JP6475163B2 - 乳汁からラクトフェリンを精製するための改良されたプロセスおよびその製品 - Google Patents

乳汁からラクトフェリンを精製するための改良されたプロセスおよびその製品 Download PDF

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Publication number
JP6475163B2
JP6475163B2 JP2015534883A JP2015534883A JP6475163B2 JP 6475163 B2 JP6475163 B2 JP 6475163B2 JP 2015534883 A JP2015534883 A JP 2015534883A JP 2015534883 A JP2015534883 A JP 2015534883A JP 6475163 B2 JP6475163 B2 JP 6475163B2
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Prior art keywords
lactoferrin
milk
membrane
salt
protein
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Expired - Fee Related
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Japanese (ja)
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JP2015536905A5 (enExample
JP2015536905A (ja
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アンドリュー・ブラウン
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マレー・ゴールバーン・コー−オペラティヴ・カンパニー・リミテッド
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Priority claimed from AU2012904391A external-priority patent/AU2012904391A0/en
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79Transferrins, e.g. lactoferrins, ovotransferrins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23JPROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A23J1/20Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40Transferrins, e.g. lactoferrins, ovotransferrins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/34Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Water Supply & Treatment (AREA)
  • Nutrition Science (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
JP2015534883A 2012-10-08 2013-10-08 乳汁からラクトフェリンを精製するための改良されたプロセスおよびその製品 Expired - Fee Related JP6475163B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AU2012904391A AU2012904391A0 (en) 2012-10-08 Improved process for purifying milk proteins and products thereof
AU2012904391 2012-10-08
AU2013204858 2013-04-12
AU2013204858A AU2013204858B2 (en) 2012-10-08 2013-04-12 Improved process for purifying milk proteins and products thereof
PCT/AU2013/001152 WO2014056025A1 (en) 2012-10-08 2013-10-08 Improved process for purifying lactoferrin from milk and products thereof

Publications (3)

Publication Number Publication Date
JP2015536905A JP2015536905A (ja) 2015-12-24
JP2015536905A5 JP2015536905A5 (enExample) 2016-11-24
JP6475163B2 true JP6475163B2 (ja) 2019-02-27

Family

ID=50476773

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015534883A Expired - Fee Related JP6475163B2 (ja) 2012-10-08 2013-10-08 乳汁からラクトフェリンを精製するための改良されたプロセスおよびその製品

Country Status (12)

Country Link
US (1) US10016487B2 (enExample)
EP (1) EP2904006A4 (enExample)
JP (1) JP6475163B2 (enExample)
KR (1) KR20150068404A (enExample)
CN (1) CN104768971B (enExample)
AU (1) AU2013204858B2 (enExample)
BR (1) BR112015007674A2 (enExample)
CA (1) CA2886892A1 (enExample)
IN (1) IN2015DN02971A (enExample)
NZ (1) NZ631826A (enExample)
RU (1) RU2683228C2 (enExample)
WO (1) WO2014056025A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013204858B2 (en) 2012-10-08 2015-06-25 Saputo Dairy Australia Pty Limited Improved process for purifying milk proteins and products thereof
CN106215174A (zh) * 2016-08-04 2016-12-14 无锡科捷诺生物科技有限责任公司 一种人乳铁蛋白的制剂化制备方法
AU2019291666B2 (en) 2018-06-22 2023-09-21 Fonterra Co-Operative Group Limited Use of polar lipids to treat or prevent gestational diabetes mellitus
JP7370224B2 (ja) * 2019-11-08 2023-10-27 ライオン株式会社 ラクトフェリン含有腸溶製剤
FR3115037B1 (fr) * 2020-10-12 2025-02-21 Cie Laitiere Europeenne Procédé de purification de fraction de protéines cationiques et fraction ainsi obtenue
CN113278063A (zh) * 2021-05-13 2021-08-20 上海仁统生物科技中心 一种利用超滤法自初乳中获取乳铁蛋白的方法
IL311036A (en) * 2021-08-23 2024-04-01 Lactea Therapeutics Llc Lactoferrin compositions and methods of use
PL444766A1 (pl) * 2023-05-07 2024-11-12 Polmlek Spółka Z Ograniczoną Odpowiedzialnością Sposób uzyskiwania laktoferyny w proszku z surowego mleka

Family Cites Families (24)

* Cited by examiner, † Cited by third party
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FR2584727B1 (fr) * 1985-07-11 1988-06-17 Roussel Uclaf Procede d'extraction de proteines du lait, produits, application du procede, et compositions pharmaceutiques
US5221734A (en) 1987-10-01 1993-06-22 Ciba-Geigy Corporation Process for preparing a polypeptide growth factor for milk
GB8729031D0 (en) * 1987-12-11 1988-01-27 Express Foods Group Ltd Isolation of immunoglobulin rich fraction from whey
JP2686831B2 (ja) * 1989-09-22 1997-12-08 雪印乳業株式会社 鉄結合性蛋白質を分離、精製し、採取する方法
NZ249235A (en) * 1992-01-15 1995-12-21 Campina Melkunie Bv Isolating lactoperoxidase or lactoferrin from milk and/or milk derivatives
JPH05202098A (ja) 1992-01-29 1993-08-10 Snow Brand Milk Prod Co Ltd 乳質原料から生理活性物質の製造法
US5756680A (en) * 1994-01-05 1998-05-26 Sepragen Corporation Sequential separation of whey proteins and formulations thereof
JPH09509165A (ja) * 1994-02-16 1997-09-16 ファーミング ベスローテン フェンノートシャップ ミルクからのラクトフェリンの分離
NL1005677C2 (nl) * 1997-03-27 1998-09-29 Campina Melkunie Bv Werkwijze voor het winnen van groeifactoren, of een samenstelling die één of meer groeifactoren bevat, uit melk of een derivaat daarvan.
EP1409538B1 (en) * 2001-07-20 2009-01-07 Campina B.V. Process for obtaining growth factor (tgf-beta and igf-1), lactoperoxidase and immunoglobulins preparations from milk products having low mutual cross-contamination
US6875459B2 (en) 2001-09-10 2005-04-05 Henry B. Kopf Method and apparatus for separation of milk, colostrum, and whey
DK1480524T3 (da) * 2002-03-07 2013-07-15 Upfront Chromatography As Fremgangsmåde til isolering af lactoferrin
FR2841747B1 (fr) * 2002-07-02 2004-08-20 Cie Laitiere Europeenne Isolat de proteines de lait et procede pour sa preparation
GB0313892D0 (en) * 2003-06-16 2003-07-23 Hannah Res Inst Control of lactation
US20050208638A1 (en) * 2004-03-22 2005-09-22 Chao Wu Process for preparing bioactive protein-enriched whey products
WO2006029518A1 (en) 2004-09-14 2006-03-23 Nexcell Biosciences Inc. Isolation of growth and differentiating factors from colostrum
CA2621739A1 (en) * 2005-09-09 2007-03-15 Murray Goulburn Co-Operative Co. Limited Composition of whey growth factor extract for reducing muscle inflammation
FR2901796A1 (fr) * 2006-05-31 2007-12-07 Lab Francais Du Fractionnement Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait
US8551547B2 (en) * 2006-11-10 2013-10-08 Murray Goulburn Co-Operative Co., Limited Process for the preparation of angiogenin
BRPI0911957A2 (pt) * 2008-05-14 2016-08-23 Agriculture Victoria Serv Pty frações de leite enriquecidas com angiogenina
RU2579661C2 (ru) * 2009-01-28 2016-04-10 Жан-Поль ПЕРРОДЭН Способ производства лактоферрина, фракция, содержащая лактоферрин, и ее применения
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AU2013204858B2 (en) * 2012-10-08 2015-06-25 Saputo Dairy Australia Pty Limited Improved process for purifying milk proteins and products thereof

Also Published As

Publication number Publication date
BR112015007674A2 (pt) 2017-07-04
US10016487B2 (en) 2018-07-10
WO2014056025A1 (en) 2014-04-17
NZ631826A (en) 2017-08-25
AU2013204858A1 (en) 2014-04-24
IN2015DN02971A (enExample) 2015-09-18
CA2886892A1 (en) 2014-04-17
EP2904006A1 (en) 2015-08-12
CN104768971B (zh) 2017-12-05
AU2013204858B2 (en) 2015-06-25
EP2904006A4 (en) 2016-04-06
RU2683228C2 (ru) 2019-03-26
CN104768971A (zh) 2015-07-08
JP2015536905A (ja) 2015-12-24
KR20150068404A (ko) 2015-06-19
WO2014056025A8 (en) 2015-05-14
US20150315264A1 (en) 2015-11-05
RU2015116933A (ru) 2016-11-27

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