JP6403685B2 - 胆汁酸ホメオスタシス調整並びに胆汁酸障害及び疾患の治療の方法 - Google Patents
胆汁酸ホメオスタシス調整並びに胆汁酸障害及び疾患の治療の方法 Download PDFInfo
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- JP6403685B2 JP6403685B2 JP2015550762A JP2015550762A JP6403685B2 JP 6403685 B2 JP6403685 B2 JP 6403685B2 JP 2015550762 A JP2015550762 A JP 2015550762A JP 2015550762 A JP2015550762 A JP 2015550762A JP 6403685 B2 JP6403685 B2 JP 6403685B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/08—Hepato-biliairy disorders other than hepatitis
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- Organic Chemistry (AREA)
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- Medicinal Chemistry (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
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- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Diabetes (AREA)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261746499P | 2012-12-27 | 2012-12-27 | |
| US61/746,499 | 2012-12-27 | ||
| US201361779604P | 2013-03-13 | 2013-03-13 | |
| US61/779,604 | 2013-03-13 | ||
| US201361887129P | 2013-10-04 | 2013-10-04 | |
| US61/887,129 | 2013-10-04 | ||
| PCT/US2013/077782 WO2014105939A1 (en) | 2012-12-27 | 2013-12-26 | Methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513073A JP2016513073A (ja) | 2016-05-12 |
| JP2016513073A5 JP2016513073A5 (cg-RX-API-DMAC7.html) | 2017-02-02 |
| JP6403685B2 true JP6403685B2 (ja) | 2018-10-17 |
Family
ID=51022055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015550762A Active JP6403685B2 (ja) | 2012-12-27 | 2013-12-26 | 胆汁酸ホメオスタシス調整並びに胆汁酸障害及び疾患の治療の方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (6) | US9925242B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2938740B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6403685B2 (cg-RX-API-DMAC7.html) |
| KR (3) | KR20150104579A (cg-RX-API-DMAC7.html) |
| CN (2) | CN108888757A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2013370404B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2895517C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2938740T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2915851T3 (cg-RX-API-DMAC7.html) |
| IL (2) | IL292303A (cg-RX-API-DMAC7.html) |
| MX (2) | MX383664B (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ630469A (cg-RX-API-DMAC7.html) |
| PL (1) | PL2938740T3 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2675514C2 (cg-RX-API-DMAC7.html) |
| SG (2) | SG10202100667SA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014105939A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201504484B (cg-RX-API-DMAC7.html) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190083A1 (ar) | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
| LT2726511T (lt) | 2011-07-01 | 2019-11-11 | Ngm Biopharmaceuticals Inc | Kompozicijos, panaudojimai ir būdai, skirti metabolinių sutrikimų ir ligų gydymui |
| US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
| AU2013352363B2 (en) | 2012-11-28 | 2018-04-12 | Ngm Biopharmaceuticals, Inc. | Compositions and methods for treatment of metabolic disorders and diseases |
| AU2013370404B2 (en) | 2012-12-27 | 2017-11-02 | Ngm Biopharmaceuticals, Inc. | Methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| MX377380B (es) | 2013-10-28 | 2025-03-10 | Ngm Biopharmaceuticals Inc | Modelos de cáncer y métodos asociados. |
| SI3097122T1 (sl) | 2014-01-24 | 2020-07-31 | Ngm Biopharmaceuticals, Inc. | Protitelesa, ki se vežejo v domeni beta klotho 2, in metode za njihovo uporabo |
| US20170065678A1 (en) | 2014-03-11 | 2017-03-09 | Novartis Ag | Methods of treating metabolic disorders associated with lipodystrophies and defects in insulin production or signaling |
| WO2015183890A2 (en) | 2014-05-28 | 2015-12-03 | Ngm Biopharmaceuticals, Inc. | Methods and compositions for the treatment of metabolic disorders and diseases |
| EP3155005A4 (en) * | 2014-06-16 | 2018-07-11 | NGM Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| UA123763C2 (uk) * | 2014-10-23 | 2021-06-02 | Енджіем Байофармасьютикалз, Інк. | Фармацевтична композиція для контролю або лікування захворювання або порушення, пов’язаного з fgf19 |
| US10434144B2 (en) | 2014-11-07 | 2019-10-08 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
| AU2015371056B2 (en) * | 2014-12-23 | 2020-06-25 | Novo Nordisk A/S | FGF21 derivatives and uses thereof |
| WO2017019957A2 (en) | 2015-07-29 | 2017-02-02 | Ngm Biopharmaceuticals, Inc. | Binding proteins and methods of use thereof |
| JP2018529729A (ja) * | 2015-10-01 | 2018-10-11 | アムジエン・インコーポレーテツド | 胆汁酸障害の処置 |
| CA3003616C (en) * | 2015-11-09 | 2020-07-28 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders |
| CN105424941B (zh) * | 2015-11-09 | 2018-04-10 | 湖南莱拓福生物科技有限公司 | Akr1b10蛋白和用于肝硬化诊断的试剂盒 |
| ES2979305T3 (es) * | 2016-05-30 | 2024-09-25 | Shanghai Hep Pharmaceutical Co Ltd | Composiciones y métodos para tratar enfermedades metabólicas |
| CA3034399A1 (en) | 2016-08-26 | 2018-03-01 | Ngm Biopharmaceuticals, Inc. | Methods of treating fibroblast growth factor 19-mediated cancers and tumors |
| AU2017321286A1 (en) * | 2016-08-29 | 2019-03-07 | NGM Biopharmaceuticals, Inc | Methods for treatment of bile acid-related disorders |
| CN117257800A (zh) | 2016-11-02 | 2023-12-22 | 诺华股份有限公司 | Fgfr4抑制剂和胆汁酸螯合剂的组合 |
| US20200330555A1 (en) * | 2017-04-21 | 2020-10-22 | Ngm Biopharmaceuticals, Inc. | Methods of treating gastrointestinal motility-related disorders using variants and fusions of fgf19/fgf21 polypeptides |
| JOP20190276A1 (ar) * | 2017-05-31 | 2019-11-27 | Napo Pharmaceuticals Inc | طرق وتركيبات لعلاج إسهال الحمض الصفراوي، والإسهال المرتبط باستئصال الأمعاء الدقيقة أو إزالة المرارة، ومتلازمة الأمعاء القصيرة |
| PL3727423T3 (pl) | 2017-12-22 | 2024-10-07 | Novartis Ag | Leczenie zaburzeń metabolicznych z użyciem wariantów fgf21 |
| US11524029B2 (en) | 2018-08-13 | 2022-12-13 | Viscera Labs, Inc. | Therapeutic composition and methods |
| US11590161B2 (en) | 2018-08-13 | 2023-02-28 | Viscera Labs, Inc. | Therapeutic composition and methods |
| AU2020260110A1 (en) * | 2019-04-17 | 2021-11-11 | Ngm Biopharmaceuticals, Inc. | Combination therapy for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| WO2020231909A1 (en) * | 2019-05-11 | 2020-11-19 | Steven Hoffman | Compositions and methods for treating bile acid associated diseases |
| CN111420030B (zh) * | 2020-05-12 | 2021-01-29 | 江南大学 | Fgf21在制备用于治疗结直肠癌药物中的应用 |
| CN113735960B (zh) | 2021-03-12 | 2023-04-28 | 江南大学 | 一种fgf重组蛋白治疗nash的应用 |
| CN120623308B (zh) * | 2025-08-15 | 2025-10-28 | 温州医科大学 | Fgf19突变蛋白及其应用 |
Family Cites Families (199)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0272253A4 (en) | 1986-03-07 | 1990-02-05 | Massachusetts Inst Technology | METHOD FOR IMPROVING GLYCOPROTE INSTABILITY. |
| US5273876A (en) | 1987-06-26 | 1993-12-28 | Syntro Corporation | Recombinant human cytomegalovirus containing foreign gene |
| CA2045129A1 (en) | 1989-02-01 | 1990-08-02 | Alfred I. Geller | Herpes simplex virus type i expression vector |
| US5614396A (en) | 1990-06-14 | 1997-03-25 | Baylor College Of Medicine | Methods for the genetic modification of endogenous genes in animal cells by homologous recombination |
| AU664976B2 (en) | 1990-08-29 | 1995-12-14 | Gene Pharming Europe Bv | Homologous recombination in mammalian cells |
| GB9105383D0 (en) | 1991-03-14 | 1991-05-01 | Immunology Ltd | An immunotherapeutic for cervical cancer |
| AU3972893A (en) | 1992-04-03 | 1993-11-08 | Baylor College Of Medicine | Gene therapy using the intestine |
| WO1994012629A1 (en) | 1992-12-02 | 1994-06-09 | Baylor College Of Medicine | Episomal vectors for gene therapy |
| WO1994029442A2 (en) | 1993-06-14 | 1994-12-22 | Basf Aktiengesellschaft | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters |
| AU7353494A (en) | 1993-11-12 | 1995-05-29 | Case Western Reserve University | Episomal expression vector for human gene therapy |
| US5731172A (en) | 1994-03-09 | 1998-03-24 | Sumitomo Pharmaceuticals Company, Ltd. | Recombinant adenovirus and process for producing the same |
| US5604090A (en) | 1994-06-06 | 1997-02-18 | Fred Hutchinson Cancer Research Center | Method for increasing transduction of cells by adeno-associated virus vectors |
| US5693508A (en) | 1994-11-08 | 1997-12-02 | Chang; Lung-Ji | Retroviral expression vectors containing MoMLV/CMV-IE/HIV-TAR chimeric long terminal repeats |
| JP3770333B2 (ja) | 1995-03-15 | 2006-04-26 | 大日本住友製薬株式会社 | 組換えdnaウイルスおよびその製造方法 |
| US6110456A (en) | 1995-06-07 | 2000-08-29 | Yale University | Oral delivery or adeno-associated viral vectors |
| US5695977A (en) | 1995-08-31 | 1997-12-09 | Genetic Information Research Institute | Site directed recombination |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| CA2264735C (en) | 1996-08-27 | 2008-01-29 | Chiron Corporation | Neisseria meningitidis serogroup b glycoconjugates and methods of using the same |
| US20020012961A1 (en) | 1999-04-15 | 2002-01-31 | Genentech, Inc. | Fibroblast growth factor- 19 |
| US20020042367A1 (en) | 1997-11-25 | 2002-04-11 | Genentech, Inc. | Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity and related disorders |
| US20060246540A1 (en) | 1997-08-26 | 2006-11-02 | Ashkenazi Avi J | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US6806352B2 (en) | 1997-09-17 | 2004-10-19 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US20030113718A1 (en) | 1997-09-17 | 2003-06-19 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| KR100502596B1 (ko) | 1997-09-17 | 2005-07-22 | 제넨테크, 인크. | 분비 폴리펩티드와 막횡단 폴리펩티드 및 이들을 코딩하는핵산 |
| US20030092002A1 (en) | 1997-09-17 | 2003-05-15 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US20020155543A1 (en) | 1997-11-25 | 2002-10-24 | Genentech, Inc. | Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity and related disorders |
| US20040126852A1 (en) | 1997-11-25 | 2004-07-01 | Genentech, Inc. | Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity |
| US20050026832A1 (en) | 1997-11-25 | 2005-02-03 | Genentech, Inc. | Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity and related disorders |
| US20030185846A1 (en) | 1998-09-16 | 2003-10-02 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| WO2000060085A1 (en) | 1999-04-02 | 2000-10-12 | Millennium Pharmaceuticals, Inc. | Fibroblast growth factor-20 |
| US7390879B2 (en) | 1999-06-15 | 2008-06-24 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US7129072B1 (en) | 1999-08-30 | 2006-10-31 | New York University | Crystal of fibroblast growth factor receptor 1 in complex with fibroblast growth factor |
| US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
| WO2001018209A1 (en) | 1999-09-10 | 2001-03-15 | Curagen Corporation | Fibroblast growth factor polypeptide and nucleic acids encoding same |
| US6797695B1 (en) | 1999-10-22 | 2004-09-28 | Kyoto University | Human FGF-20 gene and gene expression products |
| JP2003516731A (ja) | 1999-11-18 | 2003-05-20 | カイロン コーポレイション | ヒトfgf−21遺伝子および遺伝子発現産物 |
| US6716626B1 (en) | 1999-11-18 | 2004-04-06 | Chiron Corporation | Human FGF-21 nucleic acids |
| DE10160151A1 (de) | 2001-01-09 | 2003-06-26 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens |
| US20010044525A1 (en) | 2000-01-05 | 2001-11-22 | Conklin Darrell C. | Novel FGF Homolog zFGF12 |
| WO2001049849A1 (en) | 2000-01-05 | 2001-07-12 | Zymogenetics, Inc. | Novel fgf homolog zfgf11 |
| JP2003518944A (ja) | 2000-01-05 | 2003-06-17 | ザイモジェネティクス,インコーポレイティド | 新規fgf相同体zfgf12 |
| US20020081663A1 (en) | 2000-01-05 | 2002-06-27 | Conklin Darrell C. | Novel FGF homolog ZFGF11 |
| CA2398603A1 (en) | 2000-02-15 | 2001-08-23 | Amgen, Inc. | Fibroblast growth factor-23 molecules and uses thereof |
| US20060160181A1 (en) | 2000-02-15 | 2006-07-20 | Amgen Inc. | Fibroblast Growth Factor-23 molecules and uses thereof |
| AU2001245535A1 (en) | 2000-03-08 | 2001-09-17 | Chiron Corporation | Human fgf-23 gene and gene expression products |
| AU2001249125A1 (en) | 2000-03-08 | 2001-09-17 | Chiron Corporation | Human fgf-23 gene and gene expression products |
| WO2001072957A2 (en) | 2000-03-31 | 2001-10-04 | Nobuyuki Itoh | Fibroblast growth factor-like molecules and uses thereof |
| US20030065140A1 (en) | 2000-04-03 | 2003-04-03 | Vernet Corine A.M. | Novel proteins and nucleic acids encoding same |
| JP2002112772A (ja) | 2000-07-10 | 2002-04-16 | Takeda Chem Ind Ltd | 新規ポリペプチドおよびそのdna |
| ATE461213T1 (de) | 2000-07-19 | 2010-04-15 | Advanced Res & Tech Inst | Neuer fibroblastwachstumsfaktor (fgf23) und methoden zur verwendung |
| CA2416538A1 (en) | 2000-07-20 | 2002-01-31 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| US6812339B1 (en) | 2000-09-08 | 2004-11-02 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
| US20070037165A1 (en) | 2000-09-08 | 2007-02-15 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
| US7115415B2 (en) | 2000-09-15 | 2006-10-03 | Genentech, Inc. | PRO9821 nucleic acids |
| IL139380A0 (en) | 2000-10-31 | 2001-11-25 | Prochon Biotech Ltd | Active variants of fibroblast growth factor |
| AU2002230531A1 (en) | 2000-11-22 | 2002-06-03 | Bayer Corporation | Use of fgf-19 for inhibiting angiogenesis |
| US20020151496A1 (en) | 2000-12-08 | 2002-10-17 | Bringmann Peter W. | Novel fibroblast growth factors |
| DE10100588A1 (de) | 2001-01-09 | 2002-07-18 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Zielgens |
| DE10100587C1 (de) | 2001-01-09 | 2002-11-21 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Zielgens |
| US7135334B2 (en) | 2001-06-20 | 2006-11-14 | Genentech, Inc. | PRO20044 nucleic acids |
| WO2003080803A2 (en) | 2002-03-21 | 2003-10-02 | Smithkline Beecham Corporation | Methods of using farnesoid x receptor (fxr) agonists |
| US6987121B2 (en) | 2002-04-25 | 2006-01-17 | Smithkline Beecham Corporation | Compositions and methods for hepatoprotection and treatment of cholestasis |
| KR20050004914A (ko) | 2002-06-07 | 2005-01-12 | 제넨테크, 인크. | 종양의 진단 및 치료 방법 및 이를 위한 조성물 |
| EP2135879A3 (en) | 2002-06-28 | 2010-06-23 | Domantis Limited | Ligand |
| US20050250684A1 (en) | 2002-09-18 | 2005-11-10 | Eli Lilly And Company Patent Division | Method for reducing morbidity and mortality in critically ill patients |
| WO2004063355A2 (en) | 2003-01-10 | 2004-07-29 | Protein Design Labs, Inc. | Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of matastatic cancer |
| AU2004247042A1 (en) | 2003-06-12 | 2004-12-23 | Eli Lilly And Company | Fusion proteins |
| CN103880955A (zh) | 2003-07-18 | 2014-06-25 | 安姆根有限公司 | 肝细胞生长因子的特异性结合物 |
| EP2270163A1 (en) | 2003-12-10 | 2011-01-05 | Eli Lilly and Company | Muteins of fibroblast growth factor 21 |
| BRPI0508607A (pt) | 2004-03-11 | 2007-07-31 | Fresenius Kabi De Gmbh | conjugados de amido de hidroxialquila e uma proteìna, preparados pela aminação redutiva |
| PT1751184E (pt) | 2004-05-13 | 2009-11-10 | Lilly Co Eli | Proteínas de fusão de fgf-21 |
| TW200607523A (en) | 2004-06-01 | 2006-03-01 | Domantis Ltd | Drug compositions, fusions and conjugates |
| JP2006016323A (ja) | 2004-06-30 | 2006-01-19 | Hiroshima Industrial Promotion Organization | 生理活性バイオマテリアル |
| US7582607B2 (en) | 2004-09-02 | 2009-09-01 | Eli Lilly And Company | Muteins of fibroblast growth factor 21 |
| WO2006028714A1 (en) | 2004-09-02 | 2006-03-16 | Eli Lilly And Company | Muteins of fibroblast growth factor 21 |
| CN101724071A (zh) | 2004-10-08 | 2010-06-09 | 杜门蒂斯有限公司 | 抗肿瘤坏死因子受体1的单域抗体及其使用方法 |
| EP1817335A2 (en) | 2004-10-29 | 2007-08-15 | Genentech, Inc. | Disruptions of genes encoding secreted proteins, compositions and methods relating thereto |
| CA2586201A1 (en) | 2004-11-03 | 2006-05-11 | Almac Diagnostics Limited | Transcriptome microarray technology and methods of using the same |
| JP2008522617A (ja) | 2004-12-14 | 2008-07-03 | イーライ リリー アンド カンパニー | 線維芽細胞成長因子21の突然変異タンパク質 |
| US20060275794A1 (en) | 2005-03-07 | 2006-12-07 | Invitrogen Corporation | Collections of matched biological reagents and methods for identifying matched reagents |
| UY29460A1 (es) | 2005-04-08 | 2006-11-30 | Noxxon Pharma Ag | Acidos nucleicos de union a ghrelin |
| US7678890B2 (en) | 2005-07-22 | 2010-03-16 | Five Prime Therapeutics, Inc. | Compositions and methods of treating disease with FGFR fusion proteins |
| EP1929043A4 (en) | 2005-08-24 | 2009-10-28 | Genizon Biosciences Inc | GENETIC CARD OF HUMAN GENES ASSOCIATED WITH CROHN'S DISEASE |
| CA2637216A1 (en) | 2006-02-10 | 2007-08-16 | Dermagen Ab | Novel antimicrobial peptides and use thereof |
| US20100055730A1 (en) | 2006-05-05 | 2010-03-04 | Anny Usheva-Simidjiyska | Methods for the Diagnosis and Treatment of Female Infertility Using Molecular Markers |
| WO2008021196A2 (en) | 2006-08-09 | 2008-02-21 | The Mclean Hospital Corporation | Methods and compositions for the treatment of medical disorders |
| CN101563597A (zh) | 2006-09-01 | 2009-10-21 | 美国菌种保藏中心 | 用于诊断和治疗2型糖尿病的组合物和方法 |
| US8394927B2 (en) | 2006-11-03 | 2013-03-12 | U3 Pharma Gmbh | FGFR4 antibodies |
| WO2008085879A2 (en) | 2007-01-03 | 2008-07-17 | California Stem Cell, Inc. | Stem cell growth media and methods of making and using same |
| SI2068909T1 (sl) * | 2007-03-30 | 2012-09-28 | Ambrx Inc | Modificirani fgf-21 polipeptidi in njihova uporaba |
| ES2385114T3 (es) | 2007-03-30 | 2012-07-18 | Ambrx, Inc. | Polipéptidos de FGF-21 modificados y sus usos |
| SI2550972T1 (en) | 2007-04-02 | 2018-05-31 | Genentech, Inc. | An antibody called Klotho-beta agonist for use in the treatment of diabetes mellitus or insulin resistance |
| EP2036539A1 (en) | 2007-09-11 | 2009-03-18 | Novo Nordisk A/S | Stable formulations of amylin and its analogues |
| WO2009076478A2 (en) | 2007-12-10 | 2009-06-18 | The Johns Hopkins University | Hypomethylated genes in cancer |
| EP2080812A1 (en) | 2008-01-18 | 2009-07-22 | Transmedi SA | Compositions and methods of detecting post-stop peptides |
| US8420088B2 (en) * | 2008-01-28 | 2013-04-16 | Novartis Ag | Methods and compositions using FGF23 fusion polypeptides |
| TW200936156A (en) * | 2008-01-28 | 2009-09-01 | Novartis Ag | Methods and compositions using Klotho-FGF fusion polypeptides |
| US20090226459A1 (en) | 2008-01-29 | 2009-09-10 | Cold Spring Harbor Laboratory | Role of fgf-19 in cancer diagnosis and treatment |
| NZ579566A (en) | 2008-03-19 | 2013-01-25 | Ambrx Inc | Modified fgf-21 polypeptides and their uses |
| US20110015345A1 (en) | 2008-03-19 | 2011-01-20 | Ambrx, Inc. | Modified FGF-23 Polypeptides and Their Uses |
| CA2719001A1 (en) | 2008-03-21 | 2009-09-24 | Podiceps B.V. | Diagnostic of pre-symptomatic metabolic syndrome |
| CN101591653B (zh) | 2008-05-27 | 2013-07-31 | 中国人民解放军军事医学科学院野战输血研究所 | 低表达cyp7a1的肝细胞及其构建方法 |
| JOP20190083A1 (ar) | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
| US8363365B2 (en) | 2008-06-17 | 2013-01-29 | Semiconductor Energy Laboratory Co., Ltd. | Semiconductor device |
| WO2009155381A1 (en) | 2008-06-18 | 2009-12-23 | Abbott Laboratories | P/gf-1 companion diagnostic methods and products |
| FR2933702A1 (fr) | 2008-07-08 | 2010-01-15 | Sanofi Aventis | Antagonistes specifiques du recepteur fgf-r4 |
| WO2010006214A1 (en) | 2008-07-09 | 2010-01-14 | Ambrx, Inc. | Fgf-21 neutralizing antibodies and their uses |
| AU2009279806B2 (en) | 2008-08-04 | 2015-04-30 | Five Prime Therapeutics, Inc. | FGFR extracellular domain acidic region muteins |
| MX341149B (es) | 2008-10-10 | 2016-08-09 | Amgen Inc | Mutantes fgf21 y uso de los mismos. |
| WO2010065439A1 (en) | 2008-12-05 | 2010-06-10 | Eli Lilly And Company | Variants of fibroblast growth factor 21 |
| WO2010080730A2 (en) | 2009-01-09 | 2010-07-15 | Mayo Foundation For Medical Education And Research | Methods and materials for delivering bile acids |
| US20120035105A1 (en) | 2009-01-09 | 2012-02-09 | Sdg, Inc. | Insulin Therapies for the Treatment of Diabetes, Diabetes Related Ailments, and/or Diseases or Conditions Other Than Diabetes or Diabetes Related Ailments |
| WO2010083051A2 (en) | 2009-01-15 | 2010-07-22 | ProChon Biotech, Ltd. | Cartilage particle tissue mixtures optionally combined with a cancellous construct |
| DK3178835T3 (da) | 2009-02-03 | 2019-06-24 | Amunix Pharmaceuticals Inc | Forlængede rekombinante polypeptider og sammensætninger omfattende samme |
| HUE065036T2 (hu) | 2009-05-05 | 2024-04-28 | Amgen Inc | FGF21 mutánsok és alkalmazásaik |
| WO2010129600A2 (en) | 2009-05-05 | 2010-11-11 | Amgen Inc. | Fgf21 mutants and uses thereof |
| US8461111B2 (en) | 2009-05-20 | 2013-06-11 | Florida State University Research Foundation | Fibroblast growth factor mutants having improved functional half-life and methods of their use |
| US10241093B2 (en) | 2009-05-28 | 2019-03-26 | The Cleveland Clinic Foundation | Trimethylamine-containing compounds for diagnosis and prediction of disease |
| WO2010139741A1 (en) | 2009-06-04 | 2010-12-09 | Novartis Ag | Fgf-21 for treating cancers |
| WO2011154349A2 (en) | 2010-06-08 | 2011-12-15 | Novo Nordisk A/S | Fgf21 analogues and derivatives |
| EP2440235A1 (en) | 2009-06-11 | 2012-04-18 | Novo Nordisk A/S | Glp-1 and fgf21 combinations for treatment of diabetes type 2 |
| MX2011013903A (es) * | 2009-06-17 | 2012-05-08 | Amgen Inc | Polipeptidos quimericos y usos de los mismos. |
| CN101993485B (zh) | 2009-08-20 | 2013-04-17 | 重庆富进生物医药有限公司 | 促胰岛素分泌肽类似物同源二聚体及其用途 |
| CN101993496B (zh) * | 2009-08-20 | 2013-06-05 | 重庆富进生物医药有限公司 | 双重调节血糖血脂融合蛋白及其制法和用途 |
| WO2011047267A1 (en) | 2009-10-15 | 2011-04-21 | Genentech, Inc. | Chimeric fibroblast growth factors with altered receptor specificity |
| US8889621B2 (en) | 2009-10-30 | 2014-11-18 | New York University | Inhibiting binding of FGF23 to the binary FGFR-Klotho complex for the treatment of hypophosphatemia |
| UA109888C2 (uk) | 2009-12-07 | 2015-10-26 | ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ | |
| WO2011084808A2 (en) | 2009-12-21 | 2011-07-14 | Amunix Operating Inc. | Bifunctional polypeptide compositions and methods for treatment of metabolic and cardiovascular diseases |
| EP2460527A1 (en) | 2010-01-21 | 2012-06-06 | Sanofi | Pharmaceutical composition for treating a metabolic syndrome |
| US20110195077A1 (en) | 2010-01-29 | 2011-08-11 | Novartis Ag | Methods and compositions using fgf23 fusion ppolypeptides |
| EP3670534A3 (en) | 2010-04-15 | 2020-09-09 | Amgen Inc. | Human fgf receptor and beta-klotho binding proteins |
| JP5767314B2 (ja) | 2010-04-16 | 2015-08-19 | ソーク インスティチュート フォー バイオロジカル スタディーズ | Fgfを用いて代謝障害を処置するための方法 |
| JP6069198B2 (ja) | 2010-07-20 | 2017-02-01 | ノヴォ ノルディスク アー/エス | N末端が修飾されたfgf21化合物 |
| EP2613773A2 (en) | 2010-09-09 | 2013-07-17 | Trifoilium ApS | Airway administration of angiogenesis inhibitors |
| CA2885176C (en) | 2010-09-22 | 2018-10-23 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
| CN102464712A (zh) | 2010-11-11 | 2012-05-23 | 重庆富进生物医药有限公司 | 缺失型人成纤维细胞生长因子21变异体及其偶联物 |
| US9023791B2 (en) | 2010-11-19 | 2015-05-05 | Novartis Ag | Fibroblast growth factor 21 mutations |
| JP5613547B2 (ja) | 2010-12-14 | 2014-10-22 | 株式会社スクウェア・エニックス | タスクベースの並列プログラミング言語 |
| JP2014501762A (ja) | 2010-12-22 | 2014-01-23 | マルケイディア バイオテック, インコーポレイテッド | Gipおよびglp−1受容体活性グルカゴン系ペプチドにより代謝障害および肥満を治療するための方法 |
| JP5850435B2 (ja) | 2010-12-24 | 2016-02-03 | 国立研究開発法人産業技術総合研究所 | ヒトfgf19活性の正確で高感度な測定方法ならびにヒトfgf19活性の制御剤 |
| CN103533951B (zh) | 2011-04-08 | 2017-04-19 | 安姆根有限公司 | 使用生长分化因子15(gdf‑15)治疗或改善代谢障碍的方法 |
| WO2012140650A2 (en) | 2011-04-12 | 2012-10-18 | Hepacore Ltd. | Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof |
| EP2707718A1 (en) | 2011-05-10 | 2014-03-19 | Amgen Inc. | Method of identifying compounds that specifically modulate the interaction of fgfr1 and beta-klotho |
| MY175338A (en) | 2011-05-16 | 2020-06-19 | Genentech Inc | Fgfr1 agonists and methods of use |
| US9574002B2 (en) | 2011-06-06 | 2017-02-21 | Amgen Inc. | Human antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor |
| KR20140039278A (ko) | 2011-06-08 | 2014-04-01 | 드노보 바이오파마 (항주) 리미티드 코포레이션 | 레티노이드 x 수용체 모듈레이터 활성 예측 방법 및 조성물 |
| US20140294820A1 (en) | 2011-06-24 | 2014-10-02 | University Of Miami | Fibroblast growth factor receptor inhibition for the treatment of disease |
| LT2726511T (lt) | 2011-07-01 | 2019-11-11 | Ngm Biopharmaceuticals Inc | Kompozicijos, panaudojimai ir būdai, skirti metabolinių sutrikimų ir ligų gydymui |
| EP2548570A1 (en) | 2011-07-19 | 2013-01-23 | Sanofi | Pharmaceutical composition for treating a metabolic syndrome |
| WO2013027191A1 (en) | 2011-08-25 | 2013-02-28 | Novartis Ag | Methods and compositions using fgf23 fusion polypeptides |
| JP2014526441A (ja) | 2011-08-31 | 2014-10-06 | アムジエン・インコーポレーテツド | 1型糖尿病の治療における使用のためのfgf21 |
| TWI593708B (zh) | 2011-09-26 | 2017-08-01 | 諾華公司 | 治療代謝病症之融合蛋白質 |
| US9458214B2 (en) | 2011-09-26 | 2016-10-04 | Novartis Ag | Dual function fibroblast growth factor 21 proteins |
| AR087973A1 (es) | 2011-10-04 | 2014-04-30 | Lilly Co Eli | Variantes del factor 21 del crecimiento de fibroblastos |
| CN103127503B (zh) | 2011-11-23 | 2017-11-10 | 上海医学生命科学研究中心有限公司 | 拮抗和/或阻断IL‑6/IL‑6R/gp130信号通路在抗肝癌治疗中的用途 |
| RU2014133547A (ru) | 2012-01-18 | 2016-03-10 | Дженентек, Инк. | Способы применения модуляторов fgf19 |
| US9475856B2 (en) | 2012-03-02 | 2016-10-25 | New York University | Chimeric FGF21 proteins with enhanced binding affinity for β-klotho for the treatment of type II diabetes, obesity, and related metabolic disorders |
| JP2013194049A (ja) | 2012-03-23 | 2013-09-30 | Kazuo Todokoro | ヒト造血幹細胞を増幅させるための組成物及び方法 |
| EP2834260A4 (en) | 2012-04-02 | 2016-08-10 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES FOR THE PREPARATION OF MEMBRANE PROTEINS |
| US9771567B2 (en) | 2012-04-16 | 2017-09-26 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Klotho variant polypeptides |
| SG11201407655TA (en) | 2012-05-15 | 2014-12-30 | Lilly Co Eli | Therapeutic uses of fibroblast growth factor 21 proteins |
| US9657075B2 (en) | 2012-06-07 | 2017-05-23 | New York University | Chimeric fibroblast growth factor 23 proteins and methods of use |
| US9474785B2 (en) | 2012-06-07 | 2016-10-25 | New York University | Chimeric fibroblast growth factor 19 proteins and methods of use |
| US9464126B2 (en) | 2012-06-07 | 2016-10-11 | New York University | Chimeric fibroblast growth factor 21 proteins and methods of use |
| MX2014015258A (es) | 2012-06-11 | 2015-03-05 | Lilly Co Eli | Variantes del factor 21 de crecimiento de fibroblasto. |
| TWI513705B (zh) | 2012-06-11 | 2015-12-21 | Lilly Co Eli | 纖維母細胞生長因子21蛋白質 |
| CN109627239B (zh) | 2012-07-11 | 2021-10-12 | 缆图药品公司 | 成纤维细胞生长因子受体的抑制剂 |
| TW201420606A (zh) | 2012-08-22 | 2014-06-01 | Lilly Co Eli | 同源二聚體蛋白 |
| EP2892919A1 (en) | 2012-09-07 | 2015-07-15 | Sanofi | Fusion proteins for treating a metabolic syndrome |
| AU2013352363B2 (en) | 2012-11-28 | 2018-04-12 | Ngm Biopharmaceuticals, Inc. | Compositions and methods for treatment of metabolic disorders and diseases |
| US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
| US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| AU2013370404B2 (en) | 2012-12-27 | 2017-11-02 | Ngm Biopharmaceuticals, Inc. | Methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| US9550820B2 (en) | 2013-02-22 | 2017-01-24 | New York University | Chimeric fibroblast growth factor 23/fibroblast growth factor 19 proteins and methods of use |
| US9789160B2 (en) | 2013-03-14 | 2017-10-17 | Georgetown University | Treatments for lowering glucose levels using FGF binding protein 3 |
| WO2014152090A1 (en) | 2013-03-14 | 2014-09-25 | Georgetown University | Compositions and treatments of metabolic disorders using fgf binding protein 3 and fgf 19 |
| WO2014152089A1 (en) | 2013-03-14 | 2014-09-25 | Georgetown University | Compositions and treatments of metabolic disorders using fgf binding protein 3 |
| WO2014149699A1 (en) | 2013-03-15 | 2014-09-25 | Eli Lilly And Company | Bifunctional protein |
| US9835631B2 (en) | 2013-04-15 | 2017-12-05 | Nordic Bioscience A/S | Combined biomarker measurement of fibrosis |
| SG11201603134XA (en) | 2013-10-21 | 2016-05-30 | Salk Inst For Biological Studi | Mutated fibroblast growth factor (fgf) 1 and methods of use |
| MX377380B (es) | 2013-10-28 | 2025-03-10 | Ngm Biopharmaceuticals Inc | Modelos de cáncer y métodos asociados. |
| SI3097122T1 (sl) | 2014-01-24 | 2020-07-31 | Ngm Biopharmaceuticals, Inc. | Protitelesa, ki se vežejo v domeni beta klotho 2, in metode za njihovo uporabo |
| US20170173114A1 (en) | 2014-05-07 | 2017-06-22 | Joslin Diabetes Center, Inc. | Methods and compositions for induction of ucp1 expression |
| WO2015183890A2 (en) | 2014-05-28 | 2015-12-03 | Ngm Biopharmaceuticals, Inc. | Methods and compositions for the treatment of metabolic disorders and diseases |
| EP3155005A4 (en) | 2014-06-16 | 2018-07-11 | NGM Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| WO2016048995A2 (en) | 2014-09-23 | 2016-03-31 | Salk Institute For Biological Studies | Fgf19 truncations and mutants and uses thereof |
| UA123763C2 (uk) | 2014-10-23 | 2021-06-02 | Енджіем Байофармасьютикалз, Інк. | Фармацевтична композиція для контролю або лікування захворювання або порушення, пов’язаного з fgf19 |
| US10434144B2 (en) | 2014-11-07 | 2019-10-08 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
| EP3108893A1 (en) | 2015-06-25 | 2016-12-28 | Universite Claude Bernard - Lyon 1 | Novel therapeutic use of fgf19 |
| CA2997290A1 (en) | 2015-09-24 | 2017-03-30 | Genentech, Inc. | Methods for the treatment of epilepsy |
| CA3003616C (en) | 2015-11-09 | 2020-07-28 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders |
| CA3034399A1 (en) | 2016-08-26 | 2018-03-01 | Ngm Biopharmaceuticals, Inc. | Methods of treating fibroblast growth factor 19-mediated cancers and tumors |
| AU2017321286A1 (en) | 2016-08-29 | 2019-03-07 | NGM Biopharmaceuticals, Inc | Methods for treatment of bile acid-related disorders |
| KR102340750B1 (ko) | 2017-03-03 | 2021-12-21 | 에이치엘비테라퓨틱스 주식회사 | 티모신 베타 4를 유효성분으로 포함하는 안정화된 외용 제제 |
| CN108619490A (zh) | 2017-03-22 | 2018-10-09 | 天士力医药集团股份有限公司 | 一种长效化突变的人源成纤维生长因子的新用途 |
| US20200330555A1 (en) | 2017-04-21 | 2020-10-22 | Ngm Biopharmaceuticals, Inc. | Methods of treating gastrointestinal motility-related disorders using variants and fusions of fgf19/fgf21 polypeptides |
| CA3069143A1 (en) | 2017-07-06 | 2019-01-10 | Yale University | Compositions and methods for treating or preventing endocrine fgf-linked diseases |
| WO2020176703A1 (en) | 2019-02-28 | 2020-09-03 | Ngm Biopharmaceuticals, Inc. | Non-invasive biomarkers for use in the treatment of non-alcoholic steatohepatitis and other bile acid-related disorders |
| AU2020260110A1 (en) | 2019-04-17 | 2021-11-11 | Ngm Biopharmaceuticals, Inc. | Combination therapy for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
-
2013
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- 2013-12-26 WO PCT/US2013/077782 patent/WO2014105939A1/en not_active Ceased
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