MX2016008721A - Derivados de aril sultama como moduladores del receptor huerfano relacionado con acido retinoico (rorc). - Google Patents
Derivados de aril sultama como moduladores del receptor huerfano relacionado con acido retinoico (rorc).Info
- Publication number
- MX2016008721A MX2016008721A MX2016008721A MX2016008721A MX2016008721A MX 2016008721 A MX2016008721 A MX 2016008721A MX 2016008721 A MX2016008721 A MX 2016008721A MX 2016008721 A MX2016008721 A MX 2016008721A MX 2016008721 A MX2016008721 A MX 2016008721A
- Authority
- MX
- Mexico
- Prior art keywords
- sultam derivatives
- aryl
- rorc modulators
- compounds
- rorc
- Prior art date
Links
- 229940124824 RORC modulator Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 208000034189 Sclerosis Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000003387 muscular Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461925845P | 2014-01-10 | 2014-01-10 | |
| US201462091861P | 2014-12-15 | 2014-12-15 | |
| PCT/EP2015/050292 WO2015104354A1 (en) | 2014-01-10 | 2015-01-09 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016008721A true MX2016008721A (es) | 2017-01-26 |
Family
ID=52423686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016008721A MX2016008721A (es) | 2014-01-10 | 2015-01-09 | Derivados de aril sultama como moduladores del receptor huerfano relacionado con acido retinoico (rorc). |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10131644B2 (enExample) |
| EP (1) | EP3092239B1 (enExample) |
| JP (1) | JP6458041B2 (enExample) |
| KR (1) | KR20160106705A (enExample) |
| CN (1) | CN105899507B (enExample) |
| CA (1) | CA2935012A1 (enExample) |
| MX (1) | MX2016008721A (enExample) |
| RU (1) | RU2016131363A (enExample) |
| WO (1) | WO2015104354A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2016008499A (es) | 2014-01-10 | 2016-09-13 | Hoffmann La Roche | Derivados de arilsultamo como moduladores del receptor huerfano relacionado con el receptor de retinoide (rorc). |
| WO2017005668A1 (en) * | 2015-07-08 | 2017-01-12 | F. Hoffmann-La Roche Ag | ARYL SULTAM DERIVATIVES AS RORc MODULATORS |
| WO2017005900A1 (en) * | 2015-07-08 | 2017-01-12 | F. Hoffmann-La Roche Ag | ARYL SULTAM DERIVATIVES AS RORc MODULATORS |
| CN114901640A (zh) * | 2019-12-24 | 2022-08-12 | 兹杜斯生命科学有限公司 | 适用于治疗血脂异常的新型化合物 |
| AU2021341508A1 (en) | 2020-09-10 | 2023-05-25 | Precirix N.V. | Antibody fragment against fap |
| WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
| AU2023264245A1 (en) | 2022-05-02 | 2024-12-19 | Precirix N.V. | Pre-targeting |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6063870B2 (ja) * | 2010-11-08 | 2017-01-18 | ライセラ・コーポレイション | ＲＯＲγ活性の阻害用のＮ−スルホニル化テトラヒドロキノリンおよび関連二環化合物および病気の治療 |
| WO2013064231A1 (en) * | 2011-10-31 | 2013-05-10 | Phenex Pharmaceuticals Ag | SEVEN-MEMBERED SULFONAMIDES AS MODULATORS OF RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORγ, NR1F3) |
| US9216988B2 (en) * | 2011-12-22 | 2015-12-22 | Genentech, Inc. | Benzyl sulfonamide derivatives as RORc modulators |
| US20130190356A1 (en) * | 2011-12-22 | 2013-07-25 | Genentech, Inc. | Benzyl sulfonamide derivatives as rorc modulators |
| AR092348A1 (es) * | 2012-07-11 | 2015-04-15 | Hoffmann La Roche | DERIVADOS DE ARIL-SULTAMO COMO MODULADORES DE RORc |
| BR112015007862A2 (pt) * | 2012-12-10 | 2017-07-04 | Hoffmann La Roche | derivados benzil sulfonamida como moduladores rorc |
| EP2928866A1 (en) * | 2012-12-10 | 2015-10-14 | F. Hoffmann-La Roche AG | BENZYL SULFONAMIDE DERIVATIVES AS RORc MODULATORS |
| CN105121404A (zh) * | 2013-03-15 | 2015-12-02 | 豪夫迈·罗氏有限公司 | 作为RORc调节剂的芳基磺酰胺和氨基磺酸衍生物 |
| HK1220976A1 (zh) * | 2013-06-21 | 2017-05-19 | F. Hoffmann-La Roche Ag | 作为rorc调节剂的芳基磺内酰胺衍生物 |
| WO2015104353A1 (en) * | 2014-01-10 | 2015-07-16 | F. Hoffmann-La Roche Ag | HETEROARYL SULTAM DERIVATIVES AS RORc MODULATORS |
| MX2016008499A (es) * | 2014-01-10 | 2016-09-13 | Hoffmann La Roche | Derivados de arilsultamo como moduladores del receptor huerfano relacionado con el receptor de retinoide (rorc). |
-
2015
- 2015-01-09 CA CA2935012A patent/CA2935012A1/en not_active Abandoned
- 2015-01-09 EP EP15701305.3A patent/EP3092239B1/en active Active
- 2015-01-09 RU RU2016131363A patent/RU2016131363A/ru unknown
- 2015-01-09 MX MX2016008721A patent/MX2016008721A/es unknown
- 2015-01-09 CN CN201580004086.8A patent/CN105899507B/zh not_active Expired - Fee Related
- 2015-01-09 JP JP2016545888A patent/JP6458041B2/ja not_active Expired - Fee Related
- 2015-01-09 WO PCT/EP2015/050292 patent/WO2015104354A1/en not_active Ceased
- 2015-01-09 KR KR1020167021670A patent/KR20160106705A/ko not_active Withdrawn
-
2016
- 2016-06-30 US US15/199,447 patent/US10131644B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN105899507A (zh) | 2016-08-24 |
| CA2935012A1 (en) | 2015-07-16 |
| WO2015104354A1 (en) | 2015-07-16 |
| JP6458041B2 (ja) | 2019-01-23 |
| US20170137393A1 (en) | 2017-05-18 |
| JP2017503808A (ja) | 2017-02-02 |
| US10131644B2 (en) | 2018-11-20 |
| KR20160106705A (ko) | 2016-09-12 |
| EP3092239A1 (en) | 2016-11-16 |
| CN105899507B (zh) | 2019-06-07 |
| RU2016131363A (ru) | 2018-02-16 |
| EP3092239B1 (en) | 2019-10-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12014502788A1 (en) | ARYL SULTAM DERIVATIVES AS RORc MODULATORS | |
| MX2016008499A (es) | Derivados de arilsultamo como moduladores del receptor huerfano relacionado con el receptor de retinoide (rorc). | |
| PH12016501972A1 (en) | Bicyclic-fused heteroaryl or aryl compounds and their use as irak4 inhibitors | |
| MX2015006926A (es) | Derivados de bencil sulfonamida como moduladores del receptor huerfano relacionado con el receptor retinoide (rorc). | |
| TW201613872A (en) | IRAK4 inhibiting agents | |
| EA201790766A1 (ru) | Новые соединения метилпиперидина, подходящие для ингибирования микросомальной простагландин-e2-синтазы 1 | |
| MX2018012266A (es) | Amidas heterociclicas como moduladores de proteinas. | |
| ZA201701299B (en) | Glycosidase inhibitors | |
| MX2016015247A (es) | Derivados de benceno-sulfonamida y su uso como moduladores del receptor c huerfano relacionado a acido retinoico (rorc). | |
| MX2015011180A (es) | Derivados de aril sulfamida y sulfamato como moduladores del receptor huerfano relacionado con el receptor del retinoide (porc). | |
| PH12021551134A1 (en) | Oxysterols and methods of use thereof | |
| MX2017007748A (es) | Compuestos de heteroarilo anulares fusionados y su uso como inhibidores del receptor de la tirocina cinasa (trk). | |
| UY36226A (es) | Ácidos carboxílicos heterocíclicos como activadores de guanilato ciclasa soluble | |
| MX2015015614A (es) | Derivados de aril sultama como moduladores del receptor huerfano relacionado con el receptor del retinoide (rorc). | |
| PH12017500095A1 (en) | Imidazopyridazine compounds | |
| TW201613864A (en) | Novel compounds | |
| MX2016005128A (es) | Derivados de 5,6,7,8-tetahidro-5,8-metanocinolina como moduladores del receptor huerfano y relacionado con acido retinoico (rorc) para el tratamiento de enfermedades autoinmunes. | |
| MX2016002718A (es) | Derivados de ceto-imidazopiridina como moduladores del receptor huerfano relacionado con receptor retinoide (porc). | |
| PH12019500568A1 (en) | Dopamine-b-hydroxylase inhibitors | |
| ZA201606471B (en) | Antimitotic amides for the treatment of cancer and proliferative disorders | |
| EA033423B1 (ru) | Циклопропанбензофуранилпиридопиразиндионы | |
| PH12018500668A1 (en) | Therapeutic compounds and methods of use thereof | |
| MX2017003294A (es) | Quinolinas carboxamidas para usarse en el tratamiento de mielomas multiples. | |
| PH12016502480A1 (en) | Compounds, pharmaceutical composition and their use in treating neurodegenerative diseases | |
| MX2016008780A (es) | Derivados de sultam heteroarilo como moduladores del receptor huerfano relacionado con el acido retinoico gamma (ror gamma). |