JP6419826B2 - 自閉症スペクトラム障害の治療のためのドーパミンd3受容体拮抗薬としてのクロモン誘導体 - Google Patents

自閉症スペクトラム障害の治療のためのドーパミンd3受容体拮抗薬としてのクロモン誘導体 Download PDF

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JP6419826B2
JP6419826B2 JP2016538587A JP2016538587A JP6419826B2 JP 6419826 B2 JP6419826 B2 JP 6419826B2 JP 2016538587 A JP2016538587 A JP 2016538587A JP 2016538587 A JP2016538587 A JP 2016538587A JP 6419826 B2 JP6419826 B2 JP 6419826B2
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dopamine
treatment
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pharmaceutically acceptable
dioxolo
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JP2016540000A5 (enExample
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アニエス、オークレール
ポール、モーザー
ピエール、ソコロフ
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ピエール、ファーブル、メディカマン
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41681,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
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    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K38/095Oxytocins; Vasopressins; Related peptides
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2016538587A 2013-12-13 2014-12-12 自閉症スペクトラム障害の治療のためのドーパミンd3受容体拮抗薬としてのクロモン誘導体 Expired - Fee Related JP6419826B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13306726.4 2013-12-13
EP13306726 2013-12-13
PCT/EP2014/077635 WO2015086836A1 (en) 2013-12-13 2014-12-12 A chromone derivative as a dopamine d3 receptor antagonist for its use for the treatment of autism spectrum disorder

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JP2016540000A JP2016540000A (ja) 2016-12-22
JP2016540000A5 JP2016540000A5 (enExample) 2018-02-01
JP6419826B2 true JP6419826B2 (ja) 2018-11-07

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JP2016538587A Expired - Fee Related JP6419826B2 (ja) 2013-12-13 2014-12-12 自閉症スペクトラム障害の治療のためのドーパミンd3受容体拮抗薬としてのクロモン誘導体

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US (1) US10028948B2 (enExample)
EP (1) EP3079688B1 (enExample)
JP (1) JP6419826B2 (enExample)
KR (1) KR102280530B1 (enExample)
CN (1) CN105792824B (enExample)
AU (1) AU2014363428B2 (enExample)
BR (1) BR112016012552A8 (enExample)
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DK (1) DK3079688T3 (enExample)
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HR (1) HRP20180323T8 (enExample)
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IL (1) IL245996B (enExample)
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MX (1) MX372922B (enExample)
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NO (1) NO3079688T3 (enExample)
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PT (1) PT3079688T (enExample)
RS (1) RS56931B1 (enExample)
RU (2) RU2019104946A (enExample)
SA (1) SA516371298B1 (enExample)
SI (1) SI3079688T1 (enExample)
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SI2317852T1 (sl) 2008-07-16 2015-04-30 Richter Gedeon Nyrt. Farmacevtske formulacije, ki vsebujejo ligande dopaminskega receptorja
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
HU231500B1 (hu) 2019-04-10 2024-04-28 Richter Gedeon Nyrt Karbamoil-ciklohexán származékok autizmus spektrum betegség kezelésére
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder
WO2021048544A1 (en) * 2019-09-11 2021-03-18 Oxford Biodynamics Limited Diagnostic chromosome marker
KR20220021157A (ko) 2020-08-13 2022-02-22 원광대학교산학협력단 옥시토신 호르몬 증가효과를 갖는 자폐스펙트럼장애 아동 개선용 교육시스템

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FR2682953B1 (fr) 1991-10-23 1995-04-21 Inst Nat Sante Rech Med Nouveaux derives de naphtamides, leur procede de preparation et leur application dans le domaine therapeutique.
DE4229880A1 (de) 1992-09-04 1994-03-31 Knauf Siegfried Medikament bzw. Medikamentenzusammensetzung
PE20001088A1 (es) * 1998-10-08 2000-12-02 Smithkline Beecham Plc Compuestos derivados de tetrahidrobenzazepina
ES2367868T3 (es) * 2004-09-20 2011-11-10 Mount Sinai School Of Medicine Uso de memantina (namenda) para tratar el autismo, la compulsividad y la impulsividad.
EP2263665A1 (en) 2009-06-02 2010-12-22 Pharnext New compositions for treating CMT and related disorders
FR2949465B1 (fr) * 2009-09-01 2011-08-12 Pf Medicament Derives chromones, leur procede de preparation et leurs applications therapeutiques
WO2011150380A1 (en) 2010-05-28 2011-12-01 Xenoport, Inc. Methods of treatment of fragile x syndrome, down's syndrome, autism and related disorders
KR101921772B1 (ko) * 2011-05-13 2018-11-23 가부시키가이샤 한도오따이 에네루기 켄큐쇼 반도체 장치
FR2976179A1 (fr) 2011-06-09 2012-12-14 Pf Medicament Utilisation de la carpipramine dans le traitement de troubles psychiatriques et du developpement chez l'enfant et l'adolescent

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CN105792824A (zh) 2016-07-20
CY1119907T1 (el) 2018-06-27
HRP20180323T1 (hr) 2018-04-06
EP3079688A1 (en) 2016-10-19
AU2014363428A1 (en) 2016-06-23
HK1223563A1 (zh) 2017-08-04
WO2015086836A1 (en) 2015-06-18
TN2016000213A1 (en) 2017-10-06
RU2686110C1 (ru) 2019-04-24
BR112016012552A8 (pt) 2022-11-08
KR102280530B1 (ko) 2021-07-21
KR20160088886A (ko) 2016-07-26
DK3079688T3 (da) 2018-01-29
JP2016540000A (ja) 2016-12-22
SA516371298B1 (ar) 2018-06-07
NZ720868A (en) 2022-04-29
SI3079688T1 (en) 2018-03-30
IL245996B (en) 2018-11-29
IL245996A0 (en) 2016-07-31
CA2932791A1 (en) 2015-06-18
AU2014363428B2 (en) 2019-09-12
HRP20180323T8 (hr) 2019-01-25
MX372922B (es) 2020-04-27
CN105792824B (zh) 2018-08-03
PL3079688T3 (pl) 2018-05-30
RS56931B1 (sr) 2018-05-31
US20160303117A1 (en) 2016-10-20
UA117271C2 (uk) 2018-07-10
MY172937A (en) 2019-12-16
US10028948B2 (en) 2018-07-24
RU2019104946A (ru) 2019-04-01
ES2657706T3 (es) 2018-03-06
NO3079688T3 (enExample) 2018-04-21
MA39076A1 (fr) 2017-05-31
EP3079688B1 (en) 2017-11-22
HUE036035T2 (hu) 2018-06-28
MX2016007612A (es) 2016-09-09
CA2932791C (en) 2021-11-09
LT3079688T (lt) 2018-02-12
PT3079688T (pt) 2018-02-28

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