JP6364352B2 - 部分的ｍｈｃコンストラクト及びその使用方法 - Google Patents
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- JP6364352B2 JP6364352B2 JP2014551338A JP2014551338A JP6364352B2 JP 6364352 B2 JP6364352 B2 JP 6364352B2 JP 2014551338 A JP2014551338 A JP 2014551338A JP 2014551338 A JP2014551338 A JP 2014551338A JP 6364352 B2 JP6364352 B2 JP 6364352B2
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56977—HLA or MHC typing
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/605—MHC molecules or ligands thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Veterinary Medicine (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Analytical Chemistry (AREA)
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- Urology & Nephrology (AREA)
- Toxicology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261584045P | 2012-01-06 | 2012-01-06 | |
| US61/584,045 | 2012-01-06 | ||
| PCT/US2013/020287 WO2013103816A1 (en) | 2012-01-06 | 2013-01-04 | Partial mhc constructs and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015505315A JP2015505315A (ja) | 2015-02-19 |
| JP2015505315A5 JP2015505315A5 (cg-RX-API-DMAC10.html) | 2016-02-25 |
| JP6364352B2 true JP6364352B2 (ja) | 2018-07-25 |
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| JP2014551338A Expired - Fee Related JP6364352B2 (ja) | 2012-01-06 | 2013-01-04 | 部分的ｍｈｃコンストラクト及びその使用方法 |
Country Status (11)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2242393C1 (ru) * | 2003-05-12 | 2004-12-20 | Производственное республиканское унитарное предприятие "Минский автомобильный завод" | Механизм опрокидывания кабины |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8685404B2 (en) * | 2011-01-31 | 2014-04-01 | Oregon Health & Science University | Recombinant T-cell receptor ligand for the treatment of cognitive and neuropsychiatric impairment induced by substance addiction |
| WO2015051330A1 (en) * | 2013-10-03 | 2015-04-09 | Oregon Health & Science University | RECOMBINANT POLYPEPTIDES COMPRISING MHC CLASS II α1 DOMAINS |
| WO2015051328A1 (en) * | 2013-10-03 | 2015-04-09 | Oregon Health & Science University | TREATMENT OF ISCHEMIC STROKE WITH DRα1-MOG-35-55 |
| US10525101B2 (en) | 2015-10-23 | 2020-01-07 | Oregon Health & Science University | Methods of treating inflammatory or autoimmune disorders with compounds that bind macrophage migration inhibitory factor |
| WO2017120483A1 (en) | 2016-01-08 | 2017-07-13 | Oregon Health & Science University | Recombinant t cell receptor ligand compositions and methods for treatment of prostate cancer |
| US20190248867A1 (en) * | 2016-07-01 | 2019-08-15 | Loma Linda University | Myelin oligodendrocyte glycoprotein-specific peptide for the treatment or prevention of multiple sclerosis |
| WO2020037046A1 (en) * | 2018-08-14 | 2020-02-20 | Board Of Regents, The University Of Texas System | Single molecule sequencing peptides bound to the major histocompatibility complex |
| US11945855B2 (en) | 2018-10-05 | 2024-04-02 | Oregon Health & Science University | Recombinant polypeptides comprising modified MHC class II DRa1 domains and methods of use |
| WO2021113297A1 (en) * | 2019-12-02 | 2021-06-10 | Regeneron Pharmaceuticals, Inc. | Peptide-mhc ii protein constructs and uses thereof |
| WO2021202727A2 (en) * | 2020-03-31 | 2021-10-07 | Repertoire Immune Medicines, Inc. | Barcodable exchangeable peptide-mhc multimer libraries |
| DE102020109447A1 (de) * | 2020-04-03 | 2021-10-07 | Jacobs University Bremen Ggmbh | Synthetisches mhc-klasse-ii-protein |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5468481A (en) | 1988-06-23 | 1995-11-21 | Amergen, Inc. | MHC class II-peptide conjugates useful in ameliorating autoimmunity |
| JP3603374B2 (ja) * | 1995-04-14 | 2004-12-22 | 東レ株式会社 | 融合蛋白質およびその融合蛋白質を固定化した材料 |
| DK0935607T3 (da) * | 1996-08-16 | 2004-12-06 | Harvard College | Oplöselige monovalente og multivalente MHC klasse II-fusionsproteiner samt anvendelser deraf |
| AU741130B2 (en) | 1997-09-16 | 2001-11-22 | Oregon Health Sciences University | Recombinant MHC molecules useful for manipulation of antigen-specific T-cells |
| US20030007978A1 (en) | 1997-09-16 | 2003-01-09 | Burrows Gregory G. | Recombinant MHC molecules useful for manipulation of antigen-specific T-cells |
| US6232445B1 (en) * | 1997-10-29 | 2001-05-15 | Sunol Molecular Corporation | Soluble MHC complexes and methods of use thereof |
| BR9908082A (pt) * | 1998-02-19 | 2000-10-31 | Harvard College | Proteìna de fusão do complexo de histocompatibilidade principal classe ii, conjugado dos domìnios de ligação do complexo de histocompatibilidade principal multimérico, processos para detectar células t tendo uma especificidade do complexo definido de mhc / peptìdeo, para conferir a um indivìduo imunidade adotiva a um complexo definido de mhc / peptìdeo, para estimular ou ativar as células t reativas a um complexo definido de mhc / peptìdeo, para seletivamente matar células t reativas a um complexo definido de mhc / peptìdeo, para tolerizar um indivìduo humano a um complexo definido de mhc / peptìdeo, e, ácido nucleico isolado |
| WO2005044982A2 (en) * | 2003-09-05 | 2005-05-19 | Oregon Health & Science University | Monomeric recombinant mhc molecules useful for manipulation of antigen-specific t cells |
| US7576183B2 (en) * | 2003-12-24 | 2009-08-18 | Los Alamos National Security, Llc | Structure-based receptor MIMICS targeted against bacterial superantigen toxins |
| CA2638892A1 (en) | 2005-03-18 | 2006-09-28 | Oregon Health & Science University | Recombinant mhc molecules useful for manipulation of antigen-specific t cells |
| US20110008382A1 (en) | 2009-03-07 | 2011-01-13 | Burrows Gregory G | Compositions and methods using recombinant MHC molecules for the treatment of uveitis |
| US8491913B2 (en) | 2009-03-07 | 2013-07-23 | Oregon Health & Science University | Compositions and methods using recombinant MHC molecules for the treatment of stroke |
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2013
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- 2013-01-04 WO PCT/US2013/020287 patent/WO2013103816A1/en not_active Ceased
- 2013-01-04 CA CA2860678A patent/CA2860678A1/en not_active Abandoned
- 2013-01-04 JP JP2014551338A patent/JP6364352B2/ja not_active Expired - Fee Related
- 2013-01-04 EP EP13700425.5A patent/EP2800582A1/en not_active Withdrawn
- 2013-01-04 KR KR1020147021913A patent/KR20140114859A/ko not_active Withdrawn
- 2013-01-04 BR BR112014016652A patent/BR112014016652A2/pt not_active IP Right Cessation
- 2013-01-04 US US14/370,454 patent/US20150044245A1/en not_active Abandoned
- 2013-01-04 MX MX2014008146A patent/MX2014008146A/es unknown
- 2013-01-04 AU AU2013207489A patent/AU2013207489A1/en not_active Abandoned
- 2013-01-04 CN CN201380004958.1A patent/CN104105503A/zh active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2242393C1 (ru) * | 2003-05-12 | 2004-12-20 | Производственное республиканское унитарное предприятие "Минский автомобильный завод" | Механизм опрокидывания кабины |
Also Published As
| Publication number | Publication date |
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| WO2013103816A1 (en) | 2013-07-11 |
| EP2800582A1 (en) | 2014-11-12 |
| RU2014132426A (ru) | 2016-02-27 |
| KR20140114859A (ko) | 2014-09-29 |
| WO2013103816A8 (en) | 2014-06-26 |
| JP2015505315A (ja) | 2015-02-19 |
| MX2014008146A (es) | 2016-02-03 |
| CA2860678A1 (en) | 2013-07-11 |
| US20150044245A1 (en) | 2015-02-12 |
| BR112014016652A2 (pt) | 2019-09-24 |
| CN104105503A (zh) | 2014-10-15 |
| AU2013207489A8 (en) | 2014-09-18 |
| AU2013207489A1 (en) | 2014-08-28 |
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