ES2761449T3 - Métodos de tratamiento de tumores sólidos que usan coenzima Q10 - Google Patents
Métodos de tratamiento de tumores sólidos que usan coenzima Q10 Download PDFInfo
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| CN121197124A (zh) | 2013-09-04 | 2025-12-26 | 博格有限责任公司 | 通过持续输注辅酶q10来治疗癌症的方法 |
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| WO2018005412A1 (en) * | 2016-06-28 | 2018-01-04 | Tien Yang Der | Chemoprotective/chemoactive nanodroplets and methods of use thereof |
| CA3063916A1 (en) * | 2017-05-17 | 2018-11-22 | Berg Llc | Use of coenzyme q10 formulations in the treatment and prevention of epidermolysis bullosa |
| AU2022400186A1 (en) * | 2021-12-01 | 2024-06-20 | Gambro Lundia Ab | New dialysis fluid |
| WO2025087731A1 (en) * | 2023-10-24 | 2025-05-01 | Gambro Lundia Ab | Compositions comprising insulin and ketones bodies to treat cancer |
Family Cites Families (14)
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| EP2371363B1 (en) * | 2004-01-22 | 2020-04-08 | University of Miami | Coenzyme Q10 formulations for use in the treatment of solid tumours |
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| US8454945B2 (en) | 2007-03-22 | 2013-06-04 | Berg Pharma Llc | Topical formulations having enhanced bioavailability |
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| US8247435B2 (en) * | 2009-02-19 | 2012-08-21 | Thornthwaite Jerry T | Formulations for treating human and animal diseases |
| EP2429511B1 (en) | 2009-05-11 | 2019-02-20 | Berg LLC | Methods for treatment of oncological disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers |
| GB0913193D0 (en) | 2009-07-29 | 2009-09-02 | Johnson Matthey Plc | Deoxygenation process |
| EP3366280A1 (en) * | 2010-03-12 | 2018-08-29 | Berg LLC | Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof |
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