JP6371303B2 - 目標物質のインビトロ磁気共鳴検出 - Google Patents

目標物質のインビトロ磁気共鳴検出 Download PDF

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Publication number
JP6371303B2
JP6371303B2 JP2015547053A JP2015547053A JP6371303B2 JP 6371303 B2 JP6371303 B2 JP 6371303B2 JP 2015547053 A JP2015547053 A JP 2015547053A JP 2015547053 A JP2015547053 A JP 2015547053A JP 6371303 B2 JP6371303 B2 JP 6371303B2
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Prior art keywords
target substance
2bound
magnetic nanoparticles
2free
sample
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Japanese (ja)
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JP2016503159A (ja
JP2016503159A5 (https=
Inventor
ヴェンカテサン，ラメシュ
バラシュブラマニアン，アルン
アトレッヤ，チャンダン・ラマスワミィ
ヘッジ，ラヴィ
ムクハージェ，リティカ・アッパル
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General Electric Co
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General Electric Co
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Priority claimed from GB201301992A external-priority patent/GB201301992D0/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/448—Relaxometry, i.e. quantification of relaxation times or spin density
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/32—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Bacillus (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nanotechnology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2015547053A 2012-12-17 2013-12-13 目標物質のインビトロ磁気共鳴検出 Expired - Fee Related JP6371303B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN3886/DEL/2012 2012-12-17
IN3886DE2012 2012-12-17
GB1301992.2 2013-02-05
GB201301992A GB201301992D0 (en) 2013-02-05 2013-02-05 In-vitro magnetic resonance detection of a target substance
PCT/EP2013/076569 WO2014095645A1 (en) 2012-12-17 2013-12-13 In-vitro magnetic resonance detection of a target substance

Publications (3)

Publication Number Publication Date
JP2016503159A JP2016503159A (ja) 2016-02-01
JP2016503159A5 JP2016503159A5 (https=) 2017-01-26
JP6371303B2 true JP6371303B2 (ja) 2018-08-08

Family

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Family Applications (1)

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JP2015547053A Expired - Fee Related JP6371303B2 (ja) 2012-12-17 2013-12-13 目標物質のインビトロ磁気共鳴検出

Country Status (5)

Country Link
US (1) US10156567B2 (https=)
EP (1) EP2932289A1 (https=)
JP (1) JP6371303B2 (https=)
CN (1) CN104871026B (https=)
WO (1) WO2014095645A1 (https=)

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JP6244289B2 (ja) * 2014-10-29 2017-12-06 学校法人 神野学園 クドア・セプテンプンクタータの検出方法
US11385224B2 (en) 2016-07-21 2022-07-12 Siemens Healthcare Diagnostics Inc. Magnetic shielding for IVD automation system
CN107478834A (zh) * 2017-09-05 2017-12-15 杨蕾 一种检测沙门氏菌磁共振成像试剂盒的制备方法
EP3575813B1 (en) * 2018-05-30 2022-06-29 Siemens Healthcare GmbH Quantitative mapping of a magnetic resonance imaging parameter by data-driven signal-model learning
CN109658468B (zh) * 2018-12-12 2022-12-13 深圳先进技术研究院 磁共振参数成像方法、装置、设备及存储介质
EP4047356A4 (en) * 2019-10-17 2023-11-22 Riken DETECTION METHOD AND SYSTEM FOR DETECTION OF MASTITIS IN A DOMESTIC ANIMAL
IL295143B2 (en) * 2020-02-13 2026-02-01 Hoffmann La Roche A method for determining the loading state of AAV particles using nuclear magnetic resonance relaxometry
CN112611868A (zh) * 2020-12-18 2021-04-06 厦门大学 一种用于磁共振分析方法检测新型冠状病毒的探针及其制备方法
JP7825308B2 (ja) * 2021-10-28 2026-03-06 マサチューセッツ インスティテュート オブ テクノロジー 間葉系幹細胞の老化を迅速かつ非侵襲的に検出するためのマイクロ磁気共鳴リラクソメトリー（μＭＲＲ）
US20250000384A1 (en) * 2023-06-20 2025-01-02 Regents Of The University Of Michigan Methods for magnetic resonance imaging of nanoconstructs and uses thereof

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US20030028093A1 (en) * 2001-04-20 2003-02-06 Yong Ke Exponential decay modeling in spectroscopy
US7088102B1 (en) 2005-03-03 2006-08-08 Varian, Inc. Rapid sample multiplexing
US7781228B2 (en) * 2005-04-07 2010-08-24 Menon & Associates, Inc. Magnetic resonance system and method to detect and confirm analytes
CA2606924C (en) 2005-05-09 2013-04-16 The General Hospital Corporation Water relaxation-based sensors
US7560289B2 (en) * 2005-11-16 2009-07-14 Chin-Yih Rex Hong Methods of quantitatively measuring biomolecules
US20070166730A1 (en) 2006-01-19 2007-07-19 Menon & Associates, Inc. Magnetic resonance system and method to detect and confirm analytes
DE102007009494A1 (de) * 2007-02-27 2008-08-28 Bayer Healthcare Ag Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung
WO2009045354A1 (en) 2007-09-28 2009-04-09 T2 Biosystems, Inc. Nmr diagnostics by means of a plastic sample container
US20110091987A1 (en) 2007-10-04 2011-04-21 Ralph Weissleder Miniaturized Magnetic Resonance Systems and Methods
DE102007049701B4 (de) 2007-10-17 2010-09-23 Bruker Biospin Ag NMR-Messkopf mit mehreren Resonatorsystemen zur simultanen Vermessung mehrerer Messproben in einem gekoppelten Mode
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Also Published As

Publication number Publication date
US10156567B2 (en) 2018-12-18
US20160195526A1 (en) 2016-07-07
EP2932289A1 (en) 2015-10-21
WO2014095645A1 (en) 2014-06-26
JP2016503159A (ja) 2016-02-01
CN104871026A (zh) 2015-08-26
CN104871026B (zh) 2020-01-10

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