JP6440259B2 - Hbv感染及び関連疾患を処置するためのポリペプチド及び抗体 - Google Patents
Hbv感染及び関連疾患を処置するためのポリペプチド及び抗体 Download PDFInfo
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- JP6440259B2 JP6440259B2 JP2015516418A JP2015516418A JP6440259B2 JP 6440259 B2 JP6440259 B2 JP 6440259B2 JP 2015516418 A JP2015516418 A JP 2015516418A JP 2015516418 A JP2015516418 A JP 2015516418A JP 6440259 B2 JP6440259 B2 JP 6440259B2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/02—Hepadnaviridae, e.g. hepatitis B virus
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/532—Production of labelled immunochemicals
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- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5761—Hepatitis B
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C12N2710/00011—Details
- C12N2710/00034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- G01N2333/01—DNA viruses
- G01N2333/02—Hepadnaviridae, e.g. hepatitis B virus
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- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
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- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Wood Science & Technology (AREA)
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- Food Science & Technology (AREA)
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- Pathology (AREA)
- General Physics & Mathematics (AREA)
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- Mycology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210190329 | 2012-06-11 | ||
| CN201210190329.X | 2012-06-11 | ||
| PCT/CN2013/076832 WO2013185558A1 (zh) | 2012-06-11 | 2013-06-06 | 用于治疗hbv感染及相关疾病的多肽及抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015522563A JP2015522563A (ja) | 2015-08-06 |
| JP6440259B2 true JP6440259B2 (ja) | 2018-12-19 |
Family
ID=49757513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516418A Active JP6440259B2 (ja) | 2012-06-11 | 2013-06-06 | Hbv感染及び関連疾患を処置するためのポリペプチド及び抗体 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9751914B2 (Direct) |
| EP (2) | EP2860188B1 (Direct) |
| JP (1) | JP6440259B2 (Direct) |
| KR (2) | KR102106782B1 (Direct) |
| CN (2) | CN103483421B (Direct) |
| AU (1) | AU2013276015B2 (Direct) |
| BR (2) | BR122020023349B1 (Direct) |
| CA (2) | CA2943258C (Direct) |
| ES (2) | ES2834072T3 (Direct) |
| IN (1) | IN2014DN10288A (Direct) |
| WO (1) | WO2013185558A1 (Direct) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103483421B (zh) * | 2012-06-11 | 2019-10-22 | 厦门大学 | 用于治疗hbv感染及相关疾病的多肽及抗体 |
| WO2016085284A1 (ko) * | 2014-11-28 | 2016-06-02 | (주)셀트리온 | B형 간염 바이러스 표면 항원의 에피토프 및 이에 특이적으로 결합하는 b형 간염 바이러스 중화 결합 분자 |
| BR112018007121A2 (pt) * | 2015-10-09 | 2018-11-06 | Xiamen University | anticorpo ou antígeno de ligação ao fragmento do mesmo, anticorpo humanizado ou um fragmento de ligação ao antígeno do mesmo, molécula de ácido nucléico isolada, vetor, célula hospedeira, método para preparar o anticorpo ou um antígeno de ligação ao fragmento do mesmo, composição farmacêutica, uso do anticorpo ou um antígeno de ligação ao fragmento do mesmo e método para prevenir ou tratar infecção hbv ou uma doença associada com a infecção hbv |
| WO2018064602A1 (en) * | 2016-09-30 | 2018-04-05 | Baylor College Of Medicine | Chimeric antigen receptor therapy with reduced cytotoxicity for viral disease |
| US10987418B2 (en) | 2017-02-17 | 2021-04-27 | Xiamen University | Polypeptide carrier for presenting target polypeptide and uses thereof |
| RU2765878C2 (ru) * | 2017-04-07 | 2022-02-04 | Сямэнь Юниверсити | Антитела для лечения инфекции гепатитом в и связанных с ней заболеваний |
| CN109718364A (zh) * | 2017-10-27 | 2019-05-07 | 上海贺普药业股份有限公司 | 充分剂量条件下治疗乙肝病毒相关肝病的药物和方法 |
| JP7490574B2 (ja) * | 2018-05-31 | 2024-05-27 | ノバルティス アーゲー | B型肝炎抗体 |
| KR102084912B1 (ko) * | 2019-01-17 | 2020-03-05 | 주식회사 녹십자 | B형 간염 바이러스 표면 항원의 입체 에피토프 및 이에 특이적으로 결합하는 항체 |
| GB201904328D0 (en) * | 2019-03-28 | 2019-05-15 | Immunocore Ltd | Specific binding molecules |
| US20220251173A1 (en) * | 2019-05-23 | 2022-08-11 | Xiamen University | Anti-hepatitis b virus antibodies and use thereof |
| KR20220074917A (ko) | 2019-09-30 | 2022-06-03 | 길리애드 사이언시즈, 인코포레이티드 | Hbv 백신 및 hbv를 치료하는 방법 |
| CN111187349A (zh) * | 2019-10-30 | 2020-05-22 | 四川迈克生物新材料技术有限公司 | 单克隆抗体的制备方法 |
| CN113138276B (zh) * | 2020-01-19 | 2022-09-16 | 厦门万泰凯瑞生物技术有限公司 | 用于检测HBcAg的方法及抗体 |
| CN113717283B (zh) * | 2020-05-25 | 2023-05-26 | 厦门万泰凯瑞生物技术有限公司 | 一种抗乙型肝炎病毒e抗原的单克隆抗体及其应用 |
| CN111879932B (zh) * | 2020-06-24 | 2022-09-27 | 南方医科大学南方医院 | 乙型肝炎病毒(hbv)特异性b细胞表位检测方法及其应用 |
| CN115246881B (zh) * | 2021-02-02 | 2025-04-11 | 浙江理工大学 | 一种抗HBsAg鲨鱼单域抗体或其抗原结合片段及其应用 |
| CN113234143B (zh) * | 2021-05-10 | 2021-12-14 | 合肥金域医学检验实验室有限公司 | 一种快速检测病毒的核酸抗体试剂盒 |
| CN114671947B (zh) * | 2022-02-28 | 2024-04-09 | 中国科学院生物物理研究所 | 乙肝病毒不同亚型表面s蛋白高亲和力纳米抗体及其应用 |
| CN116162153B (zh) * | 2022-09-01 | 2024-09-10 | 复旦大学附属中山医院 | 一种乙肝病毒表面抗原的单克隆抗体及其应用 |
| CN116751262B (zh) * | 2023-07-31 | 2024-09-06 | 重庆医科大学国际体外诊断研究院 | 靶向乙型肝炎病毒核心蛋白的多肽及其应用 |
| CN119161462B (zh) * | 2024-10-09 | 2025-08-19 | 深圳市第三人民医院(深圳市肝病研究所) | 一株乙型肝炎病毒核心蛋白的单克隆抗体cAbD4及其制备与应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4599231A (en) * | 1984-03-09 | 1986-07-08 | Scripps Clinic And Research Foundation | Synthetic hepatitis B virus vaccine including both T cell and B cell determinants |
| WO1985004103A1 (en) * | 1984-03-09 | 1985-09-26 | Scripps Clinic And Research Foundation | Synthetic hepatitis b virus vaccine including both t cell anc b cell determinants |
| US20110097352A9 (en) | 1992-01-29 | 2011-04-28 | Pharmexa Inc. | Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions |
| JP2000514643A (ja) * | 1996-04-18 | 2000-11-07 | アボツト・ラボラトリーズ | B型肝炎表面抗原のa―決定基の抗原エピトープ及びその利用法 |
| DE60027581T2 (de) * | 1999-10-08 | 2007-05-10 | Celltech Pharma Europe Ltd., Slough | Design von immunogene |
| ES2307832T3 (es) | 2001-12-03 | 2008-12-01 | Amgen Fremont Inc. | Clasificacion de anticuerpos basada en las caracteristicas de union. |
| US7144712B2 (en) * | 2003-07-30 | 2006-12-05 | Vaccine Research Institute Of San Diego | Human hepatitis B virus core proteins as vaccine platforms and methods of use thereof |
| JP4948783B2 (ja) * | 2005-05-18 | 2012-06-06 | シスメックス株式会社 | 抗HBsモノクローナル抗体 |
| CN101606066A (zh) * | 2006-10-30 | 2009-12-16 | 株式会社先端生命科学研究所 | 乙型肝炎病毒表面抗原的分析方法 |
| CN101748129A (zh) * | 2008-12-04 | 2010-06-23 | 上海裕隆临床检验中心有限公司 | 人源乙肝病毒表面抗体的制备方法 |
| CN103483421B (zh) * | 2012-06-11 | 2019-10-22 | 厦门大学 | 用于治疗hbv感染及相关疾病的多肽及抗体 |
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- 2013-06-06 BR BR122020023349-4A patent/BR122020023349B1/pt active IP Right Grant
- 2013-06-06 CN CN201610394982.6A patent/CN106046155B/zh active Active
- 2013-06-06 BR BR112014030797A patent/BR112014030797A2/pt not_active Application Discontinuation
- 2013-06-06 JP JP2015516418A patent/JP6440259B2/ja active Active
- 2013-06-06 KR KR1020187034832A patent/KR102106782B1/ko active Active
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| CN106046155B (zh) | 2019-11-22 |
| CA2943258C (en) | 2020-12-22 |
| KR20150043289A (ko) | 2015-04-22 |
| HK1203978A1 (en) | 2015-11-06 |
| US9751914B2 (en) | 2017-09-05 |
| EP3308798A3 (en) | 2018-05-30 |
| CN103483421A (zh) | 2014-01-01 |
| JP2015522563A (ja) | 2015-08-06 |
| CN103483421B (zh) | 2019-10-22 |
| WO2013185558A1 (zh) | 2013-12-19 |
| EP3308798B1 (en) | 2020-09-09 |
| BR112014030797A2 (pt) | 2017-07-25 |
| EP2860188A4 (en) | 2016-04-27 |
| AU2013276015B2 (en) | 2017-04-20 |
| EP2860188B1 (en) | 2020-10-21 |
| KR20190011247A (ko) | 2019-02-01 |
| CA2876020A1 (en) | 2013-12-19 |
| US20180002382A1 (en) | 2018-01-04 |
| AU2013276015A1 (en) | 2014-12-18 |
| KR102106782B1 (ko) | 2020-05-07 |
| CA2876020C (en) | 2018-08-21 |
| IN2014DN10288A (Direct) | 2015-08-07 |
| ES2834072T3 (es) | 2021-06-16 |
| ES2843675T3 (es) | 2021-07-20 |
| KR101944263B1 (ko) | 2019-02-01 |
| EP3308798A2 (en) | 2018-04-18 |
| CA2943258A1 (en) | 2013-12-19 |
| US10246494B2 (en) | 2019-04-02 |
| EP2860188A1 (en) | 2015-04-15 |
| CN106046155A (zh) | 2016-10-26 |
| US20150246948A1 (en) | 2015-09-03 |
| BR122020023349B1 (pt) | 2023-02-07 |
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