JP6433001B2 - 腫瘍細胞へのＲＮＡｉトリガーのインビボ送達のためのポリ結合体 - Google Patents

腫瘍細胞へのＲＮＡｉトリガーのインビボ送達のためのポリ結合体 Download PDF

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JP6433001B2
JP6433001B2 JP2016533388A JP2016533388A JP6433001B2 JP 6433001 B2 JP6433001 B2 JP 6433001B2 JP 2016533388 A JP2016533388 A JP 2016533388A JP 2016533388 A JP2016533388 A JP 2016533388A JP 6433001 B2 JP6433001 B2 JP 6433001B2
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peg
rgd
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JP2016535058A (ja
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ウェイジュン チェン
ウェイジュン チェン
ソー ウォン
ソー ウォン
エアロン エム． アルメイダ
エアロン エム． アルメイダ
デイビッド ビー． ロゼマ
デイビッド ビー． ロゼマ
アンドレイ ブイ． ブロッキン
アンドレイ ブイ． ブロッキン
ジェフリー シー． カールソン
ジェフリー シー． カールソン
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アローヘッド ファーマシューティカルズ インコーポレイテッド
アローヘッド ファーマシューティカルズ インコーポレイテッド
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
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    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
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    • C07K5/06—Dipeptides
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    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
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    • C07K5/08—Tripeptides
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3535—Nitrogen
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    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2016533388A 2013-08-07 2014-08-06 腫瘍細胞へのＲＮＡｉトリガーのインビボ送達のためのポリ結合体 Active JP6433001B2 (ja)

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Application Number Priority Date Filing Date Title
US201361863056P 2013-08-07 2013-08-07
US61/863,056 2013-08-07
PCT/US2014/049851 WO2015021092A1 (en) 2013-08-07 2014-08-06 Polyconjugates for delivery of rnai triggers to tumor cells in vivo
US14/452,626 US9487556B2 (en) 2013-08-07 2014-08-06 Polyconjugates for delivery of RNAi triggers to tumor cells in vivo
US14/452,626 2014-08-06

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JP2016535058A JP2016535058A (ja) 2016-11-10
JP2016535058A5 JP2016535058A5 (https=) 2016-12-22
JP6433001B2 true JP6433001B2 (ja) 2018-12-05

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US (3) US9487556B2 (https=)
EP (1) EP3030244B1 (https=)
JP (1) JP6433001B2 (https=)
KR (1) KR20160035081A (https=)
CN (1) CN105451743B (https=)
AU (1) AU2014306021B2 (https=)
CA (1) CA2919088A1 (https=)
EA (1) EA201690051A1 (https=)
IL (1) IL243941B (https=)
MX (1) MX2016001006A (https=)
SG (1) SG11201600379TA (https=)
TW (1) TWI685347B (https=)
WO (1) WO2015021092A1 (https=)

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SG11201600379TA (en) 2016-02-26
EP3030244B1 (en) 2021-04-21
EP3030244A1 (en) 2016-06-15
KR20160035081A (ko) 2016-03-30
AU2014306021A1 (en) 2016-01-28
US20190062748A1 (en) 2019-02-28
AU2014306021B2 (en) 2018-12-13
WO2015021092A1 (en) 2015-02-12
US20170022497A1 (en) 2017-01-26
US20150045573A1 (en) 2015-02-12
IL243941A0 (en) 2016-04-21
AU2014306021A2 (en) 2016-11-24
US9487556B2 (en) 2016-11-08
HK1220397A1 (zh) 2017-05-05
EP3030244A4 (en) 2017-06-28
TWI685347B (zh) 2020-02-21
CN105451743B (zh) 2019-11-19
TW201601742A (zh) 2016-01-16
IL243941B (en) 2019-06-30
EA201690051A1 (ru) 2016-06-30
CN105451743A (zh) 2016-03-30
JP2016535058A (ja) 2016-11-10
CA2919088A1 (en) 2015-02-12
MX2016001006A (es) 2016-04-19

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