JP6463005B2 - マクロファージ識別剤、該マクロファージ識別剤を用いた識別方法、分取方法、評価方法、スクリーニング方法、およびキット - Google Patents

マクロファージ識別剤、該マクロファージ識別剤を用いた識別方法、分取方法、評価方法、スクリーニング方法、およびキット Download PDF

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JP6463005B2
JP6463005B2 JP2014111593A JP2014111593A JP6463005B2 JP 6463005 B2 JP6463005 B2 JP 6463005B2 JP 2014111593 A JP2014111593 A JP 2014111593A JP 2014111593 A JP2014111593 A JP 2014111593A JP 6463005 B2 JP6463005 B2 JP 6463005B2
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macrophage
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JP2015006173A (ja
JP2015006173A5 (enExample
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史代 小出
史代 小出
野本 毅
毅 野本
幸子 山内
幸子 山内
渡邉 耕平
耕平 渡邉
太一 新藤
太一 新藤
健 宮▲崎▼
健 宮▲崎▼
田畑 泰彦
泰彦 田畑
恵理 三田
恵理 三田
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Canon Inc
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JP2014111593A 2013-05-30 2014-05-29 マクロファージ識別剤、該マクロファージ識別剤を用いた識別方法、分取方法、評価方法、スクリーニング方法、およびキット Expired - Fee Related JP6463005B2 (ja)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11519090B2 (en) * 2016-12-16 2022-12-06 Uacj Corporation Method and apparatus for producing electrolytic aluminum foil

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016203907A1 (ja) * 2015-06-16 2016-12-22 コニカミノルタ株式会社 画像処理装置、画像処理方法、および画像処理用のプログラム
AU2016362673A1 (en) 2015-12-01 2018-06-28 Dishman Carbogen Amcis Limited An improved process for the preparation of indocyanine green
CN106510745B (zh) * 2016-09-23 2021-06-01 东软医疗系统股份有限公司 Pet和ct/mri机械联动系统及其联动扫描方法
US10534097B2 (en) * 2016-10-14 2020-01-14 Shanghai United Imaging Healthcare Co., Ltd. Detector structure in a PET system
EP3553136A4 (en) * 2017-02-14 2020-03-11 Konica Minolta, Inc. AMINOCOUMARIN COMPOUND, AND RESIN PARTICLES WITH ENCAPSULATED AMINOCOUMARIN COMPOUND
JP7095603B2 (ja) * 2017-02-14 2022-07-05 コニカミノルタ株式会社 蛍光標識法
MX2020013416A (es) * 2019-03-01 2021-04-28 Illumina Cambridge Ltd Compuestos de coumarina sustituidos con amina terciaria y sus usos como etiquetas fluorescentes.
KR102550713B1 (ko) * 2021-01-18 2023-07-03 (주)바이오액츠 히드록시 치환된 트리아진을 포함하는 형광 화합물 및 이의 제조방법

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4615878A (en) * 1980-03-12 1986-10-07 Lawrence Kass Metachromatic dye sorption means for differential determination of sub-populations of lymphocytes
US4803161A (en) * 1986-01-31 1989-02-07 Eastman Kodak Company Biological and analytical uses of phenalenone and benzphenalenone compounds
US20030157026A1 (en) 2001-06-27 2003-08-21 Katsuo Aizawa Photodynamic diagnosis and therapy for insulin-dependent diabetes mellitus
JP2003012547A (ja) 2001-06-27 2003-01-15 Meiji Seika Kaisha Ltd インスリン依存性糖尿病の診断剤および治療剤
SE0201750D0 (sv) * 2002-06-06 2002-06-06 Chalmers Technology Licensing Selective Chromophores
CA2641954C (en) * 2006-03-06 2016-04-26 Zetiq Technologies Ltd. Methods and compositions for identifying a cell phenotype
US20090258025A1 (en) * 2007-07-13 2009-10-15 Genentech, Inc. Treatments and diagnostics for cancer, inflammatory disorders and autoimmune disorders
GB2463750A (en) 2008-07-15 2010-03-31 L3 Technology Ltd Assay device comprising surfaces of different surface energies
JP5538715B2 (ja) * 2008-12-25 2014-07-02 キヤノン株式会社 網膜組織染色組成物、網膜組織の染色方法
WO2010074325A1 (en) 2008-12-25 2010-07-01 Canon Kabushiki Kaisha Labeling composition for intraocular tissue, labeling method of intraocular tissue, and screening method
JP5733716B2 (ja) 2009-12-25 2015-06-10 キヤノン株式会社 中枢神経系組織標識用組成物、中枢神経系組織の標識方法、及び中枢神経系組織標識用組成物を用いたスクリーニング方法
WO2011077733A1 (ja) 2009-12-25 2011-06-30 キヤノン株式会社 経鼻中枢神経系組織標識用組成物、経鼻中枢神経系組織標識用組成物を用いた標識方法及びスクリーニング方法
US8753608B2 (en) 2010-08-24 2014-06-17 Canon Kabushiki Kaisha Complex and contrast agent for photoimaging using the same
JP5888904B2 (ja) 2011-02-16 2016-03-22 国立大学法人三重大学 中枢神経移行性評価用プローブ、中枢神経移行性評価方法、及び、中枢神経移行性評価用プローブを用いたスクリーニング方法
JP6057574B2 (ja) * 2012-07-11 2017-01-11 キヤノン株式会社 造血幹細胞識別用プローブ
WO2014065439A1 (en) 2012-10-26 2014-05-01 Canon Kabushiki Kaisha Cancer cell inhibitory drug and cancer stem-cell detection probe
WO2014065440A1 (en) 2012-10-26 2014-05-01 Canon Kabushiki Kaisha Cancer cell inhibitory drug and cancer stem-cell detection probe

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11519090B2 (en) * 2016-12-16 2022-12-06 Uacj Corporation Method and apparatus for producing electrolytic aluminum foil

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WO2014192972A1 (en) 2014-12-04
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