JP6397912B2 - Ｒｓｖ抗ウイルス化合物としての置換ピリジンピペラジニルアナログ - Google Patents
Ｒｓｖ抗ウイルス化合物としての置換ピリジンピペラジニルアナログ Download PDFInfo
- Publication number
- JP6397912B2 JP6397912B2 JP2016530495A JP2016530495A JP6397912B2 JP 6397912 B2 JP6397912 B2 JP 6397912B2 JP 2016530495 A JP2016530495 A JP 2016530495A JP 2016530495 A JP2016530495 A JP 2016530495A JP 6397912 B2 JP6397912 B2 JP 6397912B2
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- JP
- Japan
- Prior art keywords
- compound
- mmol
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- hydrogen
- direct bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13178543 | 2013-07-30 | ||
| EP13178543.8 | 2013-07-30 | ||
| PCT/EP2014/066273 WO2015014836A1 (en) | 2013-07-30 | 2014-07-29 | Substituted pyridine-piperazinyl analogues as rsv antiviral compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016527259A JP2016527259A (ja) | 2016-09-08 |
| JP2016527259A5 JP2016527259A5 (enExample) | 2017-08-31 |
| JP6397912B2 true JP6397912B2 (ja) | 2018-09-26 |
Family
ID=48874955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016530495A Expired - Fee Related JP6397912B2 (ja) | 2013-07-30 | 2014-07-29 | Ｒｓｖ抗ウイルス化合物としての置換ピリジンピペラジニルアナログ |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20160168124A1 (enExample) |
| EP (1) | EP3027608B1 (enExample) |
| JP (1) | JP6397912B2 (enExample) |
| KR (1) | KR102297433B1 (enExample) |
| CN (1) | CN105683183B (enExample) |
| AU (1) | AU2014298561B8 (enExample) |
| CA (1) | CA2914762C (enExample) |
| EA (1) | EA027732B1 (enExample) |
| ES (1) | ES2724577T3 (enExample) |
| WO (1) | WO2015014836A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2020008061A (es) * | 2018-01-31 | 2020-09-09 | Janssen Sciences Ireland Unlimited Co | Pirazolopirimidinas sustituidas con cicloalquilo que tienen actividad contra vrs. |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL147465B1 (en) * | 1984-03-26 | 1989-06-30 | Janssen Pharmaceutica Nv | Method of obtaining novel pyridazionoamine compounds |
| US5001125A (en) | 1984-03-26 | 1991-03-19 | Janssen Pharmaceutica N.V. | Anti-virally active pyridazinamines |
| US20080194574A1 (en) * | 2003-12-16 | 2008-08-14 | Axxima Pharmaceuticals Ag | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases |
| MY145822A (en) | 2004-08-13 | 2012-04-30 | Neurogen Corp | Substituted biaryl piperazinyl-pyridine analogues |
| WO2008008453A1 (en) | 2006-07-14 | 2008-01-17 | Schering Corporation | Heterocyclic substituted piperazine compounds with cxcr3 antagonist activity |
| JP2010518064A (ja) * | 2007-02-12 | 2010-05-27 | メルク・シャープ・エンド・ドーム・コーポレイション | Ａｄおよび関連状態の治療のためのピペラジン誘導体 |
| EP2149373A1 (en) | 2008-08-01 | 2010-02-03 | Laboratorios Del. Dr. Esteve, S.A. | 5HT7 receptor ligands and compositions comprising the same |
| BR112012002331A2 (pt) * | 2009-08-05 | 2019-09-24 | Versitech Ltd | composição antiviral, composição farmacêutica e uso de quantidade efetiva de composição farmacêutica |
| JPWO2011062194A1 (ja) * | 2009-11-18 | 2013-04-04 | 武田薬品工業株式会社 | アミノピリジン誘導体 |
| US20110224229A1 (en) * | 2010-03-10 | 2011-09-15 | Astrazeneca Ab | Novel Crystalline Form |
| WO2011143129A1 (en) | 2010-05-13 | 2011-11-17 | Amgen Inc. | Nitrogen- heterocyclic compounds as phosphodiesterase 10 inhibitors |
| US20120142701A1 (en) | 2010-05-28 | 2012-06-07 | The University Of Hong Kong | Compounds and methods for the treatment of proliferative diseases |
| GB201010193D0 (en) * | 2010-06-17 | 2010-07-21 | Respivert Ltd | Medicinal use |
| LT3002278T (lt) * | 2011-03-15 | 2017-06-26 | Astellas Pharma Inc. | Guanidino junginys |
-
2014
- 2014-07-29 KR KR1020167002162A patent/KR102297433B1/ko not_active Expired - Fee Related
- 2014-07-29 EA EA201690300A patent/EA027732B1/ru not_active IP Right Cessation
- 2014-07-29 EP EP14744362.6A patent/EP3027608B1/en active Active
- 2014-07-29 CN CN201480043020.5A patent/CN105683183B/zh not_active Expired - Fee Related
- 2014-07-29 JP JP2016530495A patent/JP6397912B2/ja not_active Expired - Fee Related
- 2014-07-29 CA CA2914762A patent/CA2914762C/en active Active
- 2014-07-29 US US14/908,866 patent/US20160168124A1/en not_active Abandoned
- 2014-07-29 WO PCT/EP2014/066273 patent/WO2015014836A1/en not_active Ceased
- 2014-07-29 ES ES14744362T patent/ES2724577T3/es active Active
- 2014-07-29 AU AU2014298561A patent/AU2014298561B8/en not_active Ceased
-
2017
- 2017-06-23 US US15/632,027 patent/US10150761B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016527259A (ja) | 2016-09-08 |
| EP3027608A1 (en) | 2016-06-08 |
| CN105683183A (zh) | 2016-06-15 |
| KR102297433B1 (ko) | 2021-09-02 |
| AU2014298561A8 (en) | 2018-06-14 |
| CA2914762A1 (en) | 2015-02-05 |
| WO2015014836A1 (en) | 2015-02-05 |
| AU2014298561B8 (en) | 2018-06-14 |
| EA201690300A1 (ru) | 2016-06-30 |
| CA2914762C (en) | 2021-11-23 |
| EP3027608B1 (en) | 2019-02-20 |
| CN105683183B (zh) | 2018-06-22 |
| US20170291891A1 (en) | 2017-10-12 |
| AU2014298561B2 (en) | 2018-05-31 |
| EA027732B1 (ru) | 2017-08-31 |
| US10150761B2 (en) | 2018-12-11 |
| ES2724577T3 (es) | 2019-09-12 |
| AU2014298561A1 (en) | 2015-12-24 |
| US20160168124A1 (en) | 2016-06-16 |
| KR20160037171A (ko) | 2016-04-05 |
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