EA027732B1 - Замещенные аналоги пиридина-пиперазинила в качестве противовирусных соединений против rsv - Google Patents
Замещенные аналоги пиридина-пиперазинила в качестве противовирусных соединений против rsv Download PDFInfo
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- EA027732B1 EA027732B1 EA201690300A EA201690300A EA027732B1 EA 027732 B1 EA027732 B1 EA 027732B1 EA 201690300 A EA201690300 A EA 201690300A EA 201690300 A EA201690300 A EA 201690300A EA 027732 B1 EA027732 B1 EA 027732B1
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- Eurasian Patent Office
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 213
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- 239000001257 hydrogen Substances 0.000 claims description 33
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- 238000000034 method Methods 0.000 claims description 15
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13178543 | 2013-07-30 | ||
| PCT/EP2014/066273 WO2015014836A1 (en) | 2013-07-30 | 2014-07-29 | Substituted pyridine-piperazinyl analogues as rsv antiviral compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201690300A1 EA201690300A1 (ru) | 2016-06-30 |
| EA027732B1 true EA027732B1 (ru) | 2017-08-31 |
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| EA201690300A EA027732B1 (ru) | 2013-07-30 | 2014-07-29 | Замещенные аналоги пиридина-пиперазинила в качестве противовирусных соединений против rsv |
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| EP (1) | EP3027608B1 (enExample) |
| JP (1) | JP6397912B2 (enExample) |
| KR (1) | KR102297433B1 (enExample) |
| CN (1) | CN105683183B (enExample) |
| AU (1) | AU2014298561B8 (enExample) |
| CA (1) | CA2914762C (enExample) |
| EA (1) | EA027732B1 (enExample) |
| ES (1) | ES2724577T3 (enExample) |
| WO (1) | WO2015014836A1 (enExample) |
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| SG11202006141RA (en) * | 2018-01-31 | 2020-07-29 | Janssen Sciences Ireland Unlimited Co | Cycloalkyl substituted pyrazolopyrimidines having activity against rsv |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008099210A2 (en) * | 2007-02-12 | 2008-08-21 | Merck & Co., Inc. | Piperazine derivatives for treatment of ad and related conditions |
| WO2011015037A1 (en) * | 2009-08-05 | 2011-02-10 | The University Of Hongkong | Antiviral compounds and methods of making and using there of cross reference to related applications |
| WO2011062194A1 (ja) * | 2009-11-18 | 2011-05-26 | 武田薬品工業株式会社 | アミノピリジン誘導体 |
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|---|---|---|---|---|
| ZA852235B (en) * | 1984-03-26 | 1986-11-26 | Janssen Pharmaceutica Nv | Anti-virally active pyridazinamines |
| US5001125A (en) | 1984-03-26 | 1991-03-19 | Janssen Pharmaceutica N.V. | Anti-virally active pyridazinamines |
| US20080194574A1 (en) * | 2003-12-16 | 2008-08-14 | Axxima Pharmaceuticals Ag | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases |
| MY145822A (en) | 2004-08-13 | 2012-04-30 | Neurogen Corp | Substituted biaryl piperazinyl-pyridine analogues |
| MX2009000577A (es) | 2006-07-14 | 2009-03-09 | Schering Corp | Compuestos de piperazina sustituida heterociclica con actividad antagonista de cxcr3. |
| EP2149373A1 (en) | 2008-08-01 | 2010-02-03 | Laboratorios Del. Dr. Esteve, S.A. | 5HT7 receptor ligands and compositions comprising the same |
| WO2011110852A1 (en) * | 2010-03-10 | 2011-09-15 | Astrazeneca Ab | Polymorphic forms of 6- [2- (4 -cyanophenyl) - 2h - pyrazol - 3 - yl] - 5 -methyl - 3 - oxo - 4 - (trifluoromethyl - phenyl) 3,4-dihydropyrazine-2-carboxylic acid ethylamide |
| MX2012013128A (es) | 2010-05-13 | 2013-03-20 | Amgen Inc | Compuestos heterociclicos de nitrogeno como inhibidores de la fosfodiesterasa 10. |
| US20120142701A1 (en) | 2010-05-28 | 2012-06-07 | The University Of Hong Kong | Compounds and methods for the treatment of proliferative diseases |
| GB201010193D0 (en) * | 2010-06-17 | 2010-07-21 | Respivert Ltd | Medicinal use |
| LT3002278T (lt) * | 2011-03-15 | 2017-06-26 | Astellas Pharma Inc. | Guanidino junginys |
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2014
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- 2014-07-29 KR KR1020167002162A patent/KR102297433B1/ko not_active Expired - Fee Related
- 2014-07-29 WO PCT/EP2014/066273 patent/WO2015014836A1/en not_active Ceased
- 2014-07-29 AU AU2014298561A patent/AU2014298561B8/en not_active Ceased
- 2014-07-29 US US14/908,866 patent/US20160168124A1/en not_active Abandoned
- 2014-07-29 JP JP2016530495A patent/JP6397912B2/ja not_active Expired - Fee Related
- 2014-07-29 EP EP14744362.6A patent/EP3027608B1/en active Active
- 2014-07-29 EA EA201690300A patent/EA027732B1/ru not_active IP Right Cessation
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- 2014-07-29 CN CN201480043020.5A patent/CN105683183B/zh not_active Expired - Fee Related
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2017
- 2017-06-23 US US15/632,027 patent/US10150761B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008099210A2 (en) * | 2007-02-12 | 2008-08-21 | Merck & Co., Inc. | Piperazine derivatives for treatment of ad and related conditions |
| WO2011015037A1 (en) * | 2009-08-05 | 2011-02-10 | The University Of Hongkong | Antiviral compounds and methods of making and using there of cross reference to related applications |
| WO2011062194A1 (ja) * | 2009-11-18 | 2011-05-26 | 武田薬品工業株式会社 | アミノピリジン誘導体 |
Non-Patent Citations (5)
| Title |
|---|
| CHEMICAL ABSTRACTS, Columbus, Ohio, US; "Ethanone, 1-[4-[4-(3,6-dimethyl-2-pyrazinyl)-1-piperazinyl]phenyl]-" XP002732897 * |
| CHEMICAL ABSTRACTS, Columbus, Ohio, US; "Piperazine, 1-(6-chloro-2-methyl-3-pyridinyl)-4-(2-methoxyphenyl)-" XP002732896 * |
| CHEMICAL ABSTRACTS, Columbus, Ohio, US; "Piperazine, 1-(6-chloro-2-methyl-3-pyridinyl)-4-phenyl-" XP002732895 * |
| CHEMICAL ABSTRACTS, Columbus, Ohio, US; "Pyrazine, 2-methoxy-3-[4-(4-methoxyphenyl)-2-methyl-1-piperazinyl]-" XP002732894 * |
| WIESLAWA OLSZEWSKA; PETER OPENSHAW: "Emerging drugs for respiratory syncytial virus infection", EXPERT OPINION ON EMERGING DRUGS, INFORMA HEALTHCARE, UK, vol. 14, no. 2, 1 June 2009 (2009-06-01), UK, pages 207 - 217, XP008164921, ISSN: 1472-8214, DOI: 10.1517/14728210902946399 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105683183A (zh) | 2016-06-15 |
| US20160168124A1 (en) | 2016-06-16 |
| CN105683183B (zh) | 2018-06-22 |
| US20170291891A1 (en) | 2017-10-12 |
| EP3027608B1 (en) | 2019-02-20 |
| EA201690300A1 (ru) | 2016-06-30 |
| KR102297433B1 (ko) | 2021-09-02 |
| AU2014298561B8 (en) | 2018-06-14 |
| AU2014298561B2 (en) | 2018-05-31 |
| AU2014298561A1 (en) | 2015-12-24 |
| CA2914762C (en) | 2021-11-23 |
| JP6397912B2 (ja) | 2018-09-26 |
| ES2724577T3 (es) | 2019-09-12 |
| WO2015014836A1 (en) | 2015-02-05 |
| EP3027608A1 (en) | 2016-06-08 |
| US10150761B2 (en) | 2018-12-11 |
| KR20160037171A (ko) | 2016-04-05 |
| AU2014298561A8 (en) | 2018-06-14 |
| CA2914762A1 (en) | 2015-02-05 |
| JP2016527259A (ja) | 2016-09-08 |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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