JP6386465B2 - 抗ヘマグルチニン抗体及び使用方法 - Google Patents

抗ヘマグルチニン抗体及び使用方法 Download PDF

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Publication number
JP6386465B2
JP6386465B2 JP2015541997A JP2015541997A JP6386465B2 JP 6386465 B2 JP6386465 B2 JP 6386465B2 JP 2015541997 A JP2015541997 A JP 2015541997A JP 2015541997 A JP2015541997 A JP 2015541997A JP 6386465 B2 JP6386465 B2 JP 6386465B2
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Japan
Prior art keywords
seq
amino acid
acid sequence
antibody
hvr
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Expired - Fee Related
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JP2015541997A
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Japanese (ja)
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JP2016503413A5 (enExample
JP2016503413A (ja
Inventor
ミン シュイ，
ミン シュイ，
メルセデス バラージュ，
メルセデス バラージュ，
ニン チャイ，
ニン チャイ，
ナンシー チェン，
ナンシー チェン，
ヘンリー チウ，
ヘンリー チウ，
チャオユイ チン，
チャオユイ チン，
チョンホア リン，
チョンホア リン，
パトリック ジェー． ルパーダス，
パトリック ジェー． ルパーダス，
ジェラルド アール． ナカムラ，
ジェラルド アール． ナカムラ，
ヒョンジュ パク，
ヒョンジュ パク，
リー アール． スウェム，
リー アール． スウェム，
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Genentech Inc
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015541997A 2012-11-13 2013-11-12 抗ヘマグルチニン抗体及び使用方法 Expired - Fee Related JP6386465B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261725859P 2012-11-13 2012-11-13
US61/725,859 2012-11-13
PCT/US2013/069567 WO2014078268A2 (en) 2012-11-13 2013-11-12 Anti-hemagglutinin antibodies and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018022789A Division JP6538216B2 (ja) 2012-11-13 2018-02-13 抗ヘマグルチニン抗体及び使用方法

Publications (3)

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JP2016503413A JP2016503413A (ja) 2016-02-04
JP2016503413A5 JP2016503413A5 (enExample) 2016-12-28
JP6386465B2 true JP6386465B2 (ja) 2018-09-05

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JP2015541997A Expired - Fee Related JP6386465B2 (ja) 2012-11-13 2013-11-12 抗ヘマグルチニン抗体及び使用方法
JP2018022789A Expired - Fee Related JP6538216B2 (ja) 2012-11-13 2018-02-13 抗ヘマグルチニン抗体及び使用方法

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US (5) US9284365B2 (enExample)
EP (2) EP2919813B1 (enExample)
JP (2) JP6386465B2 (enExample)
KR (1) KR20150083124A (enExample)
CN (1) CN104968367B (enExample)
AR (1) AR093446A1 (enExample)
AU (1) AU2013345072B2 (enExample)
BR (1) BR112015010817A8 (enExample)
CA (1) CA2890669A1 (enExample)
CL (1) CL2015001266A1 (enExample)
CR (1) CR20150247A (enExample)
EA (2) EA201892509A1 (enExample)
ES (1) ES2701746T3 (enExample)
IL (2) IL238684A0 (enExample)
MA (1) MA38176A1 (enExample)
MX (2) MX2015005860A (enExample)
PE (1) PE20150945A1 (enExample)
PH (2) PH12019501031A1 (enExample)
SG (2) SG10201700488QA (enExample)
TW (2) TWI657095B (enExample)
UA (1) UA116999C2 (enExample)
WO (1) WO2014078268A2 (enExample)
ZA (1) ZA201503403B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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JP2017508002A (ja) * 2014-01-27 2017-03-23 ジェネンテック， インコーポレイテッド 抗ｈ７ウイルス抗体を用いたｈ７ｎ９インフルエンザａ型の治療法

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EP2543707B2 (en) 2011-07-08 2020-09-02 Seiko Epson Corporation Photocurable ink composition for ink jet recording and ink jet recording method
CN104968367B (zh) * 2012-11-13 2018-04-13 弗·哈夫曼-拉罗切有限公司 抗血凝素抗体和使用方法
PL3052192T3 (pl) 2013-10-02 2021-04-06 Medimmune, Llc Przeciwciała neutralizujące przeciwko grypie A i ich zastosowania
CN113563462B (zh) 2014-07-15 2024-08-13 免疫医疗有限责任公司 中和抗乙型流感抗体及其用途
TWI702229B (zh) 2014-12-19 2020-08-21 美商再生元醫藥公司 流行性感冒病毒血球凝集素之人類抗體
JP6960856B2 (ja) * 2015-04-08 2021-11-05 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド ヒト化インフルエンザモノクローナル抗体およびその使用方法
LT3303384T (lt) 2015-06-01 2021-10-11 Medimmune, Llc Neutralizuojančios surišančios molekulės prieš gripą ir jų naudojimas
IL304940A (en) 2016-01-13 2023-10-01 Medimmune Llc A method for treating type A influenza
WO2017192589A1 (en) * 2016-05-02 2017-11-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Neutralizing antibodies to influenza ha and their use and identification
MX2019007433A (es) 2016-12-22 2019-08-16 Genentech Inc Metodos y formulaciones para reducir el tiempo de reconstitucion de los polipeptidos liofilizados.
WO2018170273A1 (en) 2017-03-15 2018-09-20 University Of Washington De novo designed hemagglutinin binding proteins
WO2018213097A1 (en) * 2017-05-15 2018-11-22 University Of Rochester Broadly neutralizing anti-influenza monoclonal antibody and uses thereof
CN109666070B (zh) * 2017-10-13 2021-02-19 清华大学 单克隆抗体mers-4v2及其编码基因和应用
IL275884B2 (en) 2018-01-26 2024-11-01 Regeneron Pharma Human antibodies to influenza hemagglutinin
BR112021001626A8 (pt) * 2018-08-14 2023-04-11 Merck Sharp & Dohme Ensaio de neutralização de vírus
WO2020093159A1 (en) * 2018-11-06 2020-05-14 Mcmaster University Broadly-neutralizing antibody and neuraminidase inhibitor combinations to prevent or treat influenza virus infections
WO2022068810A1 (zh) * 2020-09-29 2022-04-07 信达生物制药(苏州)有限公司 抗Claudin18.2和CD3的双特异性抗体以及其用途

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