JP2017503808A5 - - Google Patents
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- Publication number
- JP2017503808A5 JP2017503808A5 JP2016545888A JP2016545888A JP2017503808A5 JP 2017503808 A5 JP2017503808 A5 JP 2017503808A5 JP 2016545888 A JP2016545888 A JP 2016545888A JP 2016545888 A JP2016545888 A JP 2016545888A JP 2017503808 A5 JP2017503808 A5 JP 2017503808A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aminocarbonyl
- alkoxy
- hydroxy
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 198
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims description 78
- 125000005843 halogen group Chemical group 0.000 claims description 71
- 229920006395 saturated elastomer Polymers 0.000 claims description 68
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 53
- 229910052739 hydrogen Inorganic materials 0.000 claims description 53
- 239000001257 hydrogen Substances 0.000 claims description 53
- 125000004429 atom Chemical group 0.000 claims description 44
- 125000005842 heteroatom Chemical group 0.000 claims description 36
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 30
- 125000003545 alkoxy group Chemical group 0.000 claims description 27
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 27
- 150000001875 compounds Chemical class 0.000 claims description 23
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims description 21
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 21
- -1 N-cyano-aminocarbonyl Chemical group 0.000 claims description 18
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims description 15
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims description 15
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 15
- 125000004694 alkoxyaminocarbonyl group Chemical group 0.000 claims description 15
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 15
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 12
- 125000001072 heteroaryl group Chemical group 0.000 claims description 12
- 125000000623 heterocyclic group Chemical group 0.000 claims description 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 12
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 claims description 9
- 125000003118 aryl group Chemical group 0.000 claims description 8
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 6
- 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 claims description 6
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 6
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 6
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 claims description 6
- 125000005144 cycloalkylsulfonyl group Chemical group 0.000 claims description 6
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 6
- 229920002554 vinyl polymer Polymers 0.000 claims description 6
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 3
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims description 3
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 206010025135 lupus erythematosus Diseases 0.000 claims 6
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 3
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 3
- 206010064584 Myosclerosis Diseases 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 3
- 206010003246 arthritis Diseases 0.000 claims 3
- 208000006673 asthma Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 3
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 3
- 206010015150 Erythema Diseases 0.000 claims 2
- 231100000321 erythema Toxicity 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 0 CC(*)(***)c1ccc(C(*)(*)N(C(*)CCC2c3ccccc3)S2(=O)=O)cc1 Chemical compound CC(*)(***)c1ccc(C(*)(*)N(C(*)CCC2c3ccccc3)S2(=O)=O)cc1 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461925845P | 2014-01-10 | 2014-01-10 | |
| US61/925,845 | 2014-01-10 | ||
| US201462091861P | 2014-12-15 | 2014-12-15 | |
| US62/091,861 | 2014-12-15 | ||
| PCT/EP2015/050292 WO2015104354A1 (en) | 2014-01-10 | 2015-01-09 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017503808A JP2017503808A (ja) | 2017-02-02 |
| JP2017503808A5 true JP2017503808A5 (enExample) | 2018-02-15 |
| JP6458041B2 JP6458041B2 (ja) | 2019-01-23 |
Family
ID=52423686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016545888A Expired - Fee Related JP6458041B2 (ja) | 2014-01-10 | 2015-01-09 | ＲＯＲｃモジュレーターとしてのアリールスルタム誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10131644B2 (enExample) |
| EP (1) | EP3092239B1 (enExample) |
| JP (1) | JP6458041B2 (enExample) |
| KR (1) | KR20160106705A (enExample) |
| CN (1) | CN105899507B (enExample) |
| CA (1) | CA2935012A1 (enExample) |
| MX (1) | MX2016008721A (enExample) |
| RU (1) | RU2016131363A (enExample) |
| WO (1) | WO2015104354A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105916852B (zh) * | 2014-01-10 | 2020-04-24 | 豪夫迈·罗氏有限公司 | 作为RORc调节剂的芳基磺内酰胺衍生物 |
| WO2017005900A1 (en) * | 2015-07-08 | 2017-01-12 | F. Hoffmann-La Roche Ag | ARYL SULTAM DERIVATIVES AS RORc MODULATORS |
| WO2017005668A1 (en) * | 2015-07-08 | 2017-01-12 | F. Hoffmann-La Roche Ag | ARYL SULTAM DERIVATIVES AS RORc MODULATORS |
| WO2021130723A1 (en) * | 2019-12-24 | 2021-07-01 | Cadila Healthcare Limited | Novel compounds suitable for the treatment of dyslipidemia |
| IL301285A (en) | 2020-09-10 | 2023-05-01 | Precirix N V | Antibody fragment against fap |
| WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
| CA3251753A1 (en) | 2022-05-02 | 2023-11-09 | Precirix N.V. | PRE-TARGETTING |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9512111B2 (en) * | 2010-11-08 | 2016-12-06 | Lycera Corporation | N-sulfonylated tetrahydroquinolines and related bicyclic compounds for inhibition of RORγ activity and the treatment of disease |
| WO2013064231A1 (en) * | 2011-10-31 | 2013-05-10 | Phenex Pharmaceuticals Ag | SEVEN-MEMBERED SULFONAMIDES AS MODULATORS OF RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORγ, NR1F3) |
| US20130190356A1 (en) * | 2011-12-22 | 2013-07-25 | Genentech, Inc. | Benzyl sulfonamide derivatives as rorc modulators |
| US9216988B2 (en) * | 2011-12-22 | 2015-12-22 | Genentech, Inc. | Benzyl sulfonamide derivatives as RORc modulators |
| TW201408652A (zh) * | 2012-07-11 | 2014-03-01 | Hoffmann La Roche | 作爲ＲＯＲｃ調節劑之芳基磺內醯胺衍生物 |
| CA2893638A1 (en) * | 2012-12-10 | 2014-06-19 | F. Hoffmann-La Roche Ag | Benzyl sulfonamide derivatives as rorc modulators |
| CA2886471A1 (en) * | 2012-12-10 | 2014-06-19 | F. Hoffmann-La Roche Ag | Benzyl sulfonamide derivatives as rorc modulators |
| BR112015023571A2 (pt) * | 2013-03-15 | 2017-07-18 | Hoffmann La Roche | derivados de sulfamato e sulfamida de arila como moduladores rorc |
| CA2911963A1 (en) * | 2013-06-21 | 2014-12-24 | F. Hoffmann-La Roche Ag | Aryl sultam derivatives as rorc modulators |
| RU2016131356A (ru) * | 2014-01-10 | 2018-02-16 | Ф. Хоффманн-Ля Рош Аг | Производные гетероарилсультама в качестве модуляторов орфанного рецептора гамма, связанного с ретиноевой кислотой |
| CN105916852B (zh) * | 2014-01-10 | 2020-04-24 | 豪夫迈·罗氏有限公司 | 作为RORc调节剂的芳基磺内酰胺衍生物 |
-
2015
- 2015-01-09 KR KR1020167021670A patent/KR20160106705A/ko not_active Withdrawn
- 2015-01-09 CN CN201580004086.8A patent/CN105899507B/zh not_active Expired - Fee Related
- 2015-01-09 EP EP15701305.3A patent/EP3092239B1/en active Active
- 2015-01-09 WO PCT/EP2015/050292 patent/WO2015104354A1/en not_active Ceased
- 2015-01-09 MX MX2016008721A patent/MX2016008721A/es unknown
- 2015-01-09 JP JP2016545888A patent/JP6458041B2/ja not_active Expired - Fee Related
- 2015-01-09 RU RU2016131363A patent/RU2016131363A/ru unknown
- 2015-01-09 CA CA2935012A patent/CA2935012A1/en not_active Abandoned
-
2016
- 2016-06-30 US US15/199,447 patent/US10131644B2/en not_active Expired - Fee Related