JP6359563B2 - ３−（５置換−４−オキソキナゾリン−３（４ｈ）−イル）−３−ジュウテロピペリジン−２，６−ジオン誘導体 - Google Patents

３−（５置換−４−オキソキナゾリン−３（４ｈ）−イル）−３−ジュウテロピペリジン−２，６−ジオン誘導体 Download PDF

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JP6359563B2
JP6359563B2 JP2015552887A JP2015552887A JP6359563B2 JP 6359563 B2 JP6359563 B2 JP 6359563B2 JP 2015552887 A JP2015552887 A JP 2015552887A JP 2015552887 A JP2015552887 A JP 2015552887A JP 6359563 B2 JP6359563 B2 JP 6359563B2
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deuterium
compound
disease
pharmaceutically acceptable
phenyl
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JP2016505019A (ja
JP2016505019A5 (OSRAM
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シイラ・デウィット
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DeuteRx LLC
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DeuteRx LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Diabetes (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2015552887A 2013-01-14 2014-01-14 ３−（５置換−４−オキソキナゾリン−３（４ｈ）−イル）−３−ジュウテロピペリジン−２，６−ジオン誘導体 Active JP6359563B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361752055P 2013-01-14 2013-01-14
US61/752,055 2013-01-14
US201361786024P 2013-03-14 2013-03-14
US61/786,024 2013-03-14
PCT/US2014/011440 WO2014110558A1 (en) 2013-01-14 2014-01-14 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives

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JP2018116936A Division JP6749364B2 (ja) 2013-01-14 2018-06-20 ３−（５置換−４−オキソキナゾリン−３（４ｈ）−イル）−３−ジュウテロピペリジン−２，６−ジオン誘導体

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JP2016505019A JP2016505019A (ja) 2016-02-18
JP2016505019A5 JP2016505019A5 (OSRAM) 2017-02-16
JP6359563B2 true JP6359563B2 (ja) 2018-07-18

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JP2015552887A Active JP6359563B2 (ja) 2013-01-14 2014-01-14 ３−（５置換−４−オキソキナゾリン−３（４ｈ）−イル）−３−ジュウテロピペリジン−２，６−ジオン誘導体
JP2018116936A Active JP6749364B2 (ja) 2013-01-14 2018-06-20 ３−（５置換−４−オキソキナゾリン−３（４ｈ）−イル）−３−ジュウテロピペリジン−２，６−ジオン誘導体

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US (4) US9540340B2 (OSRAM)
EP (1) EP2943201B2 (OSRAM)
JP (2) JP6359563B2 (OSRAM)
AU (1) AU2014205043B2 (OSRAM)
CA (1) CA2935495C (OSRAM)
WO (1) WO2014110558A1 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
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JP2018162279A (ja) * 2013-01-14 2018-10-18 デュートルクス・リミテッド・ライアビリティ・カンパニーＤｅｕｔｅＲｘ， ＬＬＣ ３−（５置換−４−オキソキナゾリン−３（４ｈ）−イル）−３−ジュウテロピペリジン−２，６−ジオン誘導体

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WO2014116573A1 (en) 2013-01-22 2014-07-31 Celgene Corporation Processes for the preparation of isotopologues of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof
EP2968334A4 (en) 2013-03-14 2016-08-03 Deuterx Llc 3- (SUBSTITIERTES-4-OXO-quinazolin-3 (4H) -yl) -3-deutero-PIPERIDINE-2,6-DIONE DERIVATIVES
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BR112017028530A2 (pt) 2015-07-02 2018-08-28 Celgene Corp terapia combinada para tratamento de cânceres hematológicos e tumores sólidos
US9809603B1 (en) 2015-08-18 2017-11-07 Deuterx, Llc Deuterium-enriched isoindolinonyl-piperidinonyl conjugates and oxoquinazolin-3(4H)-yl-piperidinonyl conjugates and methods of treating medical disorders using same
RU2730500C2 (ru) 2016-01-14 2020-08-24 Канпу Биофармасьютикалз, Лтд Производное хиназолинона, способ его получения, фармацевтическая композиция и применения
KR102368555B1 (ko) 2016-12-16 2022-02-28 강푸 바이오파마슈티칼즈 리미티드 조성물, 이의 적용 및 치료 방법
KR102014478B1 (ko) 2017-05-12 2019-08-26 한국화학연구원 신규한 피페리딘-2,6-디온 유도체 및 이의 용도
WO2018208123A1 (ko) * 2017-05-12 2018-11-15 한국화학연구원 신규한 피페리딘-2,6-디온 유도체 및 이의 용도
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US11807620B2 (en) 2020-02-21 2023-11-07 Plexium, Inc. Quinazolinone compounds and related compounds
JP2023535453A (ja) * 2020-07-24 2023-08-17 イニファーム，インク． キナゾリノンｈｓｄ１７ｂ１３阻害剤とその使用
WO2022103960A1 (en) 2020-11-13 2022-05-19 Inipharm, Inc. Dichlorophenol hsd17b13 inhibitors and uses thereof
WO2024108028A1 (en) 2022-11-16 2024-05-23 Salarius Pharmaceuticals, Inc. Methods of use of deuterium-enriched compounds
WO2024148164A1 (en) * 2023-01-06 2024-07-11 Salarius Pharmaceuticals, Inc Solid forms and methods of use
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