JP6458041B2 - ＲＯＲｃモジュレーターとしてのアリールスルタム誘導体 - Google Patents

ＲＯＲｃモジュレーターとしてのアリールスルタム誘導体 Download PDF

Info

Publication number
JP6458041B2
JP6458041B2 JP2016545888A JP2016545888A JP6458041B2 JP 6458041 B2 JP6458041 B2 JP 6458041B2 JP 2016545888 A JP2016545888 A JP 2016545888A JP 2016545888 A JP2016545888 A JP 2016545888A JP 6458041 B2 JP6458041 B2 JP 6458041B2
Authority
JP
Japan
Prior art keywords
alkyl
formula
aminocarbonyl
certain embodiments
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2016545888A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017503808A5 (enExample
JP2017503808A (ja
Inventor
ボーディル・ヴァン・ニール，モニク
ファウバー，ベンジャミン
ガンチア，エマヌエラ
ゲインズ，サイモン
ゴッビ，アルベルト
ハーリー，クリストファー
ラッディワヘッティ，タミー
レーネ，オリヴィエ
ヴィージー，デイビッド
ワード，スチュアート
ウィンシップ，ポール
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JP2017503808A publication Critical patent/JP2017503808A/ja
Publication of JP2017503808A5 publication Critical patent/JP2017503808A5/ja
Application granted granted Critical
Publication of JP6458041B2 publication Critical patent/JP6458041B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2016545888A 2014-01-10 2015-01-09 ＲＯＲｃモジュレーターとしてのアリールスルタム誘導体 Expired - Fee Related JP6458041B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461925845P 2014-01-10 2014-01-10
US61/925,845 2014-01-10
US201462091861P 2014-12-15 2014-12-15
US62/091,861 2014-12-15
PCT/EP2015/050292 WO2015104354A1 (en) 2014-01-10 2015-01-09 ARYL SULTAM DERIVATIVES AS RORc MODULATORS

Publications (3)

Publication Number Publication Date
JP2017503808A JP2017503808A (ja) 2017-02-02
JP2017503808A5 JP2017503808A5 (enExample) 2018-02-15
JP6458041B2 true JP6458041B2 (ja) 2019-01-23

Family

ID=52423686

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016545888A Expired - Fee Related JP6458041B2 (ja) 2014-01-10 2015-01-09 ＲＯＲｃモジュレーターとしてのアリールスルタム誘導体

Country Status (9)

Country Link
US (1) US10131644B2 (enExample)
EP (1) EP3092239B1 (enExample)
JP (1) JP6458041B2 (enExample)
KR (1) KR20160106705A (enExample)
CN (1) CN105899507B (enExample)
CA (1) CA2935012A1 (enExample)
MX (1) MX2016008721A (enExample)
RU (1) RU2016131363A (enExample)
WO (1) WO2015104354A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2016008499A (es) 2014-01-10 2016-09-13 Hoffmann La Roche Derivados de arilsultamo como moduladores del receptor huerfano relacionado con el receptor de retinoide (rorc).
WO2017005668A1 (en) * 2015-07-08 2017-01-12 F. Hoffmann-La Roche Ag ARYL SULTAM DERIVATIVES AS RORc MODULATORS
WO2017005900A1 (en) * 2015-07-08 2017-01-12 F. Hoffmann-La Roche Ag ARYL SULTAM DERIVATIVES AS RORc MODULATORS
CN114901640A (zh) * 2019-12-24 2022-08-12 兹杜斯生命科学有限公司 适用于治疗血脂异常的新型化合物
AU2021341508A1 (en) 2020-09-10 2023-05-25 Precirix N.V. Antibody fragment against fap
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
AU2023264245A1 (en) 2022-05-02 2024-12-19 Precirix N.V. Pre-targeting

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6063870B2 (ja) * 2010-11-08 2017-01-18 ライセラ・コーポレイション ＲＯＲγ活性の阻害用のＮ−スルホニル化テトラヒドロキノリンおよび関連二環化合物および病気の治療
WO2013064231A1 (en) * 2011-10-31 2013-05-10 Phenex Pharmaceuticals Ag SEVEN-MEMBERED SULFONAMIDES AS MODULATORS OF RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORγ, NR1F3)
US9216988B2 (en) * 2011-12-22 2015-12-22 Genentech, Inc. Benzyl sulfonamide derivatives as RORc modulators
US20130190356A1 (en) * 2011-12-22 2013-07-25 Genentech, Inc. Benzyl sulfonamide derivatives as rorc modulators
AR092348A1 (es) * 2012-07-11 2015-04-15 Hoffmann La Roche DERIVADOS DE ARIL-SULTAMO COMO MODULADORES DE RORc
BR112015007862A2 (pt) * 2012-12-10 2017-07-04 Hoffmann La Roche derivados benzil sulfonamida como moduladores rorc
EP2928866A1 (en) * 2012-12-10 2015-10-14 F. Hoffmann-La Roche AG BENZYL SULFONAMIDE DERIVATIVES AS RORc MODULATORS
CN105121404A (zh) * 2013-03-15 2015-12-02 豪夫迈·罗氏有限公司 作为RORc调节剂的芳基磺酰胺和氨基磺酸衍生物
HK1220976A1 (zh) * 2013-06-21 2017-05-19 F. Hoffmann-La Roche Ag 作为rorc调节剂的芳基磺内酰胺衍生物
WO2015104353A1 (en) * 2014-01-10 2015-07-16 F. Hoffmann-La Roche Ag HETEROARYL SULTAM DERIVATIVES AS RORc MODULATORS
MX2016008499A (es) * 2014-01-10 2016-09-13 Hoffmann La Roche Derivados de arilsultamo como moduladores del receptor huerfano relacionado con el receptor de retinoide (rorc).

Also Published As

Publication number Publication date
CN105899507A (zh) 2016-08-24
CA2935012A1 (en) 2015-07-16
WO2015104354A1 (en) 2015-07-16
US20170137393A1 (en) 2017-05-18
JP2017503808A (ja) 2017-02-02
US10131644B2 (en) 2018-11-20
KR20160106705A (ko) 2016-09-12
EP3092239A1 (en) 2016-11-16
CN105899507B (zh) 2019-06-07
RU2016131363A (ru) 2018-02-16
EP3092239B1 (en) 2019-10-02
MX2016008721A (es) 2017-01-26

Similar Documents

Publication Publication Date Title
JP6458040B2 (ja) ＲＯＲｃモジュレーターとしてのアリールスルタム誘導体
JP2017503808A (ja) ＲＯＲｃモジュレーターとしてのアリールスルタム誘導体
JP6378774B2 (ja) 自己免疫疾患を処置するためのＲＯＲｃモジュレーターとしての５，６，７，８−テトラヒドロ−５，８−メタノシンノリン誘導体
KR20160055185A (ko) RORc 조절제로서의 케토-이미다조피리딘 유도체
JP2018519353A (ja) ＲＯＲｃモジュレーターとしてのアリールスルタム誘導体
JP2017537966A (ja) ＲＯＲｃモジュレーターとしてのヘテロアリールアルキレンアリールスルタム誘導体
US20180263996A1 (en) ARYL SULTAM DERIVATIVES AS RORc MODULATORS
CN105899506A (zh) 作为RORc调节剂的杂芳基磺内酰胺衍生物
JP6757333B2 (ja) ＲＯＲｃモジュレーターとしてのピリダジン誘導体
HK1228382A1 (en) Aryl sultam derivatives as rorc modulators
HK1228382B (en) Aryl sultam derivatives as rorc modulators
HK1228380B (en) Aryl sultam derivatives as rorc modulators
US10280144B2 (en) Pyridazine derivatives as RORc modulators
JP2018519257A (ja) ＲＯＲｃモジュレーターとしてのピリダジン誘導体
HK1228380A1 (en) Aryl sultam derivatives as rorc modulators

Legal Events

Date Code Title Description
A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20180104

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20180104

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20180906

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180918

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181113

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20181127

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20181221

R150 Certificate of patent or registration of utility model

Ref document number: 6458041

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees