AU2013344817B2 - Transmucosal delivery of tocotrienol - Google Patents

Transmucosal delivery of tocotrienol Download PDF

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Publication number
AU2013344817B2
AU2013344817B2 AU2013344817A AU2013344817A AU2013344817B2 AU 2013344817 B2 AU2013344817 B2 AU 2013344817B2 AU 2013344817 A AU2013344817 A AU 2013344817A AU 2013344817 A AU2013344817 A AU 2013344817A AU 2013344817 B2 AU2013344817 B2 AU 2013344817B2
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AU
Australia
Prior art keywords
tocotrienol
tocopherol
administration
tocotrienols
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
AU2013344817A
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English (en)
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AU2013344817A1 (en
Inventor
Glenn Tong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Invictus Biotechnology Pty Ltd
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Invictus Biotechnology Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2012904937A external-priority patent/AU2012904937A0/en
Application filed by Invictus Biotechnology Pty Ltd filed Critical Invictus Biotechnology Pty Ltd
Priority to AU2013344817A priority Critical patent/AU2013344817B2/en
Publication of AU2013344817A1 publication Critical patent/AU2013344817A1/en
Application granted granted Critical
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Assigned to Invictus Biotechnology Pty Ltd reassignment Invictus Biotechnology Pty Ltd Request for Assignment Assignors: GORDAGEN PHARMACEUTICALS PTY LTD
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AU2013344817A 2012-11-13 2013-11-13 Transmucosal delivery of tocotrienol Active AU2013344817B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2013344817A AU2013344817B2 (en) 2012-11-13 2013-11-13 Transmucosal delivery of tocotrienol

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
AU2012904937A AU2012904937A0 (en) 2012-11-13 Sublingual and buccal delivery of tocotrienol derivatives as therapeutic agents
AUAU2012904937 2012-11-13
AU2012905406A AU2012905406A0 (en) 2012-12-11 Sublingual and buccal delivery of tocotrienol derivatives as therapeutic agents
AUAU2012905406 2012-12-11
PCT/AU2013/001310 WO2014075135A1 (en) 2012-11-13 2013-11-13 Transmucosal delivery of tocotrienol
AU2013344817A AU2013344817B2 (en) 2012-11-13 2013-11-13 Transmucosal delivery of tocotrienol

Publications (2)

Publication Number Publication Date
AU2013344817A1 AU2013344817A1 (en) 2015-02-12
AU2013344817B2 true AU2013344817B2 (en) 2015-09-17

Family

ID=50730398

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013344817A Active AU2013344817B2 (en) 2012-11-13 2013-11-13 Transmucosal delivery of tocotrienol

Country Status (22)

Country Link
US (2) US10675265B2 (enExample)
EP (1) EP2919777B1 (enExample)
JP (3) JP6460998B2 (enExample)
KR (1) KR20150082109A (enExample)
CN (2) CN104582700B (enExample)
AU (1) AU2013344817B2 (enExample)
BR (1) BR112015010703B1 (enExample)
CA (1) CA2891164C (enExample)
DK (1) DK2919777T3 (enExample)
ES (1) ES2778065T3 (enExample)
IL (1) IL238727A0 (enExample)
IN (1) IN2015DN04006A (enExample)
MY (1) MY177940A (enExample)
NZ (1) NZ628963A (enExample)
PE (1) PE20151518A1 (enExample)
PH (1) PH12015501048A1 (enExample)
PL (1) PL2919777T3 (enExample)
PT (1) PT2919777T (enExample)
RU (1) RU2015120181A (enExample)
SG (1) SG11201503640WA (enExample)
WO (1) WO2014075135A1 (enExample)
ZA (1) ZA201504191B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9171343B1 (en) 2012-09-11 2015-10-27 Aseko, Inc. Means and method for improved glycemic control for diabetic patients
US9897565B1 (en) 2012-09-11 2018-02-20 Aseko, Inc. System and method for optimizing insulin dosages for diabetic subjects
RU2015120181A (ru) * 2012-11-13 2017-01-10 Гордаген Фармасьютикалз Пти Лтд Чресслизистая доставка токотриенола
US9233204B2 (en) 2014-01-31 2016-01-12 Aseko, Inc. Insulin management
US9486580B2 (en) 2014-01-31 2016-11-08 Aseko, Inc. Insulin management
AU2015339576B2 (en) 2014-10-27 2020-02-06 Glytec, Llc Subcutaneous outpatient management
US11081226B2 (en) 2014-10-27 2021-08-03 Aseko, Inc. Method and controller for administering recommended insulin dosages to a patient
WO2017025808A1 (en) * 2015-08-11 2017-02-16 Satoru Sugiyama System and method for improved blood circulation and maintaining mitochondrial energy production
EP3337402A4 (en) 2015-08-20 2019-04-24 Aseko, Inc. THERAPY ADVISOR FOR DIABETES MANAGEMENT
US11612613B2 (en) 2017-08-08 2023-03-28 Robert Petcavich Formulations for the delivery of autophagy stimulating Trehalose
US20240139100A1 (en) * 2020-12-04 2024-05-02 Invictus Biotechnology Pty Ltd Transmucosal delivery of tocotrienols

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010151348A1 (en) * 2009-06-25 2010-12-29 Edison Pharmaceuticals, Inc. Treatment of pervasive developmental disorders with tocotrienols or tocotrienol enriched extracts
WO2011082355A1 (en) * 2009-12-31 2011-07-07 Edison Pharmaceuticals, Inc. Treatment of leigh syndrome and leigh-like syndrome with tocotrienol quinones
WO2011126998A1 (en) * 2010-04-06 2011-10-13 Edison Pharmaceuticals, Inc. Treatment of ataxia telangiectasia
WO2012068552A1 (en) * 2010-11-19 2012-05-24 Edison Pharmaceuticals, Inc. Methods for improving blood glucose control

Family Cites Families (22)

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CA2124086A1 (en) * 1991-11-22 1993-05-27 Ronald H. Lane Tocotrienols and tocotrienol-like compounds and methods for their use
JPH0892050A (ja) 1994-09-27 1996-04-09 Lion Corp 消臭剤及び口腔用組成物
JP4271742B2 (ja) 1997-08-07 2009-06-03 エーザイ・アール・アンド・ディー・マネジメント株式会社 免疫機能改善剤
US6264981B1 (en) 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
US6864280B2 (en) * 2000-03-31 2005-03-08 Eisai Co., Ltd. γ-Tocotrienol-containing diuretics
JP2001342133A (ja) 2000-03-31 2001-12-11 Eisai Co Ltd γ―トコトリエノール含有利尿剤
JP2002037727A (ja) 2000-07-26 2002-02-06 Eisai Co Ltd 脂溶性薬物を配合した速崩性固形製剤及びその製造方法
JP4693140B2 (ja) 2000-10-06 2011-06-01 富士化学工業株式会社 トコトリエノール含有医薬用剤
JP4447198B2 (ja) 2001-02-08 2010-04-07 富士化学工業株式会社 トコトリエノールを有効成分とする血管新生阻害剤、細胞増殖阻害剤、管腔形成阻害剤及びｆｇｆ阻害剤並びに食品或いは食品添加物
US6608103B2 (en) * 2001-02-08 2003-08-19 Fuji Chemical Industry Co., Ltd. Inhibitor for neovasculation, cell multiplication, lumen formation and FGF
WO2004086412A2 (en) 2003-02-14 2004-10-07 Henry M. Jackson Foundation For The Advancement Of Military Medecine, Inc. Radiation protection by gamma-tocotrienol
CA2521020C (en) * 2003-04-10 2021-04-27 Barrie Tan Annatto extract compositions including tocotrienols and tocopherols and methods of use
US20050209315A1 (en) * 2004-03-20 2005-09-22 Papas Andreas M Bioavailable nutritional supplement and method of treatment of malabsorption
US20060013901A1 (en) * 2004-05-26 2006-01-19 Kgk Synergize Inc. Compositions comprising flavonoids and tocotrienols and methods thereof
CN1775289B (zh) 2004-11-15 2011-08-24 杭州赛诺菲民生健康药业有限公司 多维生素口腔崩解片制剂及其制备方法
EP2271347B1 (en) 2008-03-28 2016-05-11 Hale Biopharma Ventures, Llc Administration of benzodiazepine compositions
WO2009126866A2 (en) * 2008-04-10 2009-10-15 Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Delta-tocotrienol as a radioprotective countermeasure agent
MX2011012078A (es) 2009-05-20 2012-03-14 Lingual Consegna Pty Ltd Formulacion terapeutica bucal y/o sublingual.
HUE037592T2 (hu) * 2009-08-26 2018-09-28 Bioelectron Tech Corp Eljárások cerebrális ischemia megelõzésére és kezelésére
KR101796340B1 (ko) 2011-02-18 2017-11-10 바이오링거스 아이피 엘엘씨 안정화된 활성제를 포함하는 생성물을 제조하는 방법 및 이를 포함하는 조성물
EP2720699B1 (en) 2011-06-14 2018-05-16 Hale Biopharma Ventures, Llc Administration of benzodiazepine
RU2015120181A (ru) * 2012-11-13 2017-01-10 Гордаген Фармасьютикалз Пти Лтд Чресслизистая доставка токотриенола

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010151348A1 (en) * 2009-06-25 2010-12-29 Edison Pharmaceuticals, Inc. Treatment of pervasive developmental disorders with tocotrienols or tocotrienol enriched extracts
WO2011082355A1 (en) * 2009-12-31 2011-07-07 Edison Pharmaceuticals, Inc. Treatment of leigh syndrome and leigh-like syndrome with tocotrienol quinones
WO2011126998A1 (en) * 2010-04-06 2011-10-13 Edison Pharmaceuticals, Inc. Treatment of ataxia telangiectasia
WO2012068552A1 (en) * 2010-11-19 2012-05-24 Edison Pharmaceuticals, Inc. Methods for improving blood glucose control

Also Published As

Publication number Publication date
JP6978392B2 (ja) 2021-12-08
JP6460998B2 (ja) 2019-01-30
MY177940A (en) 2020-09-28
PL2919777T3 (pl) 2020-07-13
BR112015010703A2 (pt) 2017-07-11
US20150265570A1 (en) 2015-09-24
PT2919777T (pt) 2020-03-30
CA2891164C (en) 2021-02-09
SG11201503640WA (en) 2015-06-29
US10675265B2 (en) 2020-06-09
EP2919777A1 (en) 2015-09-23
AU2013344817A1 (en) 2015-02-12
CN112451518B (zh) 2025-02-21
ZA201504191B (en) 2016-11-30
BR112015010703A8 (pt) 2018-08-14
US20200246306A1 (en) 2020-08-06
DK2919777T3 (da) 2020-03-09
IN2015DN04006A (enExample) 2015-10-02
PE20151518A1 (es) 2015-11-25
RU2015120181A (ru) 2017-01-10
CN104582700B (zh) 2021-01-05
BR112015010703B1 (pt) 2021-02-17
WO2014075135A1 (en) 2014-05-22
JP2019031504A (ja) 2019-02-28
PH12015501048A1 (en) 2015-07-27
EP2919777A4 (en) 2016-05-18
CN104582700A (zh) 2015-04-29
EP2919777B1 (en) 2020-01-08
JP2016503407A (ja) 2016-02-04
IL238727A0 (en) 2015-06-30
ES2778065T3 (es) 2020-08-07
CA2891164A1 (en) 2014-05-22
KR20150082109A (ko) 2015-07-15
HK1207295A1 (en) 2016-01-29
US11331302B2 (en) 2022-05-17
NZ628963A (en) 2017-02-24
JP2021008509A (ja) 2021-01-28
CN112451518A (zh) 2021-03-09

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Owner name: INVICTUS BIOTECHNOLOGY PTY LTD

Free format text: FORMER OWNER(S): GORDAGEN PHARMACEUTICALS PTY LTD