JP2017503808A5 - - Google Patents
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- Publication number
- JP2017503808A5 JP2017503808A5 JP2016545888A JP2016545888A JP2017503808A5 JP 2017503808 A5 JP2017503808 A5 JP 2017503808A5 JP 2016545888 A JP2016545888 A JP 2016545888A JP 2016545888 A JP2016545888 A JP 2016545888A JP 2017503808 A5 JP2017503808 A5 JP 2017503808A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aminocarbonyl
- alkoxy
- hydroxy
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 198
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims description 78
- 125000005843 halogen group Chemical group 0.000 claims description 71
- 229920006395 saturated elastomer Polymers 0.000 claims description 68
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 53
- 229910052739 hydrogen Inorganic materials 0.000 claims description 53
- 239000001257 hydrogen Substances 0.000 claims description 53
- 125000004429 atom Chemical group 0.000 claims description 44
- 125000005842 heteroatom Chemical group 0.000 claims description 36
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 30
- 125000003545 alkoxy group Chemical group 0.000 claims description 27
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 27
- 150000001875 compounds Chemical class 0.000 claims description 23
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims description 21
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 21
- -1 N-cyano-aminocarbonyl Chemical group 0.000 claims description 18
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims description 15
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims description 15
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 15
- 125000004694 alkoxyaminocarbonyl group Chemical group 0.000 claims description 15
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 15
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 12
- 125000001072 heteroaryl group Chemical group 0.000 claims description 12
- 125000000623 heterocyclic group Chemical group 0.000 claims description 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 12
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 claims description 9
- 125000003118 aryl group Chemical group 0.000 claims description 8
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 6
- 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 claims description 6
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 6
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 6
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 claims description 6
- 125000005144 cycloalkylsulfonyl group Chemical group 0.000 claims description 6
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 6
- 229920002554 vinyl polymer Polymers 0.000 claims description 6
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 3
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims description 3
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 206010025135 lupus erythematosus Diseases 0.000 claims 6
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 3
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 3
- 206010064584 Myosclerosis Diseases 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 3
- 206010003246 arthritis Diseases 0.000 claims 3
- 208000006673 asthma Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 3
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 3
- 206010015150 Erythema Diseases 0.000 claims 2
- 231100000321 erythema Toxicity 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 0 CC(*)(***)c1ccc(C(*)(*)N(C(*)CCC2c3ccccc3)S2(=O)=O)cc1 Chemical compound CC(*)(***)c1ccc(C(*)(*)N(C(*)CCC2c3ccccc3)S2(=O)=O)cc1 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461925845P | 2014-01-10 | 2014-01-10 | |
| US61/925,845 | 2014-01-10 | ||
| US201462091861P | 2014-12-15 | 2014-12-15 | |
| US62/091,861 | 2014-12-15 | ||
| PCT/EP2015/050292 WO2015104354A1 (en) | 2014-01-10 | 2015-01-09 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017503808A JP2017503808A (ja) | 2017-02-02 |
| JP2017503808A5 true JP2017503808A5 (enExample) | 2018-02-15 |
| JP6458041B2 JP6458041B2 (ja) | 2019-01-23 |
Family
ID=52423686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016545888A Expired - Fee Related JP6458041B2 (ja) | 2014-01-10 | 2015-01-09 | ＲＯＲｃモジュレーターとしてのアリールスルタム誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10131644B2 (enExample) |
| EP (1) | EP3092239B1 (enExample) |
| JP (1) | JP6458041B2 (enExample) |
| KR (1) | KR20160106705A (enExample) |
| CN (1) | CN105899507B (enExample) |
| CA (1) | CA2935012A1 (enExample) |
| MX (1) | MX2016008721A (enExample) |
| RU (1) | RU2016131363A (enExample) |
| WO (1) | WO2015104354A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2016008499A (es) | 2014-01-10 | 2016-09-13 | Hoffmann La Roche | Derivados de arilsultamo como moduladores del receptor huerfano relacionado con el receptor de retinoide (rorc). |
| WO2017005668A1 (en) * | 2015-07-08 | 2017-01-12 | F. Hoffmann-La Roche Ag | ARYL SULTAM DERIVATIVES AS RORc MODULATORS |
| WO2017005900A1 (en) * | 2015-07-08 | 2017-01-12 | F. Hoffmann-La Roche Ag | ARYL SULTAM DERIVATIVES AS RORc MODULATORS |
| CN114901640A (zh) * | 2019-12-24 | 2022-08-12 | 兹杜斯生命科学有限公司 | 适用于治疗血脂异常的新型化合物 |
| AU2021341508A1 (en) | 2020-09-10 | 2023-05-25 | Precirix N.V. | Antibody fragment against fap |
| WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
| AU2023264245A1 (en) | 2022-05-02 | 2024-12-19 | Precirix N.V. | Pre-targeting |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6063870B2 (ja) * | 2010-11-08 | 2017-01-18 | ライセラ・コーポレイション | ＲＯＲγ活性の阻害用のＮ−スルホニル化テトラヒドロキノリンおよび関連二環化合物および病気の治療 |
| WO2013064231A1 (en) * | 2011-10-31 | 2013-05-10 | Phenex Pharmaceuticals Ag | SEVEN-MEMBERED SULFONAMIDES AS MODULATORS OF RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORγ, NR1F3) |
| US9216988B2 (en) * | 2011-12-22 | 2015-12-22 | Genentech, Inc. | Benzyl sulfonamide derivatives as RORc modulators |
| US20130190356A1 (en) * | 2011-12-22 | 2013-07-25 | Genentech, Inc. | Benzyl sulfonamide derivatives as rorc modulators |
| AR092348A1 (es) * | 2012-07-11 | 2015-04-15 | Hoffmann La Roche | DERIVADOS DE ARIL-SULTAMO COMO MODULADORES DE RORc |
| BR112015007862A2 (pt) * | 2012-12-10 | 2017-07-04 | Hoffmann La Roche | derivados benzil sulfonamida como moduladores rorc |
| EP2928866A1 (en) * | 2012-12-10 | 2015-10-14 | F. Hoffmann-La Roche AG | BENZYL SULFONAMIDE DERIVATIVES AS RORc MODULATORS |
| CN105121404A (zh) * | 2013-03-15 | 2015-12-02 | 豪夫迈·罗氏有限公司 | 作为RORc调节剂的芳基磺酰胺和氨基磺酸衍生物 |
| HK1220976A1 (zh) * | 2013-06-21 | 2017-05-19 | F. Hoffmann-La Roche Ag | 作为rorc调节剂的芳基磺内酰胺衍生物 |
| WO2015104353A1 (en) * | 2014-01-10 | 2015-07-16 | F. Hoffmann-La Roche Ag | HETEROARYL SULTAM DERIVATIVES AS RORc MODULATORS |
| MX2016008499A (es) * | 2014-01-10 | 2016-09-13 | Hoffmann La Roche | Derivados de arilsultamo como moduladores del receptor huerfano relacionado con el receptor de retinoide (rorc). |
-
2015
- 2015-01-09 CA CA2935012A patent/CA2935012A1/en not_active Abandoned
- 2015-01-09 EP EP15701305.3A patent/EP3092239B1/en active Active
- 2015-01-09 RU RU2016131363A patent/RU2016131363A/ru unknown
- 2015-01-09 MX MX2016008721A patent/MX2016008721A/es unknown
- 2015-01-09 CN CN201580004086.8A patent/CN105899507B/zh not_active Expired - Fee Related
- 2015-01-09 JP JP2016545888A patent/JP6458041B2/ja not_active Expired - Fee Related
- 2015-01-09 WO PCT/EP2015/050292 patent/WO2015104354A1/en not_active Ceased
- 2015-01-09 KR KR1020167021670A patent/KR20160106705A/ko not_active Withdrawn
-
2016
- 2016-06-30 US US15/199,447 patent/US10131644B2/en not_active Expired - Fee Related