JP6375315B2 - 皮膚の保護に使用するための化合物 - Google Patents

皮膚の保護に使用するための化合物 Download PDF

Info

Publication number
JP6375315B2
JP6375315B2 JP2015561958A JP2015561958A JP6375315B2 JP 6375315 B2 JP6375315 B2 JP 6375315B2 JP 2015561958 A JP2015561958 A JP 2015561958A JP 2015561958 A JP2015561958 A JP 2015561958A JP 6375315 B2 JP6375315 B2 JP 6375315B2
Authority
JP
Japan
Prior art keywords
skin
composition
hydroxybutyrate
ketone
ketone body
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2015561958A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016512207A (ja
JP2016512207A5 (enExample
Inventor
キーラン クラーク
キーラン クラーク
リチャード ルイス ヴィーチ
リチャード ルイス ヴィーチ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Government of the United States of America
Original Assignee
Government of the United States of America
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Government of the United States of America filed Critical Government of the United States of America
Publication of JP2016512207A publication Critical patent/JP2016512207A/ja
Publication of JP2016512207A5 publication Critical patent/JP2016512207A5/ja
Application granted granted Critical
Publication of JP6375315B2 publication Critical patent/JP6375315B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61G—TRANSPORT, PERSONAL CONVEYANCES, OR ACCOMMODATION SPECIALLY ADAPTED FOR PATIENTS OR DISABLED PERSONS; OPERATING TABLES OR CHAIRS; CHAIRS FOR DENTISTRY; FUNERAL DEVICES
    • A61G17/00—Coffins; Funeral wrappings; Funeral urns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Toxicology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
JP2015561958A 2013-03-12 2013-09-16 皮膚の保護に使用するための化合物 Active JP6375315B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1304467.2A GB201304467D0 (en) 2013-03-12 2013-03-12 Compound for use in protecting skin
GB1304467.2 2013-03-12
PCT/EP2013/069189 WO2014139599A1 (en) 2013-03-12 2013-09-16 Compound for use in protecting skin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018060110A Division JP6789263B2 (ja) 2013-03-12 2018-03-27 皮膚の保護に使用するための化合物

Publications (3)

Publication Number Publication Date
JP2016512207A JP2016512207A (ja) 2016-04-25
JP2016512207A5 JP2016512207A5 (enExample) 2016-06-09
JP6375315B2 true JP6375315B2 (ja) 2018-08-15

Family

ID=48189804

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2015561958A Active JP6375315B2 (ja) 2013-03-12 2013-09-16 皮膚の保護に使用するための化合物
JP2018060110A Active JP6789263B2 (ja) 2013-03-12 2018-03-27 皮膚の保護に使用するための化合物
JP2020114922A Active JP7267244B2 (ja) 2013-03-12 2020-07-02 皮膚の保護に使用するための化合物
JP2022194392A Pending JP2023029344A (ja) 2013-03-12 2022-12-05 皮膚の保護に使用するための化合物

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2018060110A Active JP6789263B2 (ja) 2013-03-12 2018-03-27 皮膚の保護に使用するための化合物
JP2020114922A Active JP7267244B2 (ja) 2013-03-12 2020-07-02 皮膚の保護に使用するための化合物
JP2022194392A Pending JP2023029344A (ja) 2013-03-12 2022-12-05 皮膚の保護に使用するための化合物

Country Status (10)

Country Link
US (3) US10821062B2 (enExample)
EP (2) EP4714505A2 (enExample)
JP (4) JP6375315B2 (enExample)
AU (1) AU2013382361B2 (enExample)
CA (1) CA2905545C (enExample)
DK (1) DK2968091T3 (enExample)
ES (1) ES3059181T3 (enExample)
GB (2) GB201304467D0 (enExample)
HK (1) HK1220382A1 (enExample)
WO (1) WO2014139599A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004245567B2 (en) 2003-06-03 2011-06-23 Oxford University Innovation Limited Nutritional supplements and therapeutic compositions comprising (R)-3-hydroxybutyrate derivatives
EP2240017B1 (en) 2008-01-04 2019-03-13 Oxford University Innovation Limited Ketone bodies and ketone body esters as blood lipid lowering agents
US8642654B2 (en) 2009-04-16 2014-02-04 Isis Innovation Limited Hydroxybutyrate ester and medical use thereof
GB201002983D0 (en) 2010-02-22 2010-04-07 Tdeltas Ltd Nutritinal composition
JP6883384B2 (ja) * 2012-11-05 2021-06-09 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ 電離放射線による傷害から組織を防護するためのケトン体
GB201304467D0 (en) 2013-03-12 2013-04-24 Tdeltas Ltd Compound for use in protecting skin
SG11201507685UA (en) 2013-03-14 2015-10-29 Isis Innovation Process for producing (r)-3-hydroxybutyl (r)-3-hydroxybutyrate
US9255059B2 (en) 2013-08-02 2016-02-09 Eastman Chemical Company Method for producing an alkyl 3-hydroxybutyrate
US9249378B2 (en) 2013-08-02 2016-02-02 Eastman Chemical Company Aqueous cleaning compositions having enhanced properties
US9388114B2 (en) 2013-08-02 2016-07-12 Eastman Chemical Company Compositions including an alkyl 3-hydroxybutyrate
US9163202B2 (en) 2013-08-02 2015-10-20 Eastman Chemical Company Aqueous cleaning compositions including an alkyl 3-hydroxybutyrate
US20180057846A1 (en) 2016-08-30 2018-03-01 KetoneAid Inc. Partially buffered free acid and/or ketone blend for rapid onset ketosis and metabolic therapy
JP6804352B2 (ja) * 2017-03-22 2020-12-23 大阪瓦斯株式会社 コラゲナーゼｍｍｐ１及び３の産生抑制剤
JP2018158898A (ja) * 2017-03-22 2018-10-11 大阪瓦斯株式会社 トロポエラスチン発現促進剤
JP2018158899A (ja) * 2017-03-22 2018-10-11 大阪瓦斯株式会社 抗酸化系酵素群産生促進剤
CN109394745A (zh) * 2017-08-17 2019-03-01 博瑞生物医药（苏州）股份有限公司 一种包含左旋肉碱和β-羟基丁酸化合物的组合物
US11760963B2 (en) 2017-08-23 2023-09-19 KetoneAid Inc. Ketogenic beer and alcoholic beverage mixture containing non-racemic ethyl 3-hydroxybutyrate and/or 1,3 butanediol
JP6979918B2 (ja) * 2018-03-30 2021-12-15 大阪瓦斯株式会社 ヒト老化細胞賦活剤
JP6979919B2 (ja) * 2018-03-30 2021-12-15 大阪瓦斯株式会社 ヒト正常細胞賦活剤
ES2911191T3 (es) * 2018-04-05 2022-05-18 Beiersdorf Ag Composición cosmética para una rápida evaporación del sudor
GB2575623B (en) * 2018-06-04 2022-10-26 Tdeltas Ltd 3-hydroxybutyrate esters for treating cancer cachexia
WO2021195477A1 (en) 2020-03-27 2021-09-30 Ketoneaid, Inc. Ketone ester as a therapeutic treatment of covid-19, long covid, and related viral infections
US20240173219A1 (en) * 2022-11-29 2024-05-30 Latif Jackson Lotion Composition

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU507322A1 (ru) 1973-07-26 1976-03-25 Московский Научно-Исследовательский Институт Косметологии Регул тор гормонального обмена кожи
US3984566A (en) 1974-02-25 1976-10-05 Scott Eugene J Van Method of alleviating the symptoms of dandruff
IT1051853B (it) 1975-01-07 1981-05-20 Basf Ag Butandiol 1.3 3 mono 3 idros sibutirrati butandiol 1.3 1mono 3 idrossibutirrati e processi per la loro preparazione
US4380549A (en) * 1975-07-23 1983-04-19 Scott Eugene J Van Topical treatment of dry skin
JPS54138126A (en) 1978-04-17 1979-10-26 Ajinomoto Co Inc Remedy for diabetes
JPS5747446A (en) 1980-09-05 1982-03-18 Nippon Oil & Fats Co Ltd Nutrious food composition
EP0250559A1 (en) 1985-12-18 1988-01-07 VEECH, Richard L. Parenteral nutrition therapy with amino acids
JPH0755158B2 (ja) 1986-10-30 1995-06-14 チッソ株式会社 光学活性エステルの製造法
US4916074A (en) 1986-10-30 1990-04-10 Chisso Corporation Process for producing optically active compounds
JP2579779B2 (ja) 1987-10-08 1997-02-12 日本車輌製造株式会社 飼料の製造法
BE1001209A3 (fr) 1987-11-19 1989-08-22 Solvay Compositions pharmaceutiques contenant un derive de l'acide 3-hydroxybutanoique choisi parmi les oligomeres de cet acide et les esters de cet acide ou de ces oligomeres avec du 1,3-butanediol.
JPH0383950A (ja) 1989-08-28 1991-04-09 Kanegafuchi Chem Ind Co Ltd グリセリド誘導体およびその製造法
GB8922701D0 (en) 1989-10-09 1989-11-22 Leung Lit Hung Compositions and methods for weight reduction
JP2873497B2 (ja) 1990-09-03 1999-03-24 理化学研究所 脂質代謝調節剤
EP0537113A1 (en) 1991-10-10 1993-04-14 SANDOZ NUTRITION Ltd. Energy supplementary food
JP2884123B2 (ja) 1992-01-17 1999-04-19 高砂香料工業株式会社 生分解性光学活性ポリマー、その中間体オリゴマー、およびそれらの製造方法
US5654266A (en) 1992-02-10 1997-08-05 Chen; Chung-Ho Composition for tissues to sustain viability and biological functions in surgery and storage
US5281691A (en) 1992-06-19 1994-01-25 Eastman Kodak Company Poly(3-hydroxyalkanoates)
JPH06256157A (ja) * 1993-03-03 1994-09-13 Kanebo Ltd 老化防止皮膚化粧料
US5468507A (en) 1993-07-13 1995-11-21 Czap; Al F. Composition containing a desired flavoring agent and medium chain triglycerides
JP3193542B2 (ja) * 1993-09-08 2001-07-30 カネボウ株式会社 皮膚老化防止化粧料
WO1995009144A1 (en) 1993-09-30 1995-04-06 Eastman Chemical Company Nutritive water soluble glycerol esters of hydroxy butyric acid
DE4427492A1 (de) 1994-08-03 1996-02-08 Boehringer Mannheim Gmbh Verfahren zur Analyse einer medizinischen Probe unter Vermeidung von Störbeiträgen aufgrund von Hämolyse
ATE196486T1 (de) 1994-08-10 2000-10-15 Peter Neuenschwander Biokompatibles blockcopolymer
JPH08191664A (ja) 1995-01-12 1996-07-30 Yoshihide Hagiwara 新規コーヒー抽出物の製造法
US6306828B1 (en) 1995-04-06 2001-10-23 Baxter International, Inc. Enantiomerically-enhanced nutritional energy substrates
JP4598203B2 (ja) 1995-12-01 2010-12-15 ビーティージー・インターナショナル・リミテッド 脳機能改善剤
US6126953A (en) 1996-08-19 2000-10-03 The Procter & Gamble Company Fragrance delivery systems for personal care articles
JPH10175855A (ja) 1996-10-16 1998-06-30 Taisho Pharmaceut Co Ltd 肉体疲労改善剤
US6316038B1 (en) 1997-03-17 2001-11-13 Btg International Limited Therapeutic compositions
DK1017379T3 (en) 1997-03-17 2015-02-16 Btg Int Ltd Therapeutic compositions comprising ketone compounds and precursors thereof
US6323237B1 (en) 1997-03-17 2001-11-27 Btg International Limited Therapeutic compositions
US20090253781A1 (en) 2002-05-24 2009-10-08 Btg International Limited Therapeutic compositions
JPH10265378A (ja) 1997-03-25 1998-10-06 Ofutekusu:Kk 角膜上皮損傷治療剤
US6232346B1 (en) 1997-03-27 2001-05-15 Michael J. Sole Composition for improvement of cellular nutrition and mitochondrial energetics
JP3869071B2 (ja) 1997-05-14 2007-01-17 三栄源エフ・エフ・アイ株式会社 甘味食品
CA2289531C (en) 1997-05-15 2009-09-29 University Of Washington Composition and methods for treating alzheimer's disease and other amyloidoses
US6727258B2 (en) 1997-10-29 2004-04-27 King Pharmaceutical Research & Development, Inc. Allosteric adenosine receptor modulators
GB9723590D0 (en) 1997-11-08 1998-01-07 Glaxo Group Ltd Chemical compounds
US6380244B2 (en) 1998-07-22 2002-04-30 Metabolix, Inc. Nutritional and therapeutic uses of 3-hydroxyalkanoate oligomers
DK1123094T3 (da) 1998-09-15 2007-08-20 Btg Int Ltd Terapeutiske præparater (II)
AU6988100A (en) 1999-08-20 2001-03-19 Unilever Plc A method for reducing skin irritation and sting from weak carboxylic acid
PT1248849E (pt) 2000-01-14 2008-09-08 Serono Genetics Inst Sa Cabeça globular obg3 e suas utilizações para reduzir a massa corporal
PT1292294E (pt) 2000-05-01 2009-06-01 Accera Inc Utilização de triglicéridos de cadeia média para tratamento e prevenção da doença de alzheimer
US20070179197A1 (en) 2000-05-01 2007-08-02 Accera, Inc. Compositions and methods for improving or preserving brain function
WO2002006368A2 (en) 2000-07-14 2002-01-24 Metabolix, Inc. Polyurethanes obtained from hydroxyalkanoates and isocyanates
US6970737B1 (en) 2000-09-13 2005-11-29 Ge Medical Systems Information Technologies, Inc. Portable ECG device with wireless communication interface to remotely monitor patients and method of use
AUPR177300A0 (en) 2000-11-29 2000-12-21 Centre For Molecular Biology And Medicine Therapeutic methods
US20050129783A1 (en) 2001-04-19 2005-06-16 Mccleary Edward L. Composition and method for treatment of neurophysiological conditions and maintenance of neurophysiological health
GB0118931D0 (en) 2001-08-02 2001-09-26 Oxford Biosensors Ltd Voltammetric ion-selective biosensor
US7230144B2 (en) 2001-12-18 2007-06-12 Metabolix Inc. Methods of making intermediates from polyhydroxyalkanoates
GB0130684D0 (en) 2001-12-21 2002-02-06 Oxford Biosensors Ltd Micro-band electrode
DE20205184U1 (de) 2002-03-27 2002-12-19 Bartz, Volker, 35440 Linden Blutfettsenker zur oralen Einnahme
GB0211449D0 (en) 2002-05-17 2002-06-26 Oxford Biosensors Ltd Analyte measurement
US8996090B2 (en) 2002-06-03 2015-03-31 Exostat Medical, Inc. Noninvasive detection of a physiologic parameter within a body tissue of a patient
CN1483355A (zh) 2002-09-16 2004-03-24 岚 高 抗疲劳饮料配方
ES2574918T3 (es) 2003-06-02 2016-06-23 Isis Innovation Limited Tratamiento de la fatiga muscular
AU2004245567B2 (en) 2003-06-03 2011-06-23 Oxford University Innovation Limited Nutritional supplements and therapeutic compositions comprising (R)-3-hydroxybutyrate derivatives
JP2005247821A (ja) 2004-02-06 2005-09-15 Ophtecs Corp 炎症性サイトカインの産生を抑制するための眼科用組成物
DE102004007029A1 (de) 2004-02-12 2005-09-08 Consortium für elektrochemische Industrie GmbH Verfahren zur enantioselektiven Reduktion von Ketoverbindungen durch Enzyme
US20050181275A1 (en) 2004-02-18 2005-08-18 Jang Bor Z. Open electrochemical cell, battery and functional device
EP1778213B1 (en) 2004-07-16 2017-04-05 BTG International Limited A method for the synthesis of oligomeric compounds
US20060057691A1 (en) 2004-09-15 2006-03-16 Karunakaran Narasimhan Process for the extraction of polyhydroxyalkanoates from biomass
US8124063B2 (en) 2004-10-25 2012-02-28 Conopco, Inc. Method for moisturizing human skin using dihydroxypropyltri(C1-C3 alkyl) ammonium salts
GB0427145D0 (en) 2004-12-10 2005-01-12 Ketocytonyx Inc Compositions for use in surgery
ITTO20040918A1 (it) 2004-12-29 2005-03-29 Luigi Ambrosio Idrogel polimerici superassorbenti biodegradabili e procedimento per la loro preparazione
WO2007001883A2 (en) 2005-06-20 2007-01-04 Accera, Inc. Method to reduce oxidative damage and improve mitochondrial efficiency
PL1957550T3 (pl) 2005-11-29 2010-06-30 Basf Se Sposób transestryfikacji lub estryfikacji łańcuchów bocznych w polimerach
PT2500017T (pt) 2006-04-03 2017-11-14 Accera Inc Utilização de compostos cetogénicos para tratamento de comprometimento da memória associado à idade
PL2189155T3 (pl) 2006-04-12 2016-07-29 Unilever Nv Doustna kompozycja o przeciwstarzeniowym działaniu na skórę
US7807718B2 (en) 2006-06-30 2010-10-05 Sami A. Hashim Glyceride esters for the treatment of diseases associated with reduced neuronal metabolism of glucose
JP5030553B2 (ja) 2006-11-24 2012-09-19 有限会社ノーベル医学研究所 ドライマウスおよび／または唾液分泌障害を処置するための医薬
RU2446208C9 (ru) 2006-12-19 2012-11-10 Басф Се Применение и способ профилактики или лечения кариеса, вызванного mutans streptococci, отличных от streptococcus mutans
CN101489543A (zh) * 2007-03-14 2009-07-22 汕头大学 提高受试者的学习和/或记忆能力的3-羟基脂肪酸及其衍生物
US20080253997A1 (en) 2007-03-27 2008-10-16 Perscitus Biosciences, Llc Compositions and methods for protecting cells from toxic exposures
JP5065742B2 (ja) 2007-04-18 2012-11-07 三栄源エフ・エフ・アイ株式会社 香味の発現性及び持続性が改善された調味食品
WO2008140828A1 (en) 2007-05-14 2008-11-20 Accera, Inc. Inhibitors of acetyl-coa carboxylase for treatment of neuronal hypometabolism
WO2009023357A2 (en) 2007-05-25 2009-02-19 University Of Rochester Curcumin derivatives and their use as radioprotectors
CA2701179C (en) 2007-10-04 2021-03-16 Nestec S.A. Compositions and methods for enhancing cognitive function
EP2240017B1 (en) 2008-01-04 2019-03-13 Oxford University Innovation Limited Ketone bodies and ketone body esters as blood lipid lowering agents
CN102164884B (zh) * 2008-08-21 2015-03-11 伊希斯创新有限公司 羟基丁酸酯及其医学用途
US8642654B2 (en) * 2009-04-16 2014-02-04 Isis Innovation Limited Hydroxybutyrate ester and medical use thereof
US9034613B2 (en) * 2009-04-16 2015-05-19 Isis Innovation Limited Process for the preparation of (3R)-hydroxybutyl (3R)-hydroxybutyrate by enzymatic enantioselective reduction employing Lactobacillus brevis alcohol dehydrogenase
GB201002983D0 (en) * 2010-02-22 2010-04-07 Tdeltas Ltd Nutritinal composition
FR2958154B1 (fr) 2010-04-01 2012-06-08 Oreal Procede de soin et/ou de maquillage des rides
AU2012219321C1 (en) * 2011-02-17 2016-02-04 Armis Biopharma, Inc. Compositions comprising peroxy alpha-ketocarboxylic acid and methods for producing and using the same
WO2012113415A1 (en) 2011-02-24 2012-08-30 N.V. Nutricia Ketogenic diet composition for the treatment of chemo therapy and/or radiation therapy patients
GB201206192D0 (en) 2012-04-05 2012-05-23 Tdeltas Ltd Ketone bodies and ketone body esters and for maintaining or improving muscle power output
CN104487066B (zh) 2012-07-23 2020-06-09 国立大学法人东京大学 放射线损害的预防和/或治疗剂
JP6883384B2 (ja) 2012-11-05 2021-06-09 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ 電離放射線による傷害から組織を防護するためのケトン体
GB201304467D0 (en) 2013-03-12 2013-04-24 Tdeltas Ltd Compound for use in protecting skin
SG11201507685UA (en) 2013-03-14 2015-10-29 Isis Innovation Process for producing (r)-3-hydroxybutyl (r)-3-hydroxybutyrate
MY180761A (en) 2013-03-19 2020-12-08 Univ South Florida Compositions and methods for producing elevated and sustained ketosis
GB201314127D0 (en) 2013-08-07 2013-09-18 Tdeltas Ltd Ketone body and ketone body ester for reducing muscle breakdown

Also Published As

Publication number Publication date
GB2511941B (en) 2016-03-30
US10821062B2 (en) 2020-11-03
JP6789263B2 (ja) 2020-11-25
ES3059181T3 (en) 2026-03-19
EP2968091B1 (en) 2025-11-19
JP2016512207A (ja) 2016-04-25
DK2968091T3 (da) 2026-02-09
US20160030314A1 (en) 2016-02-04
CA2905545C (en) 2023-05-09
JP2020176125A (ja) 2020-10-29
EP2968091A1 (en) 2016-01-20
AU2013382361B2 (en) 2018-12-13
JP2018138549A (ja) 2018-09-06
GB2511941A (en) 2014-09-17
US20260108442A1 (en) 2026-04-23
GB201404400D0 (en) 2014-04-23
HK1220382A1 (zh) 2017-05-05
JP7267244B2 (ja) 2023-05-01
WO2014139599A1 (en) 2014-09-18
JP2023029344A (ja) 2023-03-03
US12377032B2 (en) 2025-08-05
GB201304467D0 (en) 2013-04-24
EP4714505A2 (en) 2026-03-25
CA2905545A1 (en) 2014-09-18
AU2013382361A1 (en) 2015-10-08
US20210015730A1 (en) 2021-01-21

Similar Documents

Publication Publication Date Title
JP7267244B2 (ja) 皮膚の保護に使用するための化合物
US11839679B2 (en) Gamma-diketones for treatment and prevention of aging skin and wrinkles
US11679284B2 (en) Skin care formulations
CN101856319B (zh) 用于改善皮肤色泽的植物提取物的组合
HK1254688A1 (zh) 化妝品組合物
CN103442691B (zh) 包含拟爱神木和腰果树果肉及其提取物的局部护肤制剂
CN118680840A (zh) 局部用组合物
TW202425945A (zh) 硫乙胺組合物在與有機酸和/或氮苯-4-羧醯胺組合時用於皮膚再生及改善增效作用之用途
HK1240093A1 (en) Gamma-diketones for treatment and prevention of aging skin and wrinkles
HK1240093B (en) Gamma-diketones for treatment and prevention of aging skin and wrinkles

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160311

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160311

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20160311

A975 Report on accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A971005

Effective date: 20160406

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160523

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160816

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160909

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20161114

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170214

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170414

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170428

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170605

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170905

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171102

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20171127

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180327

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20180604

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20180717

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20180723

R150 Certificate of patent or registration of utility model

Ref document number: 6375315

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250