CN104871026B - 靶物质的体外磁共振检测 - Google Patents

靶物质的体外磁共振检测 Download PDF

Info

Publication number
CN104871026B
CN104871026B CN201380065739.4A CN201380065739A CN104871026B CN 104871026 B CN104871026 B CN 104871026B CN 201380065739 A CN201380065739 A CN 201380065739A CN 104871026 B CN104871026 B CN 104871026B
Authority
CN
China
Prior art keywords
target substance
bound
magnetic nanoparticles
target
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201380065739.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN104871026A (zh
Inventor
R.文卡特桑
A.巴拉苏拉马尼安
C.R.阿特雷亚
R.赫格德
R.U.穆克赫杰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Electric Co
Original Assignee
General Electric Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB201301992A external-priority patent/GB201301992D0/en
Application filed by General Electric Co filed Critical General Electric Co
Publication of CN104871026A publication Critical patent/CN104871026A/zh
Application granted granted Critical
Publication of CN104871026B publication Critical patent/CN104871026B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/448—Relaxometry, i.e. quantification of relaxation times or spin density
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/32—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Bacillus (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nanotechnology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201380065739.4A 2012-12-17 2013-12-13 靶物质的体外磁共振检测 Expired - Fee Related CN104871026B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN3886/DEL/2012 2012-12-17
IN3886DE2012 2012-12-17
GB1301992.2 2013-02-05
GB201301992A GB201301992D0 (en) 2013-02-05 2013-02-05 In-vitro magnetic resonance detection of a target substance
PCT/EP2013/076569 WO2014095645A1 (en) 2012-12-17 2013-12-13 In-vitro magnetic resonance detection of a target substance

Publications (2)

Publication Number Publication Date
CN104871026A CN104871026A (zh) 2015-08-26
CN104871026B true CN104871026B (zh) 2020-01-10

Family

ID=49759340

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380065739.4A Expired - Fee Related CN104871026B (zh) 2012-12-17 2013-12-13 靶物质的体外磁共振检测

Country Status (5)

Country Link
US (1) US10156567B2 (https=)
EP (1) EP2932289A1 (https=)
JP (1) JP6371303B2 (https=)
CN (1) CN104871026B (https=)
WO (1) WO2014095645A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6244289B2 (ja) * 2014-10-29 2017-12-06 学校法人 神野学園 クドア・セプテンプンクタータの検出方法
US11385224B2 (en) 2016-07-21 2022-07-12 Siemens Healthcare Diagnostics Inc. Magnetic shielding for IVD automation system
CN107478834A (zh) * 2017-09-05 2017-12-15 杨蕾 一种检测沙门氏菌磁共振成像试剂盒的制备方法
EP3575813B1 (en) * 2018-05-30 2022-06-29 Siemens Healthcare GmbH Quantitative mapping of a magnetic resonance imaging parameter by data-driven signal-model learning
CN109658468B (zh) * 2018-12-12 2022-12-13 深圳先进技术研究院 磁共振参数成像方法、装置、设备及存储介质
EP4047356A4 (en) * 2019-10-17 2023-11-22 Riken DETECTION METHOD AND SYSTEM FOR DETECTION OF MASTITIS IN A DOMESTIC ANIMAL
IL295143B2 (en) * 2020-02-13 2026-02-01 Hoffmann La Roche A method for determining the loading state of AAV particles using nuclear magnetic resonance relaxometry
CN112611868A (zh) * 2020-12-18 2021-04-06 厦门大学 一种用于磁共振分析方法检测新型冠状病毒的探针及其制备方法
JP7825308B2 (ja) * 2021-10-28 2026-03-06 マサチューセッツ インスティテュート オブ テクノロジー 間葉系幹細胞の老化を迅速かつ非侵襲的に検出するためのマイクロ磁気共鳴リラクソメトリー（μＭＲＲ）
US20250000384A1 (en) * 2023-06-20 2025-01-02 Regents Of The University Of Michigan Methods for magnetic resonance imaging of nanoconstructs and uses thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070111330A1 (en) * 2005-11-16 2007-05-17 Chin-Yih Rex Hong Methods of quantitatively measuring biomolecules
WO2009045551A1 (en) * 2007-10-04 2009-04-09 The General Hospital Corporation Miniaturized magnetic resonance systems and methods
CN101641352A (zh) * 2007-02-27 2010-02-03 拜耳先灵制药股份公司 取代的4-芳基-1,4-二氢-1,6-萘啶酰胺和其用途
WO2010109346A1 (en) * 2009-03-25 2010-09-30 Koninklijke Philips Electronics N.V. Quantification of intracellular and extracellular spio agents with r2 and r2* mapping
WO2011120712A1 (de) * 2010-04-01 2011-10-06 Hochschule Für Angewandte Wissenschaften Fachhochschule Würzburg-Schweinfurt Verfahren zur bestimmung der anwesenheit eines analyten mittels magnetischer kleinstpartikel sowie vorrichtung hierfür
CN104614513A (zh) * 2015-01-26 2015-05-13 国家纳米科学中心 一种基于磁分离的弛豫时间免疫传感分析方法
CN105920620A (zh) * 2016-06-21 2016-09-07 东南大学 磁性荧光多模态纳米生物探针及其制备方法和应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030028093A1 (en) * 2001-04-20 2003-02-06 Yong Ke Exponential decay modeling in spectroscopy
US7088102B1 (en) 2005-03-03 2006-08-08 Varian, Inc. Rapid sample multiplexing
US7781228B2 (en) * 2005-04-07 2010-08-24 Menon & Associates, Inc. Magnetic resonance system and method to detect and confirm analytes
CA2606924C (en) 2005-05-09 2013-04-16 The General Hospital Corporation Water relaxation-based sensors
US20070166730A1 (en) 2006-01-19 2007-07-19 Menon & Associates, Inc. Magnetic resonance system and method to detect and confirm analytes
WO2009045354A1 (en) 2007-09-28 2009-04-09 T2 Biosystems, Inc. Nmr diagnostics by means of a plastic sample container
DE102007049701B4 (de) 2007-10-17 2010-09-23 Bruker Biospin Ag NMR-Messkopf mit mehreren Resonatorsystemen zur simultanen Vermessung mehrerer Messproben in einem gekoppelten Mode
AU2008325088A1 (en) * 2007-11-06 2009-05-14 T2 Biosystems, Inc. Small magnet and RF coil for magnetic resonance relaxometry
AU2008343871B2 (en) * 2007-12-21 2014-02-06 T2 Biosystems, Inc. Magnetic resonance system with implantable components and methods of use thereof
US20110262989A1 (en) 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
WO2012044387A2 (en) 2010-07-06 2012-04-05 T2 Biosystems, Inc. Methods and compositions for detection of analytes
WO2012054639A2 (en) * 2010-10-22 2012-04-26 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
US8409807B2 (en) * 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
WO2012129325A1 (en) * 2011-03-22 2012-09-27 The General Hospital Corporation Molecular analysis of tumor samples
EP3321373B1 (en) * 2011-07-13 2020-01-15 T2 Biosystems, Inc. Nmr methods for monitoring blood clot formation
JP5879189B2 (ja) * 2012-04-26 2016-03-08 株式会社日立製作所 交流磁場を用いた磁気的免疫検査方法及び検査装置
JP2014095691A (ja) * 2012-09-13 2014-05-22 Aspect Imaging Ltd 常磁性物質を使用する体外診断用途のための手段及び方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070111330A1 (en) * 2005-11-16 2007-05-17 Chin-Yih Rex Hong Methods of quantitatively measuring biomolecules
CN101641352A (zh) * 2007-02-27 2010-02-03 拜耳先灵制药股份公司 取代的4-芳基-1,4-二氢-1,6-萘啶酰胺和其用途
WO2009045551A1 (en) * 2007-10-04 2009-04-09 The General Hospital Corporation Miniaturized magnetic resonance systems and methods
WO2010109346A1 (en) * 2009-03-25 2010-09-30 Koninklijke Philips Electronics N.V. Quantification of intracellular and extracellular spio agents with r2 and r2* mapping
WO2011120712A1 (de) * 2010-04-01 2011-10-06 Hochschule Für Angewandte Wissenschaften Fachhochschule Würzburg-Schweinfurt Verfahren zur bestimmung der anwesenheit eines analyten mittels magnetischer kleinstpartikel sowie vorrichtung hierfür
CN104614513A (zh) * 2015-01-26 2015-05-13 国家纳米科学中心 一种基于磁分离的弛豫时间免疫传感分析方法
CN105920620A (zh) * 2016-06-21 2016-09-07 东南大学 磁性荧光多模态纳米生物探针及其制备方法和应用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Hakho Lee et.al.Ultrasensitive Detection of Bacteria Using Core–Shell Nanoparticles and an NMR-Filter System.《ANGEWANDTE CHEMIE》.2009,第121卷(第31期),第5767-5770页. *
Magnetic nanoparticles for biomedical NMR-based diagnostics;Huilin Shao et.al;《BEILSTEIN JOURNAL OF NANOTECHNOLOGY》;20101216;第1卷(第1期);第143页第3段，第147页第2栏第2段，第148页第2栏第1段 *
Ultrasensitive Detection of Bacteria Using Core–Shell Nanoparticles and an NMR-Filter System;Hakho Lee et.al;《ANGEWANDTE CHEMIE》;20090720;第121卷(第31期);参见第5657页第一栏至第2栏，第5658页第2段，图2,5 *

Also Published As

Publication number Publication date
JP6371303B2 (ja) 2018-08-08
US10156567B2 (en) 2018-12-18
US20160195526A1 (en) 2016-07-07
EP2932289A1 (en) 2015-10-21
WO2014095645A1 (en) 2014-06-26
JP2016503159A (ja) 2016-02-01
CN104871026A (zh) 2015-08-26

Similar Documents

Publication Publication Date Title
CN104871026B (zh) 靶物质的体外磁共振检测
US9874564B2 (en) Detection of targets using magnetic resonance
Ferguson et al. Single-EV analysis (sEVA) of mutated proteins allows detection of stage 1 pancreatic cancer
Issadore et al. Ultrasensitive clinical enumeration of rare cells ex vivo using a micro-hall detector
Lee et al. Rapid detection and profiling of cancer cells in fine-needle aspirates
Lee et al. Recent developments in magnetic diagnostic systems
Shao et al. Magnetic nanoparticles for biomedical NMR-based diagnostics
Shipunova et al. MPQ-cytometry: a magnetism-based method for quantification of nanoparticle–cell interactions
Issadore et al. Miniature magnetic resonance system for point-of-care diagnostics
Haun et al. Magnetic nanoparticle biosensors
Yang et al. Bead‐Based Extracellular Vesicle Analysis Using Flow Cytometry
US20180059114A1 (en) Magnetic nanostructure for detecting and isolating circulating tumor cells comprising antibody- and magnetic nanoparticle-conjugated conductive polymer
AU2002306561A2 (en) Methods and reagents for the rapid and efficient isolation of circulating cancer cells
US10359378B2 (en) Nuclear magnetic resonance apparatus, systems, and methods
US20170023526A1 (en) Systems and methods using paramagnetic agents for in vitro diagnostic applications
Kim et al. Subtyping of magnetically isolated breast cancer cells using magnetic force microscopy
Lin Magnetic particles for multidimensional in vitro bioanalysis
US20200124622A1 (en) Method of detecting aldosterone and renin
Baio et al. Two-step in vivo tumor targeting by biotin-conjugated antibodies and superparamagnetic nanoparticles assessed by magnetic resonance imaging at 1.5 T
US8802057B2 (en) Force-induced magnetization contrast for diagnosis and imaging
Javor et al. Automated analysis of the total choline resonance peak in breast proton magnetic resonance spectroscopy
Cavallaro et al. Signal Amplification for Fluorescent Staining of Single Particles in Liquid Biopsies: Circulating Tumour Cells and Extracellular Vesicles
Tietz et al. Design, synthesis and in vitro characterization of fluorescent and paramagnetic CXCR4-targeted imaging agents
Perez et al. An integrated NMR/nanosensor system for sensitive detection of environmental toxins and harmful microbes
Malek et al. Asian Journal of Physics

Legal Events

Date Code Title Description
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20200110

Termination date: 20201213