JP6352905B2 - コエンザイムｑ１０を用いた固形腫瘍の治療 - Google Patents

コエンザイムｑ１０を用いた固形腫瘍の治療 Download PDF

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JP6352905B2
JP6352905B2 JP2015515272A JP2015515272A JP6352905B2 JP 6352905 B2 JP6352905 B2 JP 6352905B2 JP 2015515272 A JP2015515272 A JP 2015515272A JP 2015515272 A JP2015515272 A JP 2015515272A JP 6352905 B2 JP6352905 B2 JP 6352905B2
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cancer
dose
coq10
pharmaceutical composition
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JP2015518056A5 (enExample
JP2015518056A (ja
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ナレイン，ニーブン，ラジン
マクック，ジョン，パトリック
ソン，ポール，ワイ．
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バーグ エルエルシー
バーグ エルエルシー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2015515272A 2012-06-01 2013-05-31 コエンザイムｑ１０を用いた固形腫瘍の治療 Active JP6352905B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261654245P 2012-06-01 2012-06-01
US61/654,245 2012-06-01
PCT/US2013/043785 WO2013181639A1 (en) 2012-06-01 2013-05-31 Treatment of solid tumors using coenzyme q10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018109093A Division JP2018168164A (ja) 2012-06-01 2018-06-07 コエンザイムｑ１０を用いた固形腫瘍の治療

Publications (3)

Publication Number Publication Date
JP2015518056A JP2015518056A (ja) 2015-06-25
JP2015518056A5 JP2015518056A5 (enExample) 2016-07-21
JP6352905B2 true JP6352905B2 (ja) 2018-07-04

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Family Applications (3)

Application Number Title Priority Date Filing Date
JP2015515272A Active JP6352905B2 (ja) 2012-06-01 2013-05-31 コエンザイムｑ１０を用いた固形腫瘍の治療
JP2018109093A Withdrawn JP2018168164A (ja) 2012-06-01 2018-06-07 コエンザイムｑ１０を用いた固形腫瘍の治療
JP2020127877A Active JP7225167B2 (ja) 2012-06-01 2020-07-29 コエンザイムｑ１０を用いた固形腫瘍の治療

Family Applications After (2)

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JP2018109093A Withdrawn JP2018168164A (ja) 2012-06-01 2018-06-07 コエンザイムｑ１０を用いた固形腫瘍の治療
JP2020127877A Active JP7225167B2 (ja) 2012-06-01 2020-07-29 コエンザイムｑ１０を用いた固形腫瘍の治療

Country Status (16)

Country Link
US (3) US20140017317A1 (enExample)
EP (1) EP2854528B8 (enExample)
JP (3) JP6352905B2 (enExample)
KR (2) KR20200118233A (enExample)
CN (1) CN104507308A (enExample)
AU (2) AU2013267166A1 (enExample)
BR (1) BR112014029954A2 (enExample)
CA (2) CA2875150C (enExample)
EA (1) EA032345B1 (enExample)
ES (1) ES2761449T3 (enExample)
IL (1) IL236008B (enExample)
IN (1) IN2014DN10734A (enExample)
MX (2) MX369768B (enExample)
NZ (1) NZ702369A (enExample)
SG (1) SG11201407880QA (enExample)
WO (1) WO2013181639A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018168164A (ja) * 2012-06-01 2018-11-01 バーグ エルエルシー コエンザイムｑ１０を用いた固形腫瘍の治療

Families Citing this family (11)

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EP2429511B1 (en) 2009-05-11 2019-02-20 Berg LLC Methods for treatment of oncological disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
WO2012138765A1 (en) 2011-04-04 2012-10-11 Berg Pharma Llc Methods of treating central nervous system tumors
US10933032B2 (en) * 2013-04-08 2021-03-02 Berg Llc Methods for the treatment of cancer using coenzyme Q10 combination therapies
CN121197124A (zh) 2013-09-04 2025-12-26 博格有限责任公司 通过持续输注辅酶q10来治疗癌症的方法
US9996463B2 (en) * 2015-11-10 2018-06-12 International Business Machines Corporation Selection and placement of volumes in a storage system using stripes
US20170189350A1 (en) 2015-11-16 2017-07-06 Berg Llc Methods of treatment of temozolomide-resistant glioma using coenzyme q10
US20170255565A1 (en) * 2016-03-02 2017-09-07 Intel Corporation Method and apparatus for providing a contiguously addressable memory region by remapping an address space
WO2018005412A1 (en) * 2016-06-28 2018-01-04 Tien Yang Der Chemoprotective/chemoactive nanodroplets and methods of use thereof
CA3063916A1 (en) * 2017-05-17 2018-11-22 Berg Llc Use of coenzyme q10 formulations in the treatment and prevention of epidermolysis bullosa
AU2022400186A1 (en) * 2021-12-01 2024-06-20 Gambro Lundia Ab New dialysis fluid
WO2025087731A1 (en) * 2023-10-24 2025-05-01 Gambro Lundia Ab Compositions comprising insulin and ketones bodies to treat cancer

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US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US20070104688A1 (en) 2003-02-13 2007-05-10 City Of Hope Small interfering RNA mediated transcriptional gene silencing in mammalian cells
WO2005048925A2 (en) * 2003-11-14 2005-06-02 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating a neoplastic disease in a subject using inorganic selenium-containing compounds
EP2371363B1 (en) * 2004-01-22 2020-04-08 University of Miami Coenzyme Q10 formulations for use in the treatment of solid tumours
WO2008069276A1 (ja) * 2006-12-06 2008-06-12 Kaneka Corporation 癌治療剤および発癌抑制剤
US8454945B2 (en) 2007-03-22 2013-06-04 Berg Pharma Llc Topical formulations having enhanced bioavailability
AU2008321128A1 (en) * 2007-11-12 2009-05-22 Bipar Sciences, Inc. Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents
EP4074344A1 (en) 2007-12-04 2022-10-19 Arbutus Biopharma Corporation Targeting lipids
US8247435B2 (en) * 2009-02-19 2012-08-21 Thornthwaite Jerry T Formulations for treating human and animal diseases
EP2429511B1 (en) 2009-05-11 2019-02-20 Berg LLC Methods for treatment of oncological disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
GB0913193D0 (en) 2009-07-29 2009-09-02 Johnson Matthey Plc Deoxygenation process
EP3366280A1 (en) * 2010-03-12 2018-08-29 Berg LLC Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof
MX369543B (es) 2011-06-17 2019-11-12 Berg Llc Composiciones farmaceuticas inhalables.
NZ702369A (en) * 2012-06-01 2016-12-23 Berg Llc Treatment of solid tumors using coenzyme q10

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018168164A (ja) * 2012-06-01 2018-11-01 バーグ エルエルシー コエンザイムｑ１０を用いた固形腫瘍の治療
JP2020183440A (ja) * 2012-06-01 2020-11-12 バーグ エルエルシー コエンザイムｑ１０を用いた固形腫瘍の治療
JP7225167B2 (ja) 2012-06-01 2023-02-20 バーグ エルエルシー コエンザイムｑ１０を用いた固形腫瘍の治療

Also Published As

Publication number Publication date
MX2014014492A (es) 2015-05-12
MX2019013776A (es) 2020-01-30
BR112014029954A2 (pt) 2017-06-27
MX369768B (es) 2019-11-21
IL236008A0 (en) 2015-02-01
IL236008B (en) 2018-08-30
EA032345B1 (ru) 2019-05-31
CA2875150C (en) 2020-10-27
AU2017202567A1 (en) 2017-05-11
CA3090268A1 (en) 2013-12-05
KR20150022932A (ko) 2015-03-04
EP2854528B8 (en) 2019-10-23
EP2854528B1 (en) 2019-09-18
KR20200118233A (ko) 2020-10-14
IN2014DN10734A (enExample) 2015-09-04
US20140017317A1 (en) 2014-01-16
JP2020183440A (ja) 2020-11-12
WO2013181639A8 (en) 2014-12-31
SG11201407880QA (en) 2014-12-30
US20170216223A1 (en) 2017-08-03
EP2854528A4 (en) 2016-03-09
CA2875150A1 (en) 2013-12-05
EA201492187A1 (ru) 2015-05-29
WO2013181639A1 (en) 2013-12-05
JP7225167B2 (ja) 2023-02-20
JP2015518056A (ja) 2015-06-25
HK1208995A1 (en) 2016-03-24
KR102163948B1 (ko) 2020-10-12
NZ702369A (en) 2016-12-23
ES2761449T3 (es) 2020-05-19
JP2018168164A (ja) 2018-11-01
AU2013267166A1 (en) 2014-12-18
US20220096399A1 (en) 2022-03-31
CN104507308A (zh) 2015-04-08
EP2854528A1 (en) 2015-04-08
AU2017202567B2 (en) 2019-06-13

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