EA032345B1 - Способ лечения рака с использованием кофермента q10 - Google Patents

Способ лечения рака с использованием кофермента q10 Download PDF

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Publication number
EA032345B1
EA032345B1 EA201492187A EA201492187A EA032345B1 EA 032345 B1 EA032345 B1 EA 032345B1 EA 201492187 A EA201492187 A EA 201492187A EA 201492187 A EA201492187 A EA 201492187A EA 032345 B1 EA032345 B1 EA 032345B1
Authority
EA
Eurasian Patent Office
Prior art keywords
cancer
per dose
dose
administered
cop10
Prior art date
Application number
EA201492187A
Other languages
English (en)
Russian (ru)
Other versions
EA201492187A1 (ru
Inventor
Найвен Раджин Нарайн
Джон Патрик Маккук
Пол И. Сонг
Original Assignee
Берг Ллк
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Берг Ллк filed Critical Берг Ллк
Publication of EA201492187A1 publication Critical patent/EA201492187A1/ru
Publication of EA032345B1 publication Critical patent/EA032345B1/ru

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • A61K31/122Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
EA201492187A 2012-06-01 2013-05-31 Способ лечения рака с использованием кофермента q10 EA032345B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261654245P 2012-06-01 2012-06-01
PCT/US2013/043785 WO2013181639A1 (en) 2012-06-01 2013-05-31 Treatment of solid tumors using coenzyme q10

Publications (2)

Publication Number Publication Date
EA201492187A1 EA201492187A1 (ru) 2015-05-29
EA032345B1 true EA032345B1 (ru) 2019-05-31

Family

ID=49673946

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201492187A EA032345B1 (ru) 2012-06-01 2013-05-31 Способ лечения рака с использованием кофермента q10

Country Status (16)

Country Link
US (3) US20140017317A1 (enExample)
EP (1) EP2854528B8 (enExample)
JP (3) JP6352905B2 (enExample)
KR (2) KR20200118233A (enExample)
CN (1) CN104507308A (enExample)
AU (2) AU2013267166A1 (enExample)
BR (1) BR112014029954A2 (enExample)
CA (2) CA2875150C (enExample)
EA (1) EA032345B1 (enExample)
ES (1) ES2761449T3 (enExample)
IL (1) IL236008B (enExample)
IN (1) IN2014DN10734A (enExample)
MX (2) MX369768B (enExample)
NZ (1) NZ702369A (enExample)
SG (1) SG11201407880QA (enExample)
WO (1) WO2013181639A1 (enExample)

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Publication number Priority date Publication date Assignee Title
EP2429511B1 (en) 2009-05-11 2019-02-20 Berg LLC Methods for treatment of oncological disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
WO2012138765A1 (en) 2011-04-04 2012-10-11 Berg Pharma Llc Methods of treating central nervous system tumors
NZ702369A (en) * 2012-06-01 2016-12-23 Berg Llc Treatment of solid tumors using coenzyme q10
US10933032B2 (en) * 2013-04-08 2021-03-02 Berg Llc Methods for the treatment of cancer using coenzyme Q10 combination therapies
CN121197124A (zh) 2013-09-04 2025-12-26 博格有限责任公司 通过持续输注辅酶q10来治疗癌症的方法
US9996463B2 (en) * 2015-11-10 2018-06-12 International Business Machines Corporation Selection and placement of volumes in a storage system using stripes
US20170189350A1 (en) 2015-11-16 2017-07-06 Berg Llc Methods of treatment of temozolomide-resistant glioma using coenzyme q10
US20170255565A1 (en) * 2016-03-02 2017-09-07 Intel Corporation Method and apparatus for providing a contiguously addressable memory region by remapping an address space
WO2018005412A1 (en) * 2016-06-28 2018-01-04 Tien Yang Der Chemoprotective/chemoactive nanodroplets and methods of use thereof
CA3063916A1 (en) * 2017-05-17 2018-11-22 Berg Llc Use of coenzyme q10 formulations in the treatment and prevention of epidermolysis bullosa
AU2022400186A1 (en) * 2021-12-01 2024-06-20 Gambro Lundia Ab New dialysis fluid
WO2025087731A1 (en) * 2023-10-24 2025-05-01 Gambro Lundia Ab Compositions comprising insulin and ketones bodies to treat cancer

Citations (3)

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US20100003192A1 (en) * 2007-11-12 2010-01-07 Bipar Sciences, Inc. Treatment of breast cancer with a parp inhibitor alone or in combination with anti-tumor agents
US20110027247A1 (en) * 2009-05-11 2011-02-03 Niven Rajin Narain Methods for treatment of oncological disorders using an epimetabolic shifter (coenzyme q10)
US8147825B2 (en) * 2004-01-22 2012-04-03 University Of Miami Topical co-enzyme Q10 formulations and methods of use

Family Cites Families (11)

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US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US20070104688A1 (en) 2003-02-13 2007-05-10 City Of Hope Small interfering RNA mediated transcriptional gene silencing in mammalian cells
WO2005048925A2 (en) * 2003-11-14 2005-06-02 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating a neoplastic disease in a subject using inorganic selenium-containing compounds
WO2008069276A1 (ja) * 2006-12-06 2008-06-12 Kaneka Corporation 癌治療剤および発癌抑制剤
US8454945B2 (en) 2007-03-22 2013-06-04 Berg Pharma Llc Topical formulations having enhanced bioavailability
EP4074344A1 (en) 2007-12-04 2022-10-19 Arbutus Biopharma Corporation Targeting lipids
US8247435B2 (en) * 2009-02-19 2012-08-21 Thornthwaite Jerry T Formulations for treating human and animal diseases
GB0913193D0 (en) 2009-07-29 2009-09-02 Johnson Matthey Plc Deoxygenation process
EP3366280A1 (en) * 2010-03-12 2018-08-29 Berg LLC Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof
MX369543B (es) 2011-06-17 2019-11-12 Berg Llc Composiciones farmaceuticas inhalables.
NZ702369A (en) * 2012-06-01 2016-12-23 Berg Llc Treatment of solid tumors using coenzyme q10

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8147825B2 (en) * 2004-01-22 2012-04-03 University Of Miami Topical co-enzyme Q10 formulations and methods of use
US20100003192A1 (en) * 2007-11-12 2010-01-07 Bipar Sciences, Inc. Treatment of breast cancer with a parp inhibitor alone or in combination with anti-tumor agents
US20110027247A1 (en) * 2009-05-11 2011-02-03 Niven Rajin Narain Methods for treatment of oncological disorders using an epimetabolic shifter (coenzyme q10)

Also Published As

Publication number Publication date
MX2014014492A (es) 2015-05-12
MX2019013776A (es) 2020-01-30
BR112014029954A2 (pt) 2017-06-27
MX369768B (es) 2019-11-21
IL236008A0 (en) 2015-02-01
IL236008B (en) 2018-08-30
CA2875150C (en) 2020-10-27
AU2017202567A1 (en) 2017-05-11
CA3090268A1 (en) 2013-12-05
KR20150022932A (ko) 2015-03-04
EP2854528B8 (en) 2019-10-23
EP2854528B1 (en) 2019-09-18
KR20200118233A (ko) 2020-10-14
IN2014DN10734A (enExample) 2015-09-04
US20140017317A1 (en) 2014-01-16
JP2020183440A (ja) 2020-11-12
WO2013181639A8 (en) 2014-12-31
SG11201407880QA (en) 2014-12-30
US20170216223A1 (en) 2017-08-03
EP2854528A4 (en) 2016-03-09
CA2875150A1 (en) 2013-12-05
EA201492187A1 (ru) 2015-05-29
WO2013181639A1 (en) 2013-12-05
JP7225167B2 (ja) 2023-02-20
JP2015518056A (ja) 2015-06-25
HK1208995A1 (en) 2016-03-24
KR102163948B1 (ko) 2020-10-12
NZ702369A (en) 2016-12-23
ES2761449T3 (es) 2020-05-19
JP2018168164A (ja) 2018-11-01
AU2013267166A1 (en) 2014-12-18
JP6352905B2 (ja) 2018-07-04
US20220096399A1 (en) 2022-03-31
CN104507308A (zh) 2015-04-08
EP2854528A1 (en) 2015-04-08
AU2017202567B2 (en) 2019-06-13

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