AU2013267166A1 - Treatment of solid tumors using Coenzyme Q10 - Google Patents

Treatment of solid tumors using Coenzyme Q10 Download PDF

Info

Publication number
AU2013267166A1
AU2013267166A1 AU2013267166A AU2013267166A AU2013267166A1 AU 2013267166 A1 AU2013267166 A1 AU 2013267166A1 AU 2013267166 A AU2013267166 A AU 2013267166A AU 2013267166 A AU2013267166 A AU 2013267166A AU 2013267166 A1 AU2013267166 A1 AU 2013267166A1
Authority
AU
Australia
Prior art keywords
dose
cancer
coq1o
compound
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2013267166A
Other languages
English (en)
Inventor
John Patrick Mccook
Niven Rajin Narain
Paul Y. Song
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BERG LLC
Original Assignee
BERG LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BERG LLC filed Critical BERG LLC
Publication of AU2013267166A1 publication Critical patent/AU2013267166A1/en
Priority to AU2017202567A priority Critical patent/AU2017202567B2/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • A61K31/122Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AU2013267166A 2012-06-01 2013-05-31 Treatment of solid tumors using Coenzyme Q10 Abandoned AU2013267166A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2017202567A AU2017202567B2 (en) 2012-06-01 2017-04-19 Treatment of solid tumors using Coenzyme Q10

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261654245P 2012-06-01 2012-06-01
US61/654,245 2012-06-01
PCT/US2013/043785 WO2013181639A1 (en) 2012-06-01 2013-05-31 Treatment of solid tumors using coenzyme q10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017202567A Division AU2017202567B2 (en) 2012-06-01 2017-04-19 Treatment of solid tumors using Coenzyme Q10

Publications (1)

Publication Number Publication Date
AU2013267166A1 true AU2013267166A1 (en) 2014-12-18

Family

ID=49673946

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2013267166A Abandoned AU2013267166A1 (en) 2012-06-01 2013-05-31 Treatment of solid tumors using Coenzyme Q10
AU2017202567A Ceased AU2017202567B2 (en) 2012-06-01 2017-04-19 Treatment of solid tumors using Coenzyme Q10

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2017202567A Ceased AU2017202567B2 (en) 2012-06-01 2017-04-19 Treatment of solid tumors using Coenzyme Q10

Country Status (16)

Country Link
US (3) US20140017317A1 (enExample)
EP (1) EP2854528B8 (enExample)
JP (3) JP6352905B2 (enExample)
KR (2) KR20200118233A (enExample)
CN (1) CN104507308A (enExample)
AU (2) AU2013267166A1 (enExample)
BR (1) BR112014029954A2 (enExample)
CA (2) CA3090268A1 (enExample)
EA (1) EA032345B1 (enExample)
ES (1) ES2761449T3 (enExample)
IL (1) IL236008B (enExample)
IN (1) IN2014DN10734A (enExample)
MX (2) MX369768B (enExample)
NZ (1) NZ702369A (enExample)
SG (1) SG11201407880QA (enExample)
WO (1) WO2013181639A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG175993A1 (en) 2009-05-11 2011-12-29 Berg Biosystems Llc Methods for treatment of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
JP6092844B2 (ja) 2011-04-04 2017-03-08 バーグ エルエルシー 中枢神経系腫瘍の治療方法
BR112014029954A2 (pt) * 2012-06-01 2017-06-27 Berg Llc tratamento de tumores sólidos usando coenzima q10
MX380565B (es) * 2013-04-08 2025-03-12 Berg Llc Terapias combinadas de coenzima q10 para el tratamiento de cáncer.
CN105705162A (zh) 2013-09-04 2016-06-22 博格有限责任公司 通过持续输注辅酶q10来治疗癌症的方法
US9996463B2 (en) * 2015-11-10 2018-06-12 International Business Machines Corporation Selection and placement of volumes in a storage system using stripes
US20170189350A1 (en) 2015-11-16 2017-07-06 Berg Llc Methods of treatment of temozolomide-resistant glioma using coenzyme q10
US20170255565A1 (en) * 2016-03-02 2017-09-07 Intel Corporation Method and apparatus for providing a contiguously addressable memory region by remapping an address space
WO2018005412A1 (en) * 2016-06-28 2018-01-04 Tien Yang Der Chemoprotective/chemoactive nanodroplets and methods of use thereof
CN110769818A (zh) * 2017-05-17 2020-02-07 博格有限责任公司 辅酶q10制剂在治疗和预防大疱性表皮松解症中的用途
AU2022400186A1 (en) * 2021-12-01 2024-06-20 Gambro Lundia Ab New dialysis fluid
WO2025087731A1 (en) * 2023-10-24 2025-05-01 Gambro Lundia Ab Compositions comprising insulin and ketones bodies to treat cancer

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US20070104688A1 (en) 2003-02-13 2007-05-10 City Of Hope Small interfering RNA mediated transcriptional gene silencing in mammalian cells
US8932649B2 (en) * 2003-11-14 2015-01-13 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating a neoplastic disease in a subject using inorganic selenium-containing compounds
RS52792B (sr) * 2004-01-22 2013-10-31 University Of Miami Topijske formulacije koenzima q10 i postupci upotrebe
US20080138326A1 (en) * 2006-12-06 2008-06-12 Kaneka Corporation Method for cancer treatment, carcinogenesis suppression or mitigation of adverse reactions of anticancer agents
EP2136787B1 (en) 2007-03-22 2019-08-21 Berg LLC Topical formulations having enhanced bioavailability
US7732491B2 (en) * 2007-11-12 2010-06-08 Bipar Sciences, Inc. Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents
CA2910760C (en) 2007-12-04 2019-07-09 Muthiah Manoharan Targeting lipids
US8247435B2 (en) * 2009-02-19 2012-08-21 Thornthwaite Jerry T Formulations for treating human and animal diseases
SG175993A1 (en) * 2009-05-11 2011-12-29 Berg Biosystems Llc Methods for treatment of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
GB0913193D0 (en) 2009-07-29 2009-09-02 Johnson Matthey Plc Deoxygenation process
CN105168135A (zh) 2010-03-12 2015-12-23 博格有限责任公司 辅酶Q10(CoQ10)的静脉内制剂及其使用方法
MX351781B (es) 2011-06-17 2017-10-30 Berg Llc Composiciones farmaceuticas inhalables.
BR112014029954A2 (pt) 2012-06-01 2017-06-27 Berg Llc tratamento de tumores sólidos usando coenzima q10

Also Published As

Publication number Publication date
AU2017202567A1 (en) 2017-05-11
IL236008A0 (en) 2015-02-01
MX2014014492A (es) 2015-05-12
JP2018168164A (ja) 2018-11-01
EP2854528A4 (en) 2016-03-09
EP2854528B1 (en) 2019-09-18
WO2013181639A1 (en) 2013-12-05
CN104507308A (zh) 2015-04-08
JP2015518056A (ja) 2015-06-25
US20220096399A1 (en) 2022-03-31
EA032345B1 (ru) 2019-05-31
US20170216223A1 (en) 2017-08-03
IL236008B (en) 2018-08-30
US20140017317A1 (en) 2014-01-16
NZ702369A (en) 2016-12-23
WO2013181639A8 (en) 2014-12-31
HK1208995A1 (en) 2016-03-24
MX369768B (es) 2019-11-21
IN2014DN10734A (enExample) 2015-09-04
JP6352905B2 (ja) 2018-07-04
EP2854528A1 (en) 2015-04-08
KR20200118233A (ko) 2020-10-14
ES2761449T3 (es) 2020-05-19
CA2875150A1 (en) 2013-12-05
MX2019013776A (es) 2020-01-30
EA201492187A1 (ru) 2015-05-29
EP2854528B8 (en) 2019-10-23
KR102163948B1 (ko) 2020-10-12
CA2875150C (en) 2020-10-27
KR20150022932A (ko) 2015-03-04
BR112014029954A2 (pt) 2017-06-27
JP7225167B2 (ja) 2023-02-20
AU2017202567B2 (en) 2019-06-13
JP2020183440A (ja) 2020-11-12
CA3090268A1 (en) 2013-12-05
SG11201407880QA (en) 2014-12-30

Similar Documents

Publication Publication Date Title
US20220096399A1 (en) Methods of treatment of solid tumors using coenzyme q10
US20210369645A1 (en) Methods for the treatment of cancer using coenzyme q10 combination therapies
US11452699B2 (en) Method of treating or preventing tumors of the central nervous system
US20200330400A1 (en) Methods for the treatment of cancer using coenzyme q10 and fatty acid metabolism inhibitors
HK1208995B (en) Treatment of solid tumors using coenzyme q10

Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted