JP6460998B2 - トコトリエノールの経粘膜送達 - Google Patents

トコトリエノールの経粘膜送達 Download PDF

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Publication number
JP6460998B2
JP6460998B2 JP2015540965A JP2015540965A JP6460998B2 JP 6460998 B2 JP6460998 B2 JP 6460998B2 JP 2015540965 A JP2015540965 A JP 2015540965A JP 2015540965 A JP2015540965 A JP 2015540965A JP 6460998 B2 JP6460998 B2 JP 6460998B2
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Prior art keywords
tocotrienol
administration
pharmaceutical composition
tocopherol
sublingual
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Japanese (ja)
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JP2016503407A (ja
JP2016503407A5 (enExample
Inventor
トン，グレン
Original Assignee
インビクタス バイオテクノロジー プロプライエタリー リミテッド
インビクタス バイオテクノロジー プロプライエタリー リミテッド
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Priority claimed from AU2012904937A external-priority patent/AU2012904937A0/en
Application filed by インビクタス バイオテクノロジー プロプライエタリー リミテッド, インビクタス バイオテクノロジー プロプライエタリー リミテッド filed Critical インビクタス バイオテクノロジー プロプライエタリー リミテッド
Publication of JP2016503407A publication Critical patent/JP2016503407A/ja
Publication of JP2016503407A5 publication Critical patent/JP2016503407A5/ja
Priority to JP2018177662A priority Critical patent/JP6978392B2/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2015540965A 2012-11-13 2013-11-13 トコトリエノールの経粘膜送達 Active JP6460998B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2018177662A JP6978392B2 (ja) 2012-11-13 2018-09-21 トコトリエノールの経粘膜送達

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AU2012904937A AU2012904937A0 (en) 2012-11-13 Sublingual and buccal delivery of tocotrienol derivatives as therapeutic agents
AU2012904937 2012-11-13
AU2012905406 2012-12-11
AU2012905406A AU2012905406A0 (en) 2012-12-11 Sublingual and buccal delivery of tocotrienol derivatives as therapeutic agents
PCT/AU2013/001310 WO2014075135A1 (en) 2012-11-13 2013-11-13 Transmucosal delivery of tocotrienol

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018177662A Division JP6978392B2 (ja) 2012-11-13 2018-09-21 トコトリエノールの経粘膜送達

Publications (3)

Publication Number Publication Date
JP2016503407A JP2016503407A (ja) 2016-02-04
JP2016503407A5 JP2016503407A5 (enExample) 2016-12-28
JP6460998B2 true JP6460998B2 (ja) 2019-01-30

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JP2015540965A Active JP6460998B2 (ja) 2012-11-13 2013-11-13 トコトリエノールの経粘膜送達
JP2018177662A Active JP6978392B2 (ja) 2012-11-13 2018-09-21 トコトリエノールの経粘膜送達
JP2020171008A Pending JP2021008509A (ja) 2012-11-13 2020-10-09 トコトリエノールの経粘膜送達

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JP2018177662A Active JP6978392B2 (ja) 2012-11-13 2018-09-21 トコトリエノールの経粘膜送達
JP2020171008A Pending JP2021008509A (ja) 2012-11-13 2020-10-09 トコトリエノールの経粘膜送達

Country Status (22)

Country Link
US (2) US10675265B2 (enExample)
EP (1) EP2919777B1 (enExample)
JP (3) JP6460998B2 (enExample)
KR (1) KR20150082109A (enExample)
CN (2) CN104582700B (enExample)
AU (1) AU2013344817B2 (enExample)
BR (1) BR112015010703B1 (enExample)
CA (1) CA2891164C (enExample)
DK (1) DK2919777T3 (enExample)
ES (1) ES2778065T3 (enExample)
IL (1) IL238727A0 (enExample)
IN (1) IN2015DN04006A (enExample)
MY (1) MY177940A (enExample)
NZ (1) NZ628963A (enExample)
PE (1) PE20151518A1 (enExample)
PH (1) PH12015501048A1 (enExample)
PL (1) PL2919777T3 (enExample)
PT (1) PT2919777T (enExample)
RU (1) RU2015120181A (enExample)
SG (1) SG11201503640WA (enExample)
WO (1) WO2014075135A1 (enExample)
ZA (1) ZA201504191B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019031504A (ja) * 2012-11-13 2019-02-28 インビクタス バイオテクノロジー プロプライエタリー リミテッド トコトリエノールの経粘膜送達
WO2022115919A1 (en) * 2020-12-04 2022-06-09 Invictus Biotechnology Pty Ltd Transmucosal delivery of tocotrienols

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US9171343B1 (en) 2012-09-11 2015-10-27 Aseko, Inc. Means and method for improved glycemic control for diabetic patients
US9897565B1 (en) 2012-09-11 2018-02-20 Aseko, Inc. System and method for optimizing insulin dosages for diabetic subjects
US9486580B2 (en) 2014-01-31 2016-11-08 Aseko, Inc. Insulin management
US9898585B2 (en) 2014-01-31 2018-02-20 Aseko, Inc. Method and system for insulin management
JP6989262B2 (ja) 2014-10-27 2022-01-05 アセコー インコーポレイテッド 皮下外来患者管理
US11081226B2 (en) 2014-10-27 2021-08-03 Aseko, Inc. Method and controller for administering recommended insulin dosages to a patient
WO2017025808A1 (en) * 2015-08-11 2017-02-16 Satoru Sugiyama System and method for improved blood circulation and maintaining mitochondrial energy production
EP3337402B1 (en) 2015-08-20 2026-01-07 Glytec, LLC Diabetes management therapy advisor
US11612613B2 (en) 2017-08-08 2023-03-28 Robert Petcavich Formulations for the delivery of autophagy stimulating Trehalose

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EP0543417A1 (en) * 1991-11-22 1993-05-26 Lipogenics, Incorporated Tocotrienols and tocotrienol-like compounds and methods for their use
JPH0892050A (ja) 1994-09-27 1996-04-09 Lion Corp 消臭剤及び口腔用組成物
JP4271742B2 (ja) 1997-08-07 2009-06-03 エーザイ・アール・アンド・ディー・マネジメント株式会社 免疫機能改善剤
US6264981B1 (en) 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
JP2001342133A (ja) 2000-03-31 2001-12-11 Eisai Co Ltd γ―トコトリエノール含有利尿剤
US6864280B2 (en) 2000-03-31 2005-03-08 Eisai Co., Ltd. γ-Tocotrienol-containing diuretics
JP2002037727A (ja) 2000-07-26 2002-02-06 Eisai Co Ltd 脂溶性薬物を配合した速崩性固形製剤及びその製造方法
JP4693140B2 (ja) 2000-10-06 2011-06-01 富士化学工業株式会社 トコトリエノール含有医薬用剤
JP4447198B2 (ja) 2001-02-08 2010-04-07 富士化学工業株式会社 トコトリエノールを有効成分とする血管新生阻害剤、細胞増殖阻害剤、管腔形成阻害剤及びｆｇｆ阻害剤並びに食品或いは食品添加物
US6608103B2 (en) * 2001-02-08 2003-08-19 Fuji Chemical Industry Co., Ltd. Inhibitor for neovasculation, cell multiplication, lumen formation and FGF
EP1593127B1 (en) 2003-02-14 2012-06-06 Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Radiation protection by gamma-tocotrienol, alpha-tocopherol succinate or gamma-tocopherol succinate
ES2505252T3 (es) 2003-04-10 2014-10-09 Barrie Tan Composiciones de extracto de achiote que incluyen tocotrienoles y tocoferoles y métodos de uso
US20050209315A1 (en) * 2004-03-20 2005-09-22 Papas Andreas M Bioavailable nutritional supplement and method of treatment of malabsorption
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CN1775289B (zh) 2004-11-15 2011-08-24 杭州赛诺菲民生健康药业有限公司 多维生素口腔崩解片制剂及其制备方法
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JP2012531411A (ja) 2009-06-25 2012-12-10 アンペア ライフ サイエンシーズ，インコーポレイテッド トコトリエノールまたはトコトリエノール濃縮抽出物を用いた広汎性発達障害の処置
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CA2797644A1 (en) 2009-12-31 2011-07-07 Edison Pharmaceuticals, Inc. Treatment of leigh syndrome and leigh-like syndrome with tocotrienol quinones
EA201201374A1 (ru) 2010-04-06 2013-04-30 Эдисон Фармасьютикалз, Инк. Лечение атаксии-телеангиэктазии
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AU2011323059B2 (en) 2011-02-18 2013-02-21 Biolingus Ip Llc Process for preparing products comprising stabilised actives and compositions comprising same
PT3415139T (pt) * 2011-06-14 2022-06-20 Neurelis Inc Administração de benzodiazepina
KR20150082109A (ko) * 2012-11-13 2015-07-15 고다겐 파마슈티컬스 피티와이 엘티디 토코트리에놀의 경점막 전달

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019031504A (ja) * 2012-11-13 2019-02-28 インビクタス バイオテクノロジー プロプライエタリー リミテッド トコトリエノールの経粘膜送達
WO2022115919A1 (en) * 2020-12-04 2022-06-09 Invictus Biotechnology Pty Ltd Transmucosal delivery of tocotrienols

Also Published As

Publication number Publication date
RU2015120181A (ru) 2017-01-10
WO2014075135A1 (en) 2014-05-22
CA2891164A1 (en) 2014-05-22
PH12015501048A1 (en) 2015-07-27
CA2891164C (en) 2021-02-09
AU2013344817B2 (en) 2015-09-17
PL2919777T3 (pl) 2020-07-13
JP2016503407A (ja) 2016-02-04
DK2919777T3 (da) 2020-03-09
CN112451518A (zh) 2021-03-09
ES2778065T3 (es) 2020-08-07
BR112015010703A2 (pt) 2017-07-11
US11331302B2 (en) 2022-05-17
HK1207295A1 (en) 2016-01-29
EP2919777A4 (en) 2016-05-18
US20150265570A1 (en) 2015-09-24
JP2021008509A (ja) 2021-01-28
CN104582700B (zh) 2021-01-05
MY177940A (en) 2020-09-28
IN2015DN04006A (enExample) 2015-10-02
CN112451518B (zh) 2025-02-21
AU2013344817A1 (en) 2015-02-12
JP6978392B2 (ja) 2021-12-08
CN104582700A (zh) 2015-04-29
US10675265B2 (en) 2020-06-09
US20200246306A1 (en) 2020-08-06
SG11201503640WA (en) 2015-06-29
ZA201504191B (en) 2016-11-30
EP2919777B1 (en) 2020-01-08
BR112015010703A8 (pt) 2018-08-14
EP2919777A1 (en) 2015-09-23
JP2019031504A (ja) 2019-02-28
KR20150082109A (ko) 2015-07-15
PE20151518A1 (es) 2015-11-25
PT2919777T (pt) 2020-03-30
IL238727A0 (en) 2015-06-30
NZ628963A (en) 2017-02-24
BR112015010703B1 (pt) 2021-02-17

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