JP6465592B2 - 涙液分泌促進組成物 - Google Patents
涙液分泌促進組成物 Download PDFInfo
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- JP6465592B2 JP6465592B2 JP2014174934A JP2014174934A JP6465592B2 JP 6465592 B2 JP6465592 B2 JP 6465592B2 JP 2014174934 A JP2014174934 A JP 2014174934A JP 2014174934 A JP2014174934 A JP 2014174934A JP 6465592 B2 JP6465592 B2 JP 6465592B2
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- Prior art keywords
- increases
- compound
- serotonin
- brain
- serotonin concentration
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Images
Description
[1]脳内セロトニン濃度を上昇させる化合物を有効成分として含有する、涙液分泌促進組成物。
[2] 脳内セロトニン濃度を上昇させる化合物がセロトニン再取り込み阻害薬又はセロトニン前駆体である、項[1]に記載の涙液分泌促進組成物。
[3] セロトニン再取り込み阻害薬がパロキセチン、フルボキサミン、エスシタロプラム、及びその薬学的に許容され得る塩から選択される、項[1]に記載の涙液分泌促進組成物。
[4] セロトニン前駆体がL−トリプトファンである、項[1]に記載の涙液分泌促進組成物。
[5] 経口剤である、項[1]〜[4]のいずれか一項に記載の涙液分泌促進組成物。
[6] 脳内セロトニン濃度を上昇させる化合物を有効成分として含有する、角結膜障害の予防又は治療剤。
[7] 脳内セロトニン濃度を上昇させる化合物がセロトニン再取り込み阻害薬又はセロトニン前駆体である、項[6]に記載の予防又は治療剤。
[8] セロトニン再取り込み阻害薬がパロキセチン、フルボキサミン、エスシタロプラム、及びその薬学的に許容され得る塩から選択される、項[6]に記載の予防又は治療剤。
[9] セロトニン前駆体がL−トリプトファンである、項[6]に記載の予防又は治療剤。
[10] 角結膜障害がドライアイである項[6]に記載の予防又は治療剤。
[11] 涙液分泌促進組成物又は角結膜障害の予防若しくは治療剤の製造のための脳内セロトニン濃度を上昇させる化合物の使用。
(1)賦形剤:デンプン類、乳糖、白糖、ブドウ糖、マンニトール、硫酸カルシウム、炭酸カルシウム、タルク、トレハロース、キシリトール。
(2)結合剤:デンプン、セルロース、ゼラチン、アルギン酸ナトリウム、ポリビニルアルコール、ポリビニルピロリドン、アラビアゴム、デキストリン。
(3)滑沢剤:ショ糖脂肪酸エステル、ポリエチレングリコール、タルク、ワックス類、ステアリン酸及びその塩類。
(4)安定化剤:アスコルビン酸、キレート剤、還元性物質、トコフェロール、亜硫酸水素ナトリウム。
(5)保存剤:安息香酸及びその塩類、パラオキシ安息香酸エステル類、クロロブタノール。
(6)溶剤:精製水、生理食塩水、エタノール、グリセリン、植物油類。
(7)基剤:ワセリン、植物油類、タルク、マクロゴール。
(8)コーティング剤:白糖、ゼラチン、ヒドロキシプロピルメチルセルロース。
(9)矯味剤:白糖、ブドウ糖、サッカリン、キシリトール、アスコルビン酸、クエン酸、メントール。
(10)着色剤:水溶性食用色素。
脳内セロトニン濃度を上昇させる各種化合物の角結膜障害の予防及び/又は治療因子としての可能性を、外的ストレスにより涙液分泌能の低下を惹起させたマウスドライアイモデルを用いて検討した。
(1)動物
被験動物として、7-10週齢の雌性C57BL/6系マウスを用いた。マウスは気温23±5℃、相対湿度50±15%、8時−20時点灯、20時−翌朝8時消灯の環境を維持した飼育室にて飼育した。実験の差異は各群5匹に群分けした。
マウスを、公知の方法(Tracy L. Bale et al., Nature Genetics 24: 410-414, 2000)に従って涙液分泌能を低下させる処置(ストレス負荷)を行った。
脳内セロトニン濃度を上昇させる化合物として、セロトニン選択的取り込み阻害剤であるパロキセチン塩酸塩(和光純薬工業株式会社)、フルボキサミンマレイン酸塩(和光純薬工業株式会社)及びエスシタロプラムシュウ酸塩(Sigma-Aldrich社)と、セロトニン前駆体であるL−トリプトファン(和光純薬工業株式会社)の4種類を使用した(表1)。パロキセチン塩酸塩、フルボキサミンマレイン酸塩、エスシタロプラムシュウ酸塩は溶媒として2%Dimethyl sulfoxidに溶解させ、L−トリプトファンは0.9%食塩水に溶解させた。
1日1回、ストレス負荷前(パロキセチン塩酸塩、フルボキサミンマレイン酸塩、エスシタロプラムシュウ酸塩は7日間、L-トリプトファンは実施せず)及びストレス期間中(4種とも毎日)に、試験液を経口ゾンデを用いて投与した。
涙液分泌能:マウスの左右の外眼角に綿糸(ZONE-QUICK(登録商標)、昭和薬品化工株式会社)を15秒間挿入し、綿糸が涙液の浸透により褐色変色した長さを、0.5mmの精度で測定した。測定はストレス負荷前(初期値)、ストレス負荷3日目の翌日(ストレス負荷後値)に実施した(4日目は負荷なし)。左右眼の平均値を、個体の涙液分泌量とした。
初期値とストレス負荷後値の比較では対応のあるt検定を、群間の比較では対応のないt検定もしくはDunnet 法による多重比較検定を行った。
溶媒対照、パロキセチン塩酸塩0.083、0.42、及び2.09mg/kg投与群の、ドライアイ処置前の初期値に対する涙液分泌量の変動比を調べたところ、パロキセチン塩酸塩の用量依存的に涙液分泌の減少が抑制され、0.42、及び2.09mg/kg投与群において、溶媒対照に比較し有意であった(p<0.05 Dunnett’s test)(図1A,B)。
パロキセチン塩酸塩、フルボキサミンマレイン酸塩、及びエスシタロプラムシュウ酸塩のいずれのセロトニン選択的取り込み阻害剤においても、初期値に対する涙液分泌量の変動比の低下が、溶媒対照と比較して有意に抑制された(p<0.05 Student’s t-test)(図2A,B)。
L−トリプトファン200mg/kg投与群において、初期値に対する涙液分泌量の変動比の低下が、溶媒対照と比較して有意に抑制された (p<0.05 Dunnett’s test) (図3A,B)。
Claims (9)
- 脳内セロトニン濃度を上昇させる化合物を有効成分として含有し、前記セロトニン濃度を上昇させる化合物が、パロキセチン、フルボキサミン、エスシタロプラム、及びその薬学的に許容され得る塩からなる群から選択される少なくとも一つである、涙液分泌促進組成物。
- 経口剤である、請求項1に記載の涙液分泌促進組成物。
- 脳内セロトニン濃度を上昇させる化合物を有効成分として含有し、前記セロトニン濃度を上昇させる化合物がL−トリプトファンであり、経口剤である涙液分泌促進組成物。
- 脳内セロトニン濃度を上昇させる化合物を有効成分として含有し、前記セロトニン濃度を上昇させる化合物が、パロキセチン、フルボキサミン、エスシタロプラム、及びその薬学的に許容され得る塩からなる群から選択される少なくとも一つである、角結膜障害の予防又は治療剤。
- 脳内セロトニン濃度を上昇させる化合物を有効成分として含有し、前記セロトニン濃度を上昇させる化合物がL−トリプトファンである、経口剤である角結膜障害の予防又は治療剤。
- 角結膜障害がドライアイである請求項4または5に記載の予防又は治療剤。
- 涙液分泌促進組成物又は角結膜障害の予防若しくは治療剤の製造のための脳内セロトニン濃度を上昇させる化合物の使用であって、前記セロトニン濃度を上昇させる化合物が、パロキセチン、フルボキサミン、エスシタロプラム、及びその薬学的に許容され得る塩からなる群から選択される少なくとも一つである、使用。
- 経口剤である涙液分泌促進組成物の製造のための脳内セロトニン濃度を上昇させる化合物の使用であって、前記セロトニン濃度を上昇させる化合物がL−トリプトファンである、使用。
- 経口剤である角結膜障害の予防若しくは治療剤の製造のための脳内セロトニン濃度を上昇させる化合物の使用であって、前記セロトニン濃度を上昇させる化合物がL−トリプトファンである、使用。
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