MX2014008146A - Constructos de mhc parciales y metodos de uso. - Google Patents
Constructos de mhc parciales y metodos de uso.Info
- Publication number
- MX2014008146A MX2014008146A MX2014008146A MX2014008146A MX2014008146A MX 2014008146 A MX2014008146 A MX 2014008146A MX 2014008146 A MX2014008146 A MX 2014008146A MX 2014008146 A MX2014008146 A MX 2014008146A MX 2014008146 A MX2014008146 A MX 2014008146A
- Authority
- MX
- Mexico
- Prior art keywords
- domain
- methods
- mhc class
- polypeptide
- disclosed
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56977—HLA or MHC typing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/605—MHC molecules or ligands thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Pain & Pain Management (AREA)
Abstract
Se describen en la presente polipéptidos de dominio a1 del complejo de histocompatibilidad mayor (MHC) clase II aislados y métodos de uso. En algunas modalidades, el polipéptido aislado comprende o consiste de un polipéptido de dominio a1 (o porción del mismo) del MHC clase II y no incluye un dominio a2, ß1 o ß2 del MHC clase II. Los polipéptidos de dominio a1 del MHC clase II descritos son de uso en el tratamiento o inhibición de trastornos en un sujeto, tales como trastornos inflamatorios y/o autoinmunes. También se describen métodos para evaluar la eficacia del tratamiento u optimizar el tratamiento de un sujeto con un polipéptido que incluye un polipéptido de dominio a1 (o porción del mismo) del MHC clase II o un polipéptido que incluye un dominio a1 y dominio ß1 del MHC clase II (tal como un RTL ß1a1).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261584045P | 2012-01-06 | 2012-01-06 | |
PCT/US2013/020287 WO2013103816A1 (en) | 2012-01-06 | 2013-01-04 | Partial mhc constructs and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2014008146A true MX2014008146A (es) | 2016-02-03 |
Family
ID=47561855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014008146A MX2014008146A (es) | 2012-01-06 | 2013-01-04 | Constructos de mhc parciales y metodos de uso. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20150044245A1 (es) |
EP (1) | EP2800582A1 (es) |
JP (1) | JP6364352B2 (es) |
KR (1) | KR20140114859A (es) |
CN (1) | CN104105503A (es) |
AU (1) | AU2013207489A1 (es) |
BR (1) | BR112014016652A2 (es) |
CA (1) | CA2860678A1 (es) |
MX (1) | MX2014008146A (es) |
RU (1) | RU2014132426A (es) |
WO (1) | WO2013103816A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8685404B2 (en) * | 2011-01-31 | 2014-04-01 | Oregon Health & Science University | Recombinant T-cell receptor ligand for the treatment of cognitive and neuropsychiatric impairment induced by substance addiction |
WO2015051330A1 (en) * | 2013-10-03 | 2015-04-09 | Oregon Health & Science University | RECOMBINANT POLYPEPTIDES COMPRISING MHC CLASS II α1 DOMAINS |
US20150099706A1 (en) * | 2013-10-03 | 2015-04-09 | Oregon Health & Science University | TREATMENT OF ISCHEMIC STROKE WITH DRa1-MOG-35-55 |
US10525101B2 (en) | 2015-10-23 | 2020-01-07 | Oregon Health & Science University | Methods of treating inflammatory or autoimmune disorders with compounds that bind macrophage migration inhibitory factor |
US20170196957A1 (en) | 2016-01-08 | 2017-07-13 | Oregon Health & Science University | Recombinant t cell receptor ligand compositions and methods for treatment of prostate cancer |
WO2018006067A1 (en) * | 2016-07-01 | 2018-01-04 | Loma Linda University | Myelin oligodendrocyte glycoprotein-specific peptide for the treatment or prevention of multiple sclerosis |
WO2020037046A1 (en) * | 2018-08-14 | 2020-02-20 | Board Of Regents, The University Of Texas System | Single molecule sequencing peptides bound to the major histocompatibility complex |
WO2020072992A1 (en) * | 2018-10-05 | 2020-04-09 | Oregon Health & Science University | Recombinant polypeptides comprising modified mhc class ii drα1 domains and methods of use |
EP4069722A1 (en) * | 2019-12-02 | 2022-10-12 | Regeneron Pharmaceuticals, Inc. | Peptide-mhc ii protein constructs and uses thereof |
DE102020109447A1 (de) * | 2020-04-03 | 2021-10-07 | Jacobs University Bremen Ggmbh | Synthetisches mhc-klasse-ii-protein |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5468481A (en) | 1988-06-23 | 1995-11-21 | Amergen, Inc. | MHC class II-peptide conjugates useful in ameliorating autoimmunity |
JP3603374B2 (ja) * | 1995-04-14 | 2004-12-22 | 東レ株式会社 | 融合蛋白質およびその融合蛋白質を固定化した材料 |
NZ333915A (en) * | 1996-08-16 | 2000-11-24 | Harvard College | Soluble monovalent and multivalent MHC class II fusion proteins |
PT1017721E (pt) * | 1997-09-16 | 2009-05-07 | Univ Oregon Health & Science | Moléculas de mhc recombinantes úteis para manipulação de células t específicas do antigénio |
US20030007978A1 (en) | 1997-09-16 | 2003-01-09 | Burrows Gregory G. | Recombinant MHC molecules useful for manipulation of antigen-specific T-cells |
US6232445B1 (en) * | 1997-10-29 | 2001-05-15 | Sunol Molecular Corporation | Soluble MHC complexes and methods of use thereof |
AU765378B2 (en) * | 1998-02-19 | 2003-09-18 | President And Fellows Of Harvard College | Monovalent, multivalent, and multimeric MHC binding domain fusion proteins and conjugates, and uses therefor |
WO2005044982A2 (en) * | 2003-09-05 | 2005-05-19 | Oregon Health & Science University | Monomeric recombinant mhc molecules useful for manipulation of antigen-specific t cells |
US7576183B2 (en) * | 2003-12-24 | 2009-08-18 | Los Alamos National Security, Llc | Structure-based receptor MIMICS targeted against bacterial superantigen toxins |
EP1877440A4 (en) | 2005-03-18 | 2009-07-29 | Univ Oregon Health & Science | RECOMBINANT MHC MOLECULES FOR USE IN THE MANIPULATION OF ANTIGEN-SPECIFIC T CELLS |
US8491913B2 (en) | 2009-03-07 | 2013-07-23 | Oregon Health & Science University | Compositions and methods using recombinant MHC molecules for the treatment of stroke |
US20110008382A1 (en) | 2009-03-07 | 2011-01-13 | Burrows Gregory G | Compositions and methods using recombinant MHC molecules for the treatment of uveitis |
-
2013
- 2013-01-04 RU RU2014132426A patent/RU2014132426A/ru not_active Application Discontinuation
- 2013-01-04 AU AU2013207489A patent/AU2013207489A1/en not_active Abandoned
- 2013-01-04 KR KR1020147021913A patent/KR20140114859A/ko active Search and Examination
- 2013-01-04 JP JP2014551338A patent/JP6364352B2/ja not_active Expired - Fee Related
- 2013-01-04 EP EP13700425.5A patent/EP2800582A1/en not_active Withdrawn
- 2013-01-04 CA CA2860678A patent/CA2860678A1/en not_active Abandoned
- 2013-01-04 CN CN201380004958.1A patent/CN104105503A/zh active Pending
- 2013-01-04 WO PCT/US2013/020287 patent/WO2013103816A1/en active Application Filing
- 2013-01-04 BR BR112014016652A patent/BR112014016652A2/pt not_active IP Right Cessation
- 2013-01-04 MX MX2014008146A patent/MX2014008146A/es unknown
- 2013-01-04 US US14/370,454 patent/US20150044245A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2860678A1 (en) | 2013-07-11 |
EP2800582A1 (en) | 2014-11-12 |
WO2013103816A8 (en) | 2014-06-26 |
BR112014016652A2 (pt) | 2019-09-24 |
AU2013207489A8 (en) | 2014-09-18 |
KR20140114859A (ko) | 2014-09-29 |
RU2014132426A (ru) | 2016-02-27 |
US20150044245A1 (en) | 2015-02-12 |
CN104105503A (zh) | 2014-10-15 |
JP6364352B2 (ja) | 2018-07-25 |
AU2013207489A1 (en) | 2014-08-28 |
JP2015505315A (ja) | 2015-02-19 |
WO2013103816A1 (en) | 2013-07-11 |
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