JP6381534B2 - 二環式複素環化合物およびそれらの治療での使用 - Google Patents

二環式複素環化合物およびそれらの治療での使用 Download PDF

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Publication number
JP6381534B2
JP6381534B2 JP2015537354A JP2015537354A JP6381534B2 JP 6381534 B2 JP6381534 B2 JP 6381534B2 JP 2015537354 A JP2015537354 A JP 2015537354A JP 2015537354 A JP2015537354 A JP 2015537354A JP 6381534 B2 JP6381534 B2 JP 6381534B2
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methyl
dimethyl
pyrrolo
oxoethyl
methylpiperazin
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JP2016500684A5 (enExample
JP2016500684A (ja
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ジャンニ、チェサーリ
クリストファー、ノルベルト、ジョンソン
リー、ウィリアム、ページ
イルディコ、マリア、バック
ジェームズ、エドワード、ハーベイ、デイ
スティーブン、ハワード
ゴードン、サクスティ
クリストファー、ウィリアム、マレー
アナ、ホプキンス
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Astex Therapeutics Ltd
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Astex Therapeutics Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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JP2015537354A 2012-10-19 2013-10-18 二環式複素環化合物およびそれらの治療での使用 Active JP6381534B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261716086P 2012-10-19 2012-10-19
GBGB1218862.9A GB201218862D0 (en) 2012-10-19 2012-10-19 Bicyclic heterocycle compounds and their uses in therapy
US61/716,086 2012-10-19
GB1218862.9 2012-10-19
PCT/GB2013/052720 WO2014060767A1 (en) 2012-10-19 2013-10-18 Bicyclic heterocycle compounds and their uses in therapy

Publications (3)

Publication Number Publication Date
JP2016500684A JP2016500684A (ja) 2016-01-14
JP2016500684A5 JP2016500684A5 (enExample) 2016-12-08
JP6381534B2 true JP6381534B2 (ja) 2018-08-29

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Country Link
US (1) US9617283B2 (enExample)
EP (1) EP2909196B1 (enExample)
JP (1) JP6381534B2 (enExample)
KR (1) KR102299834B1 (enExample)
CN (1) CN104870441B (enExample)
CA (1) CA2888107C (enExample)
DK (1) DK2909196T3 (enExample)
ES (1) ES2847897T3 (enExample)
GB (1) GB201218862D0 (enExample)
WO (1) WO2014060767A1 (enExample)

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ES2847897T3 (es) 2021-08-04
US20150259359A1 (en) 2015-09-17
EP2909196A1 (en) 2015-08-26
EP2909196B1 (en) 2020-12-02
WO2014060767A1 (en) 2014-04-24
CA2888107A1 (en) 2014-04-24
CA2888107C (en) 2023-10-31
CN104870441A (zh) 2015-08-26
DK2909196T3 (da) 2021-03-01
KR20150072435A (ko) 2015-06-29
CN104870441B (zh) 2017-09-29
KR102299834B1 (ko) 2021-09-07
GB201218862D0 (en) 2012-12-05
JP2016500684A (ja) 2016-01-14
US9617283B2 (en) 2017-04-11

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