015-11-26 |
| EP2608672B1 (en) | 2020-12-16 |
| JP2016164177A (ja) | 2016-09-08 |
| EP2608672A4 (en) | 2016-05-25 |
| CA2811990C (en) | 2023-03-21 |
| USRE48547E1 (en) | 2021-05-11 |
| WO2012027289A1 (en) | 2012-03-01 |
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